Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep (2012) 1.66

STRIPAK components determine mode of cancer cell migration and metastasis. Nat Cell Biol (2014) 1.59

Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J Cardiovasc Pharmacol (2013) 1.24

Genetic and epigenetic events generate multiple pathways in colorectal cancer progression. Patholog Res Int (2012) 1.24

Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol (2011) 1.18

Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease. Trends Pharmacol Sci (2011) 1.17

MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis. EMBO J (2011) 1.17

Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension. J Cell Biol (2014) 1.16

Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II. Biomaterials (2015) 1.15

Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding. J Cell Biol (2013) 1.14

The secret life of kinases: functions beyond catalysis. Cell Commun Signal (2011) 1.13

Modulation of tight junction structure and function by kinases and phosphatases targeting occludin. J Biomed Biotechnol (2012) 1.12

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment. Cell Death Dis (2013) 1.08

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun (2013) 1.08

Artificial three-dimensional niches deconstruct pancreas development in vitro. Development (2013) 1.04

Mechanical cell competition kills cells via induction of lethal p53 levels. Nat Commun (2016) 1.02

Regulation of ROCK activity in cancer. J Histochem Cytochem (2012) 1.01

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts. Inflamm Bowel Dis (2014) 1.00

ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. Mol Biol Cell (2011) 0.97

Fgfr-Ras-MAPK signaling is required for apical constriction via apical positioning of Rho-associated kinase during mechanosensory organ formation. Development (2012) 0.96

Translating cell polarity into tissue elongation. Semin Cell Dev Biol (2011) 0.95

Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev Biol (2014) 0.95

Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. PLoS One (2012) 0.93

Low intensity pulsed ultrasound (LIPUS) influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathway. J Biol Chem (2014) 0.93

Keratin 8/18 regulation of cell stiffness-extracellular matrix interplay through modulation of Rho-mediated actin cytoskeleton dynamics. PLoS One (2012) 0.93

Rho-kinase in development and heart failure: insights from genetic models. Pediatr Cardiol (2011) 0.91

Epithelial junctions and Rho family GTPases: the zonular signalosome. Small GTPases (2014) 0.91

Rho/ROCK signaling in motility and metastasis of gastric cancer. World J Gastroenterol (2014) 0.90

The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. Mol Biol Cell (2012) 0.90

Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol Reprod (2013) 0.88

ROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium. Stem Cells Transl Med (2014) 0.88

Dynamic regulation of myosin light chain phosphorylation by Rho-kinase. PLoS One (2012) 0.87

Actin filament dynamics impacts keratinocyte stem cell maintenance. EMBO Mol Med (2013) 0.87

Dissecting the roles of ROCK isoforms in stress-induced cell detachment. Cell Cycle (2013) 0.87

Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK. Cell Mol Bioeng (2013) 0.87

The roles of the actin cytoskeleton in fear memory formation. Front Behav Neurosci (2011) 0.86

Formin-mediated actin polymerization cooperates with Mushroom body defect (Mud)-Dynein during Frizzled-Dishevelled spindle orientation. J Cell Sci (2013) 0.86

Molecular pathways: targeting the kinase effectors of RHO-family GTPases. Clin Cancer Res (2014) 0.86

Metastasis tumor-associated protein 2 enhances metastatic behavior and is associated with poor outcomes in estrogen receptor-negative breast cancer. Breast Cancer Res Treat (2013) 0.86

Drosophila egg chamber elongation: insights into how tissues and organs are shaped. Fly (Austin) (2012) 0.85

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells. BMC Cancer (2014) 0.85

Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2. Oncogene (2014) 0.85

Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease. Oxid Med Cell Longev (2012) 0.85

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling. Dis Model Mech (2013) 0.85

Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease. Biomed Res Int (2014) 0.84

Molecular signatures of amyotrophic lateral sclerosis disease progression in hind and forelimb muscles of an SOD1(G93A) mouse model. Antioxid Redox Signal (2012) 0.84

Interplay between cytoskeletal stresses and cell adaptation under chronic flow. PLoS One (2012) 0.84

Neuronal necrosis and spreading death in a Drosophila genetic model. Cell Death Dis (2013) 0.84

High calcium bioglass enhances differentiation and survival of endothelial progenitor cells, inducing early vascularization in critical size bone defects. PLoS One (2013) 0.84

Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells. PLoS One (2013) 0.84

Multimodal effects of small molecule ROCK and LIMK inhibitors on mitosis, and their implication as anti-leukemia agents. PLoS One (2014) 0.83

A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. Mol Cell Biol (2012) 0.82

Efficient expansion of human keratinocyte stem/progenitor cells carrying a transgene with lentiviral vector. Stem Cell Res Ther (2013) 0.82

Role of MTA2 in human cancer. Cancer Metastasis Rev (2014) 0.82

Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats. Int J Clin Exp Pathol (2015) 0.81

Kinase-interacting substrate screening is a novel method to identify kinase substrates. J Cell Biol (2015) 0.81

RhoA Kinase (Rock) and p90 Ribosomal S6 Kinase (p90Rsk) phosphorylation of the sodium hydrogen exchanger (NHE1) is required for lysophosphatidic acid-induced transport, cytoskeletal organization and migration. Cell Signal (2015) 0.81

Diacylglycerol kinase ζ regulates RhoA activation via a kinase-independent scaffolding mechanism. Mol Biol Cell (2012) 0.81

Inhibition of macrophage migration by C. botulinum exoenzyme C3. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.80

ROCK inhibition prevents early mouse embryo development. Histochem Cell Biol (2014) 0.80

RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol (2014) 0.80

Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure. Genome Med (2015) 0.80

Rho-associated protein kinase modulates neurite extension by regulating microtubule remodeling and vinculin distribution. Neural Regen Res (2013) 0.80

An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. Sci Rep (2014) 0.80

-Back-to-back mechanisms drive actomyosin ring closure during Drosophila embryo cleavage. J Cell Biol (2016) 0.79

The Fog signaling pathway: insights into signaling in morphogenesis. Dev Biol (2014) 0.79

Y-27632, a ROCK Inhibitor, Promoted Limbal Epithelial Cell Proliferation and Corneal Wound Healing. PLoS One (2015) 0.79

Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology (2016) 0.79

Rho family GTPases: making it to the third dimension. Int J Biochem Cell Biol (2014) 0.79

Targeted inhibition of the Shroom3-Rho kinase protein-protein interaction circumvents Nogo66 to promote axon outgrowth. BMC Neurosci (2015) 0.79

HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism. J Neurochem (2014) 0.79

SDF-1α and LPA modulate microglia potassium channels through rho gtpases to regulate cell morphology. Glia (2013) 0.78

Treatment with Y-27632, a ROCK Inhibitor, Increases the Proinvasive Nature of SW620 Cells on 3D Collagen Type 1 Matrix. Int J Cell Biol (2012) 0.78

Rho/ROCK-dependent inhibition of 3T3-L1 adipogenesis by G-protein-deamidating dermonecrotic toxins: differential regulation of Notch1, Pref1/Dlk1, and β-catenin signaling. Front Cell Infect Microbiol (2012) 0.78

TIMP-1 couples RhoK activation to IL-1β-induced astrocyte responses. Neurosci Lett (2015) 0.78

Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA. FEBS Lett (2011) 0.78

Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency. PLoS One (2013) 0.78

Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscle. J Appl Physiol (1985) (2013) 0.78

Mechanical interactions and crosstalk between corneal keratocytes and the extracellular matrix. Exp Eye Res (2015) 0.78

Nanonet Force Microscopy for Measuring Cell Forces. Biophys J (2016) 0.78

Dynamic myosin activation promotes collective morphology and migration by locally balancing oppositional forces from surrounding tissue. Mol Biol Cell (2016) 0.78

MURC deficiency in smooth muscle attenuates pulmonary hypertension. Nat Commun (2016) 0.78

Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. J Pediatr Gastroenterol Nutr (2016) 0.77

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation. Science (2017) 0.77

Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way. Exp Mol Med (2012) 0.77

Prognostic correlation between MTA2 expression level and colorectal cancer. Int J Clin Exp Pathol (2015) 0.77

ROCK1 as a novel prognostic marker in vulvar cancer. BMC Cancer (2014) 0.77

ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Mol Biol Cell (2016) 0.77

Transglutaminase 2--a novel inhibitor of adipogenesis. Cell Death Dis (2015) 0.77

Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway. PLoS One (2016) 0.77

The effect of simvastatin treatment on endothelial cell response to shear stress and tumor necrosis factor alpha stimulation. Biomed Eng Online (2015) 0.77

Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss. EMBO Mol Med (2016) 0.77

Vinculin Regulates Directionality and Cell Polarity in 2D, 3D Matrix and 3D Microtrack Migration. Mol Biol Cell (2016) 0.77

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart. J Clin Med (2017) 0.77

Cockroach allergen exposure and risk of asthma. Allergy (2016) 0.76

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Lett (2014) 0.76

Combover/CG10732, a novel PCP effector for Drosophila wing hair formation. PLoS One (2014) 0.76

Leptin activates RhoA/ROCK pathway to induce cytoskeleton remodeling in nucleus pulposus cells. Int J Mol Sci (2014) 0.76

All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2. PLoS One (2015) 0.76

Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression. Sci Signal (2013) 0.76

Rho GTPases in cell biology. Nature (2002) 22.81

Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol (2005) 16.77

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature (1997) 14.91

A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol (2007) 13.56

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem (1996) 10.51

Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol (1999) 8.66

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol (2003) 7.93

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science (1999) 7.12

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell (2003) 6.46

Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol (1999) 5.84

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science (1997) 5.80

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol (2001) 5.67

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol (1996) 5.41

Rho GTPases and the control of cell behaviour. Biochem Soc Trans (2005) 5.38

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol (1998) 5.15

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J (1996) 5.09

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol (2001) 4.74

Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem (1999) 4.53

Regulation of PTEN by Rho small GTPases. Nat Cell Biol (2005) 4.51

p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett (1997) 4.31

FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol (2006) 4.23

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J Biol Chem (1995) 4.03

RhoA is required for monocyte tail retraction during transendothelial migration. J Cell Biol (2001) 3.79

Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell (2001) 3.65

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett (1996) 3.46

Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol (2003) 3.31

Regulation of myosin II during cytokinesis in higher eukaryotes. Trends Cell Biol (2005) 3.28

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons. J Neurosci (2000) 3.21

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev (2009) 3.13

Regulation and functions of Rho-associated kinase. Exp Cell Res (2000) 3.11

Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J Cell Biol (2004) 3.03

Myosin phosphatase: structure, regulation and function. Mol Cell Biochem (2004) 3.02

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99

Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol (1998) 2.81

Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov (2005) 2.66

Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol (2002) 2.64

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol (2005) 2.50

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J (2007) 2.48

RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J Biol Chem (1999) 2.32

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol (2008) 2.27

Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17

The Rho kinases I and II regulate different aspects of myosin II activity. J Cell Biol (2005) 2.16

Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures. J Biol Chem (1998) 2.09

Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene (2000) 2.08

Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol (2003) 2.07

Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. J Biol Chem (1998) 2.04

Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem (2000) 2.00

Rho-kinase--mediated contraction of isolated stress fibers. J Cell Biol (2001) 1.92

Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol Biol Cell (2001) 1.88

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. J Cell Biol (2002) 1.86

Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J Cell Biol (1998) 1.85

Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science (2003) 1.77

A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron (2000) 1.76

The structure of dimeric ROCK I reveals the mechanism for ligand selectivity. J Biol Chem (2005) 1.76

Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse. J Biol Chem (2000) 1.73

Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73

Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J Immunol (2007) 1.73

Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells (1998) 1.71

Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J Cell Biol (1998) 1.69

ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo. Genes Cells (2005) 1.69

Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell (2008) 1.67

ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. Circ Res (2009) 1.61

Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment. J Cell Sci (2003) 1.58

Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. J Neurosci (2003) 1.58

Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis. Int J Biochem Cell Biol (2002) 1.58

Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56

The Rho-Rock-Myosin signaling axis determines cell-cell integrity of self-renewing pluripotent stem cells. PLoS One (2008) 1.52

Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading. Mol Biol Cell (1998) 1.44

Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett (2000) 1.44

Structural insights into the interaction of ROCKI with the switch regions of RhoA. J Biol Chem (2003) 1.44

Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol Sci (2007) 1.41

Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med (2005) 1.38

Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil. Structure (2006) 1.37

Regulatory mechanisms and functions of intermediate filaments: a study using site- and phosphorylation state-specific antibodies. Cancer Sci (2006) 1.35

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation. Mol Cell Biol (2008) 1.35

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. PLoS Med (2005) 1.32

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27

Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies. J Biol Chem (2002) 1.22

Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells. J Immunol (2008) 1.21

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity. Cell Mol Life Sci (2009) 1.20

Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Circ Res (2005) 1.14

Rho-kinase and myosin II activities are required for cell type and environment specific migration. Genes Cells (2005) 1.11

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin. Blood Coagul Fibrinolysis (2008) 1.11

Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem (2003) 1.10

Inhibition of Rho kinases enhances the degradation of mutant huntingtin. J Biol Chem (2009) 1.10

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. J Biol Chem (2006) 1.09

Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase. Genes Cells (2005) 1.07

Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. J Biol Chem (2006) 1.06

Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells. Biochem Biophys Res Commun (2007) 1.05

Identification of calponin as a novel substrate of Rho-kinase. Biochem Biophys Res Commun (2000) 1.05

Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase. J Biol Chem (2003) 1.04

Elongation factor-1 alpha is a novel substrate of rho-associated kinase. Biochem Biophys Res Commun (2000) 1.02

Rho kinase inhibition initiates apoptosis in human airway epithelial cells. Am J Respir Cell Mol Biol (2003) 1.00

RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. J Biol Chem (2002) 0.98

Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632. J Biochem (2006) 0.98

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature (2010) 4.85

Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68

GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell (2005) 4.42

Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell (2004) 4.05

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol (2002) 3.71

Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci (2007) 3.31

Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol (2003) 3.31

PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30

Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell (2005) 3.01

Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83

IQGAP1: a key regulator of adhesion and migration. J Cell Sci (2005) 2.65

EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell (2010) 2.54

Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol (2002) 2.40

Regulation of microtubules in cell migration. Trends Cell Biol (2005) 2.29

Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron (2006) 2.23

Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19

Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol (2007) 2.15

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res (2003) 2.08

Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01

Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98

PIP3 is involved in neuronal polarization and axon formation. J Neurochem (2004) 1.97

Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89

Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry (2010) 1.89

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood (2006) 1.85

DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci (2007) 1.84

Establishment of a tissue-specific RNAi system in C. elegans. Gene (2007) 1.82

CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol (2003) 1.80

Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem (2005) 1.80

Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem (2005) 1.80

Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol (2010) 1.72

Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70

Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell (2008) 1.67

CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64

The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev (2002) 1.56

Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56

Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol (2008) 1.55

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation (2004) 1.53

A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51

Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci (2009) 1.46

Key regulators in neuronal polarity. Neuron (2005) 1.46

Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell (2009) 1.45

TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem (2009) 1.44

Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci U S A (2007) 1.41

Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell (2006) 1.40

Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell (2003) 1.39

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell (2008) 1.38

Role of CRMP-2 in neuronal polarity. J Neurobiol (2004) 1.37

Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil. Structure (2006) 1.37

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet (2011) 1.36

Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol (2009) 1.35

Signaling networks in neuronal polarization. J Neurosci (2006) 1.35

Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse. EMBO Rep (2006) 1.32

Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun (2005) 1.29

AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem (2003) 1.28

Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27

DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J Neurosci (2007) 1.27

Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension (2002) 1.24

IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci (2007) 1.24

Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. Mol Biol Cell (2007) 1.23

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet (2008) 1.23

Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci (2004) 1.21

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20

Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol (2009) 1.17

Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell (2004) 1.17

Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. J Cardiovasc Pharmacol (2006) 1.16

Axon specification in hippocampal neurons. Neurosci Res (2002) 1.16

CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. J Neurochem (2009) 1.14

Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin. J Cell Biol (2012) 1.12

Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. Cell Signal (2006) 1.11

Rho-kinase and myosin II activities are required for cell type and environment specific migration. Genes Cells (2005) 1.11

Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells. J Mol Cell Cardiol (2004) 1.11

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J (2010) 1.10

Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem (2003) 1.10

EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells. J Cell Biol (2011) 1.10

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. J Biol Chem (2006) 1.09

Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility. Schizophr Bull (2010) 1.07

Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase. Genes Cells (2005) 1.07

Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure. Biochem Biophys Res Commun (2005) 1.06

IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest (2013) 1.06

Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. J Biol Chem (2006) 1.06

Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells. Biochem Biophys Res Commun (2007) 1.05

Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase. J Biol Chem (2003) 1.04

Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem Biophys Res Commun (2002) 1.04

Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain. J Neurosci (2011) 1.02

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. J Immunol (2003) 1.02

Interaction of Rho-kinase with myosin II at stress fibres. Genes Cells (2004) 1.01

Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Circ Res (2003) 1.01

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. Biochem Biophys Res Commun (2010) 1.01

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol (2012) 1.01

CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. J Neurochem (2009) 1.00

Disruption of Rho signal transduction upon cell detachment. J Cell Sci (2004) 1.00

RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. Hypertens Res (2004) 1.00

Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse. Sci Signal (2011) 0.99

The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol (2008) 0.99