Published in Nat Struct Biol on April 01, 2002
Diversity of protein-protein interactions. EMBO J (2003) 3.35
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat Struct Mol Biol (2011) 2.23
Directed evolution of protein switches and their application to the creation of ligand-binding proteins. Proc Natl Acad Sci U S A (2005) 2.15
DNA building blocks: keeping control of manufacture. Crit Rev Biochem Mol Biol (2011) 1.64
The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter. Proc Natl Acad Sci U S A (2002) 1.59
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation. Proc Natl Acad Sci U S A (2006) 1.32
Adenosyl radical: reagent and catalyst in enzyme reactions. Chembiochem (2010) 1.19
Crystal structures of ethanolamine ammonia-lyase complexed with coenzyme B12 analogs and substrates. J Biol Chem (2010) 1.09
Ribonucleotide reduction - horizontal transfer of a required function spans all three domains. BMC Evol Biol (2010) 1.09
Turning on ribonucleotide reductase by light-initiated amino acid radical generation. Proc Natl Acad Sci U S A (2004) 1.06
Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proc Natl Acad Sci U S A (2006) 1.04
NrdH-redoxin protein mediates high enzyme activity in manganese-reconstituted ribonucleotide reductase from Bacillus anthracis. J Biol Chem (2011) 0.98
Controlling the delicate balance of tetrapyrrole biosynthesis. Philos Trans R Soc Lond B Biol Sci (2013) 0.98
Isolation of the gene for the B12-dependent ribonucleotide reductase from Anabaena sp. strain PCC 7120 and expression in Escherichia coli. J Bacteriol (2002) 0.95
Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. J Am Chem Soc (2013) 0.94
The Zn center of the anaerobic ribonucleotide reductase from E. coli. J Biol Inorg Chem (2009) 0.93
Role of vitamin B12 on methylmalonyl-CoA mutase activity. J Zhejiang Univ Sci B (2012) 0.93
Adenosylcobalamin enzymes: theory and experiment begin to converge. Biochim Biophys Acta (2012) 0.92
Ribonucleotide reductases: essential enzymes for bacterial life. Front Cell Infect Microbiol (2014) 0.91
Catalysis of methyl group transfers involving tetrahydrofolate and B(12). Vitam Horm (2008) 0.90
Cobalamin- and corrinoid-dependent enzymes. Met Ions Life Sci (2009) 0.89
The origin and evolution of ribonucleotide reduction. Life (Basel) (2015) 0.86
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical. Biochemistry (2010) 0.84
The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proc Natl Acad Sci U S A (2014) 0.81
Effector regulation in a monomeric enzyme. Nat Struct Biol (2002) 0.79
Rare group I intron with insertion sequence element in a bacterial ribonucleotide reductase gene. J Bacteriol (2006) 0.79
A rare combination of ribonucleotide reductases in the social amoeba Dictyostelium discoideum. J Biol Chem (2013) 0.79
The case for an early biological origin of DNA. J Mol Evol (2014) 0.78
Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa. PLoS One (2015) 0.78
Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy. Pharmaceuticals (Basel) (2011) 0.78
Crystallographic studies on B12 binding proteins in eukaryotes and prokaryotes. Biochimie (2013) 0.77
The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site. PLoS One (2015) 0.76
Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis. Front Mol Biosci (2015) 0.76
NMR observations of 13C-enriched coenzyme B12 bound to the ribonucleotide reductase from Lactobacillus leichmannii. Inorg Chem (2006) 0.75
MtrA of the sodium ion pumping methyltransferase binds cobalamin in a unique mode. Sci Rep (2016) 0.75
Resonance Raman spectroscopic study of the interaction between Co(II)rrinoids and the ATP:corrinoid adenosyltransferase PduO from Lactobacillus reuteri. J Biol Inorg Chem (2016) 0.75
Two distinct pools of B12 analogs reveal community interdependencies in the ocean. Proc Natl Acad Sci U S A (2016) 0.75
A DinB Ortholog Enables Mycobacterial Growth under dTTP-Limiting Conditions Induced by the Expression of a Mycobacteriophage-Derived Ribonucleotide Reductase Gene. J Bacteriol (2015) 0.75
Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans. Sci Rep (2017) 0.75
Evolutionary diversification of protein-protein interactions by interface add-ons. Proc Natl Acad Sci U S A (2017) 0.75
In silico analysis of heme oxygenase structural homologues identifies group-specific conservations. FEBS Open Bio (2017) 0.75
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Science (2002) 2.98
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science (2004) 2.65
Bleomycins: towards better therapeutics. Nat Rev Cancer (2005) 2.52
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature (2006) 2.52
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A (2003) 2.24
Structural basis for activation of class Ib ribonucleotide reductase. Science (2010) 2.07
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. Nat Struct Mol Biol (2005) 1.96
Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology. Philos Trans R Soc Lond B Biol Sci (2006) 1.94
Structural insights into radical generation by the radical SAM superfamily. Chem Rev (2011) 1.77
Crystal structure of the nickel-responsive transcription factor NikR. Nat Struct Biol (2003) 1.74
Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proc Natl Acad Sci U S A (2008) 1.71
Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry (2007) 1.69
Pre-steady-state and steady-state kinetic analysis of E. coli class I ribonucleotide reductase. Biochemistry (2003) 1.68
Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Proc Natl Acad Sci U S A (2007) 1.63
The Ralstonia eutropha PhaR protein couples synthesis of the PhaP phasin to the presence of polyhydroxybutyrate in cells and promotes polyhydroxybutyrate production. J Bacteriol (2002) 1.60
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature (2005) 1.59
pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway. J Am Chem Soc (2006) 1.57
An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol (2012) 1.56
Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. J Am Chem Soc (2007) 1.54
Ribbon-helix-helix transcription factors: variations on a theme. Nat Rev Microbiol (2007) 1.54
Competencies: a cure for pre-med curriculum. Science (2011) 1.47
Ralstonia eutropha H16 encodes two and possibly three intracellular Poly[D-(-)-3-hydroxybutyrate] depolymerase genes. J Bacteriol (2003) 1.46
Creating an interdisciplinary introductory chemistry course without time-intensive curriculum changes. ACS Chem Biol (2009) 1.38
Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. Biochemistry (2003) 1.32
YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in Escherichia coli ribonucleotide reductase. Biochemistry (2007) 1.30
Engineering antibody affinity by yeast surface display. Methods Enzymol (2004) 1.26
NikR-operator complex structure and the mechanism of repressor activation by metal ions. Proc Natl Acad Sci U S A (2006) 1.26
AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation. Nucleic Acids Res (2004) 1.24
NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Proc Natl Acad Sci U S A (2008) 1.23
Structural perspective on enzymatic halogenation. Acc Chem Res (2009) 1.21
Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proc Natl Acad Sci U S A (2011) 1.19
Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. J Biol Chem (2007) 1.19
Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate. Biochemistry (2009) 1.18
Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proc Natl Acad Sci U S A (2007) 1.18
PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. J Am Chem Soc (2007) 1.17
Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A (2006) 1.17
Shuffled antibody libraries created by in vivo homologous recombination and yeast surface display. Nucleic Acids Res (2004) 1.16
2,3-difluorotyrosine at position 356 of ribonucleotide reductase R2: a probe of long-range proton-coupled electron transfer. J Am Chem Soc (2003) 1.15
Divergent pathways in the biosynthesis of bisindole natural products. Chem Biol (2009) 1.14
Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers. Biochemistry (2004) 1.13
Xenon in and at the end of the tunnel of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Biochemistry (2008) 1.13
A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Proc Natl Acad Sci U S A (2004) 1.12
A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. J Am Chem Soc (2010) 1.12
Structural analysis of an open active site conformation of nonheme iron halogenase CytC3. J Am Chem Soc (2009) 1.11
The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. Biochemistry (2005) 1.10
Electron transfer reactions of fluorotyrosyl radicals. J Am Chem Soc (2006) 1.10
Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase. J Am Chem Soc (2007) 1.09
Crystallographic snapshots of cyanide- and water-bound C-clusters from bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Biochemistry (2009) 1.09
Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases. J Am Chem Soc (2011) 1.09
X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proc Natl Acad Sci U S A (2013) 1.08
Chris Raetz, scientist and enduring friend. Proc Natl Acad Sci U S A (2011) 1.08
Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase. J Am Chem Soc (2007) 1.07
Structural diversity in the AdoMet radical enzyme superfamily. Biochim Biophys Acta (2012) 1.06
Turning on ribonucleotide reductase by light-initiated amino acid radical generation. Proc Natl Acad Sci U S A (2004) 1.06
Synthesis and characterization of oligonucleotides containing a 4'-keto abasic site. Biochemistry (2004) 1.05
Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage. Nucleic Acids Res (2008) 1.05
Structural basis of the metal specificity for nickel regulatory protein NikR. Biochemistry (2008) 1.04
Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. Biochemistry (2009) 1.04
Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. J Am Chem Soc (2011) 1.04
Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase. Biochemistry (2008) 1.04
Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. J Biol Chem (2011) 1.03
Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry (2004) 1.02
Kinetic and structural characterization of Slr0077/SufS, the essential cysteine desulfurase from Synechocystis sp. PCC 6803. Biochemistry (2004) 1.02
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature (2013) 1.01
Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry (2006) 1.01
Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC. Proc Natl Acad Sci U S A (2007) 1.01
Visualizing molecular juggling within a B12-dependent methyltransferase complex. Nature (2012) 1.01
Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure (2012) 1.00
Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide. J Am Chem Soc (2005) 0.99
Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase. J Am Chem Soc (2011) 0.98
Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo. Biochemistry (2012) 0.98
Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy. J Am Chem Soc (2009) 0.98
Growth and localization of polyhydroxybutyrate granules in Ralstonia eutropha. J Bacteriol (2011) 0.96
Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation. Nucleic Acids Res (2002) 0.95
Probing folded and unfolded states of outer membrane protein a with steady-state and time-resolved tryptophan fluorescence. J Phys Chem B (2006) 0.95
GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin. Chem Res Toxicol (2007) 0.95
Detection of intermediates from the polymerization reaction catalyzed by a D302A mutant of class III polyhydroxyalkanoate (PHA) synthase. Biochemistry (2005) 0.95
Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. J Am Chem Soc (2013) 0.94
Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase. Biochemistry (2006) 0.94
Methodology to probe subunit interactions in ribonucleotide reductases. Biochemistry (2008) 0.94
Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species. J Biol Chem (2012) 0.94
Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase. Biochemistry (2009) 0.94
ENDOR spectroscopy and DFT calculations: evidence for the hydrogen-bond network within α2 in the PCET of E. coli ribonucleotide reductase. J Am Chem Soc (2012) 0.93
Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. J Am Chem Soc (2015) 0.93
Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762. Chem Rev (1998) 0.93
Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger. Proc Natl Acad Sci U S A (2011) 0.93
Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: a mechanistic probe for a redox-active tyrosine. J Am Chem Soc (2004) 0.93
X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proc Natl Acad Sci U S A (2013) 0.93
Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proc Natl Acad Sci U S A (2013) 0.92
Radical use of Rossmann and TIM barrel architectures for controlling coenzyme B12 chemistry. Annu Rev Biophys (2012) 0.92
Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB. J Am Chem Soc (2012) 0.92
Pulsed ELDOR spectroscopy measures the distance between the two tyrosyl dadicals in the R2 subunit of the E. coli ribonucleotide reductase. J Am Chem Soc (2003) 0.91
The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry (2004) 0.91
Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase. Biochemistry (2009) 0.91
Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate. J Am Chem Soc (2013) 0.91
First-principles study of non-heme Fe(II) halogenase SyrB2 reactivity. J Am Chem Soc (2009) 0.91
Bringing the excitement of biological research into the chemistry classroom at MIT. ACS Chem Biol (2007) 0.91
Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA. J Biol Chem (2011) 0.90
Class III polyhydroxybutyrate synthase: involvement in chain termination and reinitiation. Biochemistry (2005) 0.90
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. Biochemistry (2007) 0.90