Published in Nat Struct Mol Biol on October 02, 2005
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Viral AlkB proteins repair RNA damage by oxidative demethylation. Nucleic Acids Res (2008) 1.19
Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proc Natl Acad Sci U S A (2007) 1.18
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Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation. Nucleic Acids Res (2007) 1.07
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The aminoglycoside antibiotic kanamycin damages DNA bases in Escherichia coli: caffeine potentiates the DNA-damaging effects of kanamycin while suppressing cell killing by ciprofloxacin in Escherichia coli and Bacillus anthracis. Antimicrob Agents Chemother (2012) 0.87
Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts. DNA Repair (Amst) (2012) 0.86
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Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. EMBO J (2015) 0.84
Human ALKBH4 interacts with proteins associated with transcription. PLoS One (2012) 0.83
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Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4. Biochem J (2011) 0.82
Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry. J Nucleic Acids (2010) 0.82
A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo. PLoS One (2014) 0.81
Mass Spectrometry-Based Quantitative Strategies for Assessing the Biological Consequences and Repair of DNA Adducts. Acc Chem Res (2016) 0.81
Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB. Chem Res Toxicol (2013) 0.81
Flavin-induced oligomerization in Escherichia coli adaptive response protein AidB. Biochemistry (2011) 0.80
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones. PLoS One (2011) 0.80
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The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Res (2012) 0.80
Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease. Mol Cell Proteomics (2015) 0.80
Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB). DNA Repair (Amst) (2013) 0.80
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Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway. PLoS One (2012) 0.78
Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB. Chem Res Toxicol (2014) 0.78
The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism. J Biol Chem (2014) 0.78
Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli. Int J Biol Sci (2009) 0.78
Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by AlkA. Biochemistry (2015) 0.77
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities. PLoS One (2014) 0.77
Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk. Carcinogenesis (2014) 0.77
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA Repair (Amst) (2015) 0.77
SOS induction and mutagenesis by dnaQ missense alleles in wild type cells. Mutat Res (2012) 0.77
Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η. J Biol Chem (2016) 0.77
Electrochemical characterization of Escherichia coli adaptive response protein AidB. Int J Mol Sci (2012) 0.76
Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA. Exp Parasitol (2012) 0.76
Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities. Trends Biochem Sci (2016) 0.75
Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions. ACS Chem Biol (2016) 0.75
RecA stimulates AlkB-mediated direct repair of DNA adducts. Nucleic Acids Res (2016) 0.75
1,3-Butadiene-Induced Adenine DNA Adducts Are Genotoxic but Only Weakly Mutagenic When Replicated in Escherichia coli of Various Repair and Replication Backgrounds. Chem Res Toxicol (2017) 0.75
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods (2005) 6.23
Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping. Mol Cancer Res (2002) 5.42
A systems approach to mapping DNA damage response pathways. Science (2006) 3.55
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest (2008) 3.17
Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli. Proc Natl Acad Sci U S A (2004) 3.00
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Science (2002) 2.98
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. PLoS Genet (2010) 2.73
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science (2004) 2.65
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem Res Toxicol (2006) 2.62
Phosphorothioation of DNA in bacteria by dnd genes. Nat Chem Biol (2007) 2.57
A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates. Nature (2006) 2.55
Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer (2012) 2.52
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature (2006) 2.52
The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer. Nat Struct Biol (2002) 2.28
Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet (2007) 2.19
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J Biol Chem (2003) 1.95
The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry (2003) 1.92
Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 1.90
Probing the active site tightness of DNA polymerase in subangstrom increments. Proc Natl Acad Sci U S A (2005) 1.89
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest (2003) 1.82
Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. Mol Cell (2004) 1.81
Structural insights into radical generation by the radical SAM superfamily. Chem Rev (2011) 1.77
Crystal structure of the nickel-responsive transcription factor NikR. Nat Struct Biol (2003) 1.74
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Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proc Natl Acad Sci U S A (2008) 1.71
Assays for determining lesion bypass efficiency and mutagenicity of site-specific DNA lesions in vivo. Methods Enzymol (2006) 1.70
DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A (2011) 1.69
Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry (2007) 1.69
Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc Natl Acad Sci U S A (2012) 1.67
Epigenetic changes induced by air toxics: formaldehyde exposure alters miRNA expression profiles in human lung cells. Environ Health Perspect (2010) 1.65
A toxicogenomic comparison of primary and photochemically altered air pollutant mixtures. Environ Health Perspect (2011) 1.65
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature (2005) 1.59
Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res (2007) 1.56
An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol (2012) 1.56
Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis (2007) 1.55
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Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Mol Cell Biol (2010) 1.53
Disruption of gene expression and induction of apoptosis in prostate cancer cells by a DNA-damaging agent tethered to an androgen receptor ligand. Chem Biol (2005) 1.51
Oxidation of 7,8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo. Biochemistry (2002) 1.48
Genome-wide responses to DNA-damaging agents. Annu Rev Microbiol (2005) 1.48
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The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma. Proc Natl Acad Sci U S A (2002) 1.41
Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis. Environ Health Perspect (2014) 1.41
Creating an interdisciplinary introductory chemistry course without time-intensive curriculum changes. ACS Chem Biol (2009) 1.38
Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine. Mol Cell (2004) 1.37
Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes. FASEB J (2007) 1.35
High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds. Proc Natl Acad Sci U S A (2003) 1.32
N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proc Natl Acad Sci U S A (2006) 1.32
Chemical and biological evidence for base propenals as the major source of the endogenous M1dG adduct in cellular DNA. J Biol Chem (2005) 1.31
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Res (2008) 1.30
NikR-operator complex structure and the mechanism of repressor activation by metal ions. Proc Natl Acad Sci U S A (2006) 1.26
DNA polymerase V allows bypass of toxic guanine oxidation products in vivo. J Biol Chem (2007) 1.25
AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation. Nucleic Acids Res (2004) 1.24
Biological properties of single chemical-DNA adducts: a twenty year perspective. Chem Res Toxicol (2007) 1.24
PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A (2010) 1.21
Structural perspective on enzymatic halogenation. Acc Chem Res (2009) 1.21
Polymorphisms in DNA double-strand break repair genes and skin cancer risk. Cancer Res (2004) 1.20
Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol (2012) 1.20
Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase. J Biol Chem (2004) 1.20
Genomic predictors of interindividual differences in response to DNA damaging agents. Genes Dev (2008) 1.20
Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc Natl Acad Sci U S A (2002) 1.20
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Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide (2005) 1.19
Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. J Biol Chem (2007) 1.19
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Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol Cell Proteomics (2009) 1.19
3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance. Cancer Res (2002) 1.18
Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proc Natl Acad Sci U S A (2007) 1.18
Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG). Biochemistry (2009) 1.16
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environ Health Perspect (2012) 1.15
Divergent pathways in the biosynthesis of bisindole natural products. Chem Biol (2009) 1.14
Xenon in and at the end of the tunnel of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Biochemistry (2008) 1.13
Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen (2013) 1.13
A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Proc Natl Acad Sci U S A (2004) 1.12
Structural analysis of an open active site conformation of nonheme iron halogenase CytC3. J Am Chem Soc (2009) 1.11
AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism. Trends Biochem Sci (2003) 1.11
Crystallographic snapshots of cyanide- and water-bound C-clusters from bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Biochemistry (2009) 1.09
Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proc Natl Acad Sci U S A (2009) 1.09
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X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proc Natl Acad Sci U S A (2013) 1.08
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Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes. Nat Nanotechnol (2013) 1.08
A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase. Proc Natl Acad Sci U S A (2009) 1.08
Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. Mol Cell (2010) 1.07
Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proc Natl Acad Sci U S A (2012) 1.07
Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis. Proc Natl Acad Sci U S A (2014) 1.06
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Studies on the replication of the ring opened formamidopyrimidine, Fapy.dG in Escherichia coli. Biochemistry (2007) 1.06
Network responses to DNA damaging agents. DNA Repair (Amst) (2004) 1.05
High-throughput SISCAPA quantitation of peptides from human plasma digests by ultrafast, liquid chromatography-free mass spectrometry. J Proteome Res (2012) 1.04
Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite. Chem Res Toxicol (2005) 1.04
Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O. Chem Res Toxicol (2004) 1.04