Published in J Cell Biol on March 04, 2002
Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol (2009) 3.98
Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection. J Cell Biol (2003) 2.65
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Cell (2010) 2.35
Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A (2004) 2.28
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol (2002) 2.18
A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex. Nature (2008) 2.17
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98
Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. J Cell Biol (2002) 1.98
Differential requirements for AP-2 in clathrin-mediated endocytosis. J Cell Biol (2003) 1.93
YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood (2008) 1.86
Functional analysis of AP-2 alpha and mu2 subunits. Mol Biol Cell (2006) 1.67
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits. Mol Cell Biol (2006) 1.54
Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol (2014) 1.41
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects. J Clin Invest (2017) 1.39
Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit. Proc Natl Acad Sci U S A (2008) 1.36
Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6. J Cell Biol (2008) 1.31
Endocytic adaptors--social networking at the plasma membrane. J Cell Sci (2011) 1.29
Lessons from yeast for clathrin-mediated endocytosis. Nat Cell Biol (2011) 1.28
Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J Cell Biol (2003) 1.27
Cargo recognition in clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol (2013) 1.27
Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol (2005) 1.26
AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation. J Cell Biol (2003) 1.25
Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly. PLoS Pathog (2012) 1.24
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton. EMBO Rep (2003) 1.22
The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2004) 1.14
Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants. J Biol Chem (2010) 1.12
Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase. J Cell Biol (2003) 1.08
New links between vesicle coats and Rab-mediated vesicle targeting. Semin Cell Dev Biol (2010) 1.07
TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO Rep (2014) 1.06
Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting. Mol Biol Cell (2007) 1.02
The clathrin adaptor complexes as a paradigm for membrane-associated allostery. Protein Sci (2013) 1.02
Identification of novel recognition motifs and regulatory targets for the yeast actin-regulating kinase Prk1p. Mol Biol Cell (2003) 0.98
Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes. Mol Cell Biol (2005) 0.98
A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis. J Biol Chem (2009) 0.97
Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species. Am J Respir Cell Mol Biol (2006) 0.97
Functional roles of short sequence motifs in the endocytosis of membrane receptors. Front Biosci (Landmark Ed) (2009) 0.94
Systems biology and physical biology of clathrin-mediated endocytosis. Integr Biol (Camb) (2011) 0.94
The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis. BMC Dev Biol (2008) 0.93
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. Mol Biol Cell (2007) 0.92
Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast. Mol Biol Cell (2007) 0.91
Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb. Mol Cell Proteomics (2012) 0.91
Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR. Int J Cell Biol (2011) 0.90
The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. J Biol Chem (2011) 0.87
The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex. Elife (2014) 0.87
Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses. Traffic (2014) 0.87
Kinome analysis of receptor-induced phosphorylation in human natural killer cells. PLoS One (2012) 0.87
The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis. Mol Biol Cell (2012) 0.86
AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets. J Virol (2015) 0.85
Stochastic model of clathrin-coated pit assembly. Biophys J (2012) 0.85
Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation. PLoS One (2012) 0.82
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chem Biol (2011) 0.82
Clathrin-mediated endocytosis and adaptor proteins. Acta Naturae (2013) 0.80
Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development. Front Cell Neurosci (2015) 0.79
A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL. PLoS One (2013) 0.79
Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2. J Cell Biol (2016) 0.79
Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key. Am J Respir Cell Mol Biol (2006) 0.78
Adaptor protein2 (AP2) orchestrates CXCR2-mediated cell migration. Traffic (2014) 0.78
δ-COP contains a helix C-terminal to its longin domain key to COPI dynamics and function. Proc Natl Acad Sci U S A (2016) 0.76
Lineage-specific proteins essential for endocytosis in trypanosomes. J Cell Sci (2017) 0.75
Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival. BMC Bioinformatics (2017) 0.75
Apm4, the mu subunit of yeast AP-2 interacts with Pkc1, and mutation of the Pkc1 consensus phosphorylation site Thr176 inhibits AP-2 recruitment to endocytic sites. Commun Integr Biol (2014) 0.75
The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif. J Biol Chem (2017) 0.75
Watching real-time endocytosis in living cells. J Cell Biol (2016) 0.75
A phosphotyrosine switch for cargo sequestration at clathrin-coated buds. J Biol Chem (2014) 0.75
Differential phosphorylation signals control endocytosis of GPR15. Mol Biol Cell (2017) 0.75
A structural explanation for the recognition of tyrosine-based endocytotic signals. Science (1998) 5.03
Adaptors for clathrin-mediated traffic. Annu Rev Cell Dev Biol (1999) 3.47
The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Trends Neurosci (2001) 2.76
Role of phosphorylation in regulation of the assembly of endocytic coat complexes. Science (1998) 2.60
A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes. J Biol Chem (1995) 2.44
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol (2002) 2.18
Identification of a protein kinase as an intrinsic component of rat liver coated vesicles. Biochemistry (1984) 2.03
Phosphorylation of threonine 156 of the mu2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo. Curr Biol (2001) 1.82
Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation. Eur J Cell Biol (2000) 1.74
In vivo phosphorylation of adaptors regulates their interaction with clathrin. J Cell Biol (1996) 1.63
Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem (2000) 1.61
Functional domain mapping of the clathrin-associated adaptor medium chains mu1 and mu2. J Biol Chem (1997) 1.58
Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II. J Biol Chem (1986) 1.44
The alpha chain of the AP-2 adaptor is a clathrin binding subunit. J Biol Chem (1995) 1.35
The 46-kDa mannose 6-phosphate receptor contains multiple binding sites for clathrin adaptors. J Biol Chem (1997) 1.31
Binding of AP2 to sorting signals is modulated by AP2 phosphorylation. J Biol Chem (2000) 1.13
Protein kinase(s) in bovine brain coated vesicles. Biochim Biophys Acta (1984) 0.94
Regulated portals of entry into the cell. Nature (2003) 15.33
Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods (2008) 9.43
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet (2002) 4.19
A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol Biol Cell (2004) 3.80
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell (2008) 3.75
Cargo and dynamin regulate clathrin-coated pit maturation. PLoS Biol (2009) 3.72
GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission. Cell (2008) 3.69
Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. Cell (2003) 2.93
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. Dev Cell (2007) 2.73
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
The dynamin middle domain is critical for tetramerization and higher-order self-assembly. EMBO J (2006) 2.44
G domain dimerization controls dynamin's assembly-stimulated GTPase activity. Nature (2010) 2.31
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell (2004) 2.29
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol (2002) 2.18
SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol Biol Cell (2005) 2.08
The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis. Bioessays (2012) 2.07
Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane. EMBO J (2007) 2.00
Geometric catalysis of membrane fission driven by flexible dynamin rings. Science (2013) 1.95
Differential requirements for AP-2 in clathrin-mediated endocytosis. J Cell Biol (2003) 1.93
Conserved functions of membrane active GTPases in coated vesicle formation. Science (2009) 1.90
Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell (2008) 1.84
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis. J Cell Biol (2010) 1.83
Dissecting dynamin's role in clathrin-mediated endocytosis. Biochem Soc Trans (2009) 1.79
Discovery of antivirals against smallpox. Proc Natl Acad Sci U S A (2004) 1.76
Modulation of Rac localization and function by dynamin. Mol Biol Cell (2003) 1.75
Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme. Cell (2005) 1.71
Robust colorimetric assays for dynamin's basal and stimulated GTPase activities. Methods Enzymol (2005) 1.69
A molecular motor or a regulator? Dynamin's in a class of its own. Biochemistry (2003) 1.69
Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell (2013) 1.68
An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell (2009) 1.68
An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo. Mol Biol Cell (2004) 1.67
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Local clustering of transferrin receptors promotes clathrin-coated pit initiation. J Cell Biol (2010) 1.60
A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell (2011) 1.59
Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell (2009) 1.58
An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J Cell Biol (2005) 1.57
Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis. J Biol Chem (2004) 1.52
Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study. Hum Mol Genet (2004) 1.49
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity. Biochem J (2006) 1.48
A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme. Proc Natl Acad Sci U S A (2005) 1.45
Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. Mol Biol Cell (2009) 1.42
Clusters of bioactive compounds target dynamic endomembrane networks in vivo. Proc Natl Acad Sci U S A (2011) 1.41
Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size. Mol Biol Cell (2011) 1.41
SNX9 activities are regulated by multiple phosphoinositides through both PX and BAR domains. Traffic (2007) 1.40
Molecular characterization of the human Calpha-formylglycine-generating enzyme. J Biol Chem (2005) 1.35
Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest (2003) 1.33
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum Mol Genet (2003) 1.32
The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. J Exp Med (2003) 1.31
Crystal structure of the GTPase domain of rat dynamin 1. Proc Natl Acad Sci U S A (2005) 1.28
A new role for the dynamin GTPase in the regulation of fusion pore expansion. Mol Biol Cell (2011) 1.28
Multivalent display and receptor-mediated endocytosis of transferrin on virus-like particles. Chembiochem (2010) 1.24
Molecular basis of multiple sulfatase deficiency, mucolipidosis II/III and Niemann-Pick C1 disease - Lysosomal storage disorders caused by defects of non-lysosomal proteins. Biochim Biophys Acta (2008) 1.21
Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme. J Biol Chem (2005) 1.21
Hsc70 is required for endocytosis and clathrin function in Drosophila. J Cell Biol (2002) 1.21
The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes. Gene (2003) 1.20
Locating the anomalous scatterer substructures in halide and sulfur phasing. Acta Crystallogr D Biol Crystallogr (2002) 1.17
Autophagic vacuoles with sarcolemmal features delineate Danon disease and related myopathies. J Neuropathol Exp Neurol (2005) 1.16
Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality. Mol Cell Biol (2006) 1.15
Phosphatidic acid plays a regulatory role in clathrin-mediated endocytosis. Mol Biol Cell (2010) 1.15
A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis. J Biol Chem (2003) 1.15
Supported bilayers with excess membrane reservoir: a template for reconstituting membrane budding and fission. Biophys J (2010) 1.14
AP-1 and AP-3 mediate sorting of melanosomal and lysosomal membrane proteins into distinct post-Golgi trafficking pathways. Traffic (2008) 1.13
Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources. Traffic (2011) 1.13
Identification of novel lysosomal matrix proteins by proteome analysis. Proteomics (2005) 1.10
Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId. J Clin Invest (2002) 1.10
Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc Natl Acad Sci U S A (2011) 1.09
Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell (2012) 1.08
AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. Traffic (2003) 1.07
Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2. J Biol Chem (2013) 1.06
Molecular analysis of SUMF1 mutations: stability and residual activity of mutant formylglycine-generating enzyme determine disease severity in multiple sulfatase deficiency. Hum Mutat (2008) 1.06
Measuring the hierarchy of molecular events during clathrin-mediated endocytosis. Traffic (2011) 1.06
Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik. Am J Hum Genet (2004) 1.06
The polarized epithelia-specific mu 1B-adaptin complements mu 1A-deficiency in fibroblasts. EMBO Rep (2002) 1.04
Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II. J Biol Chem (2007) 1.03
Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. J Biol Chem (2004) 1.02
Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic (2011) 1.02
Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation. J Lipid Res (2005) 1.01
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis. J Neurosci (2005) 1.01
CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. J Biol Chem (2005) 1.00
Global and local regulation of clathrin-coated pit dynamics detected on patterned substrates. Biophys J (2009) 0.99
Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity. J Cell Mol Med (2010) 0.98
Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3. J Biol Chem (2002) 0.98
Molecular Biology of the Cell: It's Our Journal. Mol Biol Cell (2005) 0.96
ERp44 mediates a thiol-independent retention of formylglycine-generating enzyme in the endoplasmic reticulum. J Biol Chem (2008) 0.96
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis. Traffic (2008) 0.96
γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane. Traffic (2010) 0.95
Deficiency of dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl mannosyltransferase causes congenital disorder of glycosylation type Ig. Biochem J (2002) 0.93
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. Mol Biol Cell (2007) 0.92
Clathrin-coated vesicle formation from isolated plasma membranes. Methods Enzymol (2005) 0.92
Posttranslational modification of serine to formylglycine in bacterial sulfatases. Recognition of the modification motif by the iron-sulfur protein AtsB. J Biol Chem (2002) 0.91
Signal recognition particle (SRP) and SRP receptor: a new paradigm for multistate regulatory GTPases. Biochemistry (2009) 0.91
Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2. Exp Cell Res (2006) 0.90
The non-catalytic N-terminal extension of formylglycine-generating enzyme is required for its biological activity and retention in the endoplasmic reticulum. J Biol Chem (2008) 0.89
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling. Basic Res Cardiol (2006) 0.88
Cortical granule translocation is microfilament mediated and linked to meiotic maturation in the sea urchin oocyte. Development (2002) 0.88
The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes. J Cell Sci (2002) 0.88
Analyzing membrane remodeling and fission using supported bilayers with excess membrane reservoir. Nat Protoc (2013) 0.87
Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. J Biol Chem (2001) 0.87
Identification of the putative mannose 6-phosphate receptor (MPR 46) protein in the invertebrate mollusc. Biosci Rep (2003) 0.86
Identification of formylglycine in sulfatases by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Mass Spectrom (2003) 0.85