Published in Nature on March 06, 2003
Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods (2008) 9.43
Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov (2010) 7.48
The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A (2008) 7.06
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol (2003) 6.35
Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83
Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol (2009) 5.60
High accuracy 3D quantum dot tracking with multifocal plane microscopy for the study of fast intracellular dynamics in live cells. Biophys J (2008) 3.90
A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol Biol Cell (2004) 3.80
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell (2008) 3.75
GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission. Cell (2008) 3.69
Shaping cups into phagosomes and macropinosomes. Nat Rev Mol Cell Biol (2008) 3.62
Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect (2005) 3.57
Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell (2009) 3.42
Population context determines cell-to-cell variability in endocytosis and virus infection. Nature (2009) 3.37
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev (2012) 3.34
Hepatitis C virus entry depends on clathrin-mediated endocytosis. J Virol (2006) 3.33
Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae. J Cell Biol (2005) 3.26
Caveolae/raft-dependent endocytosis. J Cell Biol (2003) 3.25
Endocytosis of nanomedicines. J Control Release (2010) 3.23
Characterization of reemerging chikungunya virus. PLoS Pathog (2007) 3.22
Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev (2008) 3.18
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol (2013) 3.13
Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol (2009) 2.99
Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements. Mol Biol Cell (2004) 2.99
The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles. Nat Nanotechnol (2011) 2.98
Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol (2005) 2.98
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater (2009) 2.87
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol (2006) 2.83
Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol (2009) 2.83
Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. J Am Chem Soc (2008) 2.79
Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. Proc Natl Acad Sci U S A (2004) 2.78
Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells. PLoS Pathog (2008) 2.77
Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat Struct Mol Biol (2004) 2.77
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles. J Cell Biol (2005) 2.74
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanopart Res (2010) 2.70
Clathrin is a key regulator of basolateral polarity. Nature (2008) 2.67
Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection. J Cell Biol (2003) 2.65
The mechanochemistry of endocytosis. PLoS Biol (2009) 2.60
Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog (2010) 2.60
Virus trafficking - learning from single-virus tracking. Nat Rev Microbiol (2007) 2.59
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol (2004) 2.59
Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe (2007) 2.53
Hepatitis C virus entry requires a critical postinternalization step and delivery to early endosomes via clathrin-coated vesicles. J Virol (2006) 2.50
The dynamin middle domain is critical for tetramerization and higher-order self-assembly. EMBO J (2006) 2.44
Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport. Mol Biol Cell (2005) 2.40
Endocytosis of influenza viruses. Microbes Infect (2004) 2.38
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci (2009) 2.20
Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Mol Cell Biol (2005) 2.20
Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters. J Cell Biol (2005) 2.19
Herpes simplex virus type 1 enters human epidermal keratinocytes, but not neurons, via a pH-dependent endocytic pathway. J Virol (2005) 2.19
Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. Mol Biol Cell (2004) 2.19
Materials engineering for immunomodulation. Nature (2009) 2.18
Statistical analysis of nanoparticle dosing in a dynamic cellular system. Nat Nanotechnol (2011) 2.17
Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol (2006) 2.17
Cellular and viral requirements for rapid endocytic entry of herpes simplex virus. J Virol (2004) 2.17
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol (2006) 2.12
Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci U S A (2011) 2.11
Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane. Mol Biol Cell (2004) 2.10
A critical role for endocytosis in Wnt signaling. BMC Cell Biol (2006) 2.09
Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Proc Natl Acad Sci U S A (2004) 2.09
Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes. Proc Natl Acad Sci U S A (2005) 2.09
Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol (2006) 2.08
Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1. J Virol (2005) 2.07
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
Subcellular targeting strategies for drug design and delivery. Nat Rev Drug Discov (2010) 2.04
Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane. EMBO J (2007) 2.00
Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Proc Natl Acad Sci U S A (2006) 1.99
Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J (2009) 1.97
Endocytic vesicle scission by lipid phase boundary forces. Proc Natl Acad Sci U S A (2006) 1.95
Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans. Mol Biol Cell (2004) 1.93
Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci U S A (2008) 1.88
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling. Cell Signal (2008) 1.88
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A (2013) 1.88
Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis. EMBO J (2004) 1.87
Detection and quantification of magnetically labeled cells by cellular MRI. Eur J Radiol (2008) 1.87
Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part Fibre Toxicol (2012) 1.87
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol (2008) 1.85
B cell antigen receptor signaling and internalization are mutually exclusive events. PLoS Biol (2006) 1.85
Synaptic vesicle endocytosis. Cold Spring Harb Perspect Biol (2012) 1.84
Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. J Cell Biol (2010) 1.84
Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol (2007) 1.84
Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell (2008) 1.84
Host cell factors and functions involved in vesicular stomatitis virus entry. J Virol (2008) 1.83
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls. Mol Ther (2009) 1.83
EHD proteins: key conductors of endocytic transport. Trends Cell Biol (2010) 1.82
More effective nanomedicines through particle design. Small (2011) 1.80
Dissecting dynamin's role in clathrin-mediated endocytosis. Biochem Soc Trans (2009) 1.79
Discovery of new cargo proteins that enter cells through clathrin-independent endocytosis. Traffic (2009) 1.78
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. Proc Natl Acad Sci U S A (2008) 1.74
A unique platform for H-Ras signaling involving clathrin-independent endocytosis. Mol Biol Cell (2007) 1.73
Molecular mechanisms of clathrin-independent endocytosis. J Cell Sci (2009) 1.72
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J (2006) 1.72
Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth. Neuron (2008) 1.69
Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell (2013) 1.68
The receptor-mediated endocytosis of nonspherical particles. Biophys J (2008) 1.68
An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell (2009) 1.68
MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling. Mol Biol Cell (2009) 1.67
Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods (2008) 9.43
A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol Biol Cell (2004) 3.80
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell (2008) 3.75
Cargo and dynamin regulate clathrin-coated pit maturation. PLoS Biol (2009) 3.72
GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission. Cell (2008) 3.69
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. Dev Cell (2007) 2.73
The dynamin middle domain is critical for tetramerization and higher-order self-assembly. EMBO J (2006) 2.44
G domain dimerization controls dynamin's assembly-stimulated GTPase activity. Nature (2010) 2.31
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol (2002) 2.18
Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. J Cell Biol (2002) 2.17
SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol Biol Cell (2005) 2.08
The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis. Bioessays (2012) 2.07
Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane. EMBO J (2007) 2.00
Geometric catalysis of membrane fission driven by flexible dynamin rings. Science (2013) 1.95
Differential requirements for AP-2 in clathrin-mediated endocytosis. J Cell Biol (2003) 1.93
Conserved functions of membrane active GTPases in coated vesicle formation. Science (2009) 1.90
Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell (2008) 1.84
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis. J Cell Biol (2010) 1.83
Dissecting dynamin's role in clathrin-mediated endocytosis. Biochem Soc Trans (2009) 1.79
Discovery of antivirals against smallpox. Proc Natl Acad Sci U S A (2004) 1.76
Modulation of Rac localization and function by dynamin. Mol Biol Cell (2003) 1.75
A molecular motor or a regulator? Dynamin's in a class of its own. Biochemistry (2003) 1.69
Robust colorimetric assays for dynamin's basal and stimulated GTPase activities. Methods Enzymol (2005) 1.69
Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell (2013) 1.68
An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell (2009) 1.68
An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo. Mol Biol Cell (2004) 1.67
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Local clustering of transferrin receptors promotes clathrin-coated pit initiation. J Cell Biol (2010) 1.60
A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell (2011) 1.59
Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell (2009) 1.58
An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J Cell Biol (2005) 1.57
Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis. J Biol Chem (2004) 1.52
Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. Mol Biol Cell (2009) 1.42
Clusters of bioactive compounds target dynamic endomembrane networks in vivo. Proc Natl Acad Sci U S A (2011) 1.41
Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size. Mol Biol Cell (2011) 1.41
SNX9 activities are regulated by multiple phosphoinositides through both PX and BAR domains. Traffic (2007) 1.40
Crystal structure of the GTPase domain of rat dynamin 1. Proc Natl Acad Sci U S A (2005) 1.28
A new role for the dynamin GTPase in the regulation of fusion pore expansion. Mol Biol Cell (2011) 1.28
Multivalent display and receptor-mediated endocytosis of transferrin on virus-like particles. Chembiochem (2010) 1.24
Hsc70 is required for endocytosis and clathrin function in Drosophila. J Cell Biol (2002) 1.21
Phosphatidic acid plays a regulatory role in clathrin-mediated endocytosis. Mol Biol Cell (2010) 1.15
Supported bilayers with excess membrane reservoir: a template for reconstituting membrane budding and fission. Biophys J (2010) 1.14
Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources. Traffic (2011) 1.13
Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc Natl Acad Sci U S A (2011) 1.09
Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell (2012) 1.08
AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. Traffic (2003) 1.07
Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2. J Biol Chem (2013) 1.06
Measuring the hierarchy of molecular events during clathrin-mediated endocytosis. Traffic (2011) 1.06
Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic (2011) 1.02
CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. J Biol Chem (2005) 1.00
Global and local regulation of clathrin-coated pit dynamics detected on patterned substrates. Biophys J (2009) 0.99
Molecular Biology of the Cell: It's Our Journal. Mol Biol Cell (2005) 0.96
Clathrin-coated vesicle formation from isolated plasma membranes. Methods Enzymol (2005) 0.92
Signal recognition particle (SRP) and SRP receptor: a new paradigm for multistate regulatory GTPases. Biochemistry (2009) 0.91
Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2. Exp Cell Res (2006) 0.90
Analyzing membrane remodeling and fission using supported bilayers with excess membrane reservoir. Nat Protoc (2013) 0.87
Clathrin- and dynamin-dependent coated vesicle formation from isolated plasma membranes. Traffic (2003) 0.85
Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis. PLoS One (2013) 0.85
Cell biology: Lipid switches and traffic control. Nature (2013) 0.83
A cell-free biochemical complementation assay reveals complex and redundant cytosolic requirements for LRP endocytosis. Exp Cell Res (2006) 0.80
Intrapolypeptide interactions between the GTPase effector domain (GED) and the GTPase domain form the bundle signaling element in dynamin dimers. Biochemistry (2014) 0.79
Integrated electron microscopy: super-duper resolution. PLoS Biol (2013) 0.75