Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3567869)

Published in Mol Cell Proteomics on December 04, 2012

Authors

Jonathan R Krieger1, Paul Taylor, Aaron S Gajadhar, Abhijit Guha, Michael F Moran, C Jane McGlade

Author Affiliations

1: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada.

Articles citing this

Cargo recognition in clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol (2013) 1.27

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology (2014) 1.15

Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development (2013) 0.87

A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo. J Cell Biol (2014) 0.85

Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development. Front Cell Neurosci (2015) 0.79

Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision. Wiley Interdiscip Rev Dev Biol (2015) 0.79

Advances in targeted proteomics and applications to biomedical research. Proteomics (2016) 0.79

Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent. Oxid Med Cell Longev (2013) 0.77

Discordance between protein and transcript levels detected by selected reaction monitoring. Plant Signal Behav (2015) 0.77

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. Structure (2016) 0.76

Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear. Front Cell Neurosci (2015) 0.75

A recurrent mutation in bone morphogenetic proteins-2-inducible kinase gene is associated with developmental dysplasia of the hip. Exp Ther Med (2017) 0.75

Articles cited by this

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem (2002) 35.30

A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem (2003) 29.58

STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res (2008) 20.62

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature (1973) 15.28

Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods (2006) 12.63

ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol (2006) 7.75

Protein detection using proximity-dependent DNA ligation assays. Nat Biotechnol (2002) 6.05

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell (1994) 5.37

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron (1996) 4.69

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol (2004) 3.87

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Cell (1983) 3.85

A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. EMBO J (2002) 3.35

AP-2/Eps15 interaction is required for receptor-mediated endocytosis. J Cell Biol (1998) 3.30

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell (2002) 3.16

Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A (2009) 3.10

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev (1997) 3.01

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 2.94

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron (1996) 2.84

Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature (2002) 2.74

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell (1989) 2.72

Numb is an endocytic protein. J Cell Biol (2000) 2.39

The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development (1995) 2.29

Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. J Cell Biol (2002) 2.17

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1. Neuron (1999) 2.07

The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2. J Cell Biol (1995) 2.06

RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat Cell Biol (2011) 2.03

Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J (1999) 1.94

Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J (2007) 1.81

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem (1999) 1.81

Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron (2003) 1.73

RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J Biol Chem (2003) 1.69

Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. J Cell Biol (2012) 1.59

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. Proc Natl Acad Sci U S A (1999) 1.54

Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol Cell Biol (2010) 1.53

Affinity-purification mass spectrometry (AP-MS) of serine/threonine phosphatases. Methods (2007) 1.51

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate. Curr Biol (1996) 1.41

RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38

Segregation of myogenic lineages in Drosophila requires numb. Development (1997) 1.35

The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell (2004) 1.34

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J (2002) 1.31

Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27

An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1. J Biol Chem (1997) 1.26

Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol (2006) 1.12

Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases. J Biol Chem (2005) 1.09

Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics (2009) 1.07

Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell (2006) 1.04

Preparation of proteins and peptides for mass spectrometry analysis in a bottom-up proteomics workflow. Curr Protoc Mol Biol (2009) 1.02

A proximity ligation assay using transiently transfected, epitope-tagged proteins: application for in situ detection of dimerized receptor tyrosine kinases. Biotechniques (2010) 1.00

Measurement of protein phosphorylation stoichiometry by selected reaction monitoring mass spectrometry. J Proteome Res (2010) 0.99

Caenorhabditis elegans num-1 negatively regulates endocytic recycling. Genetics (2008) 0.98

Solution structure of the Reps1 EH domain and characterization of its binding to NPF target sequences. Biochemistry (2001) 0.97

AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis. Traffic (2008) 0.96

Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. J Biol Chem (2001) 0.93

The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion. J Biol Chem (2010) 0.93

Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2. FEBS Lett (2006) 0.89

Binding to DPF-motif by the POB1 EH domain is responsible for POB1-Eps15 interaction. BMC Biochem (2007) 0.87

Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Differentiation (2003) 0.86

Involvement of numb in vertebrate retinal development: evidence for multiple roles of numb in neural differentiation and maturation. J Neurobiol (2003) 0.86

Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation. Exp Cell Res (2010) 0.82

A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3. J Biol Chem (2000) 0.81

Articles by these authors

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99

Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol (2008) 7.30

Radial glia cells are candidate stem cells of ependymoma. Cancer Cell (2005) 5.21

Transforming fusions of FGFR and TACC genes in human glioblastoma. Science (2012) 5.09

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89

Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature (2002) 3.22

Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol (2003) 3.20

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell (2011) 3.11

Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes Chromosomes Cancer (2004) 3.05

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell (2002) 2.99

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 2.94

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med (2011) 2.93

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89

Single-center experience of encapsulating peritoneal sclerosis in patients on peritoneal dialysis for end-stage renal failure. Kidney Int (2005) 2.29

Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation (2004) 2.28

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol (2002) 2.02

Fiber density index correlates with reduced fractional anisotropy in white matter of patients with glioblastoma. AJNR Am J Neuroradiol (2005) 1.90

Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89

Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. J Am Med Inform Assoc (2004) 1.85

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J (2007) 1.81

Clinical Practice Guidelines and Recommendations on Peritoneal Dialysis Adequacy 2011. Perit Dial Int (2011) 1.76

Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res (2008) 1.75

The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Dev Cell (2006) 1.67

Computer-aided detection in the United Kingdom National Breast Screening Programme: prospective study. Radiology (2005) 1.63

Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design. Proc Natl Acad Sci U S A (2005) 1.57

Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol Cell Biol (2010) 1.53

A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr Biol (2002) 1.49

Mechanism of Mos1 transposition: insights from structural analysis. EMBO J (2006) 1.48

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol (2006) 1.47

Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J (2006) 1.47

Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene (2002) 1.45

A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res (2006) 1.42

Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget (2010) 1.42

Peripheral nerve tumors: management strategies and molecular insights. J Neurooncol (2004) 1.35

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins. Nature (2009) 1.35

Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome". Cell (2011) 1.34

High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. Clin Cancer Res (2008) 1.34

The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell (2004) 1.34

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J (2002) 1.31

Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. J Virol (2004) 1.27

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients. J Clin Invest (2011) 1.27

Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors. Am J Pathol (2002) 1.26

Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition. Mol Cell (2003) 1.24

MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1. Cancer Sci (2010) 1.23

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development (2007) 1.21

Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res (2003) 1.20

Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor. Clin Cancer Res (2011) 1.20

Extracellular vesicles--vehicles that spread cancer genes. Bioessays (2012) 1.19

Automated 2D peptide separation on a 1D nano-LC-MS system. J Proteome Res (2009) 1.19

Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis. Cancer Res (2008) 1.19

Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trial. J Thorac Oncol (2013) 1.17

S-nitrosylation of AtSABP3 antagonizes the expression of plant immunity. J Biol Chem (2008) 1.16

GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model. Proc Natl Acad Sci U S A (2007) 1.15

Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. Am J Pathol (2005) 1.15

Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J (2005) 1.14

A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90. J Biol Chem (2002) 1.13

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. J Exp Med (2011) 1.13

Multiinstitutional validation of the University of California at San Francisco Low-Grade Glioma Prognostic Scoring System. Clinical article. J Neurosurg (2009) 1.12

Visuomotor priming by pictures of hand postures: perspective matters. Neuropsychologia (2003) 1.12

PTP1B and TC-PTP: novel roles in immune-cell signaling. Can J Physiol Pharmacol (2006) 1.11

Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation. Nat Struct Mol Biol (2004) 1.10

Three-dimensional in vivo modeling of vestibular schwannomas and surrounding cranial nerves with diffusion imaging tractography. Neurosurgery (2011) 1.10

Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Cancer Res (2009) 1.10

Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med (2012) 1.09

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood (2010) 1.09

Multi-intervention management of calciphylaxis: a report of 7 cases. Am J Kidney Dis (2011) 1.08

A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients. P R Health Sci J (2005) 1.08

Immune infiltration of spontaneous mouse astrocytomas is dominated by immunosuppressive cells from early stages of tumor development. Cancer Res (2010) 1.07

The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. Genome Res (2011) 1.07

Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics (2009) 1.07

Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors. Brain Pathol (2004) 1.06

Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients. J Proteome Res (2007) 1.06

The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. J Exp Med (2004) 1.05

Orthopaedic manifestations of neurofibromatosis in children: an update. Clin Orthop Relat Res (2002) 1.05

Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure. J Biol Chem (2002) 1.04

Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literature. Neuro Oncol (2007) 1.04

Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell (2006) 1.04

Expression, purification and preliminary crystallographic studies of a single-point mutant of Mos1 mariner transposase. Acta Crystallogr D Biol Crystallogr (2004) 1.03

T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol (2006) 1.02

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. Oncogene (2004) 1.02

A systematic review of computer-assisted diagnosis in diagnostic cancer imaging. Eur J Radiol (2011) 1.02

Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma. Genome Res (2012) 1.02

The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas. Neurogenetics (2009) 1.02

A human transferrin-vascular endothelial growth factor (hnTf-VEGF) fusion protein containing an integrated binding site for (111)In for imaging tumor angiogenesis. J Nucl Med (2005) 1.01

Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue. Clin Proteomics (2012) 1.01

Targeting the Tie2/Tek receptor in astrocytomas. Am J Pathol (2004) 1.01