Published in EMBO J on December 14, 2006
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (2009) 4.25
Dynamin, a membrane-remodelling GTPase. Nat Rev Mol Cell Biol (2012) 3.92
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell (2008) 3.75
GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission. Cell (2008) 3.69
G domain dimerization controls dynamin's assembly-stimulated GTPase activity. Nature (2010) 2.31
Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol (2010) 2.27
Crystal structure of nucleotide-free dynamin. Nature (2011) 2.13
Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature (2010) 2.01
Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane. EMBO J (2007) 2.00
A corkscrew model for dynamin constriction. Structure (2007) 1.90
The crystal structure of dynamin. Nature (2011) 1.87
Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell (2008) 1.84
Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion. J Cell Biol (2009) 1.81
Dissecting dynamin's role in clathrin-mediated endocytosis. Biochem Soc Trans (2009) 1.79
An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell (2009) 1.68
A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell (2011) 1.59
Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving. Cell (2009) 1.58
A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. J Biol Chem (2010) 1.56
A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice. PLoS Genet (2010) 1.48
Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. Mol Biol Cell (2009) 1.42
Dynamin2 GTPase and cortactin remodel actin filaments. J Biol Chem (2009) 1.35
Dynamins at a glance. J Cell Sci (2009) 1.33
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients. EMBO J (2010) 1.30
Identification of CSPα clients reveals a role in dynamin 1 regulation. Neuron (2012) 1.28
Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity. J Biol Chem (2010) 1.21
Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases. Apoptosis (2010) 1.16
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic (2013) 1.14
Fluorescence applications in molecular neurobiology. Neuron (2010) 1.13
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet (2010) 1.13
Visualization of dynamins. Methods Cell Biol (2008) 1.13
Membrane traffic and muscle: lessons from human disease. Traffic (2008) 1.12
Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc Natl Acad Sci U S A (2011) 1.09
Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2. J Biol Chem (2013) 1.06
Epileptic encephalopathy-causing mutations in DNM1 impair synaptic vesicle endocytosis. Neurol Genet (2015) 1.04
Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol (2012) 1.02
Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic (2011) 1.02
Building a fission machine--structural insights into dynamin assembly and activation. J Cell Sci (2013) 1.02
Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies. Cell Calcium (2010) 1.00
S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxid Redox Signal (2011) 1.00
Dynamin 2 mutants linked to centronuclear myopathies form abnormally stable polymers. J Biol Chem (2010) 0.98
Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy. PLoS One (2011) 0.97
A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol Biol Cell (2014) 0.97
Oligomerization state of dynamin 2 in cell membranes using TIRF and number and brightness analysis. Biophys J (2011) 0.96
S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration. Mitochondrion (2010) 0.96
Membrane damage by an α-helical pore-forming protein, Equinatoxin II, proceeds through a succession of ordered steps. J Biol Chem (2013) 0.94
Dimeric endophilin A2 stimulates assembly and GTPase activity of dynamin 2. Biophys J (2011) 0.91
Mitochondria in heart failure: the emerging role of mitochondrial dynamics. Heart Fail Rev (2013) 0.90
Alternate pleckstrin homology domain orientations regulate dynamin-catalyzed membrane fission. Mol Biol Cell (2014) 0.89
Crystal structure of the dynamin tetramer. Nature (2015) 0.88
Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells. Mol Biol Cell (2009) 0.87
Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division. J Biol Chem (2014) 0.87
Functional mapping of human dynamin-1-like GTPase domain based on x-ray structure analyses. PLoS One (2013) 0.85
Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis. PLoS One (2013) 0.85
Dynamic control of electron transfers in diflavin reductases. Int J Mol Sci (2012) 0.82
Mff functions with Pex11pβ and DLP1 in peroxisomal fission. Biol Open (2013) 0.81
CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med (2014) 0.81
Kalirin12 interacts with dynamin. BMC Neurosci (2009) 0.80
Intrapolypeptide interactions between the GTPase effector domain (GED) and the GTPase domain form the bundle signaling element in dynamin dimers. Biochemistry (2014) 0.79
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy. Am J Med Genet A (2016) 0.79
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. Leukemia (2016) 0.78
Arabidopsis dynamin-related protein 1A polymers bind, but do not tubulate, liposomes. Biochem Biophys Res Commun (2010) 0.78
A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells. Biochim Biophys Acta (2013) 0.78
Identification of interaction partners of the dynamin-like protein DynA from Bacillus subtilis. Commun Integr Biol (2012) 0.78
Dimerization and its role in GMP formation by human guanylate binding proteins. Biophys J (2010) 0.78
SH3 Domains Differentially Stimulate Distinct Dynamin I Assembly Modes and G Domain Activity. PLoS One (2015) 0.77
Identification and function of conformational dynamics in the multidomain GTPase dynamin. EMBO J (2016) 0.77
Constricting membranes at the nano and micro scale. Proc Natl Acad Sci U S A (2009) 0.76
Revisiting the endocytosis of the m2 muscarinic acetylcholine receptor. Membranes (Basel) (2015) 0.76
Dynamin-related proteins in plant post-Golgi traffic. Front Plant Sci (2014) 0.76
The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of Cytochrome c from Mitochondria. PLoS Pathog (2017) 0.75
Characterization of two novel intronic OPA1 mutations resulting in aberrant pre-mRNA splicing. BMC Med Genet (2017) 0.75
NMR derived model of GTPase effector domain (GED) self association: relevance to dynamin assembly. PLoS One (2012) 0.75
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy. Neurobiol Dis (2016) 0.75
Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophys J (2000) 21.93
Regulated portals of entry into the cell. Nature (2003) 15.33
The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol (2004) 8.58
Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding. Nature (1995) 7.55
Dynamin undergoes a GTP-dependent conformational change causing vesiculation. Cell (1998) 6.06
Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis. Nature (1999) 4.84
Dynamin and its role in membrane fission. Annu Rev Cell Dev Biol (2000) 4.72
Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J (2000) 4.26
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature (2006) 4.18
GTPase activity of dynamin and resulting conformation change are essential for endocytosis. Nature (2001) 3.90
Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol (2005) 3.75
Size-exclusion chromatography with on-line light-scattering, absorbance, and refractive index detectors for studying proteins and their interactions. Anal Biochem (1996) 3.56
Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J Cell Biol (2000) 3.30
Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring. Nat Cell Biol (1999) 3.28
Three-dimensional reconstruction of dynamin in the constricted state. Nat Cell Biol (2001) 3.10
Dynamin self-assembly stimulates its GTPase activity. J Biol Chem (1996) 2.87
Domain structure and intramolecular regulation of dynamin GTPase. EMBO J (1997) 2.63
Garrotes, springs, ratchets, and whips: putting dynamin models to the test. Traffic (2000) 2.45
The stalk region of dynamin drives the constriction of dynamin tubes. Nat Struct Mol Biol (2004) 2.20
Dynamin GTPase, a force-generating molecular switch. Bioessays (1996) 2.15
A model for dynamin self-assembly based on binding between three different protein domains. J Biol Chem (1999) 2.09
The pleckstrin homology domains of dynamin isoforms require oligomerization for high affinity phosphoinositide binding. J Biol Chem (1998) 1.75
A molecular motor or a regulator? Dynamin's in a class of its own. Biochemistry (2003) 1.69
Robust colorimetric assays for dynamin's basal and stimulated GTPase activities. Methods Enzymol (2005) 1.69
An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo. Mol Biol Cell (2004) 1.67
An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J Cell Biol (2005) 1.57
Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis. J Biol Chem (2004) 1.52
The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation. J Biol Chem (1991) 1.44
Multiple distinct coiled-coils are involved in dynamin self-assembly. J Biol Chem (1999) 1.41
Correlation between self-association modes and GTPase activation of dynamin. J Protein Chem (1999) 1.33
Physical and photophysical characterization of a BODIPY phosphatidylcholine as a membrane probe. Biophys J (2002) 1.25
Dynamin forms polymeric complexes in the presence of lipid vesicles. Characterization of chemically cross-linked dynamin molecules. J Biol Chem (1995) 1.22
Accuracy in multiangle light scattering measurements for molar mass and radius estimations. Model calculations and experiments. Anal Chem (2003) 1.16
Dependence of M13 major coat protein oligomerization and lateral segregation on bilayer composition. Biophys J (2003) 1.14
Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J (2006) 1.10
Simultaneous determination of protein aggregation, degradation, and absolute molecular weight by size exclusion chromatography-multiangle laser light scattering. Anal Biochem (2006) 1.08
Rapid purification of native dynamin I and colorimetric GTPase assay. Methods Enzymol (2005) 1.01
Regulated portals of entry into the cell. Nature (2003) 15.33
Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods (2008) 9.43
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell (2006) 8.44
Semen-derived amyloid fibrils drastically enhance HIV infection. Cell (2007) 5.23
A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol Biol Cell (2004) 3.80
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell (2008) 3.75
Cargo and dynamin regulate clathrin-coated pit maturation. PLoS Biol (2009) 3.72
GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission. Cell (2008) 3.69
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. Dev Cell (2007) 2.73
Structure of the Sec13/31 COPII coat cage. Nature (2006) 2.63
G domain dimerization controls dynamin's assembly-stimulated GTPase activity. Nature (2010) 2.31
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol (2002) 2.18
Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. J Cell Biol (2002) 2.17
SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol Biol Cell (2005) 2.08
The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis. Bioessays (2012) 2.07
Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane. EMBO J (2007) 2.00
Geometric catalysis of membrane fission driven by flexible dynamin rings. Science (2013) 1.95
Electrostatic tuning of ion conductance in potassium channels. Biochemistry (2003) 1.93
Differential requirements for AP-2 in clathrin-mediated endocytosis. J Cell Biol (2003) 1.93
Conserved functions of membrane active GTPases in coated vesicle formation. Science (2009) 1.90
Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell (2008) 1.84
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis. J Cell Biol (2010) 1.83
Dissecting dynamin's role in clathrin-mediated endocytosis. Biochem Soc Trans (2009) 1.79
Discovery of antivirals against smallpox. Proc Natl Acad Sci U S A (2004) 1.76
Modulation of Rac localization and function by dynamin. Mol Biol Cell (2003) 1.75
Deep mutational scanning: assessing protein function on a massive scale. Trends Biotechnol (2011) 1.74
Robust colorimetric assays for dynamin's basal and stimulated GTPase activities. Methods Enzymol (2005) 1.69
A molecular motor or a regulator? Dynamin's in a class of its own. Biochemistry (2003) 1.69
Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell (2013) 1.68
An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell (2009) 1.68
An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo. Mol Biol Cell (2004) 1.67
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol (2006) 1.60
Local clustering of transferrin receptors promotes clathrin-coated pit initiation. J Cell Biol (2010) 1.60
A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell (2011) 1.59
Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell (2009) 1.58
An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J Cell Biol (2005) 1.57
Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis. J Biol Chem (2004) 1.52
Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. Mol Biol Cell (2009) 1.42
Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biol (2008) 1.42
Clusters of bioactive compounds target dynamic endomembrane networks in vivo. Proc Natl Acad Sci U S A (2011) 1.41
Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size. Mol Biol Cell (2011) 1.41
SNX9 activities are regulated by multiple phosphoinositides through both PX and BAR domains. Traffic (2007) 1.40
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proc Natl Acad Sci U S A (2012) 1.39
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis. Proc Natl Acad Sci U S A (2013) 1.32
N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. J Biol Chem (2009) 1.28
Crystal structure of the GTPase domain of rat dynamin 1. Proc Natl Acad Sci U S A (2005) 1.28
A new role for the dynamin GTPase in the regulation of fusion pore expansion. Mol Biol Cell (2011) 1.28
Multivalent display and receptor-mediated endocytosis of transferrin on virus-like particles. Chembiochem (2010) 1.24
Hsc70 is required for endocytosis and clathrin function in Drosophila. J Cell Biol (2002) 1.21
Phosphatidic acid plays a regulatory role in clathrin-mediated endocytosis. Mol Biol Cell (2010) 1.15
Supported bilayers with excess membrane reservoir: a template for reconstituting membrane budding and fission. Biophys J (2010) 1.14
Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources. Traffic (2011) 1.13
Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. Proc Natl Acad Sci U S A (2005) 1.12
Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc Natl Acad Sci U S A (2011) 1.09
Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell (2012) 1.08
AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. Traffic (2003) 1.07
Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2. J Biol Chem (2013) 1.06
Measuring the hierarchy of molecular events during clathrin-mediated endocytosis. Traffic (2011) 1.06
Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections. Proc Natl Acad Sci U S A (2013) 1.05
Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins. J Biol Chem (2007) 1.04
Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic (2011) 1.02
CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. J Biol Chem (2005) 1.00
Global and local regulation of clathrin-coated pit dynamics detected on patterned substrates. Biophys J (2009) 0.99
Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization. Nat Biotechnol (2010) 0.97
Molecular Biology of the Cell: It's Our Journal. Mol Biol Cell (2005) 0.96
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. J Biol Chem (2013) 0.92
Clathrin-coated vesicle formation from isolated plasma membranes. Methods Enzymol (2005) 0.92
Signal recognition particle (SRP) and SRP receptor: a new paradigm for multistate regulatory GTPases. Biochemistry (2009) 0.91
Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2. Exp Cell Res (2006) 0.90
Contemporary, yeast-based approaches to understanding human genetic variation. Curr Opin Genet Dev (2013) 0.88
Analyzing membrane remodeling and fission using supported bilayers with excess membrane reservoir. Nat Protoc (2013) 0.87
The amino acid linker between the endonuclease and helicase domains of adeno-associated virus type 5 Rep plays a critical role in DNA-dependent oligomerization. J Virol (2011) 0.86
Clathrin- and dynamin-dependent coated vesicle formation from isolated plasma membranes. Traffic (2003) 0.85
Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis. PLoS One (2013) 0.85
Helical crystallization of soluble and membrane binding proteins. Methods Enzymol (2010) 0.85
Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles. J Mol Biol (2008) 0.84
Cell biology: Lipid switches and traffic control. Nature (2013) 0.83
A cell-free biochemical complementation assay reveals complex and redundant cytosolic requirements for LRP endocytosis. Exp Cell Res (2006) 0.80
Intrapolypeptide interactions between the GTPase effector domain (GED) and the GTPase domain form the bundle signaling element in dynamin dimers. Biochemistry (2014) 0.79
A microfluidic chip-compatible bioassay based on single-molecule detection with high sensitivity and multiplexing. Lab Chip (2010) 0.78
Integrated electron microscopy: super-duper resolution. PLoS Biol (2013) 0.75