Structural basis for protein antiaggregation activity of the trigger factor chaperone.

PubWeight™: 1.86‹?› | Rank: Top 3%

🔗 View Article (PMC 4070327)

Published in Science on May 09, 2014

Authors

Tomohide Saio1, Xiao Guan, Paolo Rossi, Anastassios Economou, Charalampos G Kalodimos

Author Affiliations

1: Center for Integrative Proteomics Research and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.

Articles citing this

Protein export through the bacterial Sec pathway. Nat Rev Microbiol (2016) 0.93

Preprotein mature domains contain translocase targeting signals that are essential for secretion. J Cell Biol (2017) 0.90

Substrate-binding domain conformational dynamics mediate Hsp70 allostery. Proc Natl Acad Sci U S A (2015) 0.89

Information processing in the CNS: a supramolecular chemistry? Cogn Neurodyn (2015) 0.87

Non-chaperone proteins can inhibit aggregation and cytotoxicity of Alzheimer amyloid β peptide. J Biol Chem (2014) 0.87

Mapping the conformation of a client protein through the Hsp70 functional cycle. Proc Natl Acad Sci U S A (2015) 0.86

ClpB N-terminal domain plays a regulatory role in protein disaggregation. Proc Natl Acad Sci U S A (2015) 0.85

Visualizing chaperone-assisted protein folding. Nat Struct Mol Biol (2016) 0.84

Structured States of Disordered Proteins from Genomic Sequences. Cell (2016) 0.83

Forces Driving Chaperone Action. Cell (2016) 0.83

Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps. J Biomol NMR (2015) 0.80

Multitasking SecB chaperones in bacteria. Front Microbiol (2014) 0.79

Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proc Natl Acad Sci U S A (2016) 0.78

Structural basis for the antifolding activity of a molecular chaperone. Nature (2016) 0.78

Dimeric Structure of the Bacterial Extracellular Foldase PrsA. J Biol Chem (2014) 0.77

Exploiting E. coli auxotrophs for leucine, valine, and threonine specific methyl labeling of large proteins for NMR applications. J Biomol NMR (2016) 0.77

Capturing a Dynamic Chaperone-Substrate Interaction Using NMR-Informed Molecular Modeling. J Am Chem Soc (2016) 0.77

The Trigger Factor Chaperone Encapsulates and Stabilizes Partial Folds of Substrate Proteins. PLoS Comput Biol (2015) 0.77

E. coli metabolic protein aldehyde-alcohol dehydrogenase-E binds to the ribosome: a unique moonlighting action revealed. Sci Rep (2016) 0.77

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles. Elife (2017) 0.77

The Activity of Escherichia coli Chaperone SurA Is Regulated by Conformational Changes Involving a Parvulin Domain. J Bacteriol (2016) 0.76

The Hsp90 cochaperones Cpr6, Cpr7, and Cns1 interact with the intact ribosome. Eukaryot Cell (2014) 0.75

Ligand-driven conformational changes of MurD visualized by paramagnetic NMR. Sci Rep (2015) 0.75

The Rrp4-exosome complex recruits and channels substrate RNA by a unique mechanism. Nat Chem Biol (2017) 0.75

Quarterly intrinsic disorder digest (April-May-June, 2014). Intrinsically Disord Proteins (2017) 0.75

Biochemistry. Trigger factor flexibility. Science (2014) 0.75

(15)N and (13)C- SOFAST-HMQC editing enhances 3D-NOESY sensitivity in highly deuterated, selectively [(1)H,(13)C]-labeled proteins. J Biomol NMR (2016) 0.75

Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state. Biomol NMR Assign (2016) 0.75

A Semiautomated Assignment Protocol for Methyl Group Side Chains in Large Proteins. Methods Enzymol (2015) 0.75

Efficient production of (2)H, (13)C, (15)N-enriched industrial enzyme Rhizopus chinensis lipase with native disulfide bonds. Microb Cell Fact (2016) 0.75

Recognition and targeting mechanisms by chaperones in flagellum assembly and operation. Proc Natl Acad Sci U S A (2016) 0.75

HdeB chaperone activity is coupled to its intrinsic dynamic properties. Sci Rep (2015) 0.75

The chaperone toolbox at the single-molecule level: From clamping to confining. Protein Sci (2017) 0.75

Trigger factor chaperone acts as a mechanical foldase. Nat Commun (2017) 0.75

Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme. Proc Natl Acad Sci U S A (2017) 0.75

Facilitating unambiguous NMR assignments and enabling higher probe density through selective labeling of all methyl containing amino acids. J Biomol NMR (2016) 0.75

F 1 F 2-selective NMR spectroscopy. J Biomol NMR (2017) 0.75

Articles cited by this

NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts. J Biomol NMR (2009) 16.09

Molecular chaperones in the cytosol: from nascent chain to folded protein. Science (2002) 15.09

Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01

Automated NMR structure calculation with CYANA. Methods Mol Biol (2004) 9.31

Molecular chaperones in protein folding and proteostasis. Nature (2011) 8.63

Identification of a protein required for disulfide bond formation in vivo. Cell (1991) 8.56

Molecular chaperones and protein quality control. Cell (2006) 7.74

Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol (2004) 6.45

Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol (2009) 5.47

New tools provide new insights in NMR studies of protein dynamics. Science (2006) 4.64

NMR characterization of the dynamics of biomacromolecules. Chem Rev (2004) 4.44

Residues in chaperonin GroEL required for polypeptide binding and release. Nature (1994) 4.30

Studying excited states of proteins by NMR spectroscopy. Nat Struct Biol (2001) 4.07

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation. Protein Sci (2006) 3.73

Quantitative dynamics and binding studies of the 20S proteasome by NMR. Nature (2007) 3.63

The origin of protein interactions and allostery in colocalization. Nature (2007) 3.34

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins. Nat Struct Mol Biol (2009) 3.21

Identification and characterization of an Escherichia coli gene required for the formation of correctly folded alkaline phosphatase, a periplasmic enzyme. EMBO J (1992) 3.08

Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR. Cell (2007) 3.06

Trigger factor and DnaK cooperate in folding of newly synthesized proteins. Nature (1999) 2.95

L23 protein functions as a chaperone docking site on the ribosome. Nature (2002) 2.68

Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Cell (2011) 2.55

Protein activity regulation by conformational entropy. Nature (2012) 2.53

Getting newly synthesized proteins into shape. Cell (2000) 2.45

Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins. Nature (2004) 2.41

Structural basis for cAMP-mediated allosteric control of the catabolite activator protein. Proc Natl Acad Sci U S A (2009) 2.39

Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides. EMBO J (1995) 2.38

Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains. Cell (1999) 2.33

A TROSY CPMG sequence for characterizing chemical exchange in large proteins. J Biomol NMR (1999) 2.25

Chaperone machines for protein folding, unfolding and disaggregation. Nat Rev Mol Cell Biol (2013) 2.24

Real-time observation of trigger factor function on translating ribosomes. Nature (2006) 2.23

Unraveling the mechanism of protein disaggregation through a ClpB-DnaK interaction. Science (2013) 2.17

The "trigger factor cycle" includes ribosomes, presecretory proteins, and the plasma membrane. Cell (1988) 1.86

Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed. Cell (2004) 1.85

Chaperonin function: folding by forced unfolding. Science (1999) 1.83

Trigger Factor and DnaK possess overlapping substrate pools and binding specificities. Mol Microbiol (2003) 1.77

Multivalent binding of nonnative substrate proteins by the chaperonin GroEL. Cell (2000) 1.69

Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMR. Science (2010) 1.69

An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones. Cell (2012) 1.67

Measurement of bond vector orientations in invisible excited states of proteins. Proc Natl Acad Sci U S A (2007) 1.52

DnaK functions as a central hub in the E. coli chaperone network. Cell Rep (2012) 1.52

Direct NMR observation of a substrate protein bound to the chaperonin GroEL. Proc Natl Acad Sci U S A (2005) 1.47

Monitoring protein conformation along the pathway of chaperonin-assisted folding. Cell (2008) 1.45

Binding specificity of Escherichia coli trigger factor. Proc Natl Acad Sci U S A (2001) 1.45

In vivo analysis of the overlapping functions of DnaK and trigger factor. EMBO Rep (2004) 1.42

Molecular mechanism and structure of Trigger Factor bound to the translating ribosome. EMBO J (2008) 1.41

Trigger factor forms a protective shield for nascent polypeptides at the ribosome. J Biol Chem (2006) 1.38

Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell (2010) 1.36

Export of Escherichia coli alkaline phosphatase attached to an integral membrane protein, SecY. J Biol Chem (1989) 1.35

Trigger factor retards protein export in Escherichia coli. J Biol Chem (2002) 1.33

Ribosome-associated chaperones as key players in proteostasis. Trends Biochem Sci (2012) 1.33

Promiscuous substrate recognition in folding and assembly activities of the trigger factor chaperone. Cell (2009) 1.32

Direct observation of chaperone-induced changes in a protein folding pathway. Science (2007) 1.32

Solution NMR of supramolecular complexes: providing new insights into function. Nat Methods (2007) 1.30

The cavity-chaperone Skp protects its substrate from aggregation but allows independent folding of substrate domains. Proc Natl Acad Sci U S A (2009) 1.29

Dynamics of trigger factor interaction with translating ribosomes. J Biol Chem (2007) 1.28

Structure and function of the molecular chaperone Trigger Factor. Biochim Biophys Acta (2010) 1.26

The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction. Structure (2005) 1.26

Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action. Proc Natl Acad Sci U S A (2005) 1.24

Interaction of trigger factor with the ribosome. J Mol Biol (2003) 1.19

CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. Proc Natl Acad Sci U S A (2002) 1.17

NMR studies of protein interactions. Curr Opin Struct Biol (2006) 1.16

Concerted action of the ribosome and the associated chaperone trigger factor confines nascent polypeptide folding. Mol Cell (2012) 1.12

Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli. Proc Natl Acad Sci U S A (2007) 1.11

Identification of nascent chain interaction sites on trigger factor. J Biol Chem (2007) 1.11

Three-state equilibrium of Escherichia coli trigger factor. Biol Chem (2002) 1.11

Dynamic association of trigger factor with protein substrates. J Mol Biol (2001) 1.11

Elucidation of the protein folding landscape by NMR. Methods Enzymol (2005) 1.10

The C-terminal domain of Escherichia coli trigger factor represents the central module of its chaperone activity. J Biol Chem (2006) 1.09

The client protein p53 adopts a molten globule-like state in the presence of Hsp90. Nat Struct Mol Biol (2011) 1.07

Folding of a mutant maltose-binding protein of Escherichia coli which forms inclusion bodies. J Biol Chem (1996) 1.07

Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains. J Bacteriol (2004) 1.07

Convergent evolution of clamp-like binding sites in diverse chaperones. Nat Struct Mol Biol (2006) 1.06

Tailoring relaxation dispersion experiments for fast-associating protein complexes. J Am Chem Soc (2007) 1.06

GroEL/GroES cycling: ATP binds to an open ring before substrate protein favoring protein binding and production of the native state. Proc Natl Acad Sci U S A (2009) 1.03

Exploring the capacity of trigger factor to function as a shield for ribosome bound polypeptide chains. FEBS Lett (2005) 1.03

Reshaping of the conformational search of a protein by the chaperone trigger factor. Nature (2013) 1.01

Conformation and dynamics of the periplasmic membrane-protein-chaperone complexes OmpX-Skp and tOmpA-Skp. Nat Struct Mol Biol (2013) 1.00

Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions. J Am Chem Soc (2012) 0.99

An economical method for production of (2)H, (13)CH3-threonine for solution NMR studies of large protein complexes: application to the 670 kDa proteasome. PLoS One (2012) 0.97

Thermodynamics of maltose binding protein unfolding. Protein Sci (1997) 0.95

Structural instability tuning as a regulatory mechanism in protein-protein interactions. Mol Cell (2011) 0.92

Versatility of trigger factor interactions with ribosome-nascent chain complexes. J Biol Chem (2010) 0.91

Crystal structure of a defective folding protein. Protein Sci (2003) 0.85

Tertiary structure-dependence of misfolding substitutions in loops of the maltose-binding protein. Protein Sci (1998) 0.84

Protein folding in the cell: an inside story. Nat Med (2011) 0.84

Structure discrimination for the C-terminal domain of Escherichia coli trigger factor in solution. J Biomol NMR (2007) 0.84

Trigger factor finds new jobs and contacts. Nat Struct Mol Biol (2009) 0.81

Kinetics and energetics of the translocation of maltose binding protein folding mutants. J Mol Biol (2008) 0.79

1H, 15N and 13C assignments of the dimeric ribosome binding domain of trigger factor from Escherichia coli. Biomol NMR Assign (2008) 0.77

Articles by these authors

Gene therapy for immunodeficiency due to adenosine deaminase deficiency. N Engl J Med (2009) 8.20

Consistent blind protein structure generation from NMR chemical shift data. Proc Natl Acad Sci U S A (2008) 6.76

Dynamically driven protein allostery. Nat Struct Mol Biol (2006) 4.53

Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR. Cell (2007) 3.06

NMR structure determination for larger proteins using backbone-only data. Science (2010) 3.00

Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: an Italian multicenter study. Clin Immunol (2002) 2.77

Dynamic activation of an allosteric regulatory protein. Nature (2009) 2.61

Protein activity regulation by conformational entropy. Nature (2012) 2.53

Proline cis-trans isomerization controls autoinhibition of a signaling protein. Mol Cell (2007) 2.44

Structural basis for cAMP-mediated allosteric control of the catabolite activator protein. Proc Natl Acad Sci U S A (2009) 2.39

Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic Granulomatous Disease: an Italian multicenter study. Clin Immunol (2007) 2.38

Bacterial protein secretion through the translocase nanomachine. Nat Rev Microbiol (2007) 2.21

A worldwide perspective of atypical pathogens in community-acquired pneumonia. Am J Respir Crit Care Med (2007) 2.08

Disorder-order folding transitions underlie catalysis in the helicase motor of SecA. Nat Struct Mol Biol (2006) 2.06

Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell (2011) 2.04

A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. J Clin Invest (2003) 1.92

The high-throughput protein sample production platform of the Northeast Structural Genomics Consortium. J Struct Biol (2010) 1.90

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell (2013) 1.86

Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children. Proc Natl Acad Sci U S A (2009) 1.84

Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples. Proc Natl Acad Sci U S A (2012) 1.83

Preparation of protein samples for NMR structure, function, and small-molecule screening studies. Methods Enzymol (2011) 1.75

Protein dynamics and allostery: an NMR view. Curr Opin Struct Biol (2010) 1.75

Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study. Pain (2005) 1.74

The lower limb flexion reflex in humans. Prog Neurobiol (2005) 1.67

Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. J Gen Virol (2007) 1.63

Congenital coronary artery anomalies angiographic classification revisited. Int J Cardiovasc Imaging (2003) 1.57

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor. J Mol Biol (2006) 1.53

Quantum chemical 13C(alpha) chemical shift calculations for protein NMR structure determination, refinement, and validation. Proc Natl Acad Sci U S A (2008) 1.50

Paternal transmission of symbiotic bacteria in malaria vectors. Curr Biol (2008) 1.44

Asaia, a versatile acetic acid bacterial symbiont, capable of cross-colonizing insects of phylogenetically distant genera and orders. Environ Microbiol (2009) 1.42

Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-Acquired Pneumonia Organization International cohort study results. Arch Intern Med (2009) 1.40

Structure and function of SecA, the preprotein translocase nanomotor. Biochim Biophys Acta (2004) 1.38

Determination of the structures of symmetric protein oligomers from NMR chemical shifts and residual dipolar couplings. J Am Chem Soc (2011) 1.35

Allosteric inhibition through suppression of transient conformational states. Nat Chem Biol (2013) 1.33

Structural basis for regulation of the Crk signaling protein by a proline switch. Nat Chem Biol (2010) 1.30

Signal peptides are allosteric activators of the protein translocase. Nature (2009) 1.28

Mosquito-bacteria symbiosis: the case of Anopheles gambiae and Asaia. Microb Ecol (2010) 1.27

Solution NMR structure of the NlpC/P60 domain of lipoprotein Spr from Escherichia coli: structural evidence for a novel cysteine peptidase catalytic triad. Biochemistry (2008) 1.27

Identification of the preprotein binding domain of SecA. J Biol Chem (2005) 1.25

Blind testing of routine, fully automated determination of protein structures from NMR data. Structure (2012) 1.23

Delayed larval development in Anopheles mosquitoes deprived of Asaia bacterial symbionts. BMC Microbiol (2012) 1.20

Ten years of descending necrotizing mediastinitis: management of 23 cases. J Oral Maxillofac Surg (2007) 1.19

Comparisons of NMR spectral quality and success in crystallization demonstrate that NMR and X-ray crystallography are complementary methods for small protein structure determination. J Am Chem Soc (2005) 1.19

Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study. Circulation (2009) 1.19

Allosteric communication between signal peptides and the SecA protein DEAD motor ATPase domain. J Biol Chem (2002) 1.15

Molecular evidence for multiple infections as revealed by typing of Asaia bacterial symbionts of four mosquito species. Appl Environ Microbiol (2010) 1.15

Microgram-scale protein structure determination by NMR. Nat Methods (2007) 1.11

SecA: a tale of two protomers. Mol Microbiol (2010) 1.10

Accurate automated protein NMR structure determination using unassigned NOESY data. J Am Chem Soc (2010) 1.10

Global co-ordination of protein translocation by the SecA IRA1 switch. J Biol Chem (2004) 1.08

Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat Chem Biol (2012) 1.08

Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerization. J Biol Chem (2003) 1.08

Effects of diffuse noxious inhibitory controls on temporal summation of the RIII reflex in humans. Pain (2004) 1.08

Preprotein-controlled catalysis in the helicase motor of SecA. EMBO J (2007) 1.06

Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry. Proteins (2009) 1.05

Molecular characterization of a large cohort of patients with Chronic Granulomatous Disease and identification of novel CYBB mutations: an Italian multicenter study. Mol Immunol (2009) 1.03

The Escherichia coli peripheral inner membrane proteome. Mol Cell Proteomics (2012) 0.99

Reduced atherosclerotic burden in subjects with genetically determined low oxidative stress. Arterioscler Thromb Vasc Biol (2013) 0.98

Mosquito/microbiota interactions: from complex relationships to biotechnological perspectives. Curr Opin Microbiol (2012) 0.97

Fecal HMGB1 is a novel marker of intestinal mucosal inflammation in pediatric inflammatory bowel disease. Am J Gastroenterol (2011) 0.97

Structural defects and variations in the HIV-1 nef gene from rapid, slow and non-progressor children. AIDS (2003) 0.97

Functional large-scale production of a novel Jonesia sp. xyloglucanase by heterologous secretion from Streptomyces lividans. J Biotechnol (2005) 0.96

Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype. Hum Brain Mapp (2010) 0.96

Interactions between Asaia, Plasmodium and Anopheles: new insights into mosquito symbiosis and implications in malaria symbiotic control. Parasit Vectors (2013) 0.96

Ten-year survivorship of the Anatomique Benoist Girard I total hip arthroplasty. J Arthroplasty (2007) 0.96

Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. J Allergy Clin Immunol (2010) 0.96

Double hexameric ring assembly of the type III protein translocase ATPase HrcN. Mol Microbiol (2006) 0.95

Escherichia coli SecA truncated at its termini is functional and dimeric. FEBS Lett (2005) 0.95

Early highly active antiretroviral therapy enhances B-cell longevity: a 5 year follow up. Pediatr Infect Dis J (2014) 0.95

Exposure of workers to electromagnetic fields. A review of open questions on exposure assessment techniques. Int J Occup Saf Ergon (2009) 0.94

Accurate protein structure modeling using sparse NMR data and homologous structure information. Proc Natl Acad Sci U S A (2012) 0.94

The ATPase domain of SecA can form a tetramer in solution. J Mol Biol (2002) 0.93

Successful allogeneic hemopoietic stem cell transplantation in a child who had anhidrotic ectodermal dysplasia with immunodeficiency. Pediatrics (2006) 0.93

Oral nitric-oxide donor glyceryl-trinitrate induces sensitization in spinal cord pain processing in migraineurs: a double-blind, placebo-controlled, cross-over study. Eur J Pain (2010) 0.93

Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): perspectives on vector-borne diseases symbiotic control. Antonie Van Leeuwenhoek (2010) 0.93

Breaking on through to the other side: protein export through the bacterial Sec system. Biochem J (2013) 0.93

Mobile phones exposure induces changes of contingent negative variation in humans. Neurosci Lett (2009) 0.93

Structural instability tuning as a regulatory mechanism in protein-protein interactions. Mol Cell (2011) 0.92

Anterior spinal artery syndrome complicated by the ondine curse. Arch Neurol (2003) 0.92

Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. J Biol Chem (2010) 0.92

Tubby-tagged balancers for the Drosophila X and second chromosomes. Fly (Austin) (2011) 0.92

Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis. Mult Scler (2005) 0.92

CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression. J Virol (2003) 0.92

Co-localization of susceptibility loci for psoriasis (PSORS4) and atopic dermatitis (ATOD2) on human chromosome 1q21. Hum Hered (2006) 0.91

The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner. J Gen Virol (2006) 0.91

Indeterminate colitis: a distinctive clinical pattern of inflammatory bowel disease in children. Pediatrics (2008) 0.90

Chronic daily headache. Expert Rev Neurother (2008) 0.90

Atopic dermatitis and asthma. Allergy Asthma Proc (2007) 0.90

Substrate-activated conformational switch on chaperones encodes a targeting signal in type III secretion. Cell Rep (2013) 0.90

NMR studies of large protein systems. Methods Mol Biol (2012) 0.89

The European paediatric legislation: benefits and perspectives. Ital J Pediatr (2010) 0.89

Validation of a clinical-significance-based classification of coronary artery anomalies. Angiology (2005) 0.89

Predictive accuracy of the pneumonia severity index vs CRB-65 for time to clinical stability: results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort Study. Respir Med (2010) 0.89