PubRank

Richard J Youle

Author PubWeight™ 209.57‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
2 Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008 17.81
3 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010 11.85
4 Mitochondrial dynamics and apoptosis. Genes Dev 2008 6.07
5 Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 2010 5.94
6 Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell 2004 5.94
7 Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006 5.25
8 Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol 2002 5.01
9 Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 2011 4.91
10 Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 2006 4.43
11 Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 2010 3.91
12 The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol 2007 3.83
13 Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 2010 3.68
14 p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010 3.68
15 Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol 2004 3.55
16 The role of mitochondria in apoptosis*. Annu Rev Genet 2009 3.44
17 Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Mol Cell 2004 3.28
18 Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 2011 3.23
19 PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol 2014 3.12
20 JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 2003 2.86
21 Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci 2003 2.68
22 OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain 2008 2.57
23 Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012 2.52
24 The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol Cell 2011 2.43
25 Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol 2005 2.31
26 Endophilin B1 is required for the maintenance of mitochondrial morphology. J Cell Biol 2004 2.28
27 Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. Nat Cell Biol 2012 2.25
28 Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem 2007 2.22
29 Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J 2003 2.16
30 How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol 2006 2.14
31 Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A 2010 2.10
32 PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. J Cell Biol 2013 2.04
33 Control of mitochondrial permeability by Bcl-2 family members. Biochim Biophys Acta 2004 2.00
34 A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell 2008 1.94
35 Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Dev Cell 2007 1.91
36 Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 2011 1.91
37 PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci 2012 1.89
38 Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci U S A 2004 1.85
39 Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy 2009 1.82
40 Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal 2011 1.82
41 Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J 2004 1.77
42 The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J Mol Biol 2003 1.70
43 PINK1 is degraded through the N-end rule pathway. Autophagy 2013 1.63
44 Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nat Methods 2012 1.62
45 Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Curr Opin Cell Biol 2011 1.62
46 Bid, but not Bax, regulates VDAC channels. J Biol Chem 2004 1.57
47 Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. J Biol Chem 2005 1.54
48 Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest 2011 1.52
49 Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci 2010 1.47
50 The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. FASEB J 2002 1.46
51 Outer mitochondrial membrane protein degradation by the proteasome. Novartis Found Symp 2007 1.36
52 SnapShot: BCL-2 proteins. Cell 2009 1.33
53 The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria. Autophagy 2013 1.31
54 Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. J Biol Chem 2002 1.27
55 Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. J Biol Chem 2005 1.27
56 Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis. Ann N Y Acad Sci 2008 1.26
57 Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Mol Cell Biol 2010 1.23
58 Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol Cell Biol 2013 1.16
59 Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. J Virol 2008 1.09
60 IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. EMBO J 2010 1.08
61 Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. Elife 2014 1.06
62 A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J Biol Chem 2011 1.04
63 Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited. Mol Cell Biol 2004 1.01
64 Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy. Nat Commun 2013 1.01
65 Coupling mitochondrial and cell division. Nat Cell Biol 2011 0.98
66 Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Mol Biol Cell 2013 0.98
67 Mitochondrial fission and fusion. Essays Biochem 2010 0.96
68 Atypical mitochondrial fission upon bacterial infection. Proc Natl Acad Sci U S A 2013 0.95
69 Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proc Natl Acad Sci U S A 2012 0.94
70 Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proc Natl Acad Sci U S A 2012 0.93
71 Extracellular Bad fused to toxin transport domains induces apoptosis. Cancer Res 2002 0.92
72 Mitochondrial fission and fusion and their roles in the heart. J Mol Med (Berl) 2010 0.91
73 Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. J Biol Chem 2009 0.91
74 Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. Circ Res 2016 0.91
75 Scission, spores, and apoptosis: a proposal for the evolutionary origin of mitochondria in cell death induction. Biochem Biophys Res Commun 2003 0.90
76 PINK1 rendered temperature sensitive by disease-associated and engineered mutations. Hum Mol Genet 2013 0.87
77 A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16. Hum Mol Genet 2011 0.83
78 PINK1 and Parkin flag Miro to direct mitochondrial traffic. Cell 2011 0.81
79 Neurodegeneration: Trouble in the cell's powerhouse. Nature 2012 0.80
80 Bcl-xL and caspase inhibition increase the survival of rat oxytocin and vasopressin magnocellular neurons in organotypic culture. Exp Neurol 2006 0.79
81 Endosome fusion induced by diphtheria toxin translocation domain. Proc Natl Acad Sci U S A 2008 0.79
82 A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad. Biochemistry 2005 0.78
83 The cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), can deliver Bcl-XL as an extracellular fusion protein to protect cells from apoptosis and retain differentiation induction. J Biol Chem 2007 0.78
84 Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs. Curr Biol 2013 0.76
85 Make or break for mitochondria. Elife 2013 0.76
86 Sequestration and autophagy of mitochondria do not cut proteins across the board. Proc Natl Acad Sci U S A 2013 0.75
87 Balancing cell growth and death. Curr Opin Cell Biol 2012 0.75