Published in N Engl J Med on March 21, 2002
AMSA and Amiodarone Study in Cardiac Arrest (MOSAIC) | NCT04997980
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Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. J Interferon Cytokine Res (2013) 0.75
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Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. Eur Heart J (2016) 0.75
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Community-based responses to impending or actual cardiac arrest and advances in post-cardiac arrest care. J Interv Card Electrophysiol (2003) 0.75
The structure of haplotype blocks in the human genome. Science (2002) 50.88
Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med (2007) 30.94
Detecting recent positive selection in the human genome from haplotype structure. Nature (2002) 22.00
Selective inhibition of BET bromodomains. Nature (2010) 18.79
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol (2006) 6.95
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov (2006) 6.88
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol (2006) 6.77
Routine early angioplasty after fibrinolysis for acute myocardial infarction. N Engl J Med (2009) 6.18
Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol (2004) 5.12
Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet (2006) 4.78
Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N Engl J Med (2008) 4.55
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol (2012) 3.88
Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors. Oncologist (2007) 3.42
Research capacity. Enabling the genomic revolution in Africa. Science (2014) 3.05
Should paramedics intubate patients with SARS-like symptoms? CMAJ (2003) 2.96
Racial/ethnic differences in hypertension and hypertension treatment and control in the multi-ethnic study of atherosclerosis (MESA). Am J Hypertens (2004) 2.88
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol (2011) 2.69
Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet (2010) 2.48
Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med (2006) 2.39
Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am J Hum Genet (2002) 2.29
Urine albumin excretion and subclinical cardiovascular disease. The Multi-Ethnic Study of Atherosclerosis. Hypertension (2005) 2.18
Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. J Clin Oncol (2011) 2.14
Association between chronic kidney disease and coronary artery calcification: the Dallas Heart Study. J Am Soc Nephrol (2004) 2.08
Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program. Am J Kidney Dis (2005) 2.05
Searching for signals of evolutionary selection in 168 genes related to immune function. Hum Genet (2005) 1.97
Income, education, and blood pressure in adults in Jamaica, a middle-income developing country. Int J Epidemiol (2003) 1.84
The case for selection at CCR5-Delta32. PLoS Biol (2005) 1.83
Blood mercury levels and neurobehavioral function. JAMA (2005) 1.72
Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res (2006) 1.58
Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma. Cancer Biol Ther (2008) 1.58
Ethnicity and human genetic linkage maps. Am J Hum Genet (2004) 1.50
Severe brain injury to neurological determination of death: Canadian forum recommendations. CMAJ (2006) 1.47
Increasing body mass index and obesity in the incident ESRD population. J Am Soc Nephrol (2006) 1.44
Is there a predictive profile for clinical inertia in hypertensive patients? An observational, cross-sectional, multicentre study. Drugs Aging (2011) 1.44
A classical likelihood based approach for admixture mapping using EM algorithm. Hum Genet (2006) 1.43
Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer. Clin Lung Cancer (2012) 1.40
Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial. Cancer (2012) 1.36
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. Am J Hum Genet (2011) 1.35
Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma. Clin Cancer Res (2007) 1.35
Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. Hypertension (2005) 1.32
Fine Mapping and Identification of BMI Loci in African Americans. Am J Hum Genet (2013) 1.27
A phase I dose-escalation study of Tivantinib (ARQ 197) in adult patients with metastatic solid tumors. Clin Cancer Res (2011) 1.27
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes (2006) 1.26
Increasing BMI and waist circumference and prevalence of obesity among adults with Type 2 diabetes: the National Health and Nutrition Examination Surveys. J Diabetes Complications (2009) 1.25
Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides. Hum Mol Genet (2002) 1.24
Results of a phase I trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors, including colorectal cancer. Clin Colorectal Cancer (2005) 1.22
Look who's taking notes in your clinic: mystery shoppers as evaluators in sexual health services. Health Expect (2008) 1.17
Early clinical development of ARQ 197, a selective, non-ATP-competitive inhibitor targeting MET tyrosine kinase for the treatment of advanced cancers. Oncologist (2011) 1.15
Positive association between resting energy expenditure and weight gain in a lean adult population. Am J Clin Nutr (2006) 1.15
A genome-wide linkage and association study using COGA data. BMC Genet (2005) 1.14
Impact of seasonal and pandemic influenza on emergency department visits, 2003-2010, Ontario, Canada. Acad Emerg Med (2013) 1.13
To predict progression-free survival and overall survival in metastatic renal cancer treated with sorafenib: pilot study using dynamic contrast-enhanced Doppler ultrasound. Eur J Cancer (2006) 1.12
Admixture mapping of quantitative trait loci for BMI in African Americans: evidence for loci on chromosomes 3q, 5q, and 15q. Obesity (Silver Spring) (2009) 1.12
Guidance on surgery for morbid obesity. Br J Perioper Nurs (2002) 1.10
Associations between hypertension and genes in the renin-angiotensin system. Hypertension (2003) 1.09
Interleukin-12 receptor β1 deficiency predisposing to disseminated Coccidioidomycosis. Clin Infect Dis (2011) 1.09
Do hospital E-codes consistently capture suicidal behaviour? Chronic Dis Can (2002) 1.09
An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program. Nutr Metab (Lond) (2005) 1.09
Randomized controlled study of detection enhancements versus rate-only detection to prevent inappropriate therapy in a dual-chamber implantable cardioverter-defibrillator. Heart Rhythm (2004) 1.09
The videolaryngoscope is less traumatic than the classic laryngoscope for a difficult airway in an obese patient. J Anesth (2009) 1.09
Comparison of the medical priority dispatch system to an out-of-hospital patient acuity score. Acad Emerg Med (2006) 1.07
Genome-wide linkage analysis for loci affecting pulse pressure: the Family Blood Pressure Program. Hypertension (2005) 1.07
Nonuse of bicycle helmets and risk of fatal head injury: a proportional mortality, case-control study. CMAJ (2012) 1.06
Migration of an amplatzer septal occluder device for closure of atrial septal defect into the ascending aorta with formation of an aorta-to-right atrial fistula. Am J Cardiol (2005) 1.05
Measuring the EMS patient access time interval and the impact of responding to high-rise buildings. Prehosp Emerg Care (2005) 1.05
The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. J Am Coll Cardiol (2006) 1.04
Temporal and spatial variation of heat-related illness using 911 medical dispatch data. Environ Res (2009) 1.02
Obesity management in adults with CKD. Am J Kidney Dis (2009) 1.02
Self-reported symptoms of depression and memory dysfunction in survivors of ARDS. Chest (2009) 1.01
Paramedic determinations of medical necessity: a meta-analysis. Prehosp Emerg Care (2009) 1.00
Evaluation of an insecticide dust band treatment method for controlling bed bugs. J Econ Entomol (2013) 1.00
A genome-wide scan for body mass index among Nigerian families. Obes Res (2003) 0.99
A phase I clinical trial of darinaparsin in patients with refractory solid tumors. Clin Cancer Res (2009) 0.98
A randomized controlled feasibility trial comparing safety and effectiveness of prehospital pacing versus conventional treatment: 'PrePACE'. Resuscitation (2007) 0.98
A combinatorial searching method for detecting a set of interacting loci associated with complex traits. Ann Hum Genet (2006) 0.97
The relationship between temperature and ambulance response calls for heat-related illness in Toronto, Ontario, 2005. J Epidemiol Community Health (2010) 0.96
Bone mineral density in the complete androgen insensitivity and 5alpha-reductase-2 deficiency syndromes. J Clin Endocrinol Metab (2006) 0.95
Half-a-million strong: the emergency medical services response to a single-day, mass-gathering event. Prehosp Disaster Med (2005) 0.94
Effectiveness of bed bug monitors for detecting and trapping bed bugs in apartments. J Econ Entomol (2011) 0.94
Out-of-hospital cardiac arrest rectilinear biphasic to monophasic damped sine defibrillation waveforms with advanced life support intervention trial (ORBIT). Resuscitation (2005) 0.92
A cluster-randomized trial of task shifting and blood pressure control in Ghana: study protocol. Implement Sci (2014) 0.91
Effect of widespread restrictions on the use of hospital services during an outbreak of severe acute respiratory syndrome. CMAJ (2007) 0.91
Linkage for BMI at 3q27 region confirmed in an African-American population. Diabetes (2003) 0.91
Prevalence, determinants and systems-thinking approaches to optimal hypertension control in West Africa. Global Health (2014) 0.91
Effect of trap design, chemical lure, carbon dioxide release rate, and source of carbon dioxide on efficacy of bed bug monitors. J Econ Entomol (2013) 0.89
Phase I trial of BAY 50-4798, an interleukin-2-specific agonist in advanced melanoma and renal cancer. Clin Cancer Res (2007) 0.88
Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Am Heart J (2002) 0.87
Emergency preparedness: what every health care worker needs to know. CJEM (2005) 0.87
Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats. Can J Anaesth (2003) 0.86
Affective instability and suicidal ideation and behavior in patients with borderline personality disorder. J Pers Disord (2007) 0.86
The Toronto prehospital hypertonic resuscitation--head injury and multiorgan dysfunction trial: feasibility study of a randomized controlled trial. J Crit Care (2010) 0.86
Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the Orbofiban in Patients with Unstable coronary Syndromes- (OPUS-TIMI 16) trial. J Thromb Thrombolysis (2006) 0.85
Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors. Invest New Drugs (2014) 0.85
The burden of illness associated with renal cell carcinoma in the United States. Urol Oncol (2007) 0.85
Magnetic resonance imaging assessment of airway status after orthognathic surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2006) 0.85