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Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69

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The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med (2012) 2.72

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Spurious inferences about long-term outcomes: the case of severe sepsis and geriatric conditions. Am J Respir Crit Care Med (2012) 2.60

The effect of primary graft dysfunction on survival after lung transplantation. Am J Respir Crit Care Med (2005) 2.57

Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28

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Obesity and 1-year outcomes in older Americans with severe sepsis. Crit Care Med (2014) 2.10

p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration. Nature (2014) 2.06

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A simple clinical predictive index for objective estimates of mortality in acute lung injury. Crit Care Med (2009) 1.91

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The economic effect of extracorporeal membrane oxygenation to support adults with severe respiratory failure in Brazil: a hypothetical analysis. Rev Bras Ter Intensiva (2014) 1.78

An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study. Crit Care (2013) 1.78

Intensive care of the cancer patient: recent achievements and remaining challenges. Ann Intensive Care (2011) 1.77

Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med (2008) 1.76

Are intensive care factors associated with depressive symptoms 6 months after acute lung injury? Crit Care Med (2009) 1.74

A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med (2012) 1.74

Sepsis-induced myopathy. Crit Care Med (2009) 1.72

One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med (2014) 1.70

Acute respiratory distress syndrome: a historical perspective. Am J Respir Crit Care Med (2005) 1.69

Clinical review: Critical illness polyneuropathy and myopathy. Crit Care (2008) 1.69

Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury. Crit Care Med (2008) 1.65

Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med (2012) 1.62

Early mobilization in the intensive care unit: a systematic review. Cardiopulm Phys Ther J (2012) 1.62

Evaluation Following Staggered Implementation of the "Rethinking Critical Care" ICU Care Bundle in a Multicenter Community Setting. Crit Care Med (2016) 1.61

Quality of life of survivors from severe sepsis and septic shock may be similar to that of others who survive critical illness. Crit Care (2004) 1.60

Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PLoS One (2008) 1.52

One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ (2013) 1.51

Bench-to-bedside review: mobilizing patients in the intensive care unit--from pathophysiology to clinical trials. Crit Care (2009) 1.49

Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med (2014) 1.49

Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation. Eur Respir J (2012) 1.46

Health-related quality of life and physical recovery after a critical illness: a multi-centre randomised controlled trial of a home-based physical rehabilitation program. Crit Care (2011) 1.45

How the relationships between general practitioners and intensivists can be improved: the general practitioners' point of view. Crit Care (2010) 1.45

Pro/con clinical debate: steroids are a key component in the treatment of SARS. Pro: Yes, steroids are a key component of the treatment regimen for SARS. Crit Care (2004) 1.45

Early and late unplanned rehospitalizations for survivors of critical illness*. Crit Care Med (2015) 1.43

Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care (2013) 1.43

Joint contracture following prolonged stay in the intensive care unit. CMAJ (2008) 1.36

Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med (2007) 1.36

Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study. Crit Care (2012) 1.34

Inter-rater reliability of manual muscle strength testing in ICU survivors and simulated patients. Intensive Care Med (2010) 1.33

Pulmonary sequelae in a patient recovered from swine flu. Lung India (2012) 1.32

Follow-up after acute respiratory distress syndrome caused by influenza a (H1N1) virus infection. Clinics (Sao Paulo) (2011) 1.29

Determinants of tracheostomy decannulation: an international survey. Crit Care (2008) 1.27

Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-a unifying hypothesis? What we have learned from small interfering RNAs. Mol Med (2008) 1.26

Neuromuscular sequelae of critical illness. N Engl J Med (2003) 1.25

Bench-to-bedside review: beta2-Agonists and the acute respiratory distress syndrome. Crit Care (2003) 1.23

A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure. Am J Respir Crit Care Med (2016) 1.21

Social support during intensive care unit stay might improve mental impairment and consequently health-related quality of life in survivors of severe acute respiratory distress syndrome. Crit Care (2006) 1.21

The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill. Physiol Rev (2015) 1.20

Acute respiratory distress syndrome: new definition, current and future therapeutic options. J Thorac Dis (2013) 1.19

Association between ultrasound measurements of muscle thickness, pennation angle, echogenicity and skeletal muscle strength in the elderly. Age (Dordr) (2013) 1.18

Acute respiratory distress syndrome. BMJ (2007) 1.18

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms. J Physiol (2011) 1.17

Cost-effectiveness of implementing low-tidal volume ventilation in patients with acute lung injury. Chest (2009) 1.17

Surviving critical illness: acute respiratory distress syndrome as experienced by patients and their caregivers. Crit Care Med (2009) 1.15

Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med (2014) 1.14

Population-based epidemiology of intensive care: critical importance of ascertainment of residency status. Crit Care (2004) 1.14

Epidemiology and outcomes of acute respiratory failure in the United States, 2001 to 2009: a national survey. J Hosp Med (2013) 1.13

The changing role of palliative care in the ICU. Crit Care Med (2014) 1.10

Toward an integrated research agenda for critical illness in aging. Am J Respir Crit Care Med (2010) 1.10

Risk factors for dementia after critical illness in elderly Medicare beneficiaries. Crit Care (2012) 1.07

Update in acute respiratory distress syndrome. J Intensive Care (2014) 1.06

Clinical predictive value of manual muscle strength testing during critical illness: an observational cohort study. Crit Care (2013) 1.05

Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype? Crit Care (2012) 1.04

Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats. J Clin Invest (2009) 1.04

The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injury. PLoS One (2011) 1.03

Hyperosmolarity enhances the lung capillary barrier. J Clin Invest (2003) 1.03

Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review. Crit Care (2015) 1.02

Clinical review: intensive care unit acquired weakness. Crit Care (2015) 1.01

Caregivers of the chronically critically ill after discharge from the intensive care unit: six months' experience. Am J Crit Care (2011) 1.01

Critical illness polyneuropathy and myopathy in the intensive care unit. Nat Rev Neurol (2009) 1.01

Self-reported symptoms of depression and memory dysfunction in survivors of ARDS. Chest (2009) 1.01

Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care (2015) 1.00

Pharmacological treatments in ARDS; a state-of-the-art update. BMC Med (2013) 0.99

Corticosteroids influence the mortality and morbidity of acute critical illness. Crit Care (2006) 0.99

Structure to function: muscle failure in critically ill patients. J Physiol (2010) 0.99

Mechanisms of neuromuscular dysfunction in critical illness. Crit Care Clin (2008) 0.99

Disability in activities of daily living, depression, and quality of life among older medical ICU survivors: a prospective cohort study. Health Qual Life Outcomes (2011) 0.98

Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus. J Virol (2007) 0.97

Surrogate and patient discrepancy regarding consent for critical care research. Crit Care Med (2012) 0.96

Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression. Pflugers Arch (2006) 0.96

Plasma from septic shock patients induces loss of muscle protein. Crit Care (2011) 0.96

Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Curr Pharm Biotechnol (2011) 0.96

Epidemiology and long-term clinical and biologic risk factors for pneumonia in community-dwelling older Americans: analysis of three cohorts. Chest (2013) 0.96

Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading. Crit Care (2012) 0.95

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J (2013) 0.95

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68

Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30

Acute respiratory distress syndrome: the Berlin Definition. JAMA (2012) 21.04

Identification of severe acute respiratory syndrome in Canada. N Engl J Med (2003) 14.29

Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med (2008) 11.00

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39

Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med (2011) 9.96

Critically Ill patients with 2009 influenza A(H1N1) in Mexico. JAMA (2009) 9.41

A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med (2013) 8.94

Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med (2011) 8.19

Point: High-frequency ventilation is the optimal physiological approach to ventilate ARDS patients. J Appl Physiol (1985) (2007) 7.96

Transfusion strategies for patients in pediatric intensive care units. N Engl J Med (2007) 7.21

Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69

High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA (2008) 6.39

2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ (2010) 6.37

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med (2006) 6.22

Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17

Aspirin in patients undergoing noncardiac surgery. N Engl J Med (2014) 6.10

Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med (2015) 6.06

Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA (2002) 6.00

Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res (2010) 6.00

Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*. Crit Care Med (2013) 5.88

Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res (2013) 5.76

A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med (2006) 5.74

Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med (2002) 5.52

Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg (2007) 5.32

Handheld computing in medicine. J Am Med Inform Assoc (2003) 5.23

A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA (2004) 5.20

A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med (2008) 5.20

Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review. Am J Respir Crit Care Med (2008) 5.06

2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg (2011) 4.84

An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol (2011) 4.65

Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA (2010) 4.64

Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med (2011) 4.59

Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults. N Engl J Med (2015) 4.54

Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 4.41

Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med (2013) 4.29

Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 4.11

Impact of androgen deprivation therapy on cardiovascular disease and diabetes. J Clin Oncol (2009) 4.07

Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med (2011) 3.87

Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med (2010) 3.83

Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med (2003) 3.75

Partial liquid ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2005) 3.75

Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA (2003) 3.69

Clinical consequences of red cell storage in the critically ill. Transfusion (2006) 3.57

Publication bias in editorial decision making. JAMA (2002) 3.52

High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: a randomized, controlled trial. Am J Respir Crit Care Med (2002) 3.43

What tidal volumes should be used in patients without acute lung injury? Anesthesiology (2007) 3.28

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med (2005) 3.26

The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18

Acute kidney injury after cardiac surgery: focus on modifiable risk factors. Circulation (2009) 3.10

Critically ill patients with severe acute respiratory syndrome. JAMA (2003) 3.10

Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature (2005) 3.09

Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med (2006) 3.06

The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Crit Care Med (2015) 2.85

Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med (2010) 2.82

The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med (2015) 2.77

Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock. Crit Care Med (2009) 2.77

Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial. JAMA (2010) 2.77

Ventilator-induced lung injury: from the bench to the bedside. Intensive Care Med (2005) 2.75

Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One (2012) 2.75

Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res (2015) 2.74

One-Year Outcomes in Caregivers of Critically Ill Patients. N Engl J Med (2016) 2.73

Facilitating clinician adherence to guidelines in the intensive care unit: A multicenter, qualitative study. Crit Care Med (2007) 2.72

Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med (2014) 2.71

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Selective β1-antagonism with bisoprolol is associated with fewer postoperative strokes than atenolol or metoprolol: a single-center cohort study of 44,092 consecutive patients. Anesthesiology (2013) 2.69

Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting. CMAJ (2011) 2.67

PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med (2004) 2.66

Clinician predictions of intensive care unit mortality. Crit Care Med (2004) 2.65

Alveolar dynamics in acute lung injury: heterogeneous distension rather than cyclic opening and collapse. Crit Care Med (2009) 2.54

A family-based approach to the prevention of depressive symptoms in children at risk: evidence of parental and child change. Pediatrics (2003) 2.54