Published in J Biol Chem on March 28, 2002
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Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts. J Biol Chem (2003) 1.27
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Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. J Biol Chem (2004) 1.21
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. J Biol Chem (2004) 1.20
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. J Biol Chem (2004) 1.20
Evidence for glucocorticoid receptor transport on microtubules by dynein. J Biol Chem (2004) 1.20
The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem (2003) 1.18
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Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations. Pharm Res (2008) 1.09
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. Brain Res Mol Brain Res (2004) 1.06
Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. Neoplasia (2012) 1.04
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry (2005) 1.04
The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase. J Biol Chem (2004) 1.03
Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors. J Neurosci (2004) 1.03
Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex. J Biol Chem (2004) 1.02
Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. J Biol Chem (2003) 1.01
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry (2009) 1.01
Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc Natl Acad Sci U S A (2009) 1.00
Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis. Mol Pharmacol (2004) 0.99
Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones. J Pharmacol Exp Ther (2003) 0.96
Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. Drug Metab Dispos (2013) 0.92
C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination. J Biol Chem (2010) 0.90
All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells. Biochemistry (2002) 0.90
Characterization of a plant homolog of hop, a cochaperone of hsp90. Plant Physiol (2003) 0.89
Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo. Drug Metab Dispos (2006) 0.89
Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. Brain Res Mol Brain Res (2005) 0.89
Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. Biochemistry (2013) 0.87
Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor. Mol Pharmacol (2011) 0.87
Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo. Mol Pharmacol (2002) 0.86
Use of artificial dermis and recombinant basic fibroblast growth factor for creating a neovagina in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome. Hum Reprod (2004) 0.86
The protein chaperone HSP90 can facilitate the divergence of gene duplicates. Genetics (2013) 0.85
Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes. Drug Metab Dispos (2004) 0.85
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry (2011) 0.85
Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly. Endocr J (2008) 0.85
Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. J Biol Chem (2011) 0.85
Ocular pharmacokinetics of mapracorat, a novel, selective glucocorticoid receptor agonist, in rabbits and monkeys. Drug Metab Dispos (2011) 0.84
Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization. J Biol Chem (2013) 0.82
Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke. Drug Metab Dispos (2003) 0.82
Regulation of glucocorticoid receptor ligand-binding activity by the hsp90/hsp70-based chaperone machinery. Methods Enzymol (2003) 0.82
Assembly and activation of heme-deficient neuronal NO synthase with various porphyrins. J Inorg Biochem (2002) 0.81
Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Phytomedicine (2006) 0.80
Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly. J Biol Chem (2002) 0.80
Dynamic changes in lipids and proteins of maternal, fetal, and pup blood and milk during perinatal development in CD and Wistar rats. Toxicol Sci (2008) 0.79
Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxidoprogesterone. Biochim Biophys Acta (2002) 0.78
In vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol. Xenobiotica (2010) 0.78
Pregnancy complications and glucose intolerance in women with polycystic ovary syndrome. Endocr J (2015) 0.78
Investigations of oxidative stress, antioxidant response, and protein binding in chlorpyrifos exposed rat neuronal PC12 cells. Toxicol Mech Methods (2008) 0.78
Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. Bioorg Med Chem Lett (2009) 0.78
Adverse effects of advanced glycation end products on embryonal development. Acta Med Okayama (2008) 0.77
Impaired uterine perfusion associated with metabolic disorders in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand (2005) 0.77
Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein. J Biol Chem (2012) 0.77
Nafamostat mesilate suppresses NF-kappaB activation and NO overproduction in LPS-treated macrophages. Int Immunopharmacol (2003) 0.77
Correlation between pregnanesteroid conformation, receptor affinity, and anti-natriuretic effect. Eur J Pharmacol (2002) 0.76
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Plant-Derived Small Molecule Inhibitors of Neuronal NO-Synthase: Potential Effects on Protein Degradation. Plant Signal Behav (2007) 0.75
Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group. Chem Res Toxicol (2005) 0.75