PubRank

Keiichi I Nakayama

Author PubWeight™ 269.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 2007 5.94
2 Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004 4.95
3 Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 2004 4.35
4 The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell 2003 3.87
5 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev 2004 3.82
6 SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011 3.69
7 Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 2006 3.63
8 Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J 2006 3.53
9 Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell 2004 3.27
10 Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol 2004 3.14
11 Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature 2010 3.09
12 Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol 2009 2.91
13 Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 2002 2.68
14 Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Nat Cell Biol 2003 2.64
15 Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol 2005 2.62
16 Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 2003 2.59
17 p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell 2011 2.58
18 p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell 2011 2.54
19 ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol 2004 2.50
20 Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A 2003 2.45
21 Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 2007 2.41
22 Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 2008 2.36
23 The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell 2012 2.30
24 An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A 2005 2.18
25 Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 2005 2.18
26 Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem 2002 2.12
27 Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 2008 2.12
28 Large-scale analysis of the human ubiquitin-related proteome. Proteomics 2005 2.00
29 Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med 2007 1.99
30 Protrudin induces neurite formation by directional membrane trafficking. Science 2006 1.84
31 CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol 2009 1.75
32 The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab 2011 1.74
33 miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1. Blood 2011 1.73
34 Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J Clin Invest 2005 1.61
35 Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J Biol Chem 2006 1.61
36 Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4. Structure 2010 1.58
37 Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase. Cardiovasc Res 2008 1.57
38 Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J 2004 1.57
39 Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest 2006 1.52
40 Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance. Int J Cancer 2010 1.49
41 Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9. Mol Endocrinol 2004 1.47
42 USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol 2008 1.44
43 FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell 2013 1.42
44 Skp2 controls adipocyte proliferation during the development of obesity. J Biol Chem 2006 1.41
45 Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc Natl Acad Sci U S A 2003 1.38
46 Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Mol Cell Biol 2005 1.37
47 p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res 2009 1.37
48 Blue light-induced autophosphorylation of phototropin is a primary step for signaling. Proc Natl Acad Sci U S A 2008 1.37
49 Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. Cancer Sci 2006 1.34
50 Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway. J Biol Chem 2003 1.34
51 Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. J Biol Chem 2004 1.32
52 Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res 2006 1.31
53 Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol 2009 1.28
54 Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem Biophys Res Commun 2003 1.28
55 A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 2008 1.27
56 Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell 2013 1.27
57 Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway. Mol Cell Biol 2011 1.27
58 KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev 2010 1.26
59 The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. J Virol 2004 1.25
60 Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res 2004 1.24
61 HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells. FASEB J 2006 1.21
62 AIRE functions as an E3 ubiquitin ligase. J Exp Med 2004 1.19
63 Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest 2010 1.17
64 Mammalian E4 is required for cardiac development and maintenance of the nervous system. Mol Cell Biol 2005 1.17
65 Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol Cell Biol 2012 1.17
66 Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem 2011 1.17
67 Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease. Blood 2008 1.17
68 GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J Neurosci 2004 1.17
69 The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex. J Biol Chem 2006 1.16
70 PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2006 1.16
71 Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. FASEB J 2006 1.15
72 Geminin is essential for the development of preimplantation mouse embryos. Genes Cells 2006 1.14
73 Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev 2004 1.14
74 Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem 2004 1.14
75 Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36. J Cell Sci 2009 1.14
76 Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Genes Cells 2004 1.13
77 PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood 2006 1.12
78 Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. J Biol Chem 2005 1.12
79 UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nat Med 2011 1.12
80 Fbxw7 in cell cycle exit and stem cell maintenance: insight from gene-targeted mice. Cell Cycle 2008 1.11
81 Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem 2006 1.10
82 Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Res 2006 1.10
83 Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice. Am J Pathol 2007 1.10
84 Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res 2003 1.09
85 Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis. J Immunol 2009 1.09
86 Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene 2002 1.09
87 Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell 2013 1.08
88 Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. J Biol Chem 2008 1.08
89 S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo. J Vasc Surg 2009 1.08
90 Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. J Biol Chem 2009 1.08
91 Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res 2007 1.07
92 Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J Mol Cell Cardiol 2010 1.06
93 Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol 2011 1.06
94 Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Mol Biol Cell 2011 1.05
95 Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis. J Cell Sci 2008 1.05
96 Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum Mol Genet 2008 1.05
97 Anchoring of the 26S proteasome to the organellar membrane by FKBP38. Genes Cells 2007 1.04
98 Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol Cell Biol 2006 1.04
99 SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. Cell Rep 2012 1.03
100 Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. J Biol Chem 2006 1.03
101 p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J Cell Biol 2005 1.03
102 U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J Neurochem 2004 1.03
103 Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J Biol Chem 2008 1.03
104 Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. J Biol Chem 2004 1.02
105 Multiple mechanisms for p27(Kip1) translocation and degradation. Cell Cycle 2007 1.01
106 Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. J Biol Chem 2004 1.01
107 Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways. Proteomics 2009 1.00
108 Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model. Proc Natl Acad Sci U S A 2009 1.00
109 Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner. Biochem Biophys Res Commun 2006 1.00
110 Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res 2006 0.99
111 Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Hum Mol Genet 2005 0.99
112 Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci 2007 0.99
113 Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol 2004 0.98
114 Functional analyses of the activation loop of phototropin2 in Arabidopsis. Plant Physiol 2011 0.98
115 Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a. Biochem Biophys Res Commun 2003 0.97
116 F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest 2015 0.97
117 The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. J Biochem 2008 0.96
118 p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase. J Biol Chem 2003 0.96
119 Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts. J Bone Miner Res 2012 0.96
120 Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages. J Biol Chem 2006 0.96
121 Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. J Biol Chem 2009 0.96
122 Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition. Mol Cell Biol 2007 0.95
123 Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. Mol Cancer Res 2010 0.95
124 Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. J Biol Chem 2009 0.94
125 Suppression of cell migration by protein kinase Cdelta. Oncogene 2005 0.94
126 Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. J Biol Chem 2005 0.93
127 Ubiquitylation as a quality control system for intracellular proteins. J Biochem 2003 0.93
128 Selective escape of proteins from the mitochondria during mitophagy. Nat Commun 2013 0.93
129 Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse. Genes Cells 2008 0.93
130 Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1. Immunity 2010 0.93
131 Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body. Anat Embryol (Berl) 2004 0.93
132 Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. Mol Cell Biol 2006 0.92
133 Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment. Graefes Arch Clin Exp Ophthalmol 2004 0.91
134 Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3. Biochem Biophys Res Commun 2010 0.91
135 p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis. EMBO J 2013 0.90
136 Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J Proteome Res 2011 0.90
137 Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment. Graefes Arch Clin Exp Ophthalmol 2005 0.90
138 Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. J Biol Chem 2005 0.90
139 nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells. Am J Physiol Cell Physiol 2007 0.89
140 Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. J Biol Chem 2014 0.89
141 Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol. Carcinogenesis 2007 0.89
142 Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts. J Bone Miner Res 2007 0.89
143 Involvement of p27KIP1 in the proliferation of the developing corneal endothelium. Invest Ophthalmol Vis Sci 2004 0.89
144 TRIM8 modulates STAT3 activity through negative regulation of PIAS3. J Cell Sci 2010 0.89
145 Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4. Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation. J Biol Chem 2004 0.89
146 Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression. Blood 2010 0.89
147 Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation. Genes Cells 2011 0.88
148 Identification and characterization of a neuron-specific isoform of protrudin. Genes Cells 2013 0.88
149 Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. J Biol Chem 2010 0.88
150 Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. J Bone Miner Res 2012 0.87
151 CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P. J Cell Physiol 2009 0.87
152 Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci 2011 0.87
153 Role of key regulators of the cell cycle in maintenance of hematopoietic stem cells. Biochim Biophys Acta 2012 0.87
154 Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation. Cancer Res 2005 0.87
155 Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. J Immunol 2003 0.87
156 Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma. Int J Oncol 2012 0.87
157 Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin. J Biol Chem 2011 0.86
158 Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens. Curr Eye Res 2005 0.86
159 Mapping of ubiquitination sites on target proteins. Methods Enzymol 2005 0.86
160 Association of cathepsin E deficiency with development of atopic dermatitis. J Biochem 2003 0.86
161 Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma. Int J Mol Med 2005 0.86
162 UPS delivers pluripotency. Cell Stem Cell 2012 0.86
163 Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. Pharmacogenet Genomics 2008 0.86
164 Comprehensive identification of substrates for F-box proteins by differential proteomics analysis. J Proteome Res 2012 0.86
165 TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells. Biochim Biophys Acta 2011 0.85
166 Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels. Biol Reprod 2009 0.85
167 Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation. Genes Cells 2012 0.84
168 Functional similarities and uniqueness of p27 and p57: insight from a knock-in mouse model. Cell Cycle 2009 0.84
169 Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice. Am J Pathol 2007 0.84
170 Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. J Biol Chem 2013 0.83
171 Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. PLoS One 2013 0.83
172 Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3. Adv Exp Med Biol 2010 0.83
173 Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors. J Biochem 2006 0.82
174 Impaired ovarian development and reduced fertility in female mice deficient in Skp2. J Anat 2011 0.82
175 GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice. J Neurochem 2010 0.81
176 Development of mice without Cip/Kip CDK inhibitors. Biochem Biophys Res Commun 2012 0.81
177 Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration. Neuroreport 2007 0.81
178 Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice. Cell Div 2006 0.81
179 Mechanoregulation of proliferation. Mol Cell Biol 2009 0.81
180 Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling. EMBO J 2012 0.81
181 Comparative analysis of human SRC-family kinase substrate specificity in vitro. J Proteome Res 2010 0.81
182 Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7L. Genes Cells 2012 0.81
183 Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin. J Cell Mol Med 2011 0.81
184 Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. Lab Invest 2009 0.80
185 The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice. PLoS One 2012 0.80
186 Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. Mol Biol Cell 2002 0.80
187 The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo. Obesity (Silver Spring) 2007 0.80
188 Four mood stabilizers commonly induce FEZ1 expression in human astrocytes. Bipolar Disord 2011 0.80
189 F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. J Biol Chem 2013 0.79
190 Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival. J Neurochem 2007 0.79
191 An animal model manifesting neurodegeneration and obesity. Aging (Albany NY) 2010 0.79
192 Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells. Exp Hematol 2007 0.79
193 Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43. Biol Pharm Bull 2010 0.78
194 Association of cathepsin E deficiency with the increased territorial aggressive response of mice. J Neurochem 2008 0.78
195 Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development. Mol Cell Biol 2014 0.78
196 In vitro histone demethylase assay. Cold Spring Harb Protoc 2010 0.78
197 [Immunophilin FKBP38, an inherent inhibitor of calcineurin, targets Bcl-2 to mitochondria and inhibits apoptosis]. Nihon Rinsho 2004 0.78
198 Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice. Mol Cell Biol 2011 0.78
199 Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism. Arterioscler Thromb Vasc Biol 2011 0.78
200 Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection. J Immunol 2014 0.77
201 [Proliferative regulation in the cornea and lens]. Nippon Ganka Gakkai Zasshi 2003 0.77
202 Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1. FEBS J 2013 0.77
203 Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. Biochem Biophys Res Commun 2010 0.77
204 Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages. J Biochem 2009 0.77
205 The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity. Int J Cancer 2009 0.77
206 [Comprehensive study of protein ubiquitylation sites by conjugation of engineered lysine-less ubiquitin]. Seikagaku 2012 0.77
207 Glomerular differentiation in p27 and p57 double-mutant metanephroi. Anat Embryol (Berl) 2002 0.77
208 Phosphorylation of p27(KIP1) in the mitotic cells of the corneal epithelium. Curr Eye Res 2006 0.76
209 Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem 2015 0.75
210 Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy. J Neurol 2013 0.75
211 Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma. Int J Mol Med 2006 0.75