Published in Hum Mol Genet on May 01, 2002
Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol (2010) 7.97
Ethical, legal, and social dimensions of epilepsy genetics. Epilepsia (2006) 5.95
Neuronal autoantigens--pathogenesis, associated disorders and antibody testing. Nat Rev Neurol (2012) 3.20
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet (2010) 2.61
Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med (2009) 2.20
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A (2010) 2.07
The prevalence of psychosis in epilepsy; a systematic review and meta-analysis. BMC Psychiatry (2014) 1.71
LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Neurology (2004) 1.67
Classification of partial seizure symptoms in genetic studies of the epilepsies. Neurology (2006) 1.59
Analysis of genetically complex epilepsies. Epilepsia (2005) 1.58
Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families. J Neurol (2007) 1.54
Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. Hum Mol Genet (2010) 1.52
Genetic testing in the epilepsies--report of the ILAE Genetics Commission. Epilepsia (2010) 1.51
Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci (2013) 1.48
Enhanced synaptic connectivity and epilepsy in C1q knockout mice. Proc Natl Acad Sci U S A (2010) 1.38
LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology. Mol Cell Neurosci (2009) 1.32
Defining the expression pattern of the LGI1 gene in BAC transgenic mice. Mamm Genome (2007) 1.25
Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice. Brain (2010) 1.24
Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus. Epilepsia (2007) 1.19
Schizophrenia and epilepsy: is there a shared susceptibility? Neurosci Res (2009) 1.09
CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. PLoS Genet (2012) 1.07
Autosomal dominant nocturnal frontal lobe epilepsy--a critical overview. J Neurol (2004) 1.01
Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J Biol Chem (2012) 1.01
Clinical spectrum and diagnostic value of antibodies against the potassium channel related protein complex. Neurologia (2014) 0.97
Penetrance of LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Neurology (2008) 0.97
LGI proteins in the nervous system. ASN Neuro (2013) 0.97
Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. Mol Autism (2010) 0.97
Continuous muscle activity, Morvan's syndrome and limbic encephalitis: ionic or non ionic disorders? Acta Myol (2011) 0.95
K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy. Front Cell Neurosci (2013) 0.94
Use of chromosome substitution strains to identify seizure susceptibility loci in mice. Mamm Genome (2007) 0.92
LGI1 gene mutation screening in sporadic partial epilepsy with auditory features. J Neurol (2005) 0.91
Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy. Am J Hum Genet (2015) 0.89
Epilepsy with auditory features: A heterogeneous clinico-molecular disease. Neurol Genet (2015) 0.89
Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures. Brain (2014) 0.86
Neurexins, neuroligins and LRRTMs: synaptic adhesion getting fishy. J Neurochem (2011) 0.85
Somatic alterations in brain tumors. Oncol Rep (2008) 0.85
Potassium Channels and Human Epileptic Phenotypes: An Updated Overview. Front Cell Neurosci (2016) 0.85
LGI1: a gene involved in epileptogenesis and glioma progression? Neurogenetics (2005) 0.83
A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. PLoS One (2011) 0.83
Autoimmune synaptopathies. Nat Rev Neurosci (2016) 0.82
Genetic variations and associated pathophysiology in the management of epilepsy. Appl Clin Genet (2011) 0.82
Inactivation of LGI1 expression accompanies early stage hyperplasia of prostate epithelium in the TRAMP murine model of prostate cancer. Exp Mol Pathol (2009) 0.81
Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis. Front Cell Neurosci (2015) 0.81
Altered language processing in autosomal dominant partial epilepsy with auditory features. Neurology (2008) 0.80
Expression of the LGI1 gene product in astrocytic gliomas: downregulation with malignant progression. Virchows Arch (2003) 0.80
Domain-dependent clustering and genotype-phenotype analysis of LGI1 mutations in ADPEAF. Neurology (2012) 0.80
Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels. J Neurochem (2012) 0.79
Arrested glutamatergic synapse development in human partial epilepsy. Epilepsy Curr (2010) 0.79
ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy. Epilepsy Res Treat (2010) 0.79
Genetics of temporal lobe epilepsy: a review. Epilepsy Res Treat (2012) 0.78
Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1. Neuro Oncol (2006) 0.78
Distribution of the epilepsy-related Lgi1 protein in rat cortical neurons. Histochem Cell Biol (2009) 0.78
Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev (2017) 0.78
LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development. Sci Rep (2016) 0.77
Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells. Int J Cell Biol (2009) 0.77
Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2. BMC Biochem (2010) 0.76
Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling. Mol Genet Genomic Med (2016) 0.76
The functional anatomy of central auditory processing. Pract Neurol (2015) 0.76
Deja vu in neurology. J Neurol (2005) 0.76
Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis. Case Rep Neurol Med (2016) 0.75
"Fold Here"-Chemical Correctors in the Treatment of Epilepsy. Epilepsy Curr (2015) 0.75
Putting the Horse Before the Cart: Looking to Presynaptic Mechanisms in Genetic Models. Epilepsy Curr (2016) 0.75
Enteroviruses in chronic fatigue syndrome: "now you see them, now you don't". J Neurol Neurosurg Psychiatry (2003) 0.75
Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors. PLoS Genet (2016) 0.75
Hyponatraemia caused by LGI1-associated limbic encephalitis. NDT Plus (2011) 0.75
The clinical phenotype of autosomal dominant lateral temporal lobe epilepsy related to reelin mutations. Epilepsy Behav (2017) 0.75
Refined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1. BMC Genomics (2003) 0.75
LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. Proc Natl Acad Sci U S A (2017) 0.75
Genetic and epigenetic mechanisms of epilepsy: a review. Neuropsychiatr Dis Treat (2017) 0.75
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Signatures of mutational processes in human cancer. Nature (2013) 21.63
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron (2004) 13.99
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
A genotype calling algorithm for the Illumina BeadArray platform. Bioinformatics (2007) 8.03
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med (2006) 7.42
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
The DNA sequence of the human X chromosome. Nature (2005) 6.97
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia (2010) 6.23
Microbial exposure during early life has persistent effects on natural killer T cell function. Science (2012) 5.90
Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res (2006) 5.50
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood (2009) 3.50
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Double-hit B-cell lymphomas. Blood (2010) 3.19
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell (2012) 3.10
Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet (2009) 3.09
MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood (2013) 3.03
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet (2010) 2.99
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med (2009) 2.80
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
A genome-wide association study of testicular germ cell tumor. Nat Genet (2009) 2.79
Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ Res (2007) 2.71
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
FCGR3 variants and expression of human neutrophil antigen-1a, -1b, and -1c in the populations of northern Germany and Uganda. Transfusion (2002) 2.52
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes (2004) 2.43
FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffin-embedded tissue. J Mol Diagn (2006) 2.28
Prevalence of neurofibromatosis 1 in German children at elementary school enrollment. Arch Dermatol (2005) 2.23
Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood (2009) 2.22
Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood (2005) 2.19
The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome. Cell (2006) 2.19
A DNA methylation fingerprint of 1628 human samples. Genome Res (2011) 2.16
High-throughput genotyping of Salmonella enterica serovar Typhi allowing geographical assignment of haplotypes and pathotypes within an urban District of Jakarta, Indonesia. J Clin Microbiol (2008) 2.14
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion. Nat Genet (2006) 2.11
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood (2006) 2.10
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet (2012) 2.07
ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. Blood (2003) 2.05
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A (2013) 2.00
Mutations in NHLRC1 cause progressive myoclonus epilepsy. Nat Genet (2003) 2.00
Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS One (2009) 1.98
New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood (2008) 1.97
Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. Bioessays (2004) 1.96
Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. Cancer Res (2009) 1.95
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. J Exp Med (2007) 1.94
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat Med (2010) 1.93
Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2. J Clin Invest (2005) 1.88
Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet (2013) 1.87
Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome. Am J Hum Genet (2010) 1.83
Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation. Hum Mol Genet (2007) 1.83
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J Clin Oncol (2007) 1.82
High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. Genes Chromosomes Cancer (2012) 1.82
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res (2006) 1.80
Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization. Haematologica (2008) 1.80
CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma. Blood (2012) 1.79
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP. Neurobiol Aging (2008) 1.76
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood (2006) 1.74
CAPN3 mutations in patients with idiopathic eosinophilic myositis. Ann Neurol (2006) 1.73
Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma. Blood (2003) 1.73
MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Blood (2003) 1.69
Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Clin Cancer Res (2006) 1.66
Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma. Haematologica (2006) 1.65
The human retinoblastoma gene is imprinted. PLoS Genet (2009) 1.63
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. J Mol Biol (2003) 1.61
LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy. Hum Mutat (2009) 1.58
Oncogenicity of the developmental transcription factor Sox9. Cancer Res (2012) 1.55
Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma. BMC Cancer (2010) 1.55
DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metab (2013) 1.55
The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective. J Clin Oncol (2011) 1.54
Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families. J Neurol (2007) 1.54
Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. Blood (2002) 1.53
Progressive myoclonic epilepsies: definitive and still undetermined causes. Neurology (2014) 1.52
Is refractory epilepsy preventable? Epilepsia (2002) 1.52
Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome. Blood (2005) 1.51
Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survival. J Pathol (2005) 1.51
The SYSTERS Protein Family Database in 2005. Nucleic Acids Res (2005) 1.49