Published in Mol Biol Cell on May 01, 2002
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci U S A (2007) 1.17
LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. J Clin Invest (2009) 1.02
A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting. Mol Biol Cell (2012) 1.00
Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Mol Biol Cell (2008) 0.90
Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem (2011) 0.90
Trafficking of siderophore transporters in Saccharomyces cerevisiae and intracellular fate of ferrioxamine B conjugates. Traffic (2007) 0.88
CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene (2012) 0.87
Macrophage transcriptional responses following in vitro infection with a highly virulent African swine fever virus isolate. J Virol (2006) 0.85
Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Res Ther (2014) 0.82
On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin. Front Endocrinol (Lausanne) (2017) 0.75
Novel interaction of Rab13 and Rab8 with endospanins. FEBS Open Bio (2013) 0.75
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (1998) 48.29
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
Autophagy as a regulated pathway of cellular degradation. Science (2000) 17.27
Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell (1992) 9.63
Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease. Cell (1987) 5.92
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. J Cell Biol (1991) 5.76
Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell (1986) 5.73
Isolation of yeast mutants defective in protein targeting to the vacuole. Proc Natl Acad Sci U S A (1986) 5.71
Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae. Yeast (1997) 5.61
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell (1994) 5.10
VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J Cell Biol (1995) 5.04
Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Mol Biol Cell (1996) 4.71
Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol Biol Cell (1996) 4.58
Methods for studying the yeast vacuole. Methods Enzymol (1991) 4.55
Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae. J Cell Biol (1991) 4.54
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors. Mol Cell Biol (1986) 4.23
Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation. EMBO J (1989) 4.19
Localization of components involved in protein transport and processing through the yeast Golgi apparatus. J Cell Biol (1991) 3.86
Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y. J Cell Biol (1986) 3.85
The leptin receptor. J Biol Chem (1997) 3.76
Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol (1997) 3.61
The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell (1997) 3.30
Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes. J Cell Biol (1994) 3.27
Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment. J Cell Biol (1993) 3.25
Yeast endocytosis assays. Methods Enzymol (1991) 3.24
Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. J Cell Biol (1996) 3.23
Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. J Biol Chem (1996) 3.13
Endocytosis and degradation of the yeast uracil permease under adverse conditions. J Biol Chem (1994) 3.09
Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins. Annu Rev Cell Dev Biol (1995) 2.93
The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport. Mol Cell Biol (1991) 2.87
The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast. Mol Biol Cell (1999) 2.73
An oligomeric protein is imported into peroxisomes in vivo. J Cell Biol (1994) 2.71
A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol (1996) 2.62
Golgi structure correlates with transitional endoplasmic reticulum organization in Pichia pastoris and Saccharomyces cerevisiae. J Cell Biol (1999) 2.60
Vacuole biogenesis in Saccharomyces cerevisiae: protein transport pathways to the yeast vacuole. Microbiol Mol Biol Rev (1998) 2.59
The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Mol Biol Cell (1995) 2.50
Sorting in the endosomal system in yeast and animal cells. Curr Opin Cell Biol (2000) 2.50
The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. J Cell Biol (1997) 2.32
VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells. Proc Natl Acad Sci U S A (1999) 2.00
Multiple sorting pathways between the late Golgi and the vacuole in yeast. Biochim Biophys Acta (1998) 1.96
Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.91
A yeast t-SNARE involved in endocytosis. Mol Biol Cell (1998) 1.82
Sorting of membrane proteins in the yeast secretory pathway. J Biol Chem (1994) 1.79
Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis. J Biol Chem (1998) 1.73
Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase. Mol Cell Biol (2001) 1.69
Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatomer. J Cell Biol (2001) 1.67
A family of small coiled-coil-forming proteins functioning at the late endosome in yeast. Mol Biol Cell (2001) 1.57
Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum. J Cell Biol (1995) 1.54
The sodium/proton exchanger Nhx1p is required for endosomal protein trafficking in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2000) 1.53
A network approach to the systematic analysis of yeast gene function. Trends Genet (1996) 1.52
Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis. J Biol Chem (1996) 1.41
Multipurpose vectors designed for the fast generation of N- or C-terminal epitope-tagged proteins. Yeast (1994) 1.40
Cloning and functional characterization of mammalian homologues of the COPII component Sec23. Mol Biol Cell (1996) 1.39
An acidic sequence of a putative yeast Golgi membrane protein binds COPII and facilitates ER export. EMBO J (2001) 1.36
VMA11 and VMA16 encode second and third proteolipid subunits of the Saccharomyces cerevisiae vacuolar membrane H+-ATPase. J Biol Chem (1997) 1.35
Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. J Cell Sci (1996) 1.32
VIP17/MAL, a proteolipid in apical transport vesicles. FEBS Lett (1995) 1.31
Primary structure of the uracil transport protein of Saccharomyces cerevisiae. Eur J Biochem (1988) 1.31
Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex. EMBO J (1999) 1.30
Syntaxin 7 mediates endocytic trafficking to late endosomes. J Biol Chem (2000) 1.29
Pep12p is a multifunctional yeast syntaxin that controls entry of biosynthetic, endocytic and retrograde traffic into the prevacuolar compartment. Traffic (2000) 1.27
Uracil-induced down-regulation of the yeast uracil permease. J Bacteriol (1999) 1.26
A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. J Biol Chem (1998) 1.22
Shr3p mediates specific COPII coatomer-cargo interactions required for the packaging of amino acid permeases into ER-derived transport vesicles. Mol Biol Cell (1999) 1.16
Membrane transport: retromer to the rescue. Curr Biol (2001) 1.15
In vivo phosphorylation of the yeast uracil permease. J Biol Chem (1992) 1.15
Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae. Eur J Cell Biol (1997) 1.14
The leptin receptor promoter controls expression of a second distinct protein. Nucleic Acids Res (1997) 1.04
Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants. Yeast (2002) 0.96
Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett (1997) 0.94
Towards a truly integrative biology through the functional genomics of yeast. Curr Opin Biotechnol (2001) 0.89
Structure and function of the yeast vacuolar membrane proton ATPase. J Bioenerg Biomembr (1989) 0.88
An N-end rule destabilization mutant reveals pre-Golgi requirements for Sec7p in yeast membrane traffic. Biochem Biophys Res Commun (1998) 0.87
B219/OB-R 5'-UTR and leptin receptor gene-related protein gene expression in mouse brain and placenta: tissue-specific leptin receptor promoter activity. J Neuroendocrinol (2000) 0.86
Hepatitis C virus entry depends on clathrin-mediated endocytosis. J Virol (2006) 3.33
Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cells. Mol Biol Cell (2003) 1.98
The ubiquitin code of yeast permease trafficking. Trends Cell Biol (2010) 1.92
Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation. Mol Biol Cell (2003) 1.75
Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23. Nat Cell Biol (2003) 1.70
Robust production of infectious viral particles in Huh-7 cells by introducing mutations in hepatitis C virus structural proteins. J Gen Virol (2007) 1.69
NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly. PLoS Pathog (2011) 1.52
Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease. Mol Cell Biol (2006) 1.51
Identification of GBF1 as a cellular factor required for hepatitis C virus RNA replication. J Virol (2009) 1.43
Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways. Nat Cell Biol (2011) 1.38
(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry. Hepatology (2012) 1.34
Ubiquitin ligase adaptors: regulators of ubiquitylation and endocytosis of plasma membrane proteins. Exp Cell Res (2008) 1.34
The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodies. Traffic (2004) 1.29
Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking. Biochem Soc Trans (2008) 1.27
Role of low-density lipoprotein receptor in the hepatitis C virus life cycle. Hepatology (2012) 1.26
A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Mol Cell Proteomics (2011) 1.25
A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol (2012) 1.24
Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation. Traffic (2007) 1.24
Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling. PLoS One (2008) 1.20
Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs. Curr Biol (2011) 1.18
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci U S A (2007) 1.17
Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes. Proc Natl Acad Sci U S A (2006) 1.17
Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway. J Biol Chem (2004) 1.16
Proteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: implications for lytic enzyme transport and bone metabolism. Mol Cell Proteomics (2005) 1.15
Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of lysine 63-linked ubiquitin chains. J Biol Chem (2009) 1.15
Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies. Mol Biol Cell (2008) 1.14
Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nat Methods (2013) 1.14
Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. Nat Cell Biol (2010) 1.11
Bovine viral diarrhea virus entry is dependent on clathrin-mediated endocytosis. J Virol (2005) 1.11
Protein networks supporting AP-3 function in targeting lysosomal membrane proteins. Mol Biol Cell (2008) 1.09
Raft partitioning of the yeast uracil permease during trafficking along the endocytic pathway. Traffic (2003) 1.09
The cell surface proteome of human mesenchymal stromal cells. PLoS One (2011) 1.06
Antagonistic roles of ESCRT and Vps class C/HOPS complexes in the recycling of yeast membrane proteins. Mol Biol Cell (2004) 1.04
Substrate- and ubiquitin-dependent trafficking of the yeast siderophore transporter Sit1. Traffic (2008) 1.04
The GTPase-activating enzyme Gyp1p is required for recycling of internalized membrane material by inactivation of the Rab/Ypt GTPase Ypt1p. Mol Cell Biol (2004) 1.04
Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family. Biochem Res Int (2012) 1.04
Exit from the trans-Golgi network: from molecules to mechanisms. Curr Opin Cell Biol (2011) 1.03
Hepatitis C virus and natural compounds: a new antiviral approach? Viruses (2012) 1.03
Comparative study of protein and mRNA expression during osteoclastogenesis. Proteomics (2005) 1.02
Yeast functional analysis: identification of two essential genes involved in ER to Golgi trafficking. Traffic (2003) 1.02
LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. J Clin Invest (2009) 1.02
Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts. Proc Natl Acad Sci U S A (2009) 1.01
Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis. EMBO J (2006) 1.01
A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting. Mol Biol Cell (2012) 1.00
Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem (2008) 0.98
Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity. J Virol (2010) 0.98
Cytokinesis in yeast meiosis depends on the regulated removal of Ssp1p from the prospore membrane. EMBO J (2007) 0.98
Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants. Yeast (2002) 0.96
Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p. J Biol Chem (2012) 0.94
Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway. PLoS One (2009) 0.92
Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem (2011) 0.90
Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Traffic (2008) 0.89
Trafficking of siderophore transporters in Saccharomyces cerevisiae and intracellular fate of ferrioxamine B conjugates. Traffic (2007) 0.88
Anchorage of synthetic peptides onto liposomes via hydrazone and alpha-oxo hydrazone bonds. preliminary functional investigations. Bioconjug Chem (2005) 0.87
Interactions between virus proteins and host cell membranes during the viral life cycle. Int Rev Cytol (2005) 0.87
Bidirectional transport between the trans-Golgi network and the endosomal system. Mol Membr Biol (2010) 0.85
The transmembrane domains of the prM and E proteins of yellow fever virus are endoplasmic reticulum localization signals. J Virol (2004) 0.85
Hepatitis C virus assembly imaging. Viruses (2011) 0.85
Identification of increased amounts of eppin protein complex components in sperm cells of diabetic and obese individuals by difference gel electrophoresis. Mol Cell Proteomics (2011) 0.84
Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro. Eur J Cell Biol (2011) 0.84
Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis. Mol Biol Cell (2011) 0.83
Identification of diabetes- and obesity-associated proteomic changes in human spermatozoa by difference gel electrophoresis. Reprod Biomed Online (2009) 0.82
FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell Commun Signal (2014) 0.82
Heterologous expression of mammalian Na/H antiporters in Saccharomyces cerevisiae. Biochim Biophys Acta (2006) 0.81
Heterologous expression of a plant uracil transporter in yeast: improvement of plasma membrane targeting in mutants of the Rsp5p ubiquitin protein ligase. Biotechnol J (2006) 0.81
A mechanism for protein monoubiquitination dependent on a trans-acting ubiquitin-binding domain. J Biol Chem (2013) 0.81
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon. Endocrinology (2004) 0.81
Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells. Mol Cell Proteomics (2008) 0.80
Transgenic mice for a tamoxifen-induced, conditional expression of the Cre recombinase in osteoclasts. PLoS One (2012) 0.80
Identification of a dominant endoplasmic reticulum-retention signal in yellow fever virus pre-membrane protein. J Gen Virol (2009) 0.78
A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. PLoS One (2012) 0.77
Proteomic and functional consequences of hexokinase deficiency in glucose-repressible Kluyveromyces lactis. Mol Cell Proteomics (2014) 0.76
Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells. PLoS One (2013) 0.75
Hepatocyte-derived cultured cells with unusual cytoplasmic keratin-rich spheroid bodies. Exp Cell Res (2011) 0.75