Published in Nature on May 16, 2002
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36
Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol (2003) 2.27
Wnt signal transduction pathways. Organogenesis (2008) 2.14
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A (2003) 2.14
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell (2006) 1.81
Calcium at fertilization and in early development. Physiol Rev (2006) 1.76
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A (2003) 1.72
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol (2004) 1.68
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell (2010) 1.64
Wnt signalling in lung development and diseases. Respir Res (2006) 1.55
Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol (2006) 1.45
Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells. Nucleic Acids Res (2006) 1.43
Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med (2016) 1.42
Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42
From individual Wnt pathways towards a Wnt signalling network. Philos Trans R Soc Lond B Biol Sci (2008) 1.37
Wnt signalling in implantation, decidualisation and placental differentiation--review. Placenta (2010) 1.31
NFAT signaling in neural development and axon growth. Int J Dev Neurosci (2007) 1.30
When Wnts antagonize Wnts. J Cell Biol (2003) 1.29
Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism. Dev Biol (2011) 1.27
A novel biological activity of praziquantel requiring voltage-operated Ca2+ channel beta subunits: subversion of flatworm regenerative polarity. PLoS Negl Trop Dis (2009) 1.26
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proc Natl Acad Sci U S A (2006) 1.22
A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell (2007) 1.22
Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. BMC Dev Biol (2003) 1.22
Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation. Genes Dev (2007) 1.17
Calcium signaling in vertebrate embryonic patterning and morphogenesis. Dev Biol (2007) 1.14
Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling. Front Genet (2013) 1.11
Timing in cellular Ca2+ signaling. Curr Biol (2008) 1.10
Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol (2011) 1.10
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3. Br J Pharmacol (2014) 1.07
Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents. Curr Med Chem (2009) 1.02
Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening. J Biol Chem (2010) 1.00
WNT signaling: an emerging mediator of cancer cell metabolism? Mol Cell Biol (2014) 0.99
WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia (2013) 0.96
Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis. Development (2006) 0.96
Ouabain protects against adverse developmental programming of the kidney. Nat Commun (2010) 0.95
Wnt signaling in angiogenesis. Curr Drug Targets (2008) 0.95
Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol (2005) 0.94
The Xenopus oocyte: a single-cell model for studying Ca2+ signaling. Cold Spring Harb Protoc (2013) 0.93
Maternal induction of ventral fate by zebrafish radar. Proc Natl Acad Sci U S A (2003) 0.93
The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs (2006) 0.93
CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin. J Neurochem (2013) 0.92
Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/β-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria. J Biol Chem (2013) 0.92
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol (2006) 0.91
Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling. J Cancer Res Clin Oncol (2014) 0.90
The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis. Mol Cell Biol (2007) 0.88
The importance of Wnt signaling in cardiovascular development. Pediatr Cardiol (2009) 0.88
Aberrant stalk development and breakdown of tip dominance in Dictyostelium cell lines with RNAi-silenced expression of calcineurin B. BMC Dev Biol (2006) 0.87
Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS One (2010) 0.87
Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. PLoS Genet (2014) 0.86
NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation. Cell Death Dis (2013) 0.86
Developmental biology: signalling polarity. Nature (2002) 0.86
Wnt signaling in limb organogenesis. Organogenesis (2008) 0.85
Requirement of transcription factor NFAT in developing atrial myocardium. J Cell Biol (2003) 0.85
Comparative analysis of Wingless patterning in the embryonic grasshopper eye. Dev Genes Evol (2005) 0.84
Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation. Mol Biol Cell (2015) 0.83
Molecular signalling in hepatocellular carcinoma: Role of and crosstalk among WNT/ß-catenin, Sonic Hedgehog, Notch and Dickkopf-1. Can J Gastroenterol Hepatol (2015) 0.82
Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches. Mol Cancer (2016) 0.82
Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression. Oncotarget (2016) 0.81
Neural crest specification by noncanonical Wnt signaling and PAR-1. Development (2011) 0.81
xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development. Dev Biol (2005) 0.81
Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation. PLoS Biol (2012) 0.81
Glucose deprivation triggers protein kinase C-dependent β-catenin proteasomal degradation. J Biol Chem (2015) 0.80
Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron (2014) 0.80
Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling. J Mol Signal (2010) 0.80
Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits. Front Behav Neurosci (2011) 0.79
Wnt-5a expression in the rat neuronal progenitor cell line ST14A. Exp Brain Res (2004) 0.79
The Drosophila STIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning. BMC Dev Biol (2008) 0.79
Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca²⁺ signaling. Elife (2015) 0.79
WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J (2015) 0.79
Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. PLoS One (2014) 0.78
Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease. EMBO Rep (2002) 0.77
Introduction. Calcium signals and developmental patterning. Philos Trans R Soc Lond B Biol Sci (2008) 0.77
Non-canonical WNT signalling in the lung. J Biochem (2015) 0.76
CaMKII plays a part in the chondrogenesis of bone marrow-derived mesenchymal stem cells. Int J Clin Exp Pathol (2015) 0.75
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest (2017) 0.75
An intact brachyury function is necessary to prevent spurious axial development in Xenopus laevis. PLoS One (2013) 0.75
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol (2002) 22.05
Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med (2005) 4.31
Dopamine is a regulator of arousal in the fruit fly. J Neurosci (2005) 3.65
Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell (2005) 2.99
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science (2005) 2.53
Spontaneous network activity visualized by ultrasensitive Ca(2+) indicators, yellow Cameleon-Nano. Nat Methods (2010) 2.47
Insulin staining of ES cell progeny from insulin uptake. Science (2003) 2.46
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. J Biol Chem (2002) 2.40
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature (2002) 2.30
Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J Neurosci (2011) 2.17
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem (2001) 1.86
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells (2005) 1.86
Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell (2003) 1.81
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nat Neurosci (2012) 1.76
Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics. Neuron (2009) 1.74
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles. J Cell Biol (2003) 1.65
BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J (2002) 1.64
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor. Mol Cell (2005) 1.62
Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem (2004) 1.61
IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A (2006) 1.61
Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell (2002) 1.58
Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. Mol Cell Neurosci (2003) 1.57
The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+. Mol Pharmacol (2004) 1.56
Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor. J Biol Chem (2003) 1.53
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J Biol Chem (2003) 1.47
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J Biol Chem (2005) 1.46
IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol Cell (2006) 1.46
Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Mol Cell (2009) 1.42
Cdk5/p35 is required for motor coordination and cerebellar plasticity. J Neurochem (2014) 1.42
Zic2 controls cerebellar development in cooperation with Zic1. J Neurosci (2002) 1.42
Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling. J Biol Chem (2004) 1.40
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology (2005) 1.38
Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Gene (2003) 1.36
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A (2008) 1.35
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A (2011) 1.35
Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. J Biol Chem (2007) 1.34
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res (2010) 1.34
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc Natl Acad Sci U S A (2009) 1.34
Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells. J Cell Biol (2006) 1.33
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32
Tissue-specific demethylation in CpG-poor promoters during cellular differentiation. Hum Mol Genet (2011) 1.31
Three-dimensional rearrangements within inositol 1,4,5-trisphosphate receptor by calcium. J Biol Chem (2003) 1.29
Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins. Cell Calcium (2009) 1.28
Differentiation of mouse and human embryonic stem cells into hepatic lineages. Genes Cells (2008) 1.27
Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. J Biol Chem (2004) 1.26
Inositol 1,4,5-trisphosphate receptor contains multiple cavities and L-shaped ligand-binding domains. J Mol Biol (2004) 1.26
Mediolateral compartmentalization of the cerebellum is determined on the "birth date" of Purkinje cells. J Neurosci (2003) 1.26
Differential expression of Homer family proteins in the developing mouse brain. J Comp Neurol (2004) 1.25
Kinesin dependent, rapid, bi-directional transport of ER sub-compartment in dendrites of hippocampal neurons. J Cell Sci (2004) 1.23
An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites. J Biol Chem (2004) 1.23
Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations. J Biol Chem (2003) 1.23
L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. J Cell Biol (2003) 1.23
Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling. Mol Biol Cell (2005) 1.23
Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci (2008) 1.23
ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells. Cell Calcium (2006) 1.22
Cluster formation of inositol 1,4,5-trisphosphate receptor requires its transition to open state. J Biol Chem (2004) 1.21
Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm. Stem Cells (2008) 1.21
Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J Neurochem (2005) 1.20
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J (2004) 1.20
Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. Biochem J (2003) 1.19
A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP(3)) absorbent traps IP(3), resulting in specific inhibition of IP(3)-mediated calcium signaling. J Biol Chem (2001) 1.19
Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. J Neurosci (2007) 1.19
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. J Biol Chem (2001) 1.17
Two-state conformational changes in inositol 1,4,5-trisphosphate receptor regulated by calcium. J Biol Chem (2002) 1.16
Mechanism of ER stress-induced brain damage by IP(3) receptor. Neuron (2010) 1.16
Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors. J Biol Chem (2007) 1.15
Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. Dev Biol (2002) 1.14
Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine. Proc Natl Acad Sci U S A (2010) 1.14
Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3. J Cell Biol (2005) 1.13
Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. Biochem Biophys Res Commun (2005) 1.13
Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem (2008) 1.13
The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci (2004) 1.12
Quantitative comparison of genetically encoded Ca indicators in cortical pyramidal cells and cerebellar Purkinje cells. Front Cell Neurosci (2011) 1.12
Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor. J Mol Biol (2007) 1.12
Secreted Reelin molecules form homodimers. Neurosci Res (2002) 1.11
Distinct role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer. J Biol Chem (2006) 1.11
ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action. J Biol Chem (2008) 1.11
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology (2013) 1.10
Disabled1 regulates the intracellular trafficking of reelin receptors. J Biol Chem (2005) 1.09
Structural insights into the regulatory mechanism of IP3 receptor. Biochim Biophys Acta (2004) 1.09
Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice. J Neurochem (2005) 1.09
M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J Physiol (2004) 1.09
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. J Cell Biol (2012) 1.08
Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum. Eur J Neurosci (2004) 1.07
Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J Neurosci (2008) 1.07
Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human. Biochem J (2002) 1.06
Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. J Cell Biol (2003) 1.05
Cardiomyogenic potential of mesenchymal progenitors derived from human circulating CD14+ monocytes. Stem Cells Dev (2005) 1.05
Human malarial parasite, Plasmodium falciparum, displays capacitative calcium entry: 2-aminoethyl diphenylborinate blocks the signal transduction pathway of melatonin action on the P. falciparum cell cycle. J Pineal Res (2007) 1.04
Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration. J Neurosci (2006) 1.04
Novel compartment implicated in calcium signaling--is it an "induced coupling domain"? Sci STKE (2005) 1.04
Pak1 regulates dendritic branching and spine formation. Dev Neurobiol (2007) 1.04
Cerebral blood flow modulation by Basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes. PLoS One (2013) 1.04
Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain. Hum Mol Genet (2008) 1.03
Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun (2002) 1.03
Regulation of cortical neuron migration by the Reelin signaling pathway. Neurochem Res (2011) 1.03