Published in Mol Biol Cell on March 09, 2005
A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res (2010) 3.99
Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. J Mol Cell Cardiol (2008) 1.50
Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. Stem Cells Dev (2010) 1.44
Calcium handling in human induced pluripotent stem cell derived cardiomyocytes. PLoS One (2011) 1.36
Inositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes. J Physiol (2007) 1.29
Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells. J Gen Physiol (2007) 1.20
Early cardiac development: a view from stem cells to embryos. Cardiovasc Res (2012) 1.18
Excitation-contraction coupling of the mouse embryonic cardiomyocyte. J Gen Physiol (2008) 1.04
Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells. J Physiol (2007) 1.01
Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling. J Mol Cell Cardiol (2010) 0.99
Developmental aspects of cardiac Ca(2+) signaling: interplay between RyR- and IP(3)R-gated Ca(2+) stores. Am J Physiol Heart Circ Physiol (2010) 0.95
Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci (2011) 0.95
Calreticulin induces dilated cardiomyopathy. PLoS One (2013) 0.90
SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2013) 0.85
Mathematical model of mouse embryonic cardiomyocyte excitation-contraction coupling. J Gen Physiol (2008) 0.84
Pacemaking, arrhythmias, inotropy and hypertrophy: the many possible facets of IP3 signalling in cardiac myocytes. J Physiol (2007) 0.82
Spatially defined InsP3-mediated signaling in embryonic stem cell-derived cardiomyocytes. PLoS One (2014) 0.82
Electrophysiological mapping of embryonic mouse hearts: mechanisms for developmental pacemaker switch and internodal conduction pathway. J Cardiovasc Electrophysiol (2011) 0.79
Calcium signalling in developing cardiomyocytes: implications for model systems and disease. J Physiol (2015) 0.78
Spontaneous inward currents reflecting oscillatory activation of Na(+)/Ca(2+) exchangers in human embryonic stem cell-derived cardiomyocytes. Pflugers Arch (2015) 0.77
Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients. Cell Calcium (2015) 0.77
Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. PLoS One (2016) 0.76
Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells. J Physiol (2015) 0.76
Calreticulin Is Required for TGF-β-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells. Stem Cell Reports (2017) 0.75
Calcium handling precedes cardiac differentiation to initiate the first heartbeat. Elife (2016) 0.75
Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction. Dev Biol (2016) 0.75
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res (2002) 28.38
The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol (2000) 19.46
Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97
Calcium signaling. Cell (1995) 8.87
Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns. Science (1999) 3.70
Developmental regulation of myosin gene expression in mouse cardiac muscle. J Cell Biol (1990) 3.54
Mechanisms of capacitative calcium entry. J Cell Sci (2001) 3.50
The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol (2002) 3.40
Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron (1997) 3.27
Calreticulin: one protein, one gene, many functions. Biochem J (1999) 3.16
Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria. J Physiol (2000) 3.02
Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J (2001) 2.78
Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res (1994) 2.76
Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution. Cardiovasc Res (2001) 2.64
Stem cell differentiation requires a paracrine pathway in the heart. FASEB J (2002) 2.55
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A (2003) 2.53
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem (2001) 2.47
Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. Br J Pharmacol (1993) 2.28
Properties of the hyperpolarization-activated current (I(f)) in isolated mouse sino-atrial cells. Cardiovasc Res (2001) 2.27
Lineage choice and differentiation in mouse embryos and embryonic stem cells. Dev Biol (2003) 2.27
Patterning the vertebrate heart. Nat Rev Genet (2002) 2.25
Calreticulin. Cell (1997) 2.19
Differential modulation of SERCA2 isoforms by calreticulin. J Cell Biol (1998) 2.00
Control of cardiac myosin heavy chain gene expression. Microsc Res Tech (2000) 1.97
Overexpression of calreticulin increases intracellular Ca2+ storage and decreases store-operated Ca2+ influx. J Biol Chem (1996) 1.83
Control of calcium oscillations by membrane fluxes. Proc Natl Acad Sci U S A (2004) 1.72
Intracellular Ca2+ oscillations drive spontaneous contractions in cardiomyocytes during early development. Proc Natl Acad Sci U S A (1999) 1.71
From funny current to HCN channels: 20 years of excitation. News Physiol Sci (2002) 1.65
Use of developmental marker genes to define temporal and spatial patterns of differentiation during embryoid body formation. J Exp Zool (1999) 1.65
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J Biol Chem (1994) 1.54
Not so funny anymore: pacing channels are cloned. Neuron (1998) 1.53
Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. J Gen Physiol (2002) 1.52
Complete heart block and sudden death in mice overexpressing calreticulin. J Clin Invest (2001) 1.43
I(f) current and spontaneous activity in mouse embryonic ventricular myocytes. Circ Res (2001) 1.40
The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling. Proc Natl Acad Sci U S A (1995) 1.35
Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps. Cell Calcium (2000) 1.35
A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells. FEBS Lett (2000) 1.29
Calcium signalling during embryonic development. Nat Rev Mol Cell Biol (2003) 1.24
The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc Natl Acad Sci U S A (2002) 1.23
Delayed activation of the store-operated calcium current induced by calreticulin overexpression in RBL-1 cells. Mol Biol Cell (1998) 1.20
Inositol 1,4,5-trisphosphate receptor in heart: evidence for its concentration in Purkinje myocytes of the conduction system. J Cell Biol (1993) 1.18
Inositol 1,4,5-trisphosphate directs Ca(2+) flow between mitochondria and the Endoplasmic/Sarcoplasmic reticulum: a role in regulating cardiac autonomic Ca(2+) spiking. Mol Biol Cell (2000) 1.13
Ontogeny of humoral heart rate regulation in the embryonic mouse. Am J Physiol Regul Integr Comp Physiol (2001) 1.05
Calreticulin modulates capacitative Ca2+ influx by controlling the extent of inositol 1,4,5-trisphosphate-induced Ca2+ store depletion. J Biol Chem (2000) 1.04
Involvement of the C-terminus of the inositol 1,4,5-trisphosphate receptor in Ca2+ release analysed using region-specific monoclonal antibodies. Biochem J (1991) 1.03
A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart. Development (1999) 1.01
A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J Cell Biol (2001) 0.98
Antibody to the inositol trisphosphate receptor blocks thimerosal-enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs. FEBS Lett (1992) 0.96
A reassessment of the effects of luminal [Ca2+] on inositol 1,4,5-trisphosphate-induced Ca2+ release from internal stores. J Biol Chem (2003) 0.93
Modulation of the retinoic acid and retinoid X receptor signaling pathways in P19 embryonal carcinoma cells by calreticulin. Exp Cell Res (1997) 0.81
Ca2+ on the move: ways and means to translate a multifarious signal. Trends Pharmacol Sci (2002) 0.78
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol (2002) 22.05
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell (2005) 5.90
Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med (2005) 4.31
Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell (2005) 2.99
The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature (2002) 2.75
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A (2003) 2.68
Stem cell differentiation requires a paracrine pathway in the heart. FASEB J (2002) 2.55
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science (2005) 2.53
Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J (2009) 2.48
Spontaneous network activity visualized by ultrasensitive Ca(2+) indicators, yellow Cameleon-Nano. Nat Methods (2010) 2.47
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. J Biol Chem (2002) 2.40
Transplantation of cardiac-committed mouse embryonic stem cells to infarcted sheep myocardium: a preclinical study. Lancet (2005) 2.36
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature (2002) 2.30
Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J Neurosci (2011) 2.17
Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res (2005) 2.09
A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest (2010) 2.06
Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles. J Physiol (2004) 1.96
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem (2001) 1.86
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells (2005) 1.86
Calreticulin signaling in health and disease. Int J Biochem Cell Biol (2012) 1.81
Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell (2003) 1.81
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
Biology of endoplasmic reticulum stress in the heart. Circ Res (2010) 1.78
Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum. Int J Biochem Cell Biol (2005) 1.77
Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics. Neuron (2009) 1.74
Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol (2004) 1.73
Role of heteromultimers in the generation of myocardial transient outward K+ currents. Circ Res (2002) 1.68
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles. J Cell Biol (2003) 1.65
BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J (2002) 1.64
Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control. Mol Cell (2004) 1.62
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor. Mol Cell (2005) 1.62
Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem (2004) 1.61
IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A (2006) 1.61
Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell (2002) 1.58
Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. Mol Cell Neurosci (2003) 1.57
The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+. Mol Pharmacol (2004) 1.56
Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J (2004) 1.54
Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity (2002) 1.54
Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor. J Biol Chem (2003) 1.53
Calcium-binding proteins and calcium-release channels in human maturing oocytes, pronuclear zygotes and early preimplantation embryos. Hum Reprod (2002) 1.52
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J Biol Chem (2003) 1.47
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J Biol Chem (2005) 1.46
IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol Cell (2006) 1.46
Endoplasmic reticulum quality control and apoptosis. Acta Biochim Pol (2005) 1.45
Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family. Mol Phylogenet Evol (2005) 1.44
Oct-3/4 dose dependently regulates specification of embryonic stem cells toward a cardiac lineage and early heart development. Dev Cell (2006) 1.44
Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Mol Cell (2009) 1.42
Zic2 controls cerebellar development in cooperation with Zic1. J Neurosci (2002) 1.42
Cdk5/p35 is required for motor coordination and cerebellar plasticity. J Neurochem (2014) 1.42
Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling. J Biol Chem (2004) 1.40
Β-adrenergic blockade combined with subcutaneous B-type natriuretic peptide: a promising approach to reduce ventricular arrhythmia in heart failure? Heart (2014) 1.40
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Gene (2003) 1.36
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A (2008) 1.35
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A (2011) 1.35
Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. J Biol Chem (2007) 1.34
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res (2010) 1.34
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc Natl Acad Sci U S A (2009) 1.34
Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells. J Cell Biol (2006) 1.33
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32
Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57. Int Rev Cytol (2005) 1.32
Calcium signalling: past, present and future. Cell Calcium (2005) 1.31
Three-dimensional rearrangements within inositol 1,4,5-trisphosphate receptor by calcium. J Biol Chem (2003) 1.29
Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins. Cell Calcium (2009) 1.28
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol (2009) 1.28
Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol (2009) 1.28
Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. J Biol Chem (2004) 1.26
Mediolateral compartmentalization of the cerebellum is determined on the "birth date" of Purkinje cells. J Neurosci (2003) 1.26
Inositol 1,4,5-trisphosphate receptor contains multiple cavities and L-shaped ligand-binding domains. J Mol Biol (2004) 1.26
Differential expression of Homer family proteins in the developing mouse brain. J Comp Neurol (2004) 1.25
Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats. Stem Cells (2007) 1.24
The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem (2002) 1.23
L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. J Cell Biol (2003) 1.23
Kinesin dependent, rapid, bi-directional transport of ER sub-compartment in dendrites of hippocampal neurons. J Cell Sci (2004) 1.23
Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations. J Biol Chem (2003) 1.23
An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites. J Biol Chem (2004) 1.23
Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci (2008) 1.23
ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins. Mol Cell Proteomics (2003) 1.22
ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells. Cell Calcium (2006) 1.22
Cluster formation of inositol 1,4,5-trisphosphate receptor requires its transition to open state. J Biol Chem (2004) 1.21
Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J Neurochem (2005) 1.20
ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase. Int J Biochem Cell Biol (2010) 1.20
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J (2004) 1.20
Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. Biochem J (2003) 1.19
A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP(3)) absorbent traps IP(3), resulting in specific inhibition of IP(3)-mediated calcium signaling. J Biol Chem (2001) 1.19
Calcium binding chaperones of the endoplasmic reticulum. Gen Physiol Biophys (2009) 1.19
Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. J Neurosci (2007) 1.19
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. J Biol Chem (2002) 1.18
Early cardiac development: a view from stem cells to embryos. Cardiovasc Res (2012) 1.18
Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. J Biol Chem (2001) 1.17
Two-state conformational changes in inositol 1,4,5-trisphosphate receptor regulated by calcium. J Biol Chem (2002) 1.16
ERp57 modulates STAT3 signaling from the lumen of the endoplasmic reticulum. J Biol Chem (2009) 1.16
Mechanism of ER stress-induced brain damage by IP(3) receptor. Neuron (2010) 1.16
Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells. Circulation (2010) 1.15
Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors. J Biol Chem (2007) 1.15
Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. Dev Biol (2002) 1.14