Published in Biochem Biophys Res Commun on April 26, 2002
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol (2007) 2.13
Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. EMBO J (2005) 2.08
Insulin receptor signaling in the development of neuronal structure and function. Neural Dev (2010) 1.29
Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. Mol Cell Biol (2005) 1.23
The WASP and WAVE family proteins. Genome Biol (2009) 1.18
Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2. BMC Cell Biol (2005) 1.16
Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53. J Neurosci (2003) 1.14
Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2. J Cell Sci (2008) 1.10
Genomic organization and expression profile of the human and mouse WAVE gene family. Mamm Genome (2003) 1.03
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J Cell Biol (2009) 1.02
The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling. J Cell Biol (2011) 0.99
Organizational actions of metabolic hormones. Front Neuroendocrinol (2013) 0.97
The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans. Mol Cell Biol (2005) 0.94
Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization. Mol Cell Biol (2009) 0.94
Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages. J Biol Chem (2011) 0.87
The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein. Biochem J (2004) 0.84
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol (2005) 4.75
Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell (2007) 4.73
Regulation of cancer cell motility through actin reorganization. Cancer Sci (2005) 3.87
Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol (2006) 3.17
Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Dev Cell (2003) 2.56
A novel serum metabolomics-based diagnostic approach to pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2013) 2.34
Sequential signals toward podosome formation in NIH-src cells. J Cell Biol (2008) 2.18
Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation. Science (2010) 2.14
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol (2007) 2.13
WAVE2 is required for directed cell migration and cardiovascular development. Nature (2003) 2.09
Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res (2002) 1.96
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol (2004) 1.92
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J Biol Chem (2007) 1.85
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction. J Biol Chem (2004) 1.73
Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem (2003) 1.70
Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts. J Biol Chem (2004) 1.66
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
Regulation of actin dynamics by WASP family proteins. J Biochem (2003) 1.63
Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell (2002) 1.58
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem (2006) 1.56
Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J Cell Biol (2006) 1.50
Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. J Biol Chem (2003) 1.46
Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells. Oncogene (2005) 1.45
A novel serum metabolomics-based diagnostic approach for colorectal cancer. PLoS One (2012) 1.40
IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena. J Cell Sci (2003) 1.40
Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem (2002) 1.40
Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion. J Cell Sci (2006) 1.39
Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure. J Cell Sci (2003) 1.33
Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone. J Cell Sci (2003) 1.31
A metabolomic approach to lung cancer. Lung Cancer (2011) 1.30
The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal (2009) 1.29
Phosphoinositide-binding domains: Functional units for temporal and spatial regulation of intracellular signalling. Cell Signal (2002) 1.28
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Cancer Res (2004) 1.27
A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique. Proc Natl Acad Sci U S A (2009) 1.25
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature (2010) 1.21
Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth. J Cell Sci (2003) 1.21
Phosphoinositides regulate clathrin-dependent endocytosis at the tip of pollen tubes in Arabidopsis and tobacco. Plant Cell (2010) 1.20
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J (2004) 1.20
Regulation of cortical actin networks in cell migration. Int Rev Cytol (2003) 1.18
The WASP and WAVE family proteins. Genome Biol (2009) 1.18
Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr (2011) 1.16
SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. Mol Cell Biol (2003) 1.15
Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. Cell Microbiol (2002) 1.15
SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. J Biol Chem (2007) 1.11
WAVE/Scars in platelets. Blood (2004) 1.09
Visualization and force measurement of branching by Arp2/3 complex and N-WASP in actin filament. Biochem Biophys Res Commun (2002) 1.08
Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor. J Biol Chem (2002) 1.08
DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. J Cell Biol (2007) 1.06
WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. J Cell Sci (2005) 1.05
Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. J Cell Biol (2003) 1.05
Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex. J Biochem (2007) 1.05
N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor. J Biol Chem (2004) 1.04
Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. J Biol Chem (2003) 1.04
WASP and WAVE family proteins: friends or foes in cancer invasion? Cancer Sci (2010) 1.03
Crystal structure of human DAAM1 formin homology 2 domain. Genes Cells (2007) 1.02
Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J (2003) 1.02
PtdIns(3,4)P2 instigates focal adhesions to generate podosomes. Cell Adh Migr (2009) 1.00
SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. J Cell Biol (2011) 1.00
Spatial and temporal regulation of actin polymerization for cytoskeleton formation through Arp2/3 complex and WASP/WAVE proteins. Cell Motil Cytoskeleton (2002) 1.00
WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. Biochem Biophys Res Commun (2002) 1.00
A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading. Genes Cells (2005) 0.99
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci (2007) 0.99
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol (2005) 0.99
Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. EMBO J (2005) 0.98
Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes. J Biol Chem (2009) 0.97
Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol Cell Biol (2003) 0.96
Mechanisms of membrane deformation by lipid-binding domains. Prog Lipid Res (2009) 0.96
Neural Wiskott-Aldrich syndrome protein is involved in hepatocyte growth factor-induced migration, invasion, and tubulogenesis of epithelial cells. Cancer Res (2002) 0.96
Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. J Biol Chem (2009) 0.94
Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry. J Gastroenterol (2011) 0.94
Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels. Biochem Biophys Res Commun (2005) 0.94
GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis. Inflamm Res (2011) 0.94
Evidence that activation of Src family kinase is not required for fertilization-associated [Ca2+]i oscillations in mouse eggs. Reproduction (2004) 0.94
Involvement of the nectin-afadin complex in PDGF-induced cell survival. J Cell Sci (2008) 0.93
WAVE3 functions as a negative regulator of LDOC1. J Biochem (2005) 0.92
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood (2007) 0.92
Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides. Anal Biochem (2006) 0.92
Increased insulin action in SKIP heterozygous knockout mice. Mol Cell Biol (2008) 0.91
HSP90 cross-links branched actin filaments induced by N-WASP and the Arp2/3 complex. Genes Cells (2007) 0.91
FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. Biochem Biophys Res Commun (2004) 0.91
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. Mol Biol Cell (2012) 0.90
Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. J Biol Chem (2009) 0.90
Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Mamm Genome (2007) 0.89
Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development. FASEB J (2007) 0.89
Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion. J Biol Chem (2013) 0.89
WICH, a member of WASP-interacting protein family, cross-links actin filaments. Biochem Biophys Res Commun (2005) 0.89
RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C. Mol Biol Cell (2012) 0.88
Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo. Cancer Res (2007) 0.88
Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation. J Cell Sci (2013) 0.87
srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity. Mol Biol Cell (2013) 0.87
Characterization of the EFC/F-BAR domain protein, FCHO2. Genes Cells (2011) 0.86
GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients. Clin Exp Rheumatol (2014) 0.86
Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels. Biol Reprod (2009) 0.85
Phosphatidylinositol 3-kinase is a key regulator of early phase differentiation in keratinocytes. J Biol Chem (2002) 0.85
Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. J Pharmacol Sci (2003) 0.85
Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus. Neurosci Res (2006) 0.84