Published in Biochem Biophys Res Commun on March 25, 2005
The yeast actin cytoskeleton: from cellular function to biochemical mechanism. Microbiol Mol Biol Rev (2006) 2.55
Arp2/3-independent assembly of actin by Vibrio type III effector VopL. Proc Natl Acad Sci U S A (2007) 2.05
N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway. Nat Cell Biol (2011) 1.92
Requirement for a complex of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein in podosome formation in macrophages. J Immunol (2007) 1.11
Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium. J Biol Chem (2006) 1.05
Myosin heavy-chain kinase A from Dictyostelium possesses a novel actin-binding domain that cross-links actin filaments. Biochem J (2006) 0.90
There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton. Biophys J (2013) 0.86
WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions. Int J Mol Sci (2012) 0.78
WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. Sci Rep (2016) 0.75
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol (2005) 4.75
Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell (2007) 4.73
Regulation of cancer cell motility through actin reorganization. Cancer Sci (2005) 3.87
Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol (2006) 3.17
Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Dev Cell (2003) 2.56
A novel serum metabolomics-based diagnostic approach to pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2013) 2.34
Sequential signals toward podosome formation in NIH-src cells. J Cell Biol (2008) 2.18
Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation. Science (2010) 2.14
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol (2007) 2.13
WAVE2 is required for directed cell migration and cardiovascular development. Nature (2003) 2.09
Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res (2002) 1.96
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol (2004) 1.92
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J Biol Chem (2007) 1.85
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction. J Biol Chem (2004) 1.73
Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem (2003) 1.70
Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts. J Biol Chem (2004) 1.66
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
Regulation of actin dynamics by WASP family proteins. J Biochem (2003) 1.63
Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell (2002) 1.58
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem (2006) 1.56
Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J Cell Biol (2006) 1.50
Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. J Biol Chem (2003) 1.46
Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells. Oncogene (2005) 1.45
A novel serum metabolomics-based diagnostic approach for colorectal cancer. PLoS One (2012) 1.40
IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena. J Cell Sci (2003) 1.40
Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem (2002) 1.40
Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion. J Cell Sci (2006) 1.39
Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure. J Cell Sci (2003) 1.33
Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone. J Cell Sci (2003) 1.31
A metabolomic approach to lung cancer. Lung Cancer (2011) 1.30
The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal (2009) 1.29
Phosphoinositide-binding domains: Functional units for temporal and spatial regulation of intracellular signalling. Cell Signal (2002) 1.28
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Cancer Res (2004) 1.27
A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique. Proc Natl Acad Sci U S A (2009) 1.25
Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth. J Cell Sci (2003) 1.21
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature (2010) 1.21
Phosphoinositides regulate clathrin-dependent endocytosis at the tip of pollen tubes in Arabidopsis and tobacco. Plant Cell (2010) 1.20
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J (2004) 1.20
Regulation of cortical actin networks in cell migration. Int Rev Cytol (2003) 1.18
The WASP and WAVE family proteins. Genome Biol (2009) 1.18
Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr (2011) 1.16
Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. Cell Microbiol (2002) 1.15
SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. Mol Cell Biol (2003) 1.15
SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. J Biol Chem (2007) 1.11
WAVE/Scars in platelets. Blood (2004) 1.09
Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor. J Biol Chem (2002) 1.08
Visualization and force measurement of branching by Arp2/3 complex and N-WASP in actin filament. Biochem Biophys Res Commun (2002) 1.08
DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. J Cell Biol (2007) 1.06
WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. J Cell Sci (2005) 1.05
Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. J Cell Biol (2003) 1.05
Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex. J Biochem (2007) 1.05
N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor. J Biol Chem (2004) 1.04
Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. J Biol Chem (2003) 1.04
WASP and WAVE family proteins: friends or foes in cancer invasion? Cancer Sci (2010) 1.03
Crystal structure of human DAAM1 formin homology 2 domain. Genes Cells (2007) 1.02
Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J (2003) 1.02
PtdIns(3,4)P2 instigates focal adhesions to generate podosomes. Cell Adh Migr (2009) 1.00
SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. J Cell Biol (2011) 1.00
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. Biochem Biophys Res Commun (2002) 1.00
Spatial and temporal regulation of actin polymerization for cytoskeleton formation through Arp2/3 complex and WASP/WAVE proteins. Cell Motil Cytoskeleton (2002) 1.00
WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. Biochem Biophys Res Commun (2002) 1.00
A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading. Genes Cells (2005) 0.99
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci (2007) 0.99
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol (2005) 0.99
Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. EMBO J (2005) 0.98
Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes. J Biol Chem (2009) 0.97
Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol Cell Biol (2003) 0.96
Mechanisms of membrane deformation by lipid-binding domains. Prog Lipid Res (2009) 0.96
Neural Wiskott-Aldrich syndrome protein is involved in hepatocyte growth factor-induced migration, invasion, and tubulogenesis of epithelial cells. Cancer Res (2002) 0.96
Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. J Biol Chem (2009) 0.94
Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry. J Gastroenterol (2011) 0.94
Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels. Biochem Biophys Res Commun (2005) 0.94
GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis. Inflamm Res (2011) 0.94
Evidence that activation of Src family kinase is not required for fertilization-associated [Ca2+]i oscillations in mouse eggs. Reproduction (2004) 0.94
Involvement of the nectin-afadin complex in PDGF-induced cell survival. J Cell Sci (2008) 0.93
WAVE3 functions as a negative regulator of LDOC1. J Biochem (2005) 0.92
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood (2007) 0.92
Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides. Anal Biochem (2006) 0.92
HSP90 cross-links branched actin filaments induced by N-WASP and the Arp2/3 complex. Genes Cells (2007) 0.91
Increased insulin action in SKIP heterozygous knockout mice. Mol Cell Biol (2008) 0.91
FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. Biochem Biophys Res Commun (2004) 0.91
Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. J Biol Chem (2009) 0.90
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. Mol Biol Cell (2012) 0.90
Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Mamm Genome (2007) 0.89
Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development. FASEB J (2007) 0.89
Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion. J Biol Chem (2013) 0.89
RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C. Mol Biol Cell (2012) 0.88
Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo. Cancer Res (2007) 0.88
Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation. J Cell Sci (2013) 0.87
srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity. Mol Biol Cell (2013) 0.87
Characterization of the EFC/F-BAR domain protein, FCHO2. Genes Cells (2011) 0.86
GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients. Clin Exp Rheumatol (2014) 0.86
Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels. Biol Reprod (2009) 0.85
Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. J Pharmacol Sci (2003) 0.85
Phosphatidylinositol 3-kinase is a key regulator of early phase differentiation in keratinocytes. J Biol Chem (2002) 0.85
ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. Mol Biol Cell (2012) 0.84