Published in J Biol Chem on June 13, 2002
The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol (2008) 2.98
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell (2007) 2.48
Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell (2009) 2.18
Caspases: pharmacological manipulation of cell death. J Clin Invest (2005) 2.10
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat Rev Cancer (2009) 1.84
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol (2008) 1.75
Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity (2015) 1.74
Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol (2009) 1.74
Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J (2006) 1.74
Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hear Res (2006) 1.71
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A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol (2002) 1.58
Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol (2011) 1.47
Cellular mechanisms controlling caspase activation and function. Cold Spring Harb Perspect Biol (2013) 1.47
KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol (2009) 1.43
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J (2009) 1.42
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell (2009) 1.41
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A (2005) 1.40
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc Natl Acad Sci U S A (2008) 1.40
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death Differ (2012) 1.33
The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction. Cell Death Differ (2003) 1.32
Deadly conversations: nuclear-mitochondrial cross-talk. J Bioenerg Biomembr (2004) 1.31
The mitochondrial death pathway: a promising therapeutic target in diseases. J Cell Mol Med (2009) 1.30
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Mol Biol Cell (2005) 1.29
Biology of mitochondria in neurodegenerative diseases. Prog Mol Biol Transl Sci (2012) 1.22
Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes. Neurosci Lett (2006) 1.21
Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep (2004) 1.21
Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9. J Cell Biol (2004) 1.18
Simplified apoptotic cascades. Heart Fail Rev (2008) 1.14
Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases. Pharmaceuticals (Basel) (2010) 1.13
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis. J Biol Chem (2008) 1.12
Ocular neuroprotection by siRNA targeting caspase-2. Cell Death Dis (2011) 1.12
The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats. Proc Natl Acad Sci U S A (2008) 1.10
Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol (2009) 1.09
Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med (2006) 1.07
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell (2006) 1.07
Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis. Cell Death Differ (2006) 1.07
Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons. J Biol Chem (2011) 1.04
Cleavage of Bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells. J Biol Chem (2009) 1.03
Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines. Infect Immun (2004) 1.03
Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells. J Biol Chem (2008) 1.01
Requirement of Apaf-1 for mitochondrial events and the cleavage or activation of all procaspases during genotoxic stress-induced apoptosis. Biochem J (2007) 0.99
The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells. Mol Cell Biol (2004) 0.99
Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme. Cell Death Differ (2011) 0.95
Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2. Mol Cell Biol (2005) 0.94
Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. J Biol Chem (2012) 0.93
Hepatitis C virus core protein and cellular protein HAX-1 promote 5-fluorouracil-mediated hepatocyte growth inhibition. J Virol (2009) 0.92
The role of caspase-2 in stress-induced apoptosis. J Cell Mol Med (2010) 0.91
NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. PLoS One (2010) 0.91
Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor. Cell Death Dis (2011) 0.91
New Arabidopsis thaliana cytochrome c partners: a look into the elusive role of cytochrome c in programmed cell death in plants. Mol Cell Proteomics (2013) 0.90
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death. Oncotarget (2011) 0.89
Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain. Am J Pathol (2009) 0.88
Role of caspase 2 in apoptotic signaling in primate and murine germ cells. Biol Reprod (2008) 0.88
LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway. Leukemia (2011) 0.87
Inflammatory cells regulate p53 and caspases in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol (2009) 0.86
Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells. World J Gastroenterol (2007) 0.86
The PIDDosome, DNA-damage-induced apoptosis and beyond. Cell Death Differ (2011) 0.85
Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2010) 0.84
Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species. Biogerontology (2013) 0.84
Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL. Mol Cancer (2010) 0.84
TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells. Apoptosis (2013) 0.83
The antiangiogenic compound aeroplysinin-1 induces apoptosis in endothelial cells by activating the mitochondrial pathway. Mar Drugs (2012) 0.83
Overexpression of the anti-apoptotic caspase-2 short isoform in macrophage-derived foam cells of human atherosclerotic plaques. Am J Pathol (2003) 0.83
Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression. Dev Biol (2013) 0.83
Signalling mechanisms involved in renal pathological changes during cisplatin-induced nephropathy. Eur J Clin Pharmacol (2013) 0.82
Evidence for caspase effects on release of cytochrome c and AIF in a model of ischemia in cortical neurons. Neurosci Lett (2009) 0.82
Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II Jurkat cells. J Biol Chem (2009) 0.82
The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PLoS One (2015) 0.81
Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells. J Biol Chem (2011) 0.81
Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells. Dis Model Mech (2015) 0.81
E1A enhances cellular sensitivity to DNA-damage-induced apoptosis through PIDD-dependent caspase-2 activation. Cell Death Discov (2016) 0.80
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions. Cell Death Dis (2014) 0.80
Caspase-2-Based Regulation of the Androgen Receptor and Cell Cycle in the Prostate Cancer Cell Line LNCaP. Genes Cancer (2011) 0.79
Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis. PLoS One (2013) 0.79
BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS One (2014) 0.78
Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation. J Biol Chem (2013) 0.78
Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer (2014) 0.78
Caspase 2 activation and ER stress drive rapid Jurkat cell apoptosis by clofibrate. PLoS One (2012) 0.77
A novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase 2 in primary human fibroblast cells. Biosci Rep (2015) 0.77
CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis. Nucleic Acids Res (2003) 0.77
Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges. Front Cell Neurosci (2017) 0.76
Variation of pathways and network profiles reveals the differential pharmacological mechanisms of each effective component to treat middle cerebral artery ischemia-reperfusion mice. Exp Biol Med (Maywood) (2015) 0.75
Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discov (2016) 0.75
Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A). J Biol Chem (2014) 0.75
Mitotic Catastrophe in BC3H1 Cells following Yessotoxin Exposure. Front Cell Dev Biol (2017) 0.75
Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases. Sci Rep (2016) 0.75
Hypoxia/re-oxygenation injury induces apoptosis of LLC-PK1 cells by activation of caspase-2. Pediatr Nephrol (2006) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol (2003) 9.07
Mitochondria, oxidative stress and cell death. Apoptosis (2007) 4.29
Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol (2007) 3.90
Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci U S A (2002) 3.57
Mitochondria in cancer cells: what is so special about them? Trends Cell Biol (2008) 2.97
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A (2004) 2.85
DNA damage-induced apoptosis. Oncogene (2004) 2.32
Profiling constitutive proteolytic events in vivo. Biochem J (2007) 1.78
Role of mitochondria in toxic oxidative stress. Mol Interv (2005) 1.76
Cysteine protease mcII-Pa executes programmed cell death during plant embryogenesis. Proc Natl Acad Sci U S A (2005) 1.72
Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF). Biochem Biophys Res Commun (2010) 1.70
Caspase-2 function in response to DNA damage. Biochem Biophys Res Commun (2005) 1.60
Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. Nat Cell Biol (2009) 1.60
A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol (2002) 1.56
Metacaspase-dependent programmed cell death is essential for plant embryogenesis. Curr Biol (2004) 1.56
Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim Biophys Acta (2006) 1.54
Mechanisms of Interferon-alpha induced apoptosis in malignant cells. Oncogene (2002) 1.50
Mathematical modelling of cell-fate decision in response to death receptor engagement. PLoS Comput Biol (2010) 1.49
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res (2006) 1.48
Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes. Blood (2005) 1.44
Cell death mechanisms and their implications in toxicology. Toxicol Sci (2010) 1.43
Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells. J Cell Mol Med (2011) 1.42
Calcium and cell death mechanisms: a perspective from the cell death community. Cell Calcium (2011) 1.39
The Warburg effect and mitochondrial stability in cancer cells. Mol Aspects Med (2009) 1.37
Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells. Exp Hematol (2008) 1.34
The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis. Arch Biochem Biophys (2004) 1.33
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Mol Biol Cell (2005) 1.29
Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J Biol Chem (2004) 1.24
Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release. Biochem Biophys Res Commun (2005) 1.21
Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep (2004) 1.21
Mitochondria as targets for chemotherapy. Apoptosis (2009) 1.20
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. J Biol Chem (2004) 1.20
Evaluation of caspase activity in apoptotic cells. J Immunol Methods (2002) 1.20
Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment. Oncogene (2002) 1.20
Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation. Autophagy (2012) 1.19
The unpredictable caspase-2: what can it do? Trends Cell Biol (2010) 1.19
Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. Proc Natl Acad Sci U S A (2004) 1.16
Mitochondria as targets for cancer chemotherapy. Semin Cancer Biol (2008) 1.14
Free radicals in cross talk between autophagy and apoptosis. Antioxid Redox Signal (2014) 1.13
Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment. Curr Pharm Des (2006) 1.12
Cardiolipin is not required for Bax-mediated cytochrome c release from yeast mitochondria. J Biol Chem (2003) 1.11
Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas. Oncogene (2004) 1.10
Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis. Microbes Infect (2006) 1.09
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Carcinogenesis (2011) 1.07
Cardiolipin oxidation sets cytochrome c free. Nat Chem Biol (2005) 1.07
Concern Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. J Cell Sci (2011) 1.03
A quantitative assay for the monitoring of autophagosome accumulation in different phases of the cell cycle. Autophagy (2011) 1.02
Proteases in autophagy. Biochim Biophys Acta (2011) 1.01
Mitochondrial regulation of apoptotic cell death. Chem Biol Interact (2006) 0.99
Autophagy and metacaspase determine the mode of cell death in plants. J Cell Biol (2013) 0.99
Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells. FASEB J (2002) 0.98
Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance. Blood (2005) 0.97
The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation. Free Radic Biol Med (2004) 0.97
Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. Cancer Res (2004) 0.97
Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members. Haematologica (2007) 0.97
The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release. J Biol Chem (2007) 0.97
Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. Exp Cell Res (2006) 0.97
Carcinogenesis and apoptosis: paradigms and paradoxes. Carcinogenesis (2006) 0.96
Caspase-2 activation in neural stem cells undergoing oxidative stress-induced apoptosis. Apoptosis (2008) 0.96
Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model. Cancer Res (2012) 0.96
Reactive oxygen species generated in different compartments induce cell death, survival, or senescence. Free Radic Biol Med (2013) 0.96
Full-length p73alpha represses drug-induced apoptosis in small cell lung carcinoma cells. J Biol Chem (2005) 0.95
Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing. Free Radic Biol Med (2010) 0.94
Cell death mechanisms: cross-talk and role in disease. Exp Cell Res (2010) 0.93
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells. Int J Cancer (2006) 0.93
Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis. EMBO J (2010) 0.93
Caspases: determination of their activities in apoptotic cells. Methods Enzymol (2008) 0.92
Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks. FEBS Lett (2004) 0.92
Differential regulation of the mitochondrial and death receptor pathways in neural stem cells. Eur J Neurosci (2004) 0.92
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res (2009) 0.92
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells. Exp Cell Res (2002) 0.91
Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations. Clin Cancer Res (2005) 0.90
Autophagy in toxicology: cause or consequence? Annu Rev Pharmacol Toxicol (2012) 0.90
HAMLET, protein folding, and tumor cell death. Biochem Biophys Res Commun (2006) 0.89
Role of mitochondria in toxic cell death. Toxicology (2002) 0.89
Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF. Br J Haematol (2010) 0.89
Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer. Cancer Lett (2009) 0.89
Expression of caspase-3 and -7 does not correlate with the extent of apoptosis in primary breast carcinomas. Cell Cycle (2002) 0.89