Published in Immunity on April 01, 2008
Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell (2009) 4.56
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev (2009) 4.10
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98
Interleukin-10: new perspectives on an old cytokine. Immunol Rev (2008) 3.94
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest (2011) 3.69
Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51
Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity (2009) 3.51
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity (2011) 3.40
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis (2009) 3.32
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity (2012) 2.85
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med (2010) 2.42
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab (2012) 2.36
Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol (2012) 2.16
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A (2008) 2.13
Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol (2009) 2.12
Cholinergic control of inflammation. J Intern Med (2009) 2.12
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A (2009) 2.07
Inborn errors of human JAKs and STATs. Immunity (2012) 1.90
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. J Biol Chem (2010) 1.87
Alternatively activated and immunoregulatory monocytes in human filarial infections. J Infect Dis (2009) 1.82
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol (2009) 1.81
Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol (2013) 1.71
The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol (2012) 1.63
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis. Proc Natl Acad Sci U S A (2008) 1.58
CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8(+) T cells. Oncoimmunology (2013) 1.57
Type 2 cytokines: mechanisms and therapeutic strategies. Nat Rev Immunol (2015) 1.57
PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem (2009) 1.51
Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages. J Leukoc Biol (2009) 1.51
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol (2012) 1.49
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem (2008) 1.44
Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A (2012) 1.40
Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity. PLoS One (2012) 1.39
Role of neutrophils in innate immunity: a systems biology-level approach. Wiley Interdiscip Rev Syst Biol Med (2010) 1.37
IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice. J Immunol (2010) 1.36
The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells. Hepatology (2010) 1.33
Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey. Medicine (Baltimore) (2012) 1.31
Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. J Neuroinflammation (2009) 1.29
Mechanisms of Jak/STAT signaling in immunity and disease. J Immunol (2015) 1.27
The Current STATus of lymphocyte signaling: new roles for old players. Curr Opin Immunol (2009) 1.26
The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity. J Immunol (2009) 1.26
The problem of choice: current biologic agents and future prospects in RA. Nat Rev Rheumatol (2013) 1.24
A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response. PLoS Biol (2010) 1.20
Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment. Semin Immunol (2012) 1.18
Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med (2010) 1.15
Interleukin-10 provides direct trophic support to neurons. J Neurochem (2009) 1.14
Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes. J Appl Physiol (1985) (2010) 1.13
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol Rev (2010) 1.12
Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc Natl Acad Sci U S A (2011) 1.12
Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci (2009) 1.11
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J Clin Invest (2012) 1.10
Cytokine determinants of viral tropism. Nat Rev Immunol (2009) 1.10
Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart. J Biol Chem (2009) 1.10
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function. Blood (2012) 1.09
Anti-inflammatory pathways and alcoholic liver disease: role of an adiponectin/interleukin-10/heme oxygenase-1 pathway. World J Gastroenterol (2010) 1.09
IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol (2011) 1.07
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med (2012) 1.07
Age predicts cytokine kinetics and innate immune cell activation following intranasal delivery of IFNγ and GM-CSF in a mouse model of RSV infection. Cytokine (2017) 1.06
Elevation in body temperature to fever range enhances and prolongs subsequent responsiveness of macrophages to endotoxin challenge. PLoS One (2012) 1.06
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis. Arthritis Res Ther (2011) 1.05
Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet (2010) 1.04
Glycogen synthase kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264.7 cells. Cell Signal (2009) 1.03
Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1. J Biol Chem (2009) 1.02
IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. Proc Natl Acad Sci U S A (2014) 1.02
Molecular control of activation and priming in macrophages. Nat Immunol (2015) 1.00
Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1, -3 and p38 MAPK. Arch Oral Biol (2013) 0.99
Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation. JAKSTAT (2012) 0.99
Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation. J Mol Histol (2011) 0.99
Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats. PLoS One (2009) 0.99
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem (2011) 0.98
Involvement of MAPK/NF-κB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation. PLoS One (2013) 0.98
Comparison of sensitivity of Th1, Th2, and Th17 cells to Fas-mediated apoptosis. J Leukoc Biol (2010) 0.98
Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease. Expert Rev Clin Immunol (2012) 0.96
STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells. J Immunol (2014) 0.96
The anti-inflammatory effects of a methanolic extract from Radix Isatidis in murine macrophages and mice. Inflammation (2010) 0.96
Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase. Mol Med (2012) 0.95
Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood (2011) 0.95
Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infect Immun (2011) 0.94
Emerging role for TNF-α in erectile dysfunction. J Sex Med (2010) 0.93
Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation. Mol Pain (2010) 0.93
Cooperativity of adaptive and innate immunity: implications for cancer therapy. Cancer Immunol Immunother (2011) 0.93
Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling. J Biol Chem (2009) 0.93
Dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid induce lipid peroxidation by the proliferation of intestinal gram-negative bacteria in mice. J Inflamm (Lond) (2010) 0.93
Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells. Immunol Cell Biol (2010) 0.91
Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases. Toxins (Basel) (2012) 0.91
Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies. J Interferon Cytokine Res (2011) 0.89
Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One (2014) 0.88
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go? Purinergic Signal (2012) 0.88
MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5. Sci Signal (2014) 0.88
Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. Dig Dis Sci (2010) 0.88
Undernutrition, the acute phase response to infection, and its effects on micronutrient status indicators. Adv Nutr (2014) 0.86
Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro. PLoS One (2013) 0.86
A lipidomic perspective on inflammatory macrophage eicosanoid signaling. Adv Biol Regul (2013) 0.86
Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis Res Ther (2015) 0.85
A Toll-like receptor-responsive kinase, protein kinase R, is inactivated in endotoxin tolerance through differential K63/K48 ubiquitination. MBio (2010) 0.85
Opposing roles for heat and heat shock proteins in macrophage functions during inflammation: a function of cell activation state? Front Immunol (2012) 0.85
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun (2014) 0.85
The novel association of the chemokine CCL22 with abdominal aortic aneurysm. Am J Pathol (2010) 0.85
Changes in serum creatinine in patients with active rheumatoid arthritis treated with tofacitinib: results from clinical trials. Arthritis Res Ther (2014) 0.85
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 14.28
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature (2006) 13.75
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med (2006) 13.74
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity (2007) 12.12
Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol (2005) 11.57
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med (2007) 9.80
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05
STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99
A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest (2007) 8.54
IL-22 increases the innate immunity of tissues. Immunity (2004) 8.30
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature (2008) 8.17
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity (1999) 7.90
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol (2007) 7.64
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature (2007) 7.07
SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol (2007) 6.89
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med (2005) 6.58
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest (2008) 6.17
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med (2003) 5.96
Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol (2003) 5.77
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity (2007) 5.73
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A (2006) 5.69
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14
The JAK-STAT signaling pathway: input and output integration. J Immunol (2007) 4.92
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77
Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55
Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood (2007) 4.50
IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol (2005) 4.49
Complex modulation of cell type-specific signaling in response to type I interferons. Immunity (2006) 4.48
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell (2003) 4.37
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell (1999) 4.29
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity (2006) 4.02
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A (1999) 3.91
Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med (2003) 3.89
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology (2004) 3.84
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol (2004) 3.76
The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol (2000) 3.71
Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A (2006) 3.66
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity (2008) 3.56
SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol (2003) 3.45
SOCS-1 participates in negative regulation of LPS responses. Immunity (2002) 3.39
IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol (2003) 3.26
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity (2002) 3.25
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science (2002) 3.05
IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology (2007) 2.97
The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J Leukoc Biol (2004) 2.81
Th17 cells: effector T cells with inflammatory properties. Semin Immunol (2007) 2.81
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity (2002) 2.77
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity (2002) 2.72
The SOCS box: a tale of destruction and degradation. Trends Biochem Sci (2002) 2.64
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol (2007) 2.60
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58
A critical role for Stat3 signaling in immune tolerance. Immunity (2003) 2.41
Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr Opin Pharmacol (2006) 2.30
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem (2001) 2.29
A role for T cell-derived interleukin 22 in psoriatic skin inflammation. Clin Exp Immunol (2007) 2.16
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol (2005) 2.01
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest (2006) 1.92
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol (2007) 1.87
Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem (2004) 1.86
Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease. Nat Clin Pract Rheumatol (2006) 1.85
STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity (2001) 1.81
Molecular phylogeny within type I cytokines and their cognate receptors. Immunity (2003) 1.79
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem (2006) 1.77
A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discov (2004) 1.73
Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol (2004) 1.64
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity (2003) 1.55
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med (2003) 1.49
A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity (1999) 1.42
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc Natl Acad Sci U S A (2001) 1.40
Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages. J Biol Chem (2006) 1.38
Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem (2004) 1.35
IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3. J Immunol (2007) 1.34
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem (2003) 1.33
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J Immunol (2002) 1.29
Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation. J Exp Med (2002) 1.21
The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene. Proc Natl Acad Sci U S A (2000) 1.15
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood (2007) 1.13
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity (2007) 1.10
Jak3 and the pathogenesis of severe combined immunodeficiency. Mol Immunol (2004) 1.09
Human tyk2 kinase deficiency: another primary immunodeficiency syndrome. Immunity (2006) 1.09
Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals. J Immunol (2006) 1.06
Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency. Hum Mutat (2001) 1.04
Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. J Immunol (2006) 0.96
Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. J Biol Chem (2006) 0.91
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab (2006) 6.44
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol (2004) 5.59
Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol (2006) 4.55
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog (2009) 4.12
Shaping gene expression in activated and resting primary macrophages by IL-10. J Immunol (2002) 3.82
SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol (2003) 3.45
Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol (2004) 2.95
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest (2008) 2.88
Cell phone short messaging service (SMS) for HIV/AIDS in South Africa: a literature review. Stud Health Technol Inform (2010) 2.60
IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism. J Immunol (2004) 2.60
Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res (2005) 2.50
Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol (2003) 2.12
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity (2006) 2.06
Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol (2002) 2.03
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol (2006) 2.00
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell (2009) 1.98
Development and application of biochemical and haematological reference intervals to identify unhealthy green sea turtles (Chelonia mydas). Vet J (2009) 1.94
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol (2005) 1.83
A critical role for SOCS3 in innate resistance to Toxoplasma gondii. Cell Host Microbe (2011) 1.70
Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K. J Exp Med (2012) 1.66
Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal (2010) 1.66
IL-10 inhibits miR-155 induction by toll-like receptors. J Biol Chem (2010) 1.65
The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol (2012) 1.63
Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol (2007) 1.62
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun (2005) 1.60
Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur J Immunol (2005) 1.56
IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem (2006) 1.54
STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood (2010) 1.51
Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity. J Immunol (2009) 1.47
Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J (2011) 1.38
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol (2009) 1.37
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37
Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem (2004) 1.35
LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol (2009) 1.33
Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol (2006) 1.27
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood (2009) 1.24
The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls. Cell Microbiol (2008) 1.23
Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis. Infect Immun (2007) 1.21
Cell wall-mediated neuronal damage in early sepsis. Infect Immun (2006) 1.14
IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo. J Immunol (2008) 1.11
The potential of 3-D virtual worlds in professional nursing education. Stud Health Technol Inform (2009) 1.10
Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1. Cell Host Microbe (2012) 1.06
Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis. PLoS Pathog (2008) 1.06
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS One (2013) 1.02
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem (2011) 0.98
WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. Exp Hematol (2005) 0.98
Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2. Vaccine (2008) 0.96
Non-canonical alternatives: what a macrophage is 4. J Exp Med (2012) 0.95
NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. J Immunol (2014) 0.92
Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol (2009) 0.91
The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza. Scand J Infect Dis (2007) 0.90
Interleukin-10 induces apoptosis in developing mast cells and macrophages. J Leukoc Biol (2006) 0.89
Interpreting mixed signals: the cell's cytokine conundrum. Curr Opin Immunol (2011) 0.88
Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo. J Immunol Methods (2012) 0.88
Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. J Clin Invest (2015) 0.86
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. Inflamm Bowel Dis (2011) 0.85
Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. J Immunol (2008) 0.84
Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation. Eur J Immunol (2014) 0.80
A double agent in cancer: stopping macrophages wounds tumors. Nat Med (2010) 0.80
Tumor macrophages protective and pathogenic roles in cancer development. Curr Top Dev Biol (2011) 0.80
Beyond peptidoglycan for Nod2. Nat Immunol (2009) 0.78
Thirty years later: enrichment practices for captive mammals. Zoo Biol (2010) 0.77
T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. Cancer Cell (2016) 0.76
The potential for microchip-automated technology to improve enrichment practices. Zoo Biol (2010) 0.75
OpenClinical. CIN Plus (2002) 0.75
osni.info-Using free/libre/open source software to build a virtual international community for open source nursing informatics. Int J Med Inform (2005) 0.75
What if nurses get what they have always sought: totally personalized care? Trends affecting nursing informatics. Stud Health Technol Inform (2007) 0.75
Why nursing needs to explore and shape its own future--closing summation and remarks. Stud Health Technol Inform (2007) 0.75