Published in J Biol Chem on November 07, 2003
STAT3 signaling: anticancer strategies and challenges. Mol Interv (2011) 1.95
Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog (2009) 1.78
The STAT pathway mediates late-phase immunity against Plasmodium in the mosquito Anopheles gambiae. Cell Host Microbe (2009) 1.71
Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest (2006) 1.69
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. Blood (2010) 1.66
The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis. Biophys J (2004) 1.55
IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem (2006) 1.54
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol (2004) 1.43
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol (2009) 1.35
Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword? FEBS J (2013) 1.33
Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Mol Cell Biol (2006) 1.32
RNA-destabilizing factor tristetraprolin negatively regulates NF-kappaB signaling. J Biol Chem (2009) 1.19
Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells. J Dent Res (2008) 1.18
SOCS proteins in development and disease. Am J Clin Exp Immunol (2013) 1.17
Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1. Endocrinology (2008) 1.16
Targeting the Jak/STAT pathway for immunosuppression. Ann Rheum Dis (2004) 1.16
STAT proteins - key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver. J Hepatol (2012) 1.15
Role of LIM kinases in normal and psoriatic human epidermis. Mol Biol Cell (2006) 1.14
Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol (2011) 1.13
Growth hormone axis in chronic kidney disease. Pediatr Nephrol (2007) 1.10
The JAK-STAT pathway controls Plasmodium vivax load in early stages of Anopheles aquasalis infection. PLoS Negl Trop Dis (2011) 1.06
A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation. J Biol Chem (2009) 1.03
Suppressors of cytokine signaling in health and disease. Pediatr Nephrol (2005) 1.02
STAT dynamics. Cytokine Growth Factor Rev (2007) 1.00
Mechanisms of ErbB receptor negative regulation and relevance in cancer. Exp Cell Res (2008) 0.99
Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation. Neoplasia (2006) 0.99
Interferon-gamma produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells. PLoS One (2010) 0.99
The Anopheles innate immune system in the defense against malaria infection. J Innate Immun (2013) 0.98
SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. Mol Cell Biol (2009) 0.97
Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell Death Dis (2014) 0.97
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res (2010) 0.96
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. Diabetologia (2012) 0.94
Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals. Mol Cell Biol (2008) 0.94
Activated Ras/MEK inhibits the antiviral response of alpha interferon by reducing STAT2 levels. J Virol (2009) 0.94
Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One (2012) 0.94
Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. PLoS One (2010) 0.93
Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways. Blood (2011) 0.93
Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers. Genes Dev (2015) 0.91
Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica (2012) 0.91
Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. Pediatr Nephrol (2005) 0.91
Modulation of inducible nitric oxide synthase expression by sumoylation. J Neuroinflammation (2009) 0.91
Proximal genomic localization of STAT1 binding and regulated transcriptional activity. BMC Genomics (2006) 0.90
Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. Biochem J (2006) 0.90
Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users. PLoS One (2010) 0.90
Molecular analysis of human cancer cells infected by an oncolytic HSV-1 reveals multiple upregulated cellular genes and a role for SOCS1 in virus replication. Cancer Gene Ther (2008) 0.89
Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders. Cytokine Growth Factor Rev (2006) 0.89
Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells. BMC Cancer (2010) 0.88
Model-based analysis of interferon-beta induced signaling pathway. Bioinformatics (2008) 0.87
A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation. J Biol Chem (2011) 0.87
Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3. PLoS One (2012) 0.87
SOCS3 expression correlates with severity of inflammation, expression of proinflammatory cytokines, and activation of STAT3 and p38 MAPK in LPS-induced inflammation in vivo. Mediators Inflamm (2013) 0.87
Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem (2010) 0.86
Altered levels of STAT1 and STAT3 influence the neuronal response to interferon gamma. J Neuroimmunol (2007) 0.86
Cytokine-modulating strategies and newer cytokine targets for arthritis therapy. Int J Mol Sci (2014) 0.85
Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia. Leuk Res (2008) 0.84
The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation. J Leukoc Biol (2014) 0.84
Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition. PLoS One (2011) 0.83
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis. Neoplasia (2012) 0.83
Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. Blood (2007) 0.83
Advances in understanding the pathogenesis of primary familial and congenital polycythaemia. Br J Haematol (2010) 0.83
Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells. Br J Cancer (2014) 0.83
Activation of STAT3 signaling in human stomach adenocarcinoma drug-resistant cell line and its relationship with expression of vascular endothelial growth factor. World J Gastroenterol (2005) 0.82
SOCS3 promotor hypermethylation and STAT3-NF-κB interaction downregulate SOCS3 expression in human coronary artery smooth muscle cells. Am J Physiol Heart Circ Physiol (2013) 0.82
Extended JAK activation and delayed STAT1 dephosphorylation contribute to the distinct signaling profile of CNS neurons exposed to interferon-gamma. J Neuroimmunol (2012) 0.82
The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma. BMC Cancer (2014) 0.82
The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood (2007) 0.82
New insights in hepatocellular carcinoma: from bench to bedside. Ann Transl Med (2013) 0.80
Silencing of Anopheles stephensi Heme Peroxidase HPX15 Activates Diverse Immune Pathways to Regulate the Growth of Midgut Bacteria. Front Microbiol (2016) 0.80
Expression of interleukin-8 receptor CXCR2 and suppressor of cytokine signaling-3 in astrocytic tumors. Mol Med (2012) 0.80
STAT3 signaling in immunity. Cytokine Growth Factor Rev (2016) 0.80
Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma. Reprod Biol Endocrinol (2010) 0.79
Platelet factor 4 inhibits IL-17/Stat3 pathway via upregulation of SOCS3 expression in melanoma. Inflammation (2014) 0.79
Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation. J Immunol (2015) 0.79
Immunohistochemical analysis of IL-6, IL-8/CXCR2 axis, Tyr p-STAT-3, and SOCS-3 in lymph nodes from patients with chronic lymphocytic leukemia: correlation between microvascular characteristics and prognostic significance. Biomed Res Int (2014) 0.79
The role of glycoprotein 130 family of cytokines in fetal rat lung development. PLoS One (2013) 0.79
The Complex Role of STAT3 in Viral Infections. J Immunol Res (2015) 0.79
Quantitative analysis of interferon alpha receptor subunit 1 and suppressor of cytokine signaling 1 gene transcription in blood cells of patients with chronic hepatitis C. Virol J (2010) 0.79
Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis. Pediatr Nephrol (2009) 0.79
Inhibition of HCV 3a core gene through Silymarin and its fractions. Virol J (2011) 0.79
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12. Mol Cancer (2010) 0.79
Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression. J Immunol (2013) 0.79
Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells. JAKSTAT (2012) 0.78
Simvastatin attenuates rhinovirus-induced interferon and CXCL10 secretion from monocytic cells in vitro. J Leukoc Biol (2014) 0.78
Modulation of human JAK-STAT pathway signaling by functionally conserved regulators. JAKSTAT (2012) 0.78
CCR5 Blockade Suppresses Melanoma Development Through Inhibition of IL-6-Stat3 Pathway via Upregulation of SOCS3. Inflammation (2015) 0.77
Ciliary neurotrophic factor protects mice against streptozotocin-induced type 1 diabetes through SOCS3: the role of STAT1/STAT3 ratio in β-cell death. J Biol Chem (2012) 0.77
Simvastatin impairs growth hormone-activated signal transducer and activator of transcription (STAT) signaling pathway in UMR-106 osteosarcoma cells. PLoS One (2014) 0.76
Down-regulation of hsa-miR-1264 contributes to DNMT1-mediated silencing of SOCS3. Mol Biol Rep (2015) 0.76
HIC1 interacts with and modulates the activity of STAT3. Cell Cycle (2013) 0.76
A novel VIP signaling pathway in T cells cAMP-->protein tyrosine phosphatase (SHP-2?)-->JAK2/STAT4-->Th1 differentiation. Peptides (2007) 0.76
Cytokines in dermatology - a basic overview. Indian J Dermatol (2011) 0.76
Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing. Int J Mol Med (2016) 0.75
Escape from IFN-γ-dependent immunosurveillance in tumorigenesis. J Biomed Sci (2017) 0.75
Signal transducer and activator of transcription 1 (STAT1) acts like an oncogene in malignant pleural mesothelioma. Virchows Arch (2014) 0.75
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol (2004) 3.76
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
The SOCS box: a tale of destruction and degradation. Trends Biochem Sci (2002) 2.64
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity. Nucleic Acids Res (2011) 2.23
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet (2008) 2.19
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol (2005) 2.01
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol (2002) 1.92
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A (2004) 1.81
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood (2010) 1.71
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood (2011) 1.69
SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest (2005) 1.66
Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol (2009) 1.61
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity (2003) 1.55
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol (2008) 1.53
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem (2006) 1.45
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1. Biochem J (2013) 1.45
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell (2006) 1.41
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet (2008) 1.40
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol (2002) 1.39
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem (2003) 1.38
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol (2007) 1.34
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev (2011) 1.30
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol (2002) 1.28
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry (2002) 1.27
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J Biol Chem (2002) 1.26
Suppression of cytokine signaling: the SOCS perspective. Cytokine Growth Factor Rev (2013) 1.20
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem (2002) 1.18
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A (2009) 1.18
Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects. Mol Endocrinol (2004) 1.16
Estimating the proportion of microarray probes expressed in an RNA sample. Nucleic Acids Res (2010) 1.14
Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood (2005) 1.13
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood (2007) 1.13
Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci U S A (2010) 1.09
Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood (2010) 1.09
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci U S A (2006) 1.09
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. Proc Natl Acad Sci U S A (2014) 1.08
The art and design of genetic screens: mouse. Nat Rev Genet (2005) 1.08
Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol (2003) 1.07
Development of hydrocephalus in mice lacking SOCS7. Proc Natl Acad Sci U S A (2004) 1.07
Hematopoietic defects in the Ts1Cje mouse model of Down syndrome. Blood (2008) 1.07
Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. J Biol Chem (2006) 1.05
Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood (2009) 1.04
Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Mol Cell Biol (2007) 1.03
An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. Proc Natl Acad Sci U S A (2007) 1.01
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A (2005) 1.00
Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. J Biol Chem (2010) 0.99
A new role for SOCS in insulin action. Suppressor of cytokine signaling. Sci STKE (2003) 0.99
Differential regulation of SOCS genes in normal and transformed erythroid cells. Oncogene (2003) 0.97
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc Natl Acad Sci U S A (2002) 0.96
The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways. Curr Opin Hematol (2007) 0.95
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. Blood (2007) 0.95
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood (2008) 0.95
SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Mol Cell Biol (2004) 0.94
Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease. Gastroenterology (2002) 0.92
An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets. Am J Pathol (2002) 0.91
Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. Exp Hematol (2008) 0.91
Proximal genomic localization of STAT1 binding and regulated transcriptional activity. BMC Genomics (2006) 0.90
Epigenetic regulator Smchd1 functions as a tumor suppressor. Cancer Res (2012) 0.90
Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. Growth Factors (2009) 0.89
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. J Immunol (2009) 0.88
Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood (2004) 0.88
A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Proc Natl Acad Sci U S A (2006) 0.87
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha. Growth Factors (2007) 0.84
Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice. Proc Natl Acad Sci U S A (2010) 0.84
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma. Blood (2013) 0.84
More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Blood (2006) 0.82
Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3. Mol Immunol (2008) 0.81
Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. J Immunol (2011) 0.80
An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood (2011) 0.79
A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity. Growth Factors (2010) 0.78
Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest (2017) 0.75
Donald Metcalf (1929-2014). Cell (2015) 0.75
Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1. Immunity (2003) 0.75
Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain. Proc Natl Acad Sci U S A (2011) 0.75
Special Issue Collection: In Memoriam. Stem Cells (2015) 0.75
Probabilistic analysis of recessive mutagenesis screen strategies. Mamm Genome (2007) 0.75
A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction. J Biol Chem (2002) 0.75
Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A (2015) 0.75
In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology. Exp Hematol (2015) 0.75