Published in J Biol Chem on June 19, 2002
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch (2005) 1.54
Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation. J Physiol (2006) 1.35
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J (2006) 1.25
Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation. J Am Soc Nephrol (2009) 1.24
Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol (2003) 1.18
(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6. Pflugers Arch (2003) 1.03
Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. J Physiol (2003) 1.02
Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J Biol Chem (2008) 1.01
Parallel selection on TRPV6 in human populations. PLoS One (2008) 0.95
The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.94
TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival. Proc Natl Acad Sci U S A (2014) 0.92
Muscarinic receptor stimulation activates a Ca(2+)-dependent Cl(-) conductance in rat distal colon. J Membr Biol (2005) 0.92
Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4. Pflugers Arch (2006) 0.91
Calcium feedback mechanisms regulate oscillatory activity of a TRP-like Ca2+ conductance in C. elegans intestinal cells. J Physiol (2005) 0.90
Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport. Mol Pharmacol (2008) 0.88
Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity. Pflugers Arch (2008) 0.84
Effects of a high-sodium diet on renal tubule Ca2+ transporter and claudin expression in Wistar-Kyoto rats. BMC Nephrol (2012) 0.83
Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channels. J Biol Chem (2013) 0.82
Functional and structural studies of TRP channels heterologously expressed in budding yeast. Adv Exp Med Biol (2011) 0.81
The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties. J Struct Funct Genomics (2012) 0.80
A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation. Cell Calcium (2010) 0.79
Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling? PLoS One (2016) 0.76
A Gate Hinge Controls the Epithelial Calcium Channel TRPV5. Sci Rep (2017) 0.75
A molecular determinant of phosphoinositide affinity in mammalian TRPV channels. Sci Rep (2016) 0.75
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature (2003) 4.45
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem (2003) 3.15
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci (2007) 2.78
Calcium absorption across epithelia. Physiol Rev (2005) 2.57
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol (2004) 2.35
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
Gating of TRP channels: a voltage connection? J Physiol (2005) 2.30
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall. Eur Urol (2013) 2.15
Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study. Lancet Oncol (2007) 2.14
Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest (2005) 2.14
Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest (2003) 2.09
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol (2002) 1.94
Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol (2004) 1.84
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Outer pore architecture of a Ca2+-selective TRP channel. J Biol Chem (2004) 1.79
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab (2008) 1.79
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem (2006) 1.71
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium (2005) 1.70
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome. J Am Soc Nephrol (2002) 1.65
Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line. Nephrol Dial Transplant (2004) 1.59
The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol (2011) 1.56
Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. Kidney Int (2004) 1.52
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Transient receptor potential channels in endothelium: solving the calcium entry puzzle? Endothelium (2003) 1.46
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med (2009) 1.42
Volume-regulated anion channels serve as an auto/paracrine nucleotide release pathway in aortic endothelial cells. J Gen Physiol (2002) 1.41
Epithelial Ca2+ and Mg2+ channels in health and disease. J Am Soc Nephrol (2004) 1.38
Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. FASEB J (2002) 1.36
Irritating channels: the case of TRPA1. J Physiol (2010) 1.32
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol (2011) 1.30
Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies. J Physiol (2005) 1.28
Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch (2004) 1.27
The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation. Cell Calcium (2003) 1.27
Active Ca(2+) reabsorption in the connecting tubule. Pflugers Arch (2008) 1.26
Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J Biol Chem (2008) 1.26
Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Mol Cell Biol (2006) 1.25
Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation. J Am Soc Nephrol (2009) 1.24
The selectivity filter of the cation channel TRPM4. J Biol Chem (2005) 1.24
Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin. J Biol Chem (2004) 1.23
The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci U S A (2005) 1.23
Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Kidney Int (2003) 1.22
Acid-base status determines the renal expression of Ca2+ and Mg2+ transport proteins. J Am Soc Nephrol (2006) 1.22
Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. J Am Soc Nephrol (2003) 1.22
Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6. Am J Physiol Gastrointest Liver Physiol (2006) 1.20
The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer. J Biol Chem (2003) 1.19
Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol (2003) 1.18
Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family. J Physiol (2010) 1.18
Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia. J Am Soc Nephrol (2004) 1.15
Modulation of TRPV4 gating by intra- and extracellular Ca2+. Cell Calcium (2003) 1.15
Calciotropic and magnesiotropic TRP channels. Physiology (Bethesda) (2008) 1.13
Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1. Biophys J (2010) 1.12
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med (2012) 1.11
Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone. Kidney Int (2005) 1.10
The role of transient receptor potential channels in kidney disease. Nat Rev Nephrol (2009) 1.08