Published in Nature on July 24, 2003
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Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A (2003) 2.95
C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron (2010) 2.89
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res (2009) 2.71
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Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circ Res (2006) 2.49
Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem (2007) 2.45
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol (2006) 2.34
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet (2009) 2.32
Endothelium-derived hyperpolarising factors and associated pathways: a synopsis. Pflugers Arch (2010) 2.29
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
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The transient receptor potential family of ion channels. Genome Biol (2011) 2.08
Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol (2004) 2.03
Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum (2009) 2.02
Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci (2007) 2.00
Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest (2006) 1.90
TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol (2006) 1.90
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest (2010) 1.85
The mechanosensitive nature of TRPV channels. Pflugers Arch (2005) 1.84
Epoxides and soluble epoxide hydrolase in cardiovascular physiology. Physiol Rev (2012) 1.82
Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One (2007) 1.79
Epoxyeicosatrienoic acids and endothelium-dependent responses. Pflugers Arch (2010) 1.77
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol (2009) 1.76
Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sci (2006) 1.71
Multiple functions of endocannabinoid signaling in the brain. Annu Rev Neurosci (2012) 1.60
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
beta-adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.56
TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch (2005) 1.54
Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem (2009) 1.54
Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain (2010) 1.51
Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension (2009) 1.51
The TRPA1 channel in migraine mechanism and treatment. Br J Pharmacol (2014) 1.50
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. EMBO J (2005) 1.48
Tone-dependent vascular responses to astrocyte-derived signals. Am J Physiol Heart Circ Physiol (2008) 1.48
TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. Am J Physiol Heart Circ Physiol (2009) 1.47
TRPV channels as thermosensory receptors in epithelial cells. Pflugers Arch (2005) 1.44
Arachidonic acid and ion channels: an update. Br J Pharmacol (2008) 1.44
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev (2014) 1.40
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci U S A (2006) 1.39
Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol (2009) 1.39
Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol (2016) 1.38
Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol (2011) 1.37
Epoxyeicosanoid signaling in CNS function and disease. Prostaglandins Other Lipid Mediat (2009) 1.35
Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids. Br J Pharmacol (2007) 1.34
The puzzle of TRPV4 channelopathies. EMBO Rep (2013) 1.33
Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force. J Biol Chem (2010) 1.32
Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol (2006) 1.31
From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma. Curr Eye Res (2013) 1.31
Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther (2007) 1.30
Activation of the TRPV4 ion channel is enhanced by phosphorylation. J Biol Chem (2009) 1.30
Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol (2004) 1.30
Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol (2014) 1.25
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A (2009) 1.25
TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch (2008) 1.24
Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons. Proc Natl Acad Sci U S A (2015) 1.24
High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. Am J Respir Cell Mol Biol (2007) 1.24
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. Br J Pharmacol (2010) 1.23
Feeling the hidden mechanical forces in lipid bilayer is an original sense. Proc Natl Acad Sci U S A (2014) 1.22
Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. J Physiol (2006) 1.22
IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J Cell Biol (2008) 1.22
Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Am J Physiol Heart Circ Physiol (2011) 1.20
A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy. J Biol Chem (2009) 1.20
Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. Gastroenterology (2010) 1.20
TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. Proc Natl Acad Sci U S A (2013) 1.20
Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. J Biol Chem (2008) 1.17
TRPV channels and vascular function. Acta Physiol (Oxf) (2010) 1.16
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Proc Natl Acad Sci U S A (2006) 1.15
TRPV4 channels augment macrophage activation and ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2010) 1.15
Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14
Cardiovascular pharmacology of cannabinoids. Handb Exp Pharmacol (2005) 1.14
Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations. PLoS One (2011) 1.13
Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett (2006) 1.12
17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol (2012) 1.11
Development, plasticity and modulation of visceral afferents. Brain Res Rev (2008) 1.11
Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol (2008) 1.10
Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol (2014) 1.10
Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent. Future Neurol (2009) 1.09
Function and regulation of TRP family channels in C. elegans. Pflugers Arch (2009) 1.09
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. J Biol Chem (2010) 1.08
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem (2009) 1.08
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol (2005) 1.08
Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume. Pflugers Arch (2008) 1.08
TRP channels in neurogastroenterology: opportunities for therapeutic intervention. Br J Pharmacol (2011) 1.07
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. J Physiol (2005) 1.07
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors. Br J Pharmacol (2006) 1.07
The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem (2010) 1.07
Optical recording reveals novel properties of GSK1016790A-induced vanilloid transient receptor potential channel TRPV4 activity in primary human endothelial cells. Mol Pharmacol (2012) 1.06
Transient receptor potential (TRP) channels in the airway: role in airway disease. Br J Pharmacol (2014) 1.05
Invertebrate TRP proteins as functional models for mammalian channels. Pflugers Arch (2004) 1.05
Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids. FEBS Lett (2009) 1.05
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications. Pharmacol Rev (2010) 1.05
Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia. J Neurosci (2014) 1.05
Forward genetic analysis reveals multiple gating mechanisms of TRPV4. J Biol Chem (2010) 1.04
TRPing on the lung endothelium: calcium channels that regulate barrier function. Antioxid Redox Signal (2009) 1.04
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem (2003) 3.15
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
TRP channels: an overview. Cell Calcium (2005) 2.98
Permeation and selectivity of TRP channels. Annu Rev Physiol (2006) 2.96
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci (2007) 2.78
Calcium absorption across epithelia. Physiol Rev (2005) 2.57
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Sensing with TRP channels. Nat Chem Biol (2005) 2.51
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol (2007) 2.48
TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol (2004) 2.35
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
Gating of TRP channels: a voltage connection? J Physiol (2005) 2.30
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall. Eur Urol (2013) 2.15
The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol (2009) 2.13
TRPs in our senses. Curr Biol (2008) 2.12
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet (2009) 2.02
Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol (2009) 2.00
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron (2005) 1.94
Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Outer pore architecture of a Ca2+-selective TRP channel. J Biol Chem (2004) 1.79
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab (2008) 1.79
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem (2006) 1.71
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium (2005) 1.70
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol (2007) 1.68
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. Pflugers Arch (2003) 1.64
Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci (2008) 1.63
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol (2011) 1.56
TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch (2005) 1.54
Molecular mechanism of active Ca2+ reabsorption in the distal nephron. Annu Rev Physiol (2002) 1.51
The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity. Eur Urol (2008) 1.48
The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis. Proc Natl Acad Sci U S A (2002) 1.46
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Transient receptor potential channels in endothelium: solving the calcium entry puzzle? Endothelium (2003) 1.46
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44