Published in Cell on June 14, 2002
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev (2004) 7.57
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell (2005) 7.20
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol (2006) 5.01
Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci U S A (2004) 4.88
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol (2008) 4.56
The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55
Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol (2005) 3.20
Structural and sequence motifs of protein (histone) methylation enzymes. Annu Rev Biophys Biomol Struct (2005) 3.17
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A (2003) 3.09
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87
Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell (2012) 2.85
Identification of novel histone post-translational modifications by peptide mass fingerprinting. Chromosoma (2003) 2.67
The diverse functions of Dot1 and H3K79 methylation. Genes Dev (2011) 2.66
Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions. Cell (2009) 2.62
Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. J Biol Chem (2006) 2.59
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol (2005) 2.48
A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae. Genes Dev (2008) 2.44
Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast. Mol Cell (2007) 2.38
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet (2008) 2.35
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol (2005) 2.33
The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol (2006) 2.29
Targeting of cohesin by transcriptionally silent chromatin. Genes Dev (2005) 2.28
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22
Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol Cell (2007) 2.07
Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev (2004) 2.04
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struct Mol Biol (2010) 2.04
Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood (2010) 2.03
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood (2011) 1.99
Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants. Cell (2008) 1.99
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A (2005) 1.96
Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95
Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science (2011) 1.93
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer (2010) 1.93
Proteomic and genomic characterization of chromatin complexes at a boundary. J Cell Biol (2005) 1.92
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J (2008) 1.89
Domain-wide displacement of histones by activated heat shock factor occurs independently of Swi/Snf and is not correlated with RNA polymerase II density. Mol Cell Biol (2005) 1.89
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood (2011) 1.88
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nat Struct Mol Biol (2009) 1.85
Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z. Proc Natl Acad Sci U S A (2007) 1.85
Tissue-specific expression and post-translational modification of histone H3 variants. J Proteome Res (2008) 1.84
Heterochromatin formation involves changes in histone modifications over multiple cell generations. EMBO J (2005) 1.82
Mechanisms for the inheritance of chromatin states. Cell (2011) 1.78
Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res (2010) 1.77
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat Struct Mol Biol (2008) 1.73
A histone methyltransferase modulates antigenic variation in African trypanosomes. PLoS Biol (2008) 1.72
Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta (2008) 1.69
Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha. J Clin Invest (2007) 1.69
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat Med (2015) 1.66
Chromatin and transcription in yeast. Genetics (2012) 1.61
SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster. Genes Dev (2007) 1.61
A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. Genes Dev (2007) 1.60
The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control. J Cell Biol (2005) 1.59
Aqp2-expressing cells give rise to renal intercalated cells. J Am Soc Nephrol (2013) 1.59
Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin. Mol Cell Biol (2006) 1.58
A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J (2009) 1.56
Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferase. Am J Physiol Cell Physiol (2005) 1.56
The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion. Genome Res (2009) 1.56
Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Mol Cell Biol (2005) 1.55
Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54
LSD1 and the chemistry of histone demethylation. Curr Opin Chem Biol (2007) 1.52
The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure. Nucleic Acids Res (2006) 1.51
Application of mass spectrometry to the identification and quantification of histone post-translational modifications. J Cell Biochem (2004) 1.49
Dynamic protein methylation in chromatin biology. Cell Mol Life Sci (2009) 1.48
Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.47
Barrier proteins remodel and modify chromatin to restrict silenced domains. Mol Cell Biol (2004) 1.47
Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae. J Biol Chem (2005) 1.46
Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression. EMBO J (2004) 1.46
Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly. Mol Cell (2005) 1.45
Chromatin as an expansive canvas for chemical biology. Nat Chem Biol (2012) 1.45
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase. Biochem J (2004) 1.44
Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. Genetics (2004) 1.42
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
Silent chromatin at the middle and ends: lessons from yeasts. EMBO J (2009) 1.36
The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2. Mol Cell Biol (2006) 1.35
Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin. Mol Cell Biol (2004) 1.34
The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states. Biochim Biophys Acta (2012) 1.32
Dot1 and histone H3K79 methylation in natural telomeric and HM silencing. Mol Cell (2011) 1.32
Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem (2007) 1.28
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28
Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers. Nucleic Acids Res (2009) 1.26
Protein modifications in transcription elongation. Biochim Biophys Acta (2008) 1.26
Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex. Genetics (2006) 1.25
Epigenetic chromatin silencing: bistability and front propagation. Phys Biol (2007) 1.25
Heritable chromatin structure: mapping "memory" in histones H3 and H4. Proc Natl Acad Sci U S A (2002) 1.25
DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev (2011) 1.25
Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem (2012) 1.23
Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res (2007) 1.23
The establishment of gene silencing at single-cell resolution. Nat Genet (2009) 1.22
A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem (2010) 1.21
The Mcp element mediates stable long-range chromosome-chromosome interactions in Drosophila. Mol Biol Cell (2006) 1.21
Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct. J Biol Chem (2009) 1.20
Reconstitution of heterochromatin-dependent transcriptional gene silencing. Mol Cell (2009) 1.16
Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor. PLoS One (2011) 1.16
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev (2004) 7.57
Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci U S A (2004) 4.88
Myc influences global chromatin structure. EMBO J (2006) 4.71
An age-induced switch to a hyper-recombinational state. Science (2003) 3.33
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev (2003) 3.21
Degradation-mediated protein quality control in the nucleus. Cell (2005) 3.10
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell (2009) 3.00
A targeted proteomics-based pipeline for verification of biomarkers in plasma. Nat Biotechnol (2011) 2.91
Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature (2011) 2.81
The standard protein mix database: a diverse data set to assist in the production of improved Peptide and protein identification software tools. J Proteome Res (2007) 2.77
Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol Cell (2011) 2.36
Mass spectrometric quantification of acetylation at specific lysines within the amino-terminal tail of histone H4. Anal Biochem (2003) 2.04
The mother enrichment program: a genetic system for facile replicative life span analysis in Saccharomyces cerevisiae. Genetics (2009) 2.02
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature (2012) 2.00
Dynamic changes in histone acetylation regulate origins of DNA replication. Nat Struct Mol Biol (2010) 1.82
Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC. J Cell Biol (2007) 1.70
Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Mol Cell Biol (2005) 1.55
Genome-wide histone modifications: gaining specificity by preventing promiscuity. Curr Opin Cell Biol (2002) 1.50
A quantitative assay for telomere protection in Saccharomyces cerevisiae. Genetics (2002) 1.49
A mother's sacrifice: what is she keeping for herself? Curr Opin Cell Biol (2008) 1.43
Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics (2009) 1.38
Assays for gene silencing in yeast. Methods Enzymol (2002) 1.31
Heritable chromatin structure: mapping "memory" in histones H3 and H4. Proc Natl Acad Sci U S A (2002) 1.25
Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance. J Neurosci (2008) 1.24
Recombination-induced tag exchange to track old and new proteins. Proc Natl Acad Sci U S A (2009) 1.23
Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. PLoS Genet (2011) 1.22
Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry. J Biol Chem (2010) 1.20
A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae. Genetics (2008) 1.18
Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core. Mol Cell Biol (2008) 1.14
Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents. J Neurochem (2004) 1.07
Evaluation of matrix-assisted laser desorption/ionization-time of flight mass spectrometry proteomic profiling: identification of alpha 2-HS glycoprotein B-chain as a biomarker of diet. Proteomics (2005) 1.07
Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J Proteome Res (2012) 1.06
Aging and genetic instability in yeast. Curr Opin Microbiol (2004) 1.04
Mutations in the nucleosome core enhance transcriptional silencing. Mol Cell Biol (2005) 1.02
A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). J Biol Chem (2008) 0.99
The histone minority report: the variant shall not be silenced. Cell (2003) 0.98
NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. J Virol (2007) 0.97
Collision energy optimization of b- and y-ions for multiple reaction monitoring mass spectrometry. J Proteome Res (2010) 0.90
Quantitative proteomics of the Neisseria gonorrhoeae cell envelope and membrane vesicles for the discovery of potential therapeutic targets. Mol Cell Proteomics (2014) 0.90
Ultrasensitive detection and characterization of posttranslational modifications using surface-enhanced Raman spectroscopy. Anal Chem (2006) 0.88
Does age influence loss of heterozygosity? Exp Gerontol (2007) 0.82
Mass spectrometry of UV-cross-linked protein-nucleic acid complexes: identification of amino acid residues in the single-stranded DNA-binding domain of human replication protein A. Anal Chem (2004) 0.80
Kinetic analysis of BCL11B multisite phosphorylation-dephosphorylation and coupled sumoylation in primary thymocytes by multiple reaction monitoring mass spectroscopy. J Proteome Res (2014) 0.76
Quantitative proteomic analysis of the cell envelopes and native membrane vesicles derived from gram-negative bacteria. Curr Protoc Microbiol (2014) 0.76
Aberrant glycosylation of plasma proteins in severe preeclampsia promotes monocyte adhesion. Reprod Sci (2013) 0.75