Published in Annu Rev Biophys Biomol Struct on January 01, 2005
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Controlling histone methylation via trans-histone pathways. Epigenetics (2008) 1.06
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Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res (2011) 1.04
Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03
Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation. J Biol Chem (2011) 1.01
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Protein arginine methylation of non-histone proteins and its role in diseases. Cell Cycle (2013) 1.00
The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9. Nucleic Acids Res (2006) 0.99
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Structural and functional coordination of DNA and histone methylation. Cold Spring Harb Perspect Biol (2014) 0.98
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle. Cell Cycle (2014) 0.97
Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing. Development (2014) 0.97
Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Mol Biosyst (2011) 0.96
A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L. J Med Chem (2013) 0.95
Chemical probes of histone lysine methyltransferases. ACS Chem Biol (2014) 0.95
Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics. Oncogene (2012) 0.95
Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases. Q Rev Biophys (2013) 0.93
The promise and failures of epigenetic therapies for cancer treatment. Cancer Treat Rev (2013) 0.93
Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. Exp Hematol (2015) 0.93
Expression and purification of full-length mouse CARM1 from transiently transfected HEK293T cells using HaloTag technology. Protein Expr Purif (2010) 0.93
Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc Natl Acad Sci U S A (2013) 0.92
GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression. Proc Natl Acad Sci U S A (2008) 0.91
SET3p monomethylates histone H3 on lysine 9 and is required for the silencing of tandemly repeated transgenes in Chlamydomonas. Nucleic Acids Res (2007) 0.89
The functional modulation of epigenetic regulators by alternative splicing. BMC Genomics (2007) 0.89
Structural basis for activity regulation of MLL family methyltransferases. Nature (2016) 0.89
Crystal structure of the plant epigenetic protein arginine methyltransferase 10. J Mol Biol (2011) 0.88
Dynamics of histone lysine methylation: structures of methyl writers and erasers. Prog Drug Res (2011) 0.88
Structural and functional studies of S-adenosyl-L-methionine binding proteins: a ligand-centric approach. BMC Struct Biol (2013) 0.88
Continuous enzymatic assay for histone lysine methyltransferases. Biotechniques (2007) 0.87
Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region. PLoS One (2013) 0.86
Set2 mediated H3 lysine 36 methylation: regulation of transcription elongation and implications in organismal development. Wiley Interdiscip Rev Dev Biol (2013) 0.86
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives. J Hematol Oncol (2016) 0.85
Chemical and biochemical approaches in the study of histone methylation and demethylation. Med Res Rev (2012) 0.85
Investigation of the molecular origins of protein-arginine methyltransferase I (PRMT1) product specificity reveals a role for two conserved methionine residues. J Biol Chem (2011) 0.84
Human germline and pan-cancer variomes and their distinct functional profiles. Nucleic Acids Res (2014) 0.84
Structural biology and chemistry of protein arginine methyltransferases. Medchemcomm (2014) 0.83
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity. J Biol Chem (2013) 0.83
A prototypic lysine methyltransferase 4 from archaea with degenerate sequence specificity methylates chromatin proteins Sul7d and Cren7 in different patterns. J Biol Chem (2013) 0.83
Expression, purification, crystallization and preliminary crystallographic study of isolated modules of the mouse coactivator-associated arginine methyltransferase 1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.82
Prospects for the development of epigenetic drugs for CNS conditions. Nat Rev Drug Discov (2015) 0.82
An alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase. J Biol Chem (2014) 0.81
Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis. Biochim Biophys Acta (2014) 0.81
Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme. Clin Epigenetics (2015) 0.81
High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function. Biochem Soc Trans (2008) 0.80
Characterization of the PRMT gene family in rice reveals conservation of arginine methylation. PLoS One (2011) 0.79
The upstreams and downstreams of H3K79 methylation by DOT1L. Chromosoma (2016) 0.79
The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation. Protein Cell (2012) 0.78
Epigenetics of the failing heart. Heart Fail Rev (2015) 0.77
Structural genomics of histone tail recognition. Bioinformatics (2010) 0.77
Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1. PLoS One (2013) 0.77
Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev (2017) 0.76
Identification of functional modules of AKMT, a novel lysine methyltransferase regulating the motility of Toxoplasma gondii. Mol Biochem Parasitol (2013) 0.76
Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties. Sci Rep (2015) 0.76
Epigenetic polypharmacology: from combination therapy to multitargeted drugs. Clin Epigenetics (2016) 0.76
Protein post-translational modifications: In silico prediction tools and molecular modeling. Comput Struct Biotechnol J (2017) 0.75
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Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
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Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol (2008) 3.53
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature (2008) 3.28
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Measuring the thermal conductivity of a single carbon nanotube. Phys Rev Lett (2005) 2.94
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Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A (2009) 2.65
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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol (2002) 2.51
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
A common mode of recognition for methylated CpG. Trends Biochem Sci (2013) 2.28
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol (2002) 2.24
Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J Biol Chem (2002) 1.99
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Putative autocleavage of outer capsid protein micro1, allowing release of myristoylated peptide micro1N during particle uncoating, is critical for cell entry by reovirus. J Virol (2004) 1.69
Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry (2007) 1.55
Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics (2014) 1.55
A nearly modern amphibious bird from the Early Cretaceous of northwestern China. Science (2006) 1.45
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics (2009) 1.45
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Insulin alleviates posttrauma cardiac dysfunction by inhibiting tumor necrosis factor-α-mediated reactive oxygen species production. Crit Care Med (2013) 1.42
Potential role of α-synuclein in neurodegeneration: studies in a rat animal model. J Neurochem (2012) 1.41
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog (2010) 1.40
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol (2010) 1.37
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res (2012) 1.35
An antibody to the putative aphid recognition site on cucumber mosaic virus recognizes pentons but not hexons. J Virol (2002) 1.35
Improvement of antibiotic activity of Xenorhabdus bovienii by medium optimization using response surface methodology. Microb Cell Fact (2011) 1.35
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A Structural-informatics approach for tracing beta-sheets: building pseudo-C(alpha) traces for beta-strands in intermediate-resolution density maps. J Mol Biol (2004) 1.34
The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer. J Transl Med (2010) 1.33
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res (2011) 1.32
Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol (2008) 1.31
The Magnaporthe oryzae avirulence gene AvrPiz-t encodes a predicted secreted protein that triggers the immunity in rice mediated by the blast resistance gene Piz-t. Mol Plant Microbe Interact (2009) 1.30
A model-based parallel origin and orientation refinement algorithm for cryoTEM and its application to the study of virus structures. J Struct Biol (2005) 1.29
Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer (2009) 1.26
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Identification of juvenile hormone target genes in the adult female mosquitoes. Insect Biochem Mol Biol (2009) 1.09
Structural dynamics of protein lysine methylation and demethylation. Mutat Res (2007) 1.08
The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer. J Transl Med (2009) 1.08
Synergistic triggering of superoxide flashes by mitochondrial Ca2+ uniport and basal reactive oxygen species elevation. J Biol Chem (2013) 1.08
Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA. Hum Mol Genet (2010) 1.08
Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Hum Mol Genet (2005) 1.07
Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway. PLoS One (2013) 1.05
Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Mol Cancer (2010) 1.04
Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions. Acta Pharmacol Sin (2006) 1.04
Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles. J Mol Biol (2012) 1.04
Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart. J Mol Cell Cardiol (2012) 1.04
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun (2011) 1.04
Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J Mol Biol (2011) 1.04
A two-component histidine kinase, MoSLN1, is required for cell wall integrity and pathogenicity of the rice blast fungus, Magnaporthe oryzae. Curr Genet (2010) 1.03
Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Mol Endocrinol (2007) 1.03
Comparative toxicity of essential oils of Litsea pungens and Litsea cubeba and blends of their major constituents against the cabbage looper, Trichoplusia ni. J Agric Food Chem (2009) 1.02
Structure of the bacteriophage T4 DNA adenine methyltransferase. Nat Struct Biol (2003) 1.02
An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. J Mol Biol (2011) 1.01
Two phosphodiesterase genes, PDEL and PDEH, regulate development and pathogenicity by modulating intracellular cyclic AMP levels in Magnaporthe oryzae. PLoS One (2011) 1.01
A biomimetic tubular scaffold with spatially designed nanofibers of protein/PDS bio-blends. Biotechnol Bioeng (2009) 1.01
Analysis of leaf proteome after UV-B irradiation in maize lines differing in sensitivity. Mol Cell Proteomics (2005) 1.01
Retinal Fundus Image Registration via Vascular Structure Graph Matching. Int J Biomed Imaging (2010) 0.99
Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract. World J Gastroenterol (2005) 0.99
Co-expression of nuclear and cytoplasmic HMGB1 is inversely associated with infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer. BMC Cancer (2010) 0.99
Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: The role of oxidative stress and protein tyrosine kinase activation. Toxicol Appl Pharmacol (2008) 0.98
Functionally graded electrospun scaffolds with tunable mechanical properties for vascular tissue regeneration. Biomed Mater (2007) 0.98
Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease. Nucleic Acids Res (2012) 0.98
Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain. Curr Opin Struct Biol (2011) 0.97
Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res (2011) 0.97
Simultaneous determination of 10 components in traditional Chinese medicine Dachaihu Granule by reversed-phase-high-performance liquid chromatographic-diode array detector. Pharmacogn Mag (2013) 0.97
The hydrophilic amino-terminal arm of reovirus core shell protein lambda1 is dispensable for particle assembly. J Virol (2002) 0.97
Enhanced antibiotic activity of Xenorhabdus nematophila by medium optimization. Bioresour Technol (2007) 0.97
Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics (2014) 0.97
AMPK-regulated and Akt-dependent enhancement of glucose uptake is essential in ischemic preconditioning-alleviated reperfusion injury. PLoS One (2013) 0.97
Color-tuning method by filling porous alumina membrane using atomic layer deposition based on metal-dielectric-metal structure. Appl Opt (2014) 0.96
Design principles for photovoltaic devices based on Si nanowires with axial or radial p-n junctions. Nano Lett (2012) 0.96
Alkali pretreated of wheat straw and its enzymatic hydrolysis. Braz J Microbiol (2012) 0.95
Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A (2010) 0.95
Design and simulation of omnidirectional reflective color filters based on metal-dielectric-metal structure. Opt Express (2014) 0.95
Salient feature region: a new method for retinal image registration. IEEE Trans Inf Technol Biomed (2010) 0.94