Published in J Biol Chem on May 06, 2002
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab (2006) 6.44
Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol (2004) 5.66
Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest (2006) 3.48
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab (2005) 3.47
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A (2003) 1.89
PPARalpha governs glycerol metabolism. J Clin Invest (2004) 1.79
Nuclear receptors, mitochondria and lipid metabolism. Mitochondrion (2008) 1.71
Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc Natl Acad Sci U S A (2007) 1.58
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy. Proc Natl Acad Sci U S A (2004) 1.52
Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J (2008) 1.45
PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res (2010) 1.43
PPARs in the Control of Uncoupling Proteins Gene Expression. PPAR Res (2007) 1.34
Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise. Biol Rev Camb Philos Soc (2010) 1.23
The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue. Genome Biol (2011) 1.22
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress. J Biol Chem (2008) 1.16
Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr (2005) 1.16
Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes (2010) 1.13
Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity. J Biol Chem (2008) 1.10
The Role of PPARα Activation in Liver and Muscle. PPAR Res (2010) 1.07
Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. Diabetes (2014) 1.05
Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system. Diabetes (2011) 1.05
Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. Appl Physiol Nutr Metab (2010) 1.03
Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle. J Endocrinol (2005) 1.00
PPARdelta expression is influenced by muscle activity and induces slow muscle properties in adult rat muscles after somatic gene transfer. J Physiol (2007) 0.98
Differential effects of dietary intake of palmitic acid and oleic acid on oxygen consumption during and after exercise. Metabolism (2006) 0.95
Adipogenic and energy metabolism gene networks in longissimus lumborum during rapid post-weaning growth in Angus and Angus x Simmental cattle fed high-starch or low-starch diets. BMC Genomics (2009) 0.95
Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse. Genome Med (2009) 0.94
Genetic manipulations of PPARs: effects on obesity and metabolic disease. PPAR Res (2007) 0.94
Peroxisome Proliferator-Activated Receptor Delta: A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Res (2008) 0.92
The Effect of PPARalpha, PPARdelta, PPARgamma, and PPARpan Agonists on Body Weight, Body Mass, and Serum Lipid Profiles in Diet-Induced Obese AKR/J Mice. PPAR Res (2007) 0.90
Proteomic study of the effects of complex environmental stresses in the livers of goldfish (Carassius auratus) that inhabit Gaobeidian Lake in Beijing, China. Ecotoxicology (2007) 0.88
Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise. Cell Metab (2015) 0.88
Role of PPARα in Hepatic Carbohydrate Metabolism. PPAR Res (2010) 0.86
Adipocyte fatty acid storage factors enhance subcutaneous fat storage in postmenopausal women. Diabetes (2012) 0.86
Alternative splicing of human peroxisome proliferator-activated receptor delta (PPAR delta): effects on translation efficiency and trans-activation ability. BMC Mol Biol (2007) 0.86
PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS One (2013) 0.86
Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. PLoS One (2012) 0.85
TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity. Skelet Muscle (2013) 0.84
Alterations in peroxisome proliferator-activated receptor mRNA expression in skeletal muscle after acute and repeated bouts of exercise. Mol Cell Biochem (2009) 0.84
Nuclear receptors and metabolism: from feast to famine. Diabetologia (2014) 0.84
Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice. Genome Biol (2007) 0.84
Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol (2013) 0.83
PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials. PPAR Res (2012) 0.83
Lipoprotein lipase activity is required for cardiac lipid droplet production. J Lipid Res (2014) 0.83
In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy. J Cardiovasc Magn Reson (2013) 0.83
PPARδ agonist GW501516 inhibits PDGF-stimulated pulmonary arterial smooth muscle cell function related to pathological vascular remodeling. Biomed Res Int (2013) 0.83
Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle. Endocrinology (2008) 0.83
PPAR agonists as therapeutics for CNS trauma and neurological diseases. ASN Neuro (2013) 0.82
DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. J Lipid Res (2013) 0.82
Activation of peroxisome proliferator-activated receptor-alpha in mice induces expression of the hepatic low-density lipoprotein receptor. Br J Pharmacol (2008) 0.82
Metabolic Functions of Peroxisome Proliferator-Activated Receptor beta/delta in Skeletal Muscle. PPAR Res (2007) 0.80
Different metabolic responses to central and peripheral injection of enterostatin. Am J Physiol Regul Integr Comp Physiol (2005) 0.79
Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway. Amino Acids (2010) 0.79
Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women. Physiol Genomics (2015) 0.79
Generation and characterization of a humanized PPARδ mouse model. Br J Pharmacol (2011) 0.79
Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity. Am J Physiol Endocrinol Metab (2015) 0.79
Dietary heme-mediated PPARα activation does not affect the heme-induced epithelial hyperproliferation and hyperplasia in mouse colon. PLoS One (2012) 0.79
Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle. J Aging Res (2012) 0.78
Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction. Am J Physiol Heart Circ Physiol (2015) 0.78
The Functions of PPARs in Aging and Longevity. PPAR Res (2007) 0.78
PPARs and Mitochondrial Metabolism: From NAFLD to HCC. PPAR Res (2016) 0.77
Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats. Nutr Metab (Lond) (2016) 0.77
Fasting Upregulates PPARalpha Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARalpha Dependent Manner. PPAR Res (2009) 0.77
AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression. PPAR Res (2015) 0.77
Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism. PLoS One (2014) 0.77
Validation of a genomics-based hypothetical adverse outcome pathway: 2,4-dinitrotoluene perturbs PPAR signaling thus impairing energy metabolism and exercise endurance. Toxicol Sci (2014) 0.76
Relationship between postprandial endotoxemia in nonobese postmenopausal women and diabetic nonobese postmenopausal women. J Nat Sci Biol Med (2015) 0.75
Analytes and Metabolites Associated with Muscle Quality in Young, Healthy Adults. Med Sci Sports Exerc (2015) 0.75
Regulation of FADS2 transcription by SREBP-1 and PPAR-α influences LC-PUFA biosynthesis in fish. Sci Rep (2017) 0.75
Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice. Mol Metab (2016) 0.75
Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice. J Amino Acids (2014) 0.75
Muscle-Specific PPARbeta/delta Agonism May Provide Synergistic Benefits with Life Style Modifications. PPAR Res (2007) 0.75
Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations. Cold Spring Harb Perspect Med (2017) 0.75
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med (2002) 7.34
Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA (2009) 6.36
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest (2009) 5.66
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem (2005) 4.30
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem (2002) 4.11
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care (2009) 3.69
Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults: a scientific statement from the American Heart Association. Circulation (2010) 3.63
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab (2005) 3.47
Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale. Am Heart J (2007) 3.34
Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE--a randomized controlled study. Arch Intern Med (2004) 3.30
Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol (1985) (2003) 3.18
Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med (2010) 3.17
Population approaches to improve diet, physical activity, and smoking habits: a scientific statement from the American Heart Association. Circulation (2012) 2.95
Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA (2009) 2.83
Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors. J Clin Oncol (2007) 2.50
Genomic predictors of the maximal O₂ uptake response to standardized exercise training programs. J Appl Physiol (1985) (2010) 2.43
Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol (1985) (2005) 2.38
Muscle fiber type is associated with obesity and weight loss. Am J Physiol Endocrinol Metab (2002) 2.38
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ Cardiovasc Genet (2010) 2.34
Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model. Circ Heart Fail (2011) 2.28
Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the Studies of a Targeted Risk Reduction Intervention Through Defined Exercise - STRRIDE-AT/RT). Am J Cardiol (2011) 2.28
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. Mol Syst Biol (2009) 2.21
Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. Am J Physiol Cell Physiol (2002) 2.18
Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise). Am J Cardiol (2007) 2.14
Skeletal muscle lipid metabolism with obesity. Am J Physiol Endocrinol Metab (2002) 2.13
Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol (1985) (2007) 2.11
Effects of exercise training intensity on pancreatic beta-cell function. Diabetes Care (2009) 1.93
Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis. Circ Cardiovasc Genet (2008) 1.92
Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab (2011) 1.91
Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One (2012) 1.84
Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population. Clin Chim Acta (2011) 1.83
Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. Am J Physiol Endocrinol Metab (2007) 1.81
Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. J Gerontol A Biol Sci Med Sci (2010) 1.80
Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing). Am J Cardiol (2008) 1.79
PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. J Appl Physiol (1985) (2003) 1.73
Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes (2002) 1.73
A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. Am J Hum Genet (2004) 1.71
GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. Physiol Genomics (2006) 1.67
Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function. Circulation (2012) 1.64
Mechanism for improved insulin sensitivity after gastric bypass surgery. J Clin Endocrinol Metab (2008) 1.62
Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. J Am Coll Cardiol (2013) 1.61
Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease. Am Heart J (2012) 1.59
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology (2013) 1.56
Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet (2007) 1.55
Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans. Diabetes (2013) 1.55
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol (1985) (2011) 1.52
Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidation. Exerc Sport Sci Rev (2009) 1.52
Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes (2008) 1.51
Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. J Am Coll Cardiol (2008) 1.46
Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease. PLoS One (2009) 1.45
Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol (2014) 1.43
Risk stratification of serious adverse events after gastric bypass in the Bariatric Outcomes Longitudinal Database. Surg Obes Relat Dis (2012) 1.42
Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes (2003) 1.42
Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise. Med Sci Sports Exerc (2009) 1.41
Control arms in exercise training studies: transitioning from an era of intervention efficacy to one of comparative clinical effectiveness research. J Appl Physiol (1985) (2011) 1.41
Design of FRESH START: a randomized trial of exercise and diet among cancer survivors. Med Sci Sports Exerc (2003) 1.40
Baseline data from American Society for Metabolic and Bariatric Surgery-designated Bariatric Surgery Centers of Excellence using the Bariatric Outcomes Longitudinal Database. Surg Obes Relat Dis (2010) 1.40
Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients. BMC Med Genomics (2011) 1.37
The effect of the PREMIER interventions on insulin sensitivity. Diabetes Care (2004) 1.36
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet (2012) 1.35
Recommendations for clinical exercise laboratories: a scientific statement from the american heart association. Circulation (2009) 1.34
Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life (2009) 1.33
Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories. BMC Genomics (2008) 1.33
GATA2 is associated with familial early-onset coronary artery disease. PLoS Genet (2006) 1.32
Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol (2002) 1.31
Effects of exercise training amount and intensity on peak oxygen consumption in middle-age men and women at risk for cardiovascular disease. Chest (2005) 1.30
Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise. Am J Physiol Endocrinol Metab (2008) 1.29
Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Mol Cell Biol (2002) 1.29
Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study. Am Heart J (2003) 1.28
Effect of weight loss on muscle lipid content in morbidly obese subjects. Am J Physiol Endocrinol Metab (2002) 1.27
Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. Atherosclerosis (2004) 1.26
Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice. Hepatology (2002) 1.26
Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res (2013) 1.25
Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.24
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol (2007) 1.22
Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets. Hum Mol Genet (2008) 1.21
Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation. J Appl Physiol (1985) (2009) 1.21