Published in Bioorg Med Chem on October 01, 2002
Pathway for polyarginine entry into mammalian cells. Biochemistry (2004) 2.14
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. J Am Chem Soc (2009) 2.06
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res (2004) 1.84
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design. Nucleic Acids Res (2002) 1.52
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities. Nucleic Acids Res (2003) 1.48
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. Chem Biol (2012) 1.18
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
HPV episome levels are potently decreased by pyrrole-imidazole polyamides. Antiviral Res (2011) 1.11
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res (2003) 1.01
Experimental approaches to identify cellular G-quadruplex structures and functions. Methods (2012) 0.91
Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res (2013) 0.91
Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc (2009) 0.89
Programmable DNA-binding small molecules. Bioorg Med Chem (2013) 0.89
Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine. Bioorg Med Chem Lett (2009) 0.86
Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides. Nucleic Acids Res (2003) 0.86
Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity. J Am Chem Soc (2014) 0.85
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. J Med Chem (2009) 0.85
LNA-based oligonucleotide electrotransfer for miRNA inhibition. Mol Ther (2012) 0.84
The reach of linear protein-DNA dimerizers. J Am Chem Soc (2007) 0.82
Oligomerization route to Py-Im polyamide macrocycles. Org Lett (2009) 0.77
Sub-cellular temporal and spatial distribution of electrotransferred LNA/DNA oligomer. J RNAi Gene Silencing (2013) 0.77
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies. Bioorg Med Chem (2008) 0.77
Effective Cellular Morphology Analysis for Differentiation Processes by a Fluorescent 1,3a,6a-Triazapentalene Derivative Probe in Live Cells. PLoS One (2016) 0.75
Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications. Nucleic Acids Res (2015) 0.75
Effect of lanthanide complex structure on cell viability and association. Inorg Chem (2014) 0.75
Design, synthesis, and analysis of minor groove binder pyrrolepolyamide-2'-deoxyguanosine hybrids. J Nucleic Acids (2010) 0.75
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A (2004) 2.25
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A (2007) 2.04
Contemporary strategies for the stabilization of peptides in the alpha-helical conformation. Curr Opin Chem Biol (2008) 1.99
An orthosteric inhibitor of the Ras-Sos interaction. Nat Chem Biol (2011) 1.91
Arresting cancer proliferation by small-molecule gene regulation. Chem Biol (2004) 1.90
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res (2004) 1.84
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol (2007) 1.84
Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol (2003) 1.81
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A (2006) 1.70
A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation. Acc Chem Res (2008) 1.67
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. J Infect Dis (2004) 1.64
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol (2003) 1.63
Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A (2009) 1.61
Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL. Angew Chem Int Ed Engl (2005) 1.59
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate. J Am Chem Soc (2004) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. J Am Chem Soc (2006) 1.47
Assessing helical protein interfaces for inhibitor design. J Am Chem Soc (2011) 1.46
Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45
Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix. J Am Chem Soc (2010) 1.42
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression. Proc Natl Acad Sci U S A (2009) 1.38
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc Natl Acad Sci U S A (2007) 1.38
Assessment of helical interfaces in protein-protein interactions. Mol Biosyst (2009) 1.37
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based alpha helices. Angew Chem Int Ed Engl (2008) 1.32
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors. ACS Chem Biol (2010) 1.29
Molecular recognition of the nucleosomal "supergroove". Proc Natl Acad Sci U S A (2004) 1.25
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol (2002) 1.24
Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. J Am Chem Soc (2008) 1.23
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex. Chembiochem (2010) 1.19
Solid-phase synthesis of hydrogen-bond surrogate-derived alpha-helices. Org Lett (2005) 1.19
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2013) 1.13
Nonpeptidic foldamers from amino acids: synthesis and characterization of 1,3-substituted triazole oligomers. J Am Chem Soc (2005) 1.13
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate. J Am Chem Soc (2008) 1.11
Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol (2002) 1.11
Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. Bioorg Med Chem (2003) 1.10
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc (2002) 1.09
Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. J Biol Chem (2012) 1.09
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proc Natl Acad Sci U S A (2008) 1.07
Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach. Nat Protoc (2010) 1.07
DNA-templated dimerization of hairpin polyamides. J Am Chem Soc (2003) 1.07
Programmable oligomers for minor groove DNA recognition. J Am Chem Soc (2006) 1.06
Optimized synthesis of hydrogen-bond surrogate helices: surprising effects of microwave heating on the activity of Grubbs catalysts. Org Lett (2006) 1.06
Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol (2008) 1.06
Oligooxopiperazines as nonpeptidic alpha-helix mimetics. Org Lett (2010) 1.05
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2012) 1.04
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. J Am Chem Soc (2012) 1.03
Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions. Bioorg Med Chem (2012) 1.03
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. J Am Chem Soc (2005) 1.02
Addressing single molecules on DNA nanostructures. Angew Chem Int Ed Engl (2007) 1.02
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res (2003) 1.01
Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. J Mol Biol (2002) 1.01
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc (2003) 1.01
Nucleation and stability of hydrogen-bond surrogate-based alpha-helices. Org Biomol Chem (2006) 0.99
NMR structure of a cyclic polyamide-DNA complex. J Am Chem Soc (2004) 0.99
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A (2013) 0.98
Nucleosomes in solution exist as a mixture of twist-defect states. J Mol Biol (2005) 0.98
Microwave assisted synthesis of Py-Im polyamides. Org Lett (2012) 0.98
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc (2012) 0.97
Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry (2002) 0.97
Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemother Pharmacol (2012) 0.97
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling. Proc Natl Acad Sci U S A (2013) 0.96
Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol (2002) 0.96
Design of a sequence-specific DNA bisintercalator. Angew Chem Int Ed Engl (2004) 0.96
Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem (2012) 0.96
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc (2003) 0.96
Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry (2004) 0.96
Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling. Org Biomol Chem (2010) 0.94
Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design. PLoS One (2013) 0.94
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle (2006) 0.94
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res (2006) 0.94
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc (2007) 0.93
Trapping a folding intermediate of the alpha-helix: stabilization of the pi-helix. Biochemistry (2008) 0.93
Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases. J Biol Chem (2002) 0.93
Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem (2007) 0.92
Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther (2013) 0.92
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry (2011) 0.91
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry (2005) 0.91
Programming multiple protein patterns on a single DNA nanostructure. J Am Chem Soc (2008) 0.91
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther (2008) 0.91
Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition. Bioorg Med Chem (2006) 0.91
Recognition of "mirror-image" DNA by small molecules. Angew Chem Int Ed Engl (2007) 0.90
Recognition of ten base pairs of DNA by head-to-head hairpin dimers. J Am Chem Soc (2002) 0.90
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. Bioorg Med Chem (2006) 0.90