Published in J Am Chem Soc on December 15, 2004
A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors. ACS Chem Biol (2008) 1.25
Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. J Am Chem Soc (2008) 1.23
Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. Chem Biol (2010) 1.20
Design and synthesis of a cell-permeable synthetic transcription factor mimic. J Comb Chem (2007) 1.17
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides. J Med Chem (2009) 0.85
Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J (2009) 0.83
NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation. ACS Nano (2014) 0.82
The reach of linear protein-DNA dimerizers. J Am Chem Soc (2007) 0.82
Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy. ACS Chem Biol (2015) 0.81
Nucleating the assembly of macromolecular complexes. Chembiochem (2010) 0.80
Small-molecule regulators that mimic transcription factors. Biochim Biophys Acta (2010) 0.80
Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif. PLoS One (2014) 0.78
Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers. Biochem J (2014) 0.78
Oligomerization route to Py-Im polyamide macrocycles. Org Lett (2009) 0.77
Tra1 as a screening target for transcriptional activation domain discovery. Bioorg Med Chem Lett (2009) 0.77
Small molecule probes to target the human Mediator complex. Isr J Chem (2013) 0.76
Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants. Nucleic Acids Res (2012) 0.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A (2004) 2.25
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol (2009) 2.16
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A (2007) 2.04
Arresting cancer proliferation by small-molecule gene regulation. Chem Biol (2004) 1.90
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res (2004) 1.84
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol (2007) 1.84
Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol (2003) 1.81
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A (2006) 1.70
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. J Infect Dis (2004) 1.64
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol (2003) 1.63
Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A (2009) 1.61
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol (2011) 1.61
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorg Med Chem (2002) 1.52
Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45
A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol (2009) 1.39
Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action. Angew Chem Int Ed Engl (2010) 1.38
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression. Proc Natl Acad Sci U S A (2009) 1.38
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother (2011) 1.27
Molecular recognition of the nucleosomal "supergroove". Proc Natl Acad Sci U S A (2004) 1.25
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol (2002) 1.24
Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. J Am Chem Soc (2008) 1.23
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2013) 1.13
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol (2002) 1.11
Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. Bioorg Med Chem (2003) 1.10
Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc (2002) 1.09
Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene (2002) 1.09
Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. J Biol Chem (2012) 1.09
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proc Natl Acad Sci U S A (2008) 1.07
DNA-templated dimerization of hairpin polyamides. J Am Chem Soc (2003) 1.07
Programmable oligomers for minor groove DNA recognition. J Am Chem Soc (2006) 1.06
Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol (2008) 1.06
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2012) 1.04
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. J Am Chem Soc (2012) 1.03
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. J Am Chem Soc (2005) 1.02
Addressing single molecules on DNA nanostructures. Angew Chem Int Ed Engl (2007) 1.02
Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. J Mol Biol (2002) 1.01
Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin. J Am Chem Soc (2010) 1.01
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res (2003) 1.01
Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem (2002) 1.01
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc (2003) 1.01
Hetero Diels-Alder synthesis of 3-hydroxypyridines: access to the nosiheptide core. J Org Chem (2007) 1.00
NMR structure of a cyclic polyamide-DNA complex. J Am Chem Soc (2004) 0.99
A fluorescent probe for the 70 S-ribosomal GTPase-associated center. Chembiochem (2009) 0.99
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A (2013) 0.98
Nucleosomes in solution exist as a mixture of twist-defect states. J Mol Biol (2005) 0.98
Total synthesis of chondramide C and its binding mode to F-actin. Angew Chem Int Ed Engl (2008) 0.98
Biochemical target isolation for novices: affinity-based strategies. Chem Biol (2010) 0.98
Microwave assisted synthesis of Py-Im polyamides. Org Lett (2012) 0.98
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc (2012) 0.97
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget (2010) 0.97
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry (2002) 0.97
Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res (2013) 0.97
Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemother Pharmacol (2012) 0.97
Synthesis and structure-activity correlation of a brunsvicamide-inspired cyclopeptide collection. Chembiochem (2009) 0.97
Design of a sequence-specific DNA bisintercalator. Angew Chem Int Ed Engl (2004) 0.96
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc (2003) 0.96
Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry (2004) 0.96
Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol (2002) 0.96
Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem (2012) 0.96
A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J Am Chem Soc (2004) 0.95
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle (2006) 0.94
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A (2002) 0.94
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc (2007) 0.94
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res (2006) 0.94
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc (2007) 0.93
Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem (2007) 0.92
Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway. Proc Natl Acad Sci U S A (2011) 0.92
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther (2013) 0.92
Programming multiple protein patterns on a single DNA nanostructure. J Am Chem Soc (2008) 0.91
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther (2008) 0.91