Published in J Am Chem Soc on May 07, 2008
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2013) 1.13
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. J Am Chem Soc (2012) 1.03
Microwave assisted synthesis of Py-Im polyamides. Org Lett (2012) 0.98
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc (2012) 0.97
Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemother Pharmacol (2012) 0.97
Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem (2012) 0.96
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry (2011) 0.91
Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc (2009) 0.89
Binding studies of a large antiviral polyamide to a natural HPV sequence. Biochimie (2014) 0.89
Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine. Biochimie (2012) 0.88
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. J Med Chem (2009) 0.85
Synthesis of cyclic Py-Im polyamide libraries. J Org Chem (2012) 0.84
Structure-based DNA-targeting strategies with small molecule ligands for drug discovery. Med Res Rev (2013) 0.84
Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit. J Med Chem (2013) 0.83
DNA sequence selectivity of hairpin polyamide turn units. Bioorg Med Chem Lett (2009) 0.82
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. PLoS One (2015) 0.77
Oligomerization route to Py-Im polyamide macrocycles. Org Lett (2009) 0.77
RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. Proc Natl Acad Sci U S A (2016) 0.75
Addressable and unidirectional energy transfer along a DNA three-way junction programmed by pyrrole-imidazole polyamides. Sci Rep (2013) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr Opin Struct Biol (2003) 3.80
Molecular recognition of DNA by small molecules. Bioorg Med Chem (2001) 3.69
Quantitative DNase footprint titration: a method for studying protein-DNA interactions. Methods Enzymol (1986) 3.36
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A (2004) 2.25
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science (1998) 2.05
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A (2007) 2.04
Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes. Methods Enzymol (2001) 1.97
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res (2004) 1.84
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol (2007) 1.84
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
Structural basis for G.C recognition in the DNA minor groove. Nat Struct Biol (1998) 1.74
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
A cell-permeable synthetic transcription factor mimic. Angew Chem Int Ed Engl (2007) 1.29
Molecular recognition of the nucleosomal "supergroove". Proc Natl Acad Sci U S A (2004) 1.25
Binding of a hairpin polyamide in the minor groove of DNA: sequence-specific enthalpic discrimination. Proc Natl Acad Sci U S A (1996) 1.18
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates. Chem Biol (2000) 1.16
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA. Biochemistry (1999) 1.07
DNA-templated dimerization of hairpin polyamides. J Am Chem Soc (2003) 1.07
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
Addressing single molecules on DNA nanostructures. Angew Chem Int Ed Engl (2007) 1.02
Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. J Am Chem Soc (2005) 1.02
NMR structure of a cyclic polyamide-DNA complex. J Am Chem Soc (2004) 0.99
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
Design of a sequence-specific DNA bisintercalator. Angew Chem Int Ed Engl (2004) 0.96
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc (2003) 0.96
Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates. J Am Chem Soc (2001) 0.95
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res (2006) 0.94
Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc (2007) 0.93
Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem (2007) 0.92
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
Programming multiple protein patterns on a single DNA nanostructure. J Am Chem Soc (2008) 0.91
Recognition of ten base pairs of DNA by head-to-head hairpin dimers. J Am Chem Soc (2002) 0.90
Polyamide struts for DNA architectures. Angew Chem Int Ed Engl (2007) 0.87
Effects of anomalous migration and DNA to protein ratios on resolution of equilibrium constants from gel mobility-shift assays. Electrophoresis (1993) 0.84
Base pair recognition of the stereochemically alpha-substituted gamma-turn of pyrrole/imidazole hairpin polyamides. J Am Chem Soc (2006) 0.84
The reach of linear protein-DNA dimerizers. J Am Chem Soc (2007) 0.82
DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation. J Am Chem Soc (2007) 0.80
Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers. J Am Chem Soc (2006) 0.79
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A (2004) 2.25
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A (2007) 2.04
Arresting cancer proliferation by small-molecule gene regulation. Chem Biol (2004) 1.90
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res (2004) 1.84
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol (2007) 1.84
Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol (2003) 1.81
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A (2006) 1.70
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. J Infect Dis (2004) 1.64
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol (2003) 1.63
Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A (2009) 1.61
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorg Med Chem (2002) 1.52
Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression. Proc Natl Acad Sci U S A (2009) 1.38
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
Molecular recognition of the nucleosomal "supergroove". Proc Natl Acad Sci U S A (2004) 1.25
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol (2002) 1.24
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2013) 1.13
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol (2002) 1.11
Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. Bioorg Med Chem (2003) 1.10
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc (2002) 1.09
Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. J Biol Chem (2012) 1.09
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proc Natl Acad Sci U S A (2008) 1.07
DNA-templated dimerization of hairpin polyamides. J Am Chem Soc (2003) 1.07
Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol (2008) 1.06
Programmable oligomers for minor groove DNA recognition. J Am Chem Soc (2006) 1.06
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2012) 1.04
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. J Am Chem Soc (2012) 1.03
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. J Am Chem Soc (2005) 1.02
Addressing single molecules on DNA nanostructures. Angew Chem Int Ed Engl (2007) 1.02
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res (2003) 1.01
Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. J Mol Biol (2002) 1.01
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc (2003) 1.01
NMR structure of a cyclic polyamide-DNA complex. J Am Chem Soc (2004) 0.99
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A (2013) 0.98
Nucleosomes in solution exist as a mixture of twist-defect states. J Mol Biol (2005) 0.98
Microwave assisted synthesis of Py-Im polyamides. Org Lett (2012) 0.98
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc (2012) 0.97
Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemother Pharmacol (2012) 0.97
Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry (2002) 0.97
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc (2003) 0.96
Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry (2004) 0.96
Design of a sequence-specific DNA bisintercalator. Angew Chem Int Ed Engl (2004) 0.96
Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem (2012) 0.96
Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol (2002) 0.96
Promises and pitfalls of intracellular delivery of proteins. Bioconjug Chem (2014) 0.95
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle (2006) 0.94
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res (2006) 0.94
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc (2007) 0.93
Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem (2007) 0.92
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther (2013) 0.92
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry (2011) 0.91
Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition. Bioorg Med Chem (2006) 0.91
Programming multiple protein patterns on a single DNA nanostructure. J Am Chem Soc (2008) 0.91
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry (2005) 0.91
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther (2008) 0.91
Recognition of "mirror-image" DNA by small molecules. Angew Chem Int Ed Engl (2007) 0.90
Recognition of ten base pairs of DNA by head-to-head hairpin dimers. J Am Chem Soc (2002) 0.90
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. Bioorg Med Chem (2006) 0.90
U-pin polyamide motif for recognition of the DNA minor groove. Chemistry (2003) 0.89
Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc (2009) 0.89
Recognition of nucleic acid junctions using triptycene-based molecules. Angew Chem Int Ed Engl (2014) 0.89
N-Terminal labeling of filamentous phage to create cancer marker imaging agents. ACS Nano (2012) 0.88
Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray. Biophys J (2009) 0.87
Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate. J Biol Chem (2002) 0.87
Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition. J Am Chem Soc (2004) 0.86
Alternative heterocycles for DNA recognition: the benzimidazole/imidazole pair. Chemistry (2003) 0.85
Search for the optimal linker in tandem hairpin polyamides. Bioorg Med Chem (2002) 0.85
Analysis of hairpin polyamide complexes having DNA binding sites in close proximity. J Am Chem Soc (2002) 0.85
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. J Med Chem (2009) 0.85
Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition. J Am Chem Soc (2014) 0.84
Synthesis of cyclic Py-Im polyamide libraries. J Org Chem (2012) 0.84
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA. Angew Chem Int Ed Engl (2012) 0.84
Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit. J Med Chem (2013) 0.83
Synthesis and conformational dynamics of the reported structure of xylopyridine A. J Am Chem Soc (2013) 0.83
DNA sequence selectivity of hairpin polyamide turn units. Bioorg Med Chem Lett (2009) 0.82
Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorg Med Chem Lett (2012) 0.82
The reach of linear protein-DNA dimerizers. J Am Chem Soc (2007) 0.82
Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA. Org Lett (2011) 0.82
Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences. Biochemistry (2003) 0.80