Published in J Am Chem Soc on July 19, 2006
Genome engineering with zinc-finger nucleases. Genetics (2011) 4.66
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine. J Am Chem Soc (2009) 1.15
Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nucleic Acids Res (2012) 0.95
Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc (2007) 0.93
Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition. Bioorg Med Chem (2006) 0.91
Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia. PLoS One (2010) 0.86
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Toward rules for 1:1 polyamide:DNA recognition. Proc Natl Acad Sci U S A (2001) 1.07
Extending the language of DNA molecular recognition by polyamides: unexpected influence of imidazole and pyrrole arrangement on binding affinity and specificity. J Am Chem Soc (2005) 1.06
Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. J Mol Biol (2002) 1.01
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc (2003) 1.01
Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. J Mol Biol (2000) 0.96
Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition. J Am Chem Soc (2004) 0.86
Alternative heterocycles for DNA recognition: the benzimidazole/imidazole pair. Chemistry (2003) 0.85
Recognition of a 10 base pair sequence of DNA and stereochemical control of the binding affinity of chiral hairpin polyamide-Hoechst 33258 conjugates. Bioorg Med Chem Lett (2005) 0.81
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A (2004) 2.25
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A (2007) 2.04
Arresting cancer proliferation by small-molecule gene regulation. Chem Biol (2004) 1.90
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res (2004) 1.84
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol (2007) 1.84
Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol (2003) 1.81
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A (2006) 1.70
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. J Infect Dis (2004) 1.64
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol (2003) 1.63
Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A (2009) 1.61
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorg Med Chem (2002) 1.52
Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression. Proc Natl Acad Sci U S A (2009) 1.38
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
Programmable DNA binding oligomers for control of transcription. Curr Med Chem Anticancer Agents (2005) 1.28
Molecular recognition of the nucleosomal "supergroove". Proc Natl Acad Sci U S A (2004) 1.25
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol (2002) 1.24
Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. J Am Chem Soc (2008) 1.23
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2013) 1.13
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol (2002) 1.11
Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. Bioorg Med Chem (2003) 1.10
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc (2002) 1.09
Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. J Biol Chem (2012) 1.09
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proc Natl Acad Sci U S A (2008) 1.07
DNA-templated dimerization of hairpin polyamides. J Am Chem Soc (2003) 1.07
Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol (2008) 1.06
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2012) 1.04
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. J Am Chem Soc (2012) 1.03
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. J Am Chem Soc (2005) 1.02
Addressing single molecules on DNA nanostructures. Angew Chem Int Ed Engl (2007) 1.02
Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. J Mol Biol (2002) 1.01
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res (2003) 1.01
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc (2003) 1.01
NMR structure of a cyclic polyamide-DNA complex. J Am Chem Soc (2004) 0.99
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A (2013) 0.98
Microwave assisted synthesis of Py-Im polyamides. Org Lett (2012) 0.98
Nucleosomes in solution exist as a mixture of twist-defect states. J Mol Biol (2005) 0.98
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc (2012) 0.97
Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemother Pharmacol (2012) 0.97
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry (2002) 0.97
Design of a sequence-specific DNA bisintercalator. Angew Chem Int Ed Engl (2004) 0.96
Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol (2002) 0.96
Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem (2012) 0.96
Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry (2004) 0.96
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc (2003) 0.96
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle (2006) 0.94
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res (2006) 0.94
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc (2007) 0.93
Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem (2007) 0.92
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther (2013) 0.92
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther (2008) 0.91
Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition. Bioorg Med Chem (2006) 0.91
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry (2011) 0.91
Programming multiple protein patterns on a single DNA nanostructure. J Am Chem Soc (2008) 0.91
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry (2005) 0.91
Recognition of "mirror-image" DNA by small molecules. Angew Chem Int Ed Engl (2007) 0.90
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. Bioorg Med Chem (2006) 0.90
Recognition of ten base pairs of DNA by head-to-head hairpin dimers. J Am Chem Soc (2002) 0.90
U-pin polyamide motif for recognition of the DNA minor groove. Chemistry (2003) 0.89
Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc (2009) 0.89
Recognition of nucleic acid junctions using triptycene-based molecules. Angew Chem Int Ed Engl (2014) 0.89
Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray. Biophys J (2009) 0.87
Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate. J Biol Chem (2002) 0.87
Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition. J Am Chem Soc (2004) 0.86
Search for the optimal linker in tandem hairpin polyamides. Bioorg Med Chem (2002) 0.85
Alternative heterocycles for DNA recognition: the benzimidazole/imidazole pair. Chemistry (2003) 0.85
Analysis of hairpin polyamide complexes having DNA binding sites in close proximity. J Am Chem Soc (2002) 0.85
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. J Med Chem (2009) 0.85
Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition. J Am Chem Soc (2014) 0.84
Synthesis of cyclic Py-Im polyamide libraries. J Org Chem (2012) 0.84
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA. Angew Chem Int Ed Engl (2012) 0.84
Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit. J Med Chem (2013) 0.83
Synthesis and conformational dynamics of the reported structure of xylopyridine A. J Am Chem Soc (2013) 0.83
DNA sequence selectivity of hairpin polyamide turn units. Bioorg Med Chem Lett (2009) 0.82
Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA. Org Lett (2011) 0.82
Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorg Med Chem Lett (2012) 0.82
The reach of linear protein-DNA dimerizers. J Am Chem Soc (2007) 0.82
Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences. Biochemistry (2003) 0.80
Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase. J Am Chem Soc (2003) 0.80