PubRank

Jonathan Chernoff

Author PubWeight™ 108.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 2003 4.13
2 An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol 2008 3.94
3 Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 2003 3.40
4 A tale of two Paks. Biol Cell 2008 2.90
5 p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol 2002 2.61
6 Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol 2006 2.58
7 PAK signalling during the development and progression of cancer. Nat Rev Cancer 2014 2.21
8 p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem 2001 2.05
9 The genetics of Pak. J Cell Sci 2004 2.00
10 Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem 2007 1.92
11 Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem 2005 1.73
12 Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol 2010 1.60
13 p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol 2003 1.57
14 p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood 2009 1.53
15 PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci 2010 1.44
16 Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem 2004 1.42
17 Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol 2006 1.40
18 A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol 2006 1.39
19 Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol 2005 1.38
20 Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol 2007 1.38
21 p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell 2003 1.37
22 Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene 2002 1.36
23 PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci 2008 1.32
24 p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res 2012 1.32
25 p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep 2002 1.30
26 Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One 2009 1.29
27 Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell 2011 1.29
28 Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol 2011 1.28
29 Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem 2011 1.28
30 Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood 2008 1.28
31 The DeMSTification of mammalian Ste20 kinases. Curr Biol 2009 1.22
32 Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol 2005 1.21
33 alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci 2007 1.20
34 An in vivo assay to test blood vessel permeability. J Vis Exp 2013 1.19
35 AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res 2003 1.18
36 Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res 2009 1.16
37 Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol 2006 1.16
38 Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proc Natl Acad Sci U S A 2009 1.13
39 Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J 2003 1.12
40 FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem 2013 1.09
41 Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol 2011 1.09
42 Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Res 2013 1.09
43 Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res 2012 1.06
44 Cell cycle-regulated phosphorylation of p21-activated kinase 1. Curr Biol 2002 1.06
45 Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. J Biol Chem 2011 1.06
46 The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol 2002 1.00
47 p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small GTPases 2010 1.00
48 PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol 2009 1.00
49 p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arterioscler Thromb Vasc Biol 2013 0.97
50 The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. BJU Int 2010 0.97
51 p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. PLoS One 2010 0.97
52 An emerging role for p21-activated kinases (Paks) in viral infections. Trends Cell Biol 2010 0.97
53 Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure 2005 0.96
54 Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Res 2002 0.96
55 The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood 2013 0.95
56 A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. Genes Cancer 2010 0.93
57 Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene 2005 0.92
58 The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am J Physiol Cell Physiol 2013 0.92
59 Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity. J Biol Chem 2012 0.91
60 Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Biochem J 2002 0.90
61 Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. J Biol Chem 2003 0.90
62 Mouse models of PAK function. Cell Logist 2012 0.89
63 NF2: the wizardry of merlin. Genes Chromosomes Cancer 2003 0.89
64 p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Am J Physiol Heart Circ Physiol 2011 0.89
65 p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS One 2013 0.89
66 Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. J Cell Sci 2012 0.88
67 The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. J Biol Chem 2013 0.87
68 Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. Int J Biochem Cell Biol 2009 0.86
69 Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PLoS One 2012 0.86
70 Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods 2005 0.86
71 Targeting Cdc42 in cancer. Expert Opin Ther Targets 2013 0.85
72 Rho-GTPases: new members, new pathways. J Cell Biochem 2005 0.85
73 Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A 2010 0.84
74 P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. Endocrinology 2012 0.83
75 PKM2 enters the morpheein academy. Mol Cell 2012 0.83
76 Pak GITs to Aurora-A. Dev Cell 2005 0.82
77 Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. EMBO J 2011 0.82
78 The cross-Rho'ds of cell-cell adhesion. J Biol Chem 2004 0.82
79 ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. J Biol Chem 2013 0.81
80 p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol 2013 0.81
81 Role of p21-activated kinases in cardiovascular development and function. Cell Mol Life Sci 2013 0.80
82 Getting smart about p21-activated kinases. Mol Cell Biol 2010 0.80
83 Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells 2015 0.79
84 High midsummer for small GTPases. Trends Cell Biol 2002 0.78
85 Protein-tyrosine phosphatase 1B as a potential drug target for obesity. Curr Drug Targets Immune Endocr Metabol Disord 2003 0.78
86 Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. Exp Cell Res 2005 0.77
87 Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. Endocrinology 2014 0.77
88 LOV conquers (sm)All GTPases. F1000 Biol Rep 2010 0.75
89 Src transforms in a Cool way. Nat Cell Biol 2006 0.75
90 Analysis and manipulation of intracellular signaling cascades. Methods 2004 0.75
91 Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation. Small GTPases 2011 0.75