Published in J Biol Chem on May 07, 2004
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (2009) 1.14
The R(h)oads to Stat3: Stat3 activation by the Rho GTPases. Exp Cell Res (2011) 1.12
Identification of a PDZ protein, PIST, as a binding partner for Rho effector Rhotekin: biochemical and cell-biological characterization of Rhotekin-PIST interaction. Biochem J (2006) 0.87
Roles of P21-activated kinases and associated proteins in epithelial wound healing. Int Rev Cell Mol Biol (2008) 0.85
S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. Gynecol Oncol (2008) 0.81
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron (2003) 3.40
A tale of two Paks. Biol Cell (2008) 2.90
p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol (2002) 2.61
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
The genetics of Pak. J Cell Sci (2004) 2.00
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem (2005) 1.73
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol (2010) 1.60
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol (2003) 1.57
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood (2009) 1.53
PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci (2010) 1.44
Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem (2004) 1.42
Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol (2006) 1.40
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol (2005) 1.38
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol (2007) 1.38
p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell (2003) 1.37
Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene (2002) 1.36
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci (2008) 1.32
p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res (2012) 1.32
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep (2002) 1.30
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One (2009) 1.29
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell (2011) 1.29
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem (2011) 1.28
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood (2008) 1.28
The DeMSTification of mammalian Ste20 kinases. Curr Biol (2009) 1.22
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol (2005) 1.21
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci (2007) 1.20
An in vivo assay to test blood vessel permeability. J Vis Exp (2013) 1.19
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res (2003) 1.18
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res (2009) 1.16
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol (2006) 1.16
Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proc Natl Acad Sci U S A (2009) 1.13
Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J (2003) 1.12
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem (2013) 1.09
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol (2011) 1.09
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Res (2013) 1.09
Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res (2012) 1.06
Cell cycle-regulated phosphorylation of p21-activated kinase 1. Curr Biol (2002) 1.06
Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. J Biol Chem (2011) 1.06
The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol (2002) 1.00
p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small GTPases (2010) 1.00
PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol (2009) 1.00
p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arterioscler Thromb Vasc Biol (2013) 0.97
p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. PLoS One (2010) 0.97
The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. BJU Int (2010) 0.97
An emerging role for p21-activated kinases (Paks) in viral infections. Trends Cell Biol (2010) 0.97
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (2005) 0.96
Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Res (2002) 0.96
The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood (2013) 0.95
A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. Genes Cancer (2010) 0.93
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am J Physiol Cell Physiol (2013) 0.92
Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene (2005) 0.92
Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity. J Biol Chem (2012) 0.91
Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Biochem J (2002) 0.90
Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. J Biol Chem (2003) 0.90
NF2: the wizardry of merlin. Genes Chromosomes Cancer (2003) 0.89
Mouse models of PAK function. Cell Logist (2012) 0.89
p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Am J Physiol Heart Circ Physiol (2011) 0.89
p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS One (2013) 0.89
Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. J Cell Sci (2012) 0.88
The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. J Biol Chem (2013) 0.87
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods (2005) 0.86
Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. Int J Biochem Cell Biol (2009) 0.86
Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PLoS One (2012) 0.86
Rho-GTPases: new members, new pathways. J Cell Biochem (2005) 0.85
Targeting Cdc42 in cancer. Expert Opin Ther Targets (2013) 0.85
Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A (2010) 0.84
P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. Endocrinology (2012) 0.83
PKM2 enters the morpheein academy. Mol Cell (2012) 0.83
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. EMBO J (2011) 0.82
Pak GITs to Aurora-A. Dev Cell (2005) 0.82
ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. J Biol Chem (2013) 0.81
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Role of p21-activated kinases in cardiovascular development and function. Cell Mol Life Sci (2013) 0.80
Getting smart about p21-activated kinases. Mol Cell Biol (2010) 0.80
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells (2015) 0.79
Protein-tyrosine phosphatase 1B as a potential drug target for obesity. Curr Drug Targets Immune Endocr Metabol Disord (2003) 0.78
High midsummer for small GTPases. Trends Cell Biol (2002) 0.78
Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. Exp Cell Res (2005) 0.77
Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. Endocrinology (2014) 0.77
LOV conquers (sm)All GTPases. F1000 Biol Rep (2010) 0.75
Src transforms in a Cool way. Nat Cell Biol (2006) 0.75
Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation. Small GTPases (2011) 0.75
Analysis and manipulation of intracellular signaling cascades. Methods (2004) 0.75