Published in J Mol Biol on June 27, 2006
The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
PAK signaling in oncogenesis. Oncogene (2009) 2.13
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J (2008) 2.12
IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly. Mol Cell (2014) 1.52
PAK1 as a therapeutic target. Expert Opin Ther Targets (2010) 1.48
Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. J Cell Sci (2009) 1.47
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One (2009) 1.29
Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase. EMBO J (2008) 1.19
Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae. Genetics (2010) 1.17
Biochemical and structural characterization of the Pak1-LC8 interaction. J Biol Chem (2008) 1.17
Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites. BMC Bioinformatics (2008) 1.07
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Regulation of cardiac excitation and contraction by p21 activated kinase-1. Prog Biophys Mol Biol (2009) 0.99
Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. J Cell Biol (2012) 0.96
Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure (2013) 0.95
Substrate recognition of PLCγ1 via a specific docking surface on Itk. J Mol Biol (2012) 0.90
Dissecting activation of the PAK1 kinase at protrusions in living cells. J Biol Chem (2009) 0.89
Analysis of conformational changes during activation of protein kinase Pak2 by amide hydrogen/deuterium exchange. J Biol Chem (2008) 0.88
Recent advances in the development of p21-activated kinase inhibitors. Cell Logist (2012) 0.85
Autophosphorylation of Ser428 of EhC2PK plays a critical role in regulating erythrophagocytosis in the parasite Entamoeba histolytica. J Biol Chem (2012) 0.83
Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation. Biologics (2008) 0.83
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion. Adv Exp Med Biol (2015) 0.83
Identification of phosphorylation sites in betaPIX and PAK1. J Cell Sci (2007) 0.81
A new Rac/PAK/GC/cGMP signaling pathway. Mol Cell Biochem (2009) 0.81
The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity. J Biol Chem (2012) 0.80
P21-activated kinase in inflammatory and cardiovascular disease. Cell Signal (2014) 0.78
3D structure analysis of PAKs: A clue to the rational design for affinity reagents and blockers. Cell Logist (2012) 0.78
Regulation of the Ste20-like kinase, SLK: involvement of activation segment phosphorylation. J Biol Chem (2011) 0.78
Structure, biochemistry, and biology of PAK kinases. Gene (2016) 0.77
Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem (2013) 0.77
Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling. Front Pharmacol (2013) 0.76
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 13.03
The conformational plasticity of protein kinases. Cell (2002) 11.21
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature (2004) 4.37
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res (2002) 4.19
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron (2003) 3.40
A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol (2006) 3.40
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor. Science (2006) 3.15
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08
Phosphorylation-independent regulation of the diguanylate cyclase WspR. PLoS Biol (2008) 2.99
Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science (2010) 2.93
A tale of two Paks. Biol Cell (2008) 2.90
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature (2007) 2.78
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell (2007) 2.68
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization. Cell (2012) 2.67
p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol (2002) 2.61
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci U S A (2009) 2.55
Structural basis for calcium sensing by GCaMP2. Structure (2008) 2.52
Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains. Genes Dev (2003) 2.50
Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell (2013) 2.49
Structure of a sliding clamp on DNA. Cell (2008) 2.42
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A (2004) 2.41
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell (2011) 2.35
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases. Protein Sci (2005) 2.32
Architecture and membrane interactions of the EGF receptor. Cell (2013) 2.29
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc Natl Acad Sci U S A (2008) 2.18
A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage. PLoS Biol (2011) 2.05
Structural bases of unphosphorylated STAT1 association and receptor binding. Mol Cell (2005) 2.05
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
The structure, regulation, and function of ZAP-70. Immunol Rev (2009) 2.01
The genetics of Pak. J Cell Sci (2004) 2.00
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res (2006) 1.98
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell (2003) 1.98
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell (2006) 1.94
Crystal structure and mechanism of human lysine-specific demethylase-1. Nat Struct Mol Biol (2006) 1.94
Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A. Proc Natl Acad Sci U S A (2011) 1.93
Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PLoS Biol (2011) 1.93
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc Natl Acad Sci U S A (2009) 1.91
Architecture of a coat for the nuclear pore membrane. Cell (2007) 1.88
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure (2007) 1.87
Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol (2010) 1.86
Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis. Biochemistry (2004) 1.80
Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure (2009) 1.79
Clamp loaders and sliding clamps. Curr Opin Struct Biol (2002) 1.77
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding. Science (2007) 1.77
Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol (2002) 1.74
A fence-like coat for the nuclear pore membrane. Mol Cell (2008) 1.73
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem (2005) 1.73
The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell (2009) 1.72
Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70
ATP ground- and transition states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, sigma54. Structure (2007) 1.69
Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res (2009) 1.64
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol (2010) 1.60
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol (2003) 1.57
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell (2011) 1.56
How a DNA polymerase clamp loader opens a sliding clamp. Science (2011) 1.56
Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states. J Mol Biol (2002) 1.54
Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. J Biol Chem (2010) 1.54
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood (2009) 1.53
Protein-protein interactions in the allosteric regulation of protein kinases. Curr Opin Struct Biol (2006) 1.49
Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations. J Am Chem Soc (2008) 1.47
PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci (2010) 1.44
Probing the function of heme distortion in the H-NOX family. ACS Chem Biol (2008) 1.42
Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem (2004) 1.42
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis. Nat Struct Mol Biol (2008) 1.42
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J (2006) 1.40
Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol (2006) 1.40
High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain. Biochemistry (2003) 1.39
A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci (2003) 1.39