Published in Mol Cell Biol on August 01, 2003
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
PAK signaling in oncogenesis. Oncogene (2009) 2.13
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol (2005) 2.06
Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure (2007) 1.34
PAK signaling in cancer. Cell Logist (2012) 1.27
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. J Biol Chem (2008) 1.24
Evading apoptosis in cancer. Trends Cell Biol (2013) 1.17
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol (2006) 1.16
PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Mol Biol Cell (2005) 1.12
Androgen and its receptor promote Bax-mediated apoptosis. Mol Cell Biol (2006) 1.10
PAK family kinases: Physiological roles and regulation. Cell Logist (2012) 1.06
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A (2012) 0.98
The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis. Mol Cell Proteomics (2006) 0.97
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Cell Logist (2012) 0.97
Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. Prostate (2010) 0.97
p21 activated kinase 5 activates Raf-1 and targets it to mitochondria. J Cell Biochem (2008) 0.96
p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112. PLoS One (2011) 0.93
Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75. Mol Cell Biol (2004) 0.93
PAK thread from amoeba to mammals. J Cell Biochem (2009) 0.92
Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One (2011) 0.92
The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors. Mol Cell Biol (2007) 0.92
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood (2012) 0.92
The phosphorylation-dependent regulation of mitochondrial proteins in stress responses. J Signal Transduct (2012) 0.89
Huntingtin promotes cell survival by preventing Pak2 cleavage. J Cell Sci (2009) 0.87
PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy. Oncotarget (2015) 0.87
Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Proc Natl Acad Sci U S A (2012) 0.86
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. J Biol Chem (2015) 0.84
P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma. Acta Pharmacol Sin (2013) 0.84
Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac. PLoS One (2013) 0.83
PAK4-6 in cancer and neuronal development. Cell Logist (2012) 0.83
EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Mol Cell Neurosci (2012) 0.83
The role of p21-activated kinases in hepatocellular carcinoma metastasis. J Mol Signal (2014) 0.81
Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer. World J Gastroenterol (2016) 0.79
Maternal pak4 expression is required for primitive myelopoiesis in zebrafish. Mech Dev (2012) 0.79
Direct interaction between AR and PAK6 in androgen-stimulated PAK6 activation. PLoS One (2013) 0.79
Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5. Int J Biol Sci (2015) 0.78
Structure, biochemistry, and biology of PAK kinases. Gene (2016) 0.77
Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? Oncotarget (2016) 0.77
Depletion of cytotoxic T-cells does not protect NUP98-HOXD13 mice from myelodysplastic syndrome but reveals a modest tumor immunosurveillance effect. PLoS One (2012) 0.76
p21-activated kinase 7 is an oncogene in human osteosarcoma. Cell Biol Int (2014) 0.76
P21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression. PLoS One (2014) 0.75
miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2. Mol Ther Nucleic Acids (2017) 0.75
High expression of P21-activated kinase 5 protein is associated with poor survival in gastric cancer. Oncol Lett (2017) 0.75
Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res (1992) 34.33
Mitochondria and apoptosis. Science (1998) 23.41
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell (1997) 21.42
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell (1996) 10.83
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science (1997) 9.58
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol (2000) 5.85
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol (1997) 4.91
The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol (2001) 4.33
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol (1997) 4.28
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell (1999) 3.46
Pak to the future. Trends Cell Biol (1999) 3.09
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science (1997) 3.07
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol (2003) 3.01
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol (1999) 2.84
Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem (1995) 2.69
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J (1998) 2.62
p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol (2002) 2.61
Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol (1997) 2.44
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
A role for p21-activated kinase in endothelial cell migration. J Cell Biol (1999) 2.35
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol (1996) 2.15
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J Biol Chem (2001) 1.96
p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem Sci (1999) 1.94
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J Biol Chem (2001) 1.93
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation. J Biol Chem (1998) 1.86
Temporal and spatial distribution of activated Pak1 in fibroblasts. J Cell Biol (2000) 1.82
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J Biol Chem (2001) 1.78
Structure of Cdc42 bound to the GTPase binding domain of PAK. Nat Struct Biol (2000) 1.65
Controlling cell death. Science (1997) 1.64
Apoptosis meets signal transduction: elimination of a BAD influence. Cell (1996) 1.63
AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol (2002) 1.60
Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem (2001) 1.59
The Akt proto-oncogene links Ras to Pak and cell survival signals. J Biol Chem (2000) 1.53
PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol Cell Biol (2002) 1.49
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci U S A (1997) 1.48
Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol Cell Biol (1999) 1.32
Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. J Biol Chem (1998) 1.30
p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts. J Biol Chem (2001) 1.29
A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization. J Cell Biol (2001) 1.13
Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast. J Biol Chem (1998) 1.02
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron (2003) 3.40
A tale of two Paks. Biol Cell (2008) 2.90
p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol (2002) 2.61
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
The genetics of Pak. J Cell Sci (2004) 2.00
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem (2005) 1.73
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol (2010) 1.60
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood (2009) 1.53
PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci (2010) 1.44
Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem (2004) 1.42
Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol (2006) 1.40
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol (2005) 1.38
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol (2007) 1.38
p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell (2003) 1.37
Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene (2002) 1.36
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci (2008) 1.32
p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res (2012) 1.32
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep (2002) 1.30
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell (2011) 1.29
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One (2009) 1.29
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem (2011) 1.28
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood (2008) 1.28
The DeMSTification of mammalian Ste20 kinases. Curr Biol (2009) 1.22
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol (2005) 1.21
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci (2007) 1.20
An in vivo assay to test blood vessel permeability. J Vis Exp (2013) 1.19
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res (2003) 1.18
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res (2009) 1.16
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol (2006) 1.16
Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proc Natl Acad Sci U S A (2009) 1.13
Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J (2003) 1.12
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem (2013) 1.09
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol (2011) 1.09
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Res (2013) 1.09
Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res (2012) 1.06
Cell cycle-regulated phosphorylation of p21-activated kinase 1. Curr Biol (2002) 1.06
Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. J Biol Chem (2011) 1.06
The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol (2002) 1.00
p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small GTPases (2010) 1.00
PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol (2009) 1.00
p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arterioscler Thromb Vasc Biol (2013) 0.97
p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. PLoS One (2010) 0.97
The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. BJU Int (2010) 0.97
An emerging role for p21-activated kinases (Paks) in viral infections. Trends Cell Biol (2010) 0.97
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (2005) 0.96
Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Res (2002) 0.96
The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood (2013) 0.95
The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme. Mol Cancer Ther (2010) 0.93
A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. Genes Cancer (2010) 0.93
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am J Physiol Cell Physiol (2013) 0.92
Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene (2005) 0.92
Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity. J Biol Chem (2012) 0.91
Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. J Biol Chem (2003) 0.90
Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Biochem J (2002) 0.90
Mouse models of PAK function. Cell Logist (2012) 0.89
p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS One (2013) 0.89
NF2: the wizardry of merlin. Genes Chromosomes Cancer (2003) 0.89
p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Am J Physiol Heart Circ Physiol (2011) 0.89
Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. J Cell Sci (2012) 0.88
The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. J Biol Chem (2013) 0.87
Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. Int J Biochem Cell Biol (2009) 0.86
Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PLoS One (2012) 0.86
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods (2005) 0.86
Targeting Cdc42 in cancer. Expert Opin Ther Targets (2013) 0.85
Rho-GTPases: new members, new pathways. J Cell Biochem (2005) 0.85
Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A (2010) 0.84
Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2. Clin Cancer Res (2013) 0.84
PKM2 enters the morpheein academy. Mol Cell (2012) 0.83
P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. Endocrinology (2012) 0.83
Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12. PLoS One (2011) 0.82
The cross-Rho'ds of cell-cell adhesion. J Biol Chem (2004) 0.82
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. EMBO J (2011) 0.82
Pak GITs to Aurora-A. Dev Cell (2005) 0.82
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. J Biol Chem (2013) 0.81