Published in Cell on August 23, 2002
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Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol (2010) 2.43
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. EMBO J (2007) 2.37
Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses. J Virol (2005) 2.29
Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner. Stem Cells Dev (2007) 2.27
Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli. J Virol (2005) 2.23
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro. Nucleic Acids Res (2006) 2.22
Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. Retrovirology (2009) 2.20
An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog (2013) 2.16
The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol (2005) 2.13
Transcriptional burst frequency and burst size are equally modulated across the human genome. Proc Natl Acad Sci U S A (2012) 2.12
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. J Virol (2005) 2.09
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. J Virol (2006) 2.09
Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe (2008) 2.08
Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells. PLoS Pathog (2006) 2.08
Functional and structural characterization of the integrase from the prototype foamy virus. Nucleic Acids Res (2008) 2.07
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Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells. Proc Natl Acad Sci U S A (2006) 2.06
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Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndrome. JAMA (2015) 1.97
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Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant. Genes Dev (2005) 1.92
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Lineage-specific expansions of retroviral insertions within the genomes of African great apes but not humans and orangutans. PLoS Biol (2005) 1.82
Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression. Biophys J (2010) 1.80
Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses. Retrovirology (2011) 1.80
Site-directed transposon integration in human cells. Nucleic Acids Res (2007) 1.74
Controlling integration specificity of a yeast retrotransposon. Proc Natl Acad Sci U S A (2003) 1.74
Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc Natl Acad Sci U S A (2006) 1.74
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc (2007) 1.73
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LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Mol Ther (2010) 1.72
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Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci U S A (2010) 1.68
Safe harbours for the integration of new DNA in the human genome. Nat Rev Cancer (2011) 1.67
Mobile element scanning (ME-Scan) identifies thousands of novel Alu insertions in diverse human populations. Genome Res (2013) 1.66
Lentiviral delivery of short hairpin RNAs. Adv Drug Deliv Rev (2009) 1.65
Integration by design. Proc Natl Acad Sci U S A (2003) 1.64
Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe. Genome Res (2003) 1.63
Massively parallel pyrosequencing in HIV research. AIDS (2008) 1.63
Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance. J Clin Invest (2013) 1.62
Integration target site selection by a resurrected human endogenous retrovirus. Genes Dev (2009) 1.62
HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration. Virology (2007) 1.61
Adoptive immunotherapy for cancer or viruses. Annu Rev Immunol (2014) 1.61
Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome. J Virol (2005) 1.61
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Retroviral integration and human gene therapy. J Clin Invest (2007) 1.56
Determinants of the establishment of human immunodeficiency virus type 1 latency. J Virol (2009) 1.55
Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology (2005) 1.55
Nucleocapsid protein function in early infection processes. Virus Res (2008) 1.53
Genome-wide mapping of PiggyBac transposon integrations in primary human T cells. J Immunother (2009) 1.52
Control of stochastic gene expression by host factors at the HIV promoter. PLoS Pathog (2009) 1.50
Genome-wide insertional mutagenesis of Arabidopsis thaliana. Science (2003) 39.19
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell (2008) 32.65
Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell (2006) 15.24
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
Prepublication data sharing. Nature (2009) 12.24
Empirical analysis of transcriptional activity in the Arabidopsis genome. Science (2003) 11.62
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66
Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana. Science (2007) 9.85
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol (2004) 8.27
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance. Cell (2003) 5.87
Recombination and linkage disequilibrium in Arabidopsis thaliana. Nat Genet (2007) 5.69
Ethylene biosynthesis and signaling networks. Plant Cell (2002) 5.37
High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology (2009) 5.08
A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med (2005) 4.88
Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. Cell (2003) 4.70
Functional genomic analysis of the AUXIN RESPONSE FACTOR gene family members in Arabidopsis thaliana: unique and overlapping functions of ARF7 and ARF19. Plant Cell (2005) 4.41
Literature-curated protein interaction datasets. Nat Methods (2009) 4.21
Finding the fifth base: genome-wide sequencing of cytosine methylation. Genome Res (2009) 4.16
The ethylene signaling pathway: new insights. Curr Opin Plant Biol (2004) 4.12
Applications of DNA tiling arrays for whole-genome analysis. Genomics (2005) 3.94
ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis. Plant Cell Physiol (2002) 3.90
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med (2011) 3.80
Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3. Genes Dev (2002) 3.75
Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science (2011) 3.72
Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog (2006) 3.67
Transgenerational epigenetic instability is a source of novel methylation variants. Science (2011) 3.66
Type-A Arabidopsis response regulators are partially redundant negative regulators of cytokinin signaling. Plant Cell (2004) 3.56
Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1. Science (2006) 3.46
A link between RNA metabolism and silencing affecting Arabidopsis development. Dev Cell (2008) 3.39
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res (2011) 3.36
CDPKs CPK6 and CPK3 function in ABA regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. PLoS Biol (2006) 3.32
Chloroplast to nucleus communication triggered by accumulation of Mg-protoporphyrinIX. Nature (2003) 3.27
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Class III homeodomain-leucine zipper gene family members have overlapping, antagonistic, and distinct roles in Arabidopsis development. Plant Cell (2004) 3.17
LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proc Natl Acad Sci U S A (2005) 3.04
Enhanced fitness conferred by naturally occurring variation in the circadian clock. Science (2003) 3.02
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell (2012) 3.00
Auxin response factors ARF6 and ARF8 promote jasmonic acid production and flower maturation. Development (2005) 2.97
Della proteins and gibberellin-regulated seed germination and floral development in Arabidopsis. Plant Physiol (2004) 2.95
Widespread dynamic DNA methylation in response to biotic stress. Proc Natl Acad Sci U S A (2012) 2.90
The phytochrome-interacting transcription factor, PIF3, acts early, selectively, and positively in light-induced chloroplast development. Proc Natl Acad Sci U S A (2004) 2.71
Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis. Proc Natl Acad Sci U S A (2003) 2.71
Patterns of population epigenomic diversity. Nature (2013) 2.70
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69
DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer. Nucleic Acids Res (2008) 2.64
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Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome. Cell (2007) 2.58
Fluorescence spectroscopic profiling of compound libraries. J Med Chem (2008) 2.53
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A (2014) 2.50
Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. PLoS One (2007) 2.48
Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for natural flowering-time variation. Proc Natl Acad Sci U S A (2005) 2.47
GUN4, a regulator of chlorophyll synthesis and intracellular signaling. Science (2003) 2.47
The beta-subunit of the Arabidopsis G protein negatively regulates auxin-induced cell division and affects multiple developmental processes. Plant Cell (2003) 2.41
Convergence of signaling pathways in the control of differential cell growth in Arabidopsis. Dev Cell (2004) 2.37
The Arabidopsis phytochrome-interacting factor PIF7, together with PIF3 and PIF4, regulates responses to prolonged red light by modulating phyB levels. Plant Cell (2008) 2.33
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. Genetics (2005) 2.32
NPH4/ARF7 and ARF19 promote leaf expansion and auxin-induced lateral root formation. Plant J (2005) 2.32
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Functional genomic analysis of the AUXIN/INDOLE-3-ACETIC ACID gene family members in Arabidopsis thaliana. Plant Cell (2005) 2.27
CBF2/DREB1C is a negative regulator of CBF1/DREB1B and CBF3/DREB1A expression and plays a central role in stress tolerance in Arabidopsis. Proc Natl Acad Sci U S A (2004) 2.26
Regulation of ethylene gas biosynthesis by the Arabidopsis ETO1 protein. Nature (2004) 2.26
Processing and subcellular trafficking of ER-tethered EIN2 control response to ethylene gas. Science (2012) 2.17
Multiple type-B response regulators mediate cytokinin signal transduction in Arabidopsis. Plant Cell (2005) 2.14
The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones. Blood (2011) 2.11
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Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing. Infect Immun (2009) 1.91