Published in EMBO J on October 01, 2002
Mutations in PIGO, a member of the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation. Am J Hum Genet (2012) 1.65
PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Mol Biol Cell (2006) 1.38
A rivet model for channel formation by aerolysin-like pore-forming toxins. EMBO J (2006) 1.28
Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism. Nat Chem Biol (2013) 1.26
Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids. Trends Microbiol (2013) 1.19
PGAP2 mutations, affecting the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation syndrome. Am J Hum Genet (2013) 1.17
Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Mol Biol Cell (2003) 1.12
Extending the aerolysin family: from bacteria to vertebrates. PLoS One (2011) 1.09
Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure. Mol Biol Cell (2007) 1.09
Pore-forming toxins: ancient, but never really out of fashion. Nat Rev Microbiol (2015) 1.08
Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins. Mol Biol Cell (2005) 1.08
PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor. Mol Biol Cell (2003) 0.99
Identification and characterization of the carbohydrate ligands recognized by pertussis toxin via a glycan microarray and surface plasmon resonance. Biochemistry (2010) 0.98
Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin. Infect Immun (2003) 0.93
Identification of amino acids important for binding of Clostridium perfringens epsilon toxin to host cells and to HAVCR1. Biochemistry (2012) 0.92
Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Mol Biol Cell (2005) 0.90
Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis. Infect Immun (2009) 0.89
Structural insights into Bacillus thuringiensis Cry, Cyt and parasporin toxins. Toxins (Basel) (2014) 0.86
Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels. J Lipid Res (2012) 0.83
GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans. Mol Biol Cell (2012) 0.82
Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.81
Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors. PLoS One (2014) 0.81
Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells. BMC Genomics (2014) 0.80
Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major. Eukaryot Cell (2005) 0.80
Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis. PLoS One (2015) 0.79
Apical sorting of lysoGPI-anchored proteins occurs independent of association with detergent-resistant membranes but dependent on their N-glycosylation. Mol Biol Cell (2013) 0.78
Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell system. PLoS One (2012) 0.77
EMS mutant spectra generated by multi-parameter flow cytometry. Mutat Res (2009) 0.77
Long Standing Eculizumab Treatment without Anticoagulant Therapy in High-Risk Thrombogenic Paroxysmal Nocturnal Hemoglobinuria. Hematol Rep (2015) 0.75
The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem J (1993) 4.96
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell (1993) 4.04
Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature (1992) 3.19
Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J Exp Med (1988) 2.75
Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states. Nature (1994) 2.18
Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport. Cell (1984) 2.15
Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci U S A (1997) 1.97
Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation. Proc Natl Acad Sci U S A (1990) 1.81
Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis. Curr Opin Chem Biol (2000) 1.77
Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin. J Biol Chem (1998) 1.72
Improved detection and characterization of paroxysmal nocturnal hemoglobinuria using fluorescent aerolysin. Am J Clin Pathol (2000) 1.66
Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase. J Biol Chem (1997) 1.65
Swainsonine causes the production of hybrid glycoproteins by human skin fibroblasts and rat liver Golgi preparations. J Biol Chem (1983) 1.65
Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59. J Exp Med (1997) 1.65
Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis. J Biol Chem (1991) 1.52
Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine. J Biol Chem (1992) 1.49
Defective glycosyl phosphatidylinositol anchor synthesis and paroxysmal nocturnal hemoglobinuria. Adv Immunol (1995) 1.44
Adventures of a pore-forming toxin at the target cell surface. Trends Microbiol (2000) 1.43
Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositol-anchored proteins. J Immunol (1988) 1.33
Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. Mol Biol Cell (2000) 1.33
Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates. J Biol Chem (2000) 1.28
PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum. J Biol Chem (1996) 1.27
Congenital disorders of glycosylation: genetic model systems lead the way. Trends Cell Biol (2001) 1.26
Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains. J Biol Chem (2001) 1.26
Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J Biol Chem (1999) 1.26
Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin. Blood (1999) 1.24
Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters. J Biol Chem (2001) 1.20
Aerolysin--the ins and outs of a model channel-forming toxin. Mol Microbiol (1996) 1.15
Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells. J Biol Chem (1996) 1.15
The glycosylphosphatidylinositol-anchored surface glycoprotein Thy-1 is a receptor for the channel-forming toxin aerolysin. J Biol Chem (1997) 1.14
The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin. Infect Immun (1995) 1.12
The cytolytic toxin aerolysin must aggregate to disrupt erythrocytes, and aggregation is stimulated by human glycophorin. Infect Immun (1988) 1.10
Analysis of receptor binding by the channel-forming toxin aerolysin using surface plasmon resonance. J Biol Chem (1999) 1.07
Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a point mutation in N-acetylglucosaminyltransferase I gene. J Biol Chem (1996) 1.05
Clostridium septicum alpha-toxin is proteolytically activated by furin. Infect Immun (1997) 1.04
Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. J Biol Chem (2000) 1.04
The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction. FEBS Lett (2002) 0.94
The erythrocyte receptor for the channel-forming toxin aerolysin is a novel glycosylphosphatidylinositol-anchored protein. Mol Microbiol (1997) 0.92
Properties of baby-hamster kidney (BHK) cells treated with Swainsonine, an inhibitor of glycoprotein processing. Comparison with ricin-resistant BHK-cell mutants. Biochem J (1986) 0.91
Aerolysin and pertussis toxin share a common receptor-binding domain. EMBO J (1997) 0.90
Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein. Mol Microbiol (1999) 0.88
Carbohydrate-deficient glycoprotein syndrome type II. Biochim Biophys Acta (1999) 0.87
The effect of swainsonine and castanospermine on the sulfation of the oligosaccharide chains of N-linked glycoproteins. J Biol Chem (1985) 0.87
Secretion and properties of the large and small lobes of the channel-forming toxin aerolysin. Mol Microbiol (1998) 0.85
Cloning, nucleotide sequence and expression of a hemolysin gene of Clostridium septicum. FEMS Microbiol Lett (1994) 0.84
Determination of the amino acid sequence of the plant cytolysin enterolobin. Arch Biochem Biophys (1997) 0.81
One- and two-dimensional NMR studies of the N-terminal portion of glycophorin A at 11.7 Tesla. J Protein Chem (1990) 0.78
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell (2006) 4.63
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med (2005) 4.02
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J Cell Biol (2003) 3.97
Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood (2005) 3.71
Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nat Genet (2010) 3.60
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med (2009) 3.19
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc Natl Acad Sci U S A (2004) 2.93
Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nat Methods (2005) 2.70
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci U S A (2012) 2.61
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe (2009) 2.52
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol (2004) 2.31
Mechanisms of pathogen entry through the endosomal compartments. Nat Rev Mol Cell Biol (2006) 2.16
Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathog (2008) 2.16
Differential sorting and fate of endocytosed GPI-anchored proteins. EMBO J (2002) 2.15
Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. J Cell Biol (2006) 2.15
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (2012) 2.14
Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction. EMBO J (2002) 1.99
Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. Nat Med (2006) 1.97
Genetic variants in C5 and poor response to eculizumab. N Engl J Med (2014) 1.91
Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood (2006) 1.86
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol (2008) 1.85
Anthrax toxin: the long and winding road that leads to the kill. Trends Microbiol (2005) 1.68
Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore) (2004) 1.67
Mutations in PIGO, a member of the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation. Am J Hum Genet (2012) 1.65
Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2008) 1.64
A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT. Blood (2013) 1.61
Pore formation: an ancient yet complex form of attack. Biochim Biophys Acta (2008) 1.58
Crystal structures reveal a thiol protease-like catalytic triad in the C-terminal region of Pasteurella multocida toxin. Proc Natl Acad Sci U S A (2007) 1.56
ppGpp with DksA controls gene expression in the locus of enterocyte effacement (LEE) pathogenicity island of enterohaemorrhagic Escherichia coli through activation of two virulence regulatory genes. Mol Microbiol (2006) 1.53
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J Immunol (2008) 1.50
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking. PLoS One (2007) 1.50
GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier. J Invest Dermatol (2012) 1.48
In-depth analysis of hyaline fibromatosis syndrome frameshift mutations at the same site reveal the necessity of personalized therapy. Hum Mutat (2013) 1.45
Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. J Biol Chem (2004) 1.44
Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc Natl Acad Sci U S A (2006) 1.42
Bacterial invasion via lipid rafts. Cell Microbiol (2005) 1.42
Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene. Nature (2004) 1.42
Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts. J Biol Chem (2002) 1.41
Structure and assembly of pore-forming proteins. Curr Opin Struct Biol (2010) 1.40
PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Mol Biol Cell (2006) 1.38
Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization. PLoS One (2008) 1.38
PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria. J Biol Chem (2006) 1.36
NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA. PLoS Pathog (2010) 1.36
Membrane injury by pore-forming proteins. Curr Opin Cell Biol (2009) 1.36
Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors. PLoS Pathog (2010) 1.35
GPI-anchor remodeling: potential functions of GPI-anchors in intracellular trafficking and membrane dynamics. Biochim Biophys Acta (2012) 1.34
Fatty acid remodeling of GPI-anchored proteins is required for their raft association. Mol Biol Cell (2007) 1.34
Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability. Am J Hum Genet (2013) 1.34
GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat Cell Biol (2008) 1.33
Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors. J Exp Med (2004) 1.31
Pathogenic pore-forming proteins: function and host response. Cell Host Microbe (2012) 1.31
A rivet model for channel formation by aerolysin-like pore-forming toxins. EMBO J (2006) 1.28
Pore-forming toxins induce multiple cellular responses promoting survival. Cell Microbiol (2011) 1.28
Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. J Immunol (2005) 1.26
Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism. Nat Chem Biol (2013) 1.26
The role of the inflammasome in cellular responses to toxins and bacterial effectors. Semin Immunopathol (2007) 1.25
What does S-palmitoylation do to membrane proteins? FEBS J (2013) 1.23
PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol. J Biol Chem (2004) 1.22
Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome. J Med Genet (2013) 1.19
Crystal structure of Clostridium perfringens enterotoxin displays features of beta-pore-forming toxins. J Biol Chem (2011) 1.18
Bacterial subversion of lipid rafts. Curr Opin Microbiol (2004) 1.17
PGAP2 mutations, affecting the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation syndrome. Am J Hum Genet (2013) 1.17
Targeted therapy for inherited GPI deficiency. N Engl J Med (2007) 1.17
GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. Cell (2009) 1.16
Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia mental retardation syndrome. J Biol Chem (2012) 1.16
Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Mol Biol Cell (2003) 1.12
Structural remodeling, trafficking and functions of glycosylphosphatidylinositol-anchored proteins. Prog Lipid Res (2011) 1.12
A novel strategy for the enhancement of drug absorption using a claudin modulator. Mol Pharmacol (2004) 1.11
Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin. J Biol Chem (2010) 1.10
Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane. Biochem J (2008) 1.09
Extending the aerolysin family: from bacteria to vertebrates. PLoS One (2011) 1.09
Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli. Microbiology (2009) 1.08
Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins. FEBS Lett (2009) 1.08
The dark sides of capillary morphogenesis gene 2. EMBO J (2011) 1.08
Dual regulatory pathways integrating the RcsC-RcsD-RcsB signalling system control enterohaemorrhagic Escherichia coli pathogenicity. Mol Microbiol (2005) 1.07
Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI. J Cell Biol (2011) 1.06
Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6. Cell Microbiol (2008) 1.06
Integrin-linked kinase associated with integrin activation. Blood (2009) 1.06
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem Pharmacol (2008) 1.05
Elastic membrane heterogeneity of living cells revealed by stiff nanoscale membrane domains. Biophys J (2007) 1.05
Diversity of raft-like domains in late endosomes. PLoS One (2007) 1.05
Obstructive fibrinous tracheal pseudomembrane after tracheal intubation: a case report. J Korean Med Sci (2010) 1.05
Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Proc Natl Acad Sci U S A (2009) 1.05
Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. J Biol Chem (2003) 1.05
Association of dengue virus NS1 protein with lipid rafts. J Gen Virol (2008) 1.04
Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake. Proc Natl Acad Sci U S A (2010) 1.03
Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. Circulation (2002) 1.02
Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol (2006) 1.02
Biochemical membrane lipidomics during Drosophila development. Dev Cell (2012) 1.02
Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin. Cell Rep (2013) 1.01
Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J (2012) 1.01
Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysin. PLoS Pathog (2011) 1.00
Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J Immunol (2008) 1.00
PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor. Mol Biol Cell (2003) 0.99