Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters.

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Published in J Biol Chem on April 23, 2001

Authors

S Oelmann1, P Stanley, R Gerardy-Schahn

Author Affiliations

1: Institut für Physiologische Chemie, Proteinstruktur, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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[Heart tumors in children. Report of 3 cases with favorable spontaneous courses]. Arch Mal Coeur Vaiss (1975) 0.99

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Acquired aortic stenosis in a twelve-year-old girl with xanthomatosis: successful surgical correction. N Engl J Med (1965) 0.96

Induction for senior house officers. Part II: The departmental programme. Postgrad Med J (1999) 0.96

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