PubRank

Laurence A Turka

Author PubWeight™ 158.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007 6.61
2 Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol 2007 5.99
3 Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med 2003 4.12
4 Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010 3.59
5 Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol 2004 2.79
6 Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol 2004 2.54
7 The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 2012 2.52
8 Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol 2003 2.47
9 TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med 2006 2.44
10 TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 2003 2.36
11 Organ transplantation--how much of the promise has been realized? Nat Med 2005 2.26
12 A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. J Invest Dermatol 2012 2.05
13 The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 2006 2.04
14 Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes 2012 2.02
15 Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol 2003 1.95
16 Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity 2008 1.95
17 PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest 2006 1.93
18 The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity 2002 1.89
19 Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat Med 2002 1.84
20 Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A 2007 1.81
21 CTLA4Ig: bridging the basic immunology with clinical application. Immunity 2006 1.75
22 Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 2005 1.61
23 Impaired T cell function in RANTES-deficient mice. Clin Immunol 2002 1.60
24 Organ transplantation: halfway through the first century. J Am Soc Nephrol 2004 1.59
25 Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol 2005 1.58
26 Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest 2014 1.58
27 T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest 2014 1.53
28 High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE 2007 1.51
29 Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol 2006 1.51
30 The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 2008 1.50
31 The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol 2003 1.50
32 Tregs and transplantation tolerance. J Clin Invest 2004 1.49
33 Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol 2004 1.48
34 An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest 2013 1.46
35 MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol 2008 1.45
36 T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A 2008 1.43
37 Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol 2006 1.42
38 Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol 2008 1.41
39 Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A 2005 1.38
40 Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. J Immunol 2006 1.37
41 Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol 2006 1.37
42 An update on regulatory T cells in transplant tolerance and rejection. Nat Rev Nephrol 2010 1.35
43 Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA 2012 1.33
44 Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells. J Immunol 2005 1.32
45 CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett 2007 1.29
46 Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun 2007 1.26
47 Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant 2003 1.21
48 Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol 2006 1.19
49 Heterologous immunity and homeostatic proliferation as barriers to tolerance. Curr Opin Immunol 2004 1.19
50 Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest 2010 1.17
51 A role for IL-27 in limiting T regulatory cell populations. J Immunol 2011 1.17
52 Regulation of T-cell responses by PTEN. Immunol Rev 2008 1.15
53 Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest 2012 1.15
54 The innate immune system in allograft rejection and tolerance. J Immunol 2007 1.13
55 Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest 2002 1.12
56 Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. J Immunol 2004 1.10
57 Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. J Exp Med 2002 1.07
58 Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 2009 1.06
59 New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J Immunol 2011 1.06
60 The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering. J Exp Med 2002 1.05
61 Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. J Immunol Methods 2012 1.04
62 TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol 2003 1.03
63 The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol 2010 1.03
64 TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood 2010 1.01
65 The physician's voice in the health care debate. J Clin Invest 2009 1.01
66 Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity 2013 1.00
67 MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A 2013 0.97
68 New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo. Am J Transplant 2003 0.97
69 Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. J Immunol 2002 0.97
70 Regulation of T cell homeostasis and responses by pten. Front Immunol 2012 0.97
71 Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood 2011 0.96
72 Signals and pathways controlling regulatory T cells. Immunol Rev 2014 0.95
73 Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunol Rev 2003 0.95
74 A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection. J Invest Dermatol 2006 0.95
75 Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol 2008 0.95
76 Routes to transplant tolerance versus rejection; the role of cytokines. Immunity 2004 0.95
77 Animal house. J Clin Invest 2008 0.94
78 A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation 2010 0.94
79 The contribution of direct TLR signaling to T cell responses. Immunol Res 2009 0.94
80 Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. J Immunol 2003 0.93
81 Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection. J Am Soc Nephrol 2006 0.93
82 Homeostatic T cell proliferation as a barrier to T cell tolerance. Philos Trans R Soc Lond B Biol Sci 2005 0.91
83 Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol 2011 0.90
84 Tolerance: one transplant for life. Transplantation 2014 0.89
85 After further review. J Clin Invest 2009 0.89
86 Mechanism of T cell-mediated endothelial apoptosis. Transplantation 2002 0.89
87 Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection. Am J Transplant 2005 0.89
88 Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. J Immunol 2006 0.88
89 Innate immunity in transplant tolerance and rejection. Immunol Rev 2011 0.88
90 Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol 2012 0.87
91 Lymphocyte depletion as a barrier to immunological tolerance. Contrib Nephrol 2005 0.85
92 EGR-2 is not required for in vivo CD4 T cell mediated immune responses. PLoS One 2010 0.85
93 Marking a path to transplant tolerance. J Clin Invest 2008 0.85
94 Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol 2013 0.84
95 Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages. Eur J Immunol 2005 0.83
96 Challenges in the pursuit of immune tolerance. Immunol Rev 2011 0.83
97 Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation. J Immunol 2003 0.83
98 Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest 2016 0.83
99 Editorial position on publishing articles on human organ transplantation. J Clin Invest 2012 0.82
100 Regulatory cells and cell signatures in clinical transplantation tolerance. Curr Opin Immunol 2011 0.82
101 Immunotherapy as a means to induce transplantation tolerance. Curr Opin Immunol 2002 0.81
102 T-cell energy metabolism as a controller of cell fate in transplantation. Curr Opin Organ Transplant 2015 0.81
103 Bcl-XL expression in stem cells facilitates engraftment and reduces the need for host conditioning during bone marrow transplantation. Am J Transplant 2004 0.80
104 Autoimmunity heats up. Nat Med 2003 0.79
105 Bothered and bewildered, but not bewitched. J Clin Invest 2008 0.79
106 Lost in a dark wood. J Clin Invest 2007 0.78
107 Tolerance signatures in transplant recipients. Curr Opin Organ Transplant 2015 0.77
108 Senator, what is your policy on "Other"? J Clin Invest 2008 0.77
109 T-cell costimulatory blockade in organ transplantation. Cold Spring Harb Perspect Med 2013 0.77
110 Autoimmunity and transplantation: a meeting at the crossroads in Berlin. Nat Immunol 2008 0.77
111 CTLA-4: not all costimulation is stimulatory. J Immunol 2011 0.76
112 Homeostatic expansion as a barrier to lymphocyte depletion strategies. Curr Opin Organ Transplant 2014 0.76
113 Interleukin-2-mediated survival and proliferative signals are uncoupled in T lymphocytes that fail to divide after activation. Am J Transplant 2002 0.76
114 Plus ça change, plus c'est la même chose. J Clin Invest 2012 0.75
115 Stemming the tide of rejection. Nat Med 2002 0.75
116 Top priority. J Clin Invest 2009 0.75
117 What is the evidence for our standards of care? J Clin Invest 2011 0.75
118 Transplant tolerance: a new role for IL-34. J Clin Invest 2015 0.75
119 A breath of fresh aire. Immunity 2013 0.75
120 There's a goat behind door number 3: from Monty Hall to medicine. J Clin Invest 2011 0.75
121 Navigating T Cell Immunometabolism in Transplantation. Transplantation 2017 0.75
122 Designer meetings. Nat Immunol 2002 0.75
123 Control of T cell tolerance by phosphatase and tensin homolog. Ann N Y Acad Sci 2013 0.75
124 Ten years of the Immune Tolerance Network: an integrated clinical research organization. Sci Transl Med 2010 0.75
125 Immunogenetics and transplantation. Curr Opin Immunol 2011 0.75