Published in Am J Nephrol on October 09, 2002
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev (2009) 2.65
High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol (2008) 1.74
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol (2009) 1.69
The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med (2008) 1.65
Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant (2013) 1.55
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? Curr Hypertens Rep (2013) 1.20
Association of incident gout and mortality in dialysis patients. J Am Soc Nephrol (2008) 1.20
Associations among lead dose biomarkers, uric acid, and renal function in Korean lead workers. Environ Health Perspect (2005) 0.98
Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults. Am J Kidney Dis (2016) 0.97
Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia. Kidney Int (2007) 0.94
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol (2013) 0.93
Four-week effects of allopurinol and febuxostat treatments on blood pressure and serum creatinine level in gouty men. J Korean Med Sci (2014) 0.88
Association of kidney disease with prevalent gout in the United States in 1988-1994 and 2007-2010. Semin Arthritis Rheum (2013) 0.88
Uric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patients. BMC Nephrol (2014) 0.86
Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney disease. Nephrol Dial Transplant (2015) 0.83
Management of Gout and Hyperuricemia in CKD. Am J Kidney Dis (2017) 0.82
New and improved strategies for the treatment of gout. Int J Nephrol Renovasc Dis (2010) 0.81
Uric acid, hypertension, and chronic kidney disease among Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. J Clin Hypertens (Greenwich) (2012) 0.81
Comorbidities in patients with crystal diseases and hyperuricemia. Rheum Dis Clin North Am (2014) 0.81
Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. BMJ Open (2016) 0.80
Hyperuricemia: A Biomarker of Renal Hemodynamic Impairment. Cardiorenal Med (2015) 0.80
The association between hyperuricemia and betel nut chewing in Taiwanese men: a cross-sectional study. BMC Public Health (2013) 0.80
Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan. PLoS One (2013) 0.80
The Association between Serum Uric Acid Levels and the Prevalence of Vulnerable Atherosclerotic Carotid Plaque: A Cross-sectional Study. Sci Rep (2015) 0.79
Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis. Arthritis Res Ther (2009) 0.79
Association of a polymorphism in a gene encoding a urate transporter with CKD progression. Clin J Am Soc Nephrol (2014) 0.78
Time to target uric acid to retard CKD progression. Clin Exp Nephrol (2016) 0.77
Allopurinol reduces the lethality associated with acute renal failure induced by Crotalus durissus terrificus snake venom: comparison with probenecid. PLoS Negl Trop Dis (2011) 0.77
Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. Pediatr Nephrol (2013) 0.77
Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency. BMC Nephrol (2015) 0.76
Urinary transforming growth factor beta1 in children and adolescents with congenital solitary kidney. Pediatr Nephrol (2008) 0.76
COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation. Oncotarget (2016) 0.75
The Role of Uric Acid in Hypertension of Adolescents, Prehypertension and Salt Sensitivity of Blood Pressure. Med Sci Monit (2017) 0.75
Two authors reply. Am J Epidemiol (2014) 0.75
Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats. Physiol Rep (2017) 0.75
Prevalence of calcified carotid artery atheromas on panoramic images of older men with gout: a descriptive retrospective study. Dentomaxillofac Radiol (2017) 0.75
Chronic Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys. Front Physiol (2017) 0.75
Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review. J Adv Res (2016) 0.75
Hyperuricemia is Associated with Increased Apo AI Fractional Catabolic Rates and Dysfunctional HDL in New Zealand Rabbits. Lipids (2017) 0.75
Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet (2003) 7.98
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA (2008) 5.59
Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension (2003) 5.47
Hyperuricemia induces endothelial dysfunction. Kidney Int (2005) 5.36
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr (2007) 5.28
A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol (2005) 4.95
A role for uric acid in the progression of renal disease. J Am Soc Nephrol (2002) 3.77
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology (2010) 3.73
Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol (2005) 3.73
Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension (2003) 3.39
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol (2002) 3.37
Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol (2008) 3.33
Evolving importance of kidney disease: from subspecialty to global health burden. Lancet (2013) 3.30
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol (2007) 3.08
Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int (2008) 2.95
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol (2002) 2.83
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. Kidney Int (2005) 2.78
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol (2007) 2.71
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol (2009) 2.70
A strict low protein diet during the predialysis period suppresses peritoneal permeability at induction of peritoneal dialysis. Perit Dial Int (2009) 2.58
Role of the microvascular endothelium in progressive renal disease. J Am Soc Nephrol (2002) 2.51
Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis. Kidney Int (2010) 2.47
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension (2002) 2.47
Hyperuricemia in childhood primary hypertension. Hypertension (2003) 2.39
Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hypertens (Greenwich) (2012) 2.37
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun (2013) 2.29
Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol (2008) 2.28
Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol (2005) 2.24
Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol (2005) 2.24
Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J Am Soc Nephrol (2007) 2.24
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol (2003) 2.24
Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress. Clin J Am Soc Nephrol (2010) 2.16
Subtle acquired renal injury as a mechanism of salt-sensitive hypertension. N Engl J Med (2002) 2.13
Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol (2005) 2.07
Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events? Hypertension (2006) 2.02
Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats. Kidney Int (2005) 2.02
Increased fructose associates with elevated blood pressure. J Am Soc Nephrol (2010) 2.01
TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int (2004) 1.95
Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol (2006) 1.94
Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J (2003) 1.93
Mycophenolate mofetil treatment improves hypertension in patients with psoriasis and rheumatoid arthritis. J Am Soc Nephrol (2006) 1.91
Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol (2002) 1.89
J-shaped mortality relationship for uric acid in CKD. Am J Kidney Dis (2006) 1.88
Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol (2002) 1.86
Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J Am Soc Nephrol (2003) 1.84
Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol (2006) 1.83
CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance. Pediatr Nephrol (2013) 1.83
Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes (2011) 1.82
Role of uric acid in hypertension, renal disease, and metabolic syndrome. Cleve Clin J Med (2006) 1.81
Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens (2010) 1.80
The motivations and experiences of living kidney donors: a thematic synthesis. Am J Kidney Dis (2012) 1.78
Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids (2008) 1.76
Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study. Diabetes (2009) 1.76
Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all. Am J Physiol Renal Physiol (2004) 1.76
Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol (2007) 1.74
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A (2012) 1.72
Urinary CD80 excretion increases in idiopathic minimal-change disease. J Am Soc Nephrol (2008) 1.72
Pathophysiological mechanisms of salt-dependent hypertension. Am J Kidney Dis (2007) 1.71
Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens (2004) 1.71
Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am J Physiol Cell Physiol (2008) 1.69
Molecular physiology of urate transport. Physiology (Bethesda) (2005) 1.69
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol (2009) 1.69
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Physiol Renal Physiol (2008) 1.68
Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules. J Am Soc Nephrol (2003) 1.68
Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem (2012) 1.67
Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin. Nephrol Dial Transplant (2010) 1.65
The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med (2008) 1.65