Published in J Hypertens on June 01, 2010
Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes (2013) 2.03
Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem (2012) 1.67
Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria. Diabetes Care (2013) 1.62
Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant (2013) 1.55
Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans. Nutr Metab (Lond) (2012) 1.33
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism (2011) 1.27
Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLoS One (2012) 1.24
Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol (2014) 1.13
Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations. Nephron Exp Nephrol (2012) 1.12
Estimated glomerular filtration rate is a poor predictor of concentration for a broad range of uremic toxins. Clin J Am Soc Nephrol (2011) 1.10
Uric acid lowering to prevent kidney function loss in diabetes: the preventing early renal function loss (PERL) allopurinol study. Curr Diab Rep (2013) 1.09
Contribution of uric acid to cancer risk, recurrence, and mortality. Clin Transl Med (2012) 1.08
Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. Semin Nephrol (2011) 1.05
Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy. Clin Exp Nephrol (2012) 0.99
Uric Acid Puzzle: Dual Role as Anti-oxidantand Pro-oxidant. Electrolyte Blood Press (2014) 0.98
Progressive renal decline: the new paradigm of diabetic nephropathy in type 1 diabetes. Diabetes Care (2015) 0.97
Prevention of obesity-induced renal injury in male mice by DPP4 inhibition. Endocrinology (2014) 0.93
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol (2013) 0.93
Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease. Am J Nephrol (2011) 0.92
Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients? PLoS One (2013) 0.90
Serum uric acid, kidney volume and progression in autosomal-dominant polycystic kidney disease. Nephrol Dial Transplant (2012) 0.89
Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis. PLoS One (2013) 0.89
Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.88
Uric acid and pentraxin-3 levels are independently associated with coronary artery disease risk in patients with stage 2 and 3 kidney disease. Am J Nephrol (2011) 0.88
Uric acid in metabolic syndrome: From an innocent bystander to a central player. Eur J Intern Med (2015) 0.87
Serum uric acid is associated with left ventricular hypertrophy independent of serum parathyroid hormone in male cardiac patients. PLoS One (2013) 0.86
Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction. Int J Mol Med (2016) 0.83
High dietary fructose intake: Sweet or bitter life? World J Diabetes (2011) 0.83
Angiotensin II receptors and drug discovery in cardiovascular disease. Drug Discov Today (2010) 0.83
Serum uric acid levels and the risk of impaired fasting glucose: a prospective study in adults of north China. PLoS One (2013) 0.83
Management of Gout and Hyperuricemia in CKD. Am J Kidney Dis (2017) 0.82
Progressive renal decline as the major feature of diabetic nephropathy in type 1 diabetes. Clin Exp Nephrol (2013) 0.82
Mitochondria: a new therapeutic target in chronic kidney disease. Nutr Metab (Lond) (2015) 0.82
Determinants of vascular function in patients with chronic gout. J Clin Hypertens (Greenwich) (2010) 0.80
Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease. Am J Nephrol (2011) 0.80
Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis. PLoS One (2016) 0.80
Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women. BMJ Open (2013) 0.79
The significance of serum uric acid level in humans with acute paraquat poisoning. Sci Rep (2015) 0.79
Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II. Evid Based Complement Alternat Med (2013) 0.78
Protein-bound solute removal during extended multipass versus standard hemodialysis. BMC Nephrol (2015) 0.78
The effect of the addition of allopurinol on blood pressure control in African Americans treated with a thiazide-like diuretic. J Am Soc Hypertens (2015) 0.78
Correlation between renal function and common risk factors for chronic kidney disease in a healthy middle-aged population: a prospective observational 2-year study. PLoS One (2014) 0.78
Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study. BMJ Open (2015) 0.77
Allopurinol reduces the lethality associated with acute renal failure induced by Crotalus durissus terrificus snake venom: comparison with probenecid. PLoS Negl Trop Dis (2011) 0.77
Incidence and Risk Factors of Acute Kidney Injury after Radical Cystectomy: Importance of Preoperative Serum Uric Acid Level. Int J Med Sci (2015) 0.77
Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. Pediatr Nephrol (2013) 0.77
Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study. Clin Exp Nephrol (2016) 0.77
Uric acid level and erectile dysfunction in patients with coronary artery disease. J Sex Med (2013) 0.76
New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease. Oxid Med Cell Longev (2016) 0.76
Plasma metabolomic profiling of patients with diabetes-associated cognitive decline. PLoS One (2015) 0.76
Uric Acid Levels in Normotensive Children of Hypertensive Parents. Int J Chronic Dis (2015) 0.76
Hyperuricemia increases the risk of acute kidney injury: a systematic review and meta-analysis. BMC Nephrol (2017) 0.75
Advanced glycation end products upregulate angiopoietin-like protein 4 expression by activating the renin-angiotensin system in endothelial cells. Biomed Rep (2015) 0.75
Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update. Oxid Med Cell Longev (2016) 0.75
Clinically Relevant Doses of Enalapril Mitigate Multiple Organ Radiation Injury. Radiat Res (2016) 0.75
Resveratrol inhibits the intracellular calcium increase and angiotensin/endothelin system activation induced by soluble uric acid in mesangial cells. Braz J Med Biol Res (2014) 0.75
Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review. Nutrients (2017) 0.75
Urine L-carnitine excretion in hypertensive adolescents. Ir J Med Sci (2014) 0.75
Effect of Uric Acid Lowering on Renin-Angiotensin-System Activation and Ambulatory BP: A Randomized Controlled Trial. Clin J Am Soc Nephrol (2017) 0.75
Physiological functions and pathogenic potential of uric acid: A review. J Adv Res (2017) 0.75
Combined oral contraceptive-induced hypertension is accompanied by endothelial dysfunction and upregulated intrarenal angiotensin II type 1 receptor gene expression. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
Activation of Renal (Pro)Renin Receptor Contributes to High Fructose-Induced Salt Sensitivity. Hypertension (2016) 0.75
Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study. Oncotarget (2017) 0.75
Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial. J Adv Res (2017) 0.75
Uric Acid Level Has a U-shaped Association with Clinical Outcomes in Patients with Vasospastic Angina. J Korean Med Sci (2017) 0.75
Hyperuricemia, Type 2 Diabetes Mellitus, and Hypertension: an Emerging Association. Curr Hypertens Rep (2017) 0.75
Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review. J Adv Res (2016) 0.75
Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA (2008) 5.59
Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension (2003) 5.47
Hyperuricemia induces endothelial dysfunction. Kidney Int (2005) 5.36
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr (2007) 5.28
A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol (2005) 4.95
A role for uric acid in the progression of renal disease. J Am Soc Nephrol (2002) 3.77
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology (2010) 3.73
Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol (2005) 3.73
Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension (2003) 3.39
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol (2002) 3.37
Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol (2008) 3.33
Evolving importance of kidney disease: from subspecialty to global health burden. Lancet (2013) 3.30
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol (2007) 3.08
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. Kidney Int (2005) 2.78
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol (2007) 2.71
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol (2009) 2.70
Role of the microvascular endothelium in progressive renal disease. J Am Soc Nephrol (2002) 2.51
Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis. Kidney Int (2010) 2.47
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension (2002) 2.47
Hyperuricemia in childhood primary hypertension. Hypertension (2003) 2.39
Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hypertens (Greenwich) (2012) 2.37
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun (2013) 2.29
Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol (2008) 2.28
Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol (2005) 2.24
Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol (2005) 2.24
Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J Am Soc Nephrol (2007) 2.24
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol (2003) 2.24
Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress. Clin J Am Soc Nephrol (2010) 2.16
Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol (2005) 2.07
Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events? Hypertension (2006) 2.02
Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats. Kidney Int (2005) 2.02
Increased fructose associates with elevated blood pressure. J Am Soc Nephrol (2010) 2.01
TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int (2004) 1.95
Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol (2006) 1.94
Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J (2003) 1.93
Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol (2002) 1.89
J-shaped mortality relationship for uric acid in CKD. Am J Kidney Dis (2006) 1.88
Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol (2002) 1.86
Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J Am Soc Nephrol (2003) 1.84
Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol (2006) 1.83
CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance. Pediatr Nephrol (2013) 1.83
Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes (2011) 1.82
Role of uric acid in hypertension, renal disease, and metabolic syndrome. Cleve Clin J Med (2006) 1.81
Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids (2008) 1.76
Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study. Diabetes (2009) 1.76
Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all. Am J Physiol Renal Physiol (2004) 1.76
Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol (2007) 1.74
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A (2012) 1.72
Urinary CD80 excretion increases in idiopathic minimal-change disease. J Am Soc Nephrol (2008) 1.72
Pathophysiological mechanisms of salt-dependent hypertension. Am J Kidney Dis (2007) 1.71
Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens (2004) 1.71
Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am J Physiol Cell Physiol (2008) 1.69
Molecular physiology of urate transport. Physiology (Bethesda) (2005) 1.69
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol (2009) 1.69
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Physiol Renal Physiol (2008) 1.68
Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules. J Am Soc Nephrol (2003) 1.68
Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem (2012) 1.67
The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med (2008) 1.65
Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin. Nephrol Dial Transplant (2010) 1.65
Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol (2007) 1.65
Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol Renal Physiol (2002) 1.64
Systemic inflammation, metabolic syndrome and progressive renal disease. Nephrol Dial Transplant (2009) 1.63
Inactivation of nitric oxide by uric acid. Nucleosides Nucleotides Nucleic Acids (2008) 1.59
The role of uric acid in the pathogenesis of human cardiovascular disease. Heart (2013) 1.59
Impaired renal function further increases odds of 6-year coronary artery calcification progression in adults with type 1 diabetes: the CACTI study. Diabetes Care (2013) 1.58
Glomerular hemodynamic changes associated with arteriolar lesions and tubulointerstitial inflammation. Kidney Int Suppl (2003) 1.57
Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology (2012) 1.57
Could uric acid have a role in acute renal failure? Clin J Am Soc Nephrol (2006) 1.56
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology (2013) 1.56
Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant (2013) 1.55
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney Int (2011) 1.55
Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China. Nephrol Dial Transplant (2008) 1.55
Uric acid, the metabolic syndrome, and renal disease. J Am Soc Nephrol (2006) 1.54
A case report of crescentic glomerulonephritis associated with Hantaan virus infection. Nephrol Dial Transplant (2010) 1.52
Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension. Hypertension (2005) 1.52
Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study. Acta Diabetol (2014) 1.48
Effects of cyclosporine in osteopontin null mice. Kidney Int (2002) 1.47
Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol (2008) 1.46
Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study. Nephrol Dial Transplant (2010) 1.45
Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol (2010) 1.43
Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int (2004) 1.42
IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol (2005) 1.41
Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. J Clin Hypertens (Greenwich) (2014) 1.41
A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function. Clin J Am Soc Nephrol (2011) 1.40
Hyperuricemia causes glomerular hypertrophy in the rat. Am J Nephrol (2002) 1.39