Published in Am J Clin Nutr on October 01, 2007
Uric Acid and Hypertension in African Americans | NCT00241839
Influence on Food Liking of Adding Spices to Replace Dietary Sugar | NCT03134079
Influence on Food Liking of Adding Spices to Replace Sugar Using CLT | NCT03139552
Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20
Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation (2010) 6.86
Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr (2009) 4.04
Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr (2009) 3.90
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology (2010) 3.73
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence. Physiol Behav (2010) 3.66
Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol (2008) 3.33
Resolved: there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes Rev (2013) 2.93
Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome. Obesity (Silver Spring) (2015) 2.77
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol (2009) 2.70
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev (2009) 2.65
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol (2010) 2.50
Sugar-sweetened soda consumption, hyperuricemia, and kidney disease. Kidney Int (2009) 2.48
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun (2013) 2.29
Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure: a prospective study among United States adults. Circulation (2010) 2.29
Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure. Hypertension (2011) 2.29
Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol (2008) 2.28
Increased fructose associates with elevated blood pressure. J Am Soc Nephrol (2010) 2.01
The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS One (2013) 1.95
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A (2012) 1.72
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci (2009) 1.67
Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite (2010) 1.64
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab (2012) 1.64
Use of caloric and noncaloric sweeteners in US consumer packaged foods, 2005-2009. J Acad Nutr Diet (2012) 1.61
Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI. Diabetes Care (2008) 1.58
Knowledge and perceptions of diabetes in a semi-urban Omani population. BMC Public Health (2008) 1.57
Sweeteners and Risk of Obesity and Type 2 Diabetes: The Role of Sugar-Sweetened Beverages. Curr Diab Rep (2012) 1.52
Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity (Silver Spring) (2013) 1.47
Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol (2008) 1.46
Vegetable but not fruit consumption reduces the risk of type 2 diabetes in Chinese women. J Nutr (2008) 1.42
Diabetes regulates fructose absorption through thioredoxin-interacting protein. Elife (2016) 1.39
How much sugar is hidden in drinks marketed to children? A survey of fruit juices, juice drinks and smoothies. BMJ Open (2016) 1.38
Uric acid, hyperuricemia and vascular diseases. Front Biosci (Landmark Ed) (2012) 1.38
The Role of Overweight and Obesity in the Cardiorenal Syndrome. Cardiorenal Med (2011) 1.35
Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans. Nutr Metab (Lond) (2012) 1.33
Sweetening of the global diet, particularly beverages: patterns, trends, and policy responses. Lancet Diabetes Endocrinol (2015) 1.32
Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem (2009) 1.27
Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem (2008) 1.25
Does high sugar consumption exacerbate cardiometabolic risk factors and increase the risk of type 2 diabetes and cardiovascular disease? Food Nutr Res (2012) 1.24
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? J Comp Physiol B (2008) 1.23
Starches, sugars and obesity. Nutrients (2011) 1.23
The role of fructose transporters in diseases linked to excessive fructose intake. J Physiol (2012) 1.21
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? Curr Hypertens Rep (2013) 1.20
Sugary soda consumption and albuminuria: results from the National Health and Nutrition Examination Survey, 1999-2004. PLoS One (2008) 1.20
Soda consumption and the risk of stroke in men and women. Am J Clin Nutr (2012) 1.16
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism (2011) 1.15
A dual sugar challenge test for lipogenic sensitivity to dietary fructose. J Clin Endocrinol Metab (2011) 1.14
Fructose and Cardiometabolic Health: What the Evidence From Sugar-Sweetened Beverages Tells Us. J Am Coll Cardiol (2015) 1.14
Beverage Consumption Habits and Association with Total Water and Energy Intakes in the Spanish Population: Findings of the ANIBES Study. Nutrients (2016) 1.13
Fructose metabolism in humans - what isotopic tracer studies tell us. Nutr Metab (Lond) (2012) 1.12
Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr (2009) 1.12
Uric Acid and Cardiovascular Events: A Mendelian Randomization Study. J Am Soc Nephrol (2015) 1.08
The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front Endocrinol (Lausanne) (2013) 1.06
The epidemiology of uric acid and fructose. Semin Nephrol (2011) 1.06
Sugar sweetened beverage consumption by Australian children: implications for public health strategy. BMC Public Health (2011) 1.06
Uric acid as one of the important factors in multifactorial disorders--facts and controversies. Biochem Med (Zagreb) (2012) 1.05
Non-alcoholic fatty liver disease: what the clinician needs to know. World J Gastroenterol (2014) 1.02
Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know? Adv Nutr (2013) 1.02
Nutraceutical values of natural honey and its contribution to human health and wealth. Nutr Metab (Lond) (2012) 1.02
Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats. Nutr Metab (Lond) (2011) 0.99
Uric Acid Puzzle: Dual Role as Anti-oxidantand Pro-oxidant. Electrolyte Blood Press (2014) 0.98
Obesity in CKD--what should nephrologists know? J Am Soc Nephrol (2013) 0.98
Fructose: a key factor in the development of metabolic syndrome and hypertension. J Nutr Metab (2013) 0.97
Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. World J Gastroenterol (2014) 0.96
The effect of race/ethnicity on adverse perinatal outcomes among patients with gestational diabetes mellitus. Am J Obstet Gynecol (2012) 0.96
Uric Acid - key ingredient in the recipe for cardiorenal metabolic syndrome. Cardiorenal Med (2013) 0.95
Fructose consumption during pregnancy and lactation induces fatty liver and glucose intolerance in rats. Nutr Res (2012) 0.95
Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab (Lond) (2010) 0.94
Prevention of obesity-induced renal injury in male mice by DPP4 inhibition. Endocrinology (2014) 0.93
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol (2013) 0.93
Sugar intake, obesity, and diabetes in India. Nutrients (2014) 0.93
Association of raw fruit and fruit juice consumption with blood pressure: the INTERMAP Study. Am J Clin Nutr (2013) 0.92
The metabolic and endocrine response and health implications of consuming sugar-sweetened beverages: findings from recent randomized controlled trials. Adv Nutr (2013) 0.92
The effects of four hypocaloric diets containing different levels of sucrose or high fructose corn syrup on weight loss and related parameters. Nutr J (2012) 0.90
Structures of alternatively spliced isoforms of human ketohexokinase. Acta Crystallogr D Biol Crystallogr (2009) 0.90
Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats. Br J Pharmacol (2012) 0.89
Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD. J Am Soc Nephrol (2009) 0.89
Hyperuricemia and metabolic syndrome: associations with chronic kidney disease. Clin Rheumatol (2010) 0.89
Does dietary intake by Tehranian adults align with the 2005 dietary guidelines for Americans? Observations from the Tehran lipid and glucose study. J Health Popul Nutr (2011) 0.89
Energy Intake, Profile, and Dietary Sources in the Spanish Population: Findings of the ANIBES Study. Nutrients (2015) 0.89
Impact of the North American Free Trade Agreement on high-fructose corn syrup supply in Canada: a natural experiment using synthetic control methods. CMAJ (2017) 0.89
Metabolic and behavioural effects of sucrose and fructose/glucose drinks in the rat. Eur J Nutr (2011) 0.89
Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells. Int J Oncol (2010) 0.89
Diabetes knowledge and glycemic control among patients with type 2 diabetes in Bangladesh. Springerplus (2015) 0.88
Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats. J Clin Biochem Nutr (2010) 0.88
Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Adv Exp Med Biol (2009) 0.88
Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population. Int J Med Sci (2016) 0.88
Early life exposure to fructose and offspring phenotype: implications for long term metabolic homeostasis. J Obes (2014) 0.88
Uric acid in metabolic syndrome: From an innocent bystander to a central player. Eur J Intern Med (2015) 0.87
Concordance of gene expression in human protein complexes reveals tissue specificity and pathology. Nucleic Acids Res (2013) 0.87
Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion. J Diabetes Investig (2012) 0.87
DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and Associated Cardiovascular and Renal Insulin Resistance in Obesity and Diabetes. Cardiorenal Med (2013) 0.86
The effect of normally consumed amounts of sucrose or high fructose corn syrup on lipid profiles, body composition and related parameters in overweight/obese subjects. Nutrients (2014) 0.86
Elevated serum triglyceride and retinol-binding protein 4 levels associated with fructose-sweetened beverages in adolescents. PLoS One (2014) 0.86
Consumption of sugar-sweetened beverages and blood pressure in the United States: the national health and nutrition examination survey 2003-2006. Clin Nutr Res (2012) 0.85
Fructation in vivo: detrimental and protective effects of fructose. Biomed Res Int (2013) 0.85
World congress on insulin resistance, diabetes, and cardiovascular disease: Part 1. Diabetes Care (2011) 0.85
Rescue of Fructose-Induced Metabolic Syndrome by Antibiotics or Faecal Transplantation in a Rat Model of Obesity. PLoS One (2015) 0.85
Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats. Eur J Nutr (2014) 0.84
Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse (Basel) (2016) 0.84
Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20
Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension (2003) 5.47
Hyperuricemia induces endothelial dysfunction. Kidney Int (2005) 5.36
A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol (2005) 4.95
A role for uric acid in the progression of renal disease. J Am Soc Nephrol (2002) 3.77
Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation (2009) 3.75
Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension (2003) 3.39
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol (2002) 3.37
Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol (2008) 3.33
Long-term risk of mortality and acute kidney injury during hospitalization after major surgery. Ann Surg (2009) 3.18
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol (2007) 2.71
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol (2009) 2.70
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev (2009) 2.65
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension (2002) 2.47
Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol (2005) 2.24
Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J Am Soc Nephrol (2007) 2.24
Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension (2012) 2.19
Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress. Clin J Am Soc Nephrol (2010) 2.16
Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol (2005) 2.07
Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes (2013) 2.03
TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int (2004) 1.95
Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol (2006) 1.94
SDF-1 is both necessary and sufficient to promote proliferative retinopathy. J Clin Invest (2005) 1.84
Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens (2010) 1.80
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A (2012) 1.72
Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens (2004) 1.71
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol (2009) 1.69
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock. J Exp Med (2009) 1.68
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Physiol Renal Physiol (2008) 1.68
Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem (2012) 1.67
The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med (2008) 1.65
Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol (2007) 1.65
Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol Renal Physiol (2002) 1.64
Systemic inflammation, metabolic syndrome and progressive renal disease. Nephrol Dial Transplant (2009) 1.63
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol (2014) 1.62
The role of uric acid in the pathogenesis of human cardiovascular disease. Heart (2013) 1.59
Overexpression of calmodulin in pancreatic beta cells induces diabetic nephropathy. J Am Soc Nephrol (2008) 1.57
Could uric acid have a role in acute renal failure? Clin J Am Soc Nephrol (2006) 1.56
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology (2013) 1.56
Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant (2013) 1.55
Uric acid, the metabolic syndrome, and renal disease. J Am Soc Nephrol (2006) 1.54
A case report of crescentic glomerulonephritis associated with Hantaan virus infection. Nephrol Dial Transplant (2010) 1.52
Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension. Hypertension (2005) 1.52
Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol (2008) 1.46
Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int (2004) 1.42
Hyperuricemia causes glomerular hypertrophy in the rat. Am J Nephrol (2002) 1.39
Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome. Am J Physiol Renal Physiol (2008) 1.38
Resurrection of uric acid as a causal risk factor in essential hypertension. Hypertension (2004) 1.38
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis Rheum (2007) 1.36
Serum uric acid: a risk factor and a target for treatment? J Am Soc Nephrol (2006) 1.35
Dietary fructose causes tubulointerstitial injury in the normal rat kidney. Am J Physiol Renal Physiol (2010) 1.34
Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol (2005) 1.33
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Am J Physiol Renal Physiol (2006) 1.33
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Mol Ther (2011) 1.32
Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse. Am J Physiol Renal Physiol (2008) 1.28
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism (2011) 1.27
Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. Arthritis Rheum (2004) 1.27
Cost and Mortality Associated With Postoperative Acute Kidney Injury. Ann Surg (2015) 1.26
HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium. J Am Soc Nephrol (2009) 1.25
A unifying pathway for essential hypertension. Am J Hypertens (2005) 1.25
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? J Comp Physiol B (2008) 1.23
A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome. Nephrol Dial Transplant (2009) 1.21
Nitric oxide modulates vascular disease in the remnant kidney model. Am J Pathol (2002) 1.19
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice. Am J Pathol (2009) 1.19
Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. Am J Physiol Renal Physiol (2013) 1.18
Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease. Semin Nephrol (2005) 1.18
Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci (2010) 1.18
The effect of fructose on renal biology and disease. J Am Soc Nephrol (2010) 1.17
National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury. Crit Care Med (2013) 1.16
Urinary biomarkers in lupus nephritis. Autoimmun Rev (2005) 1.16
Cost-effectiveness of ambulatory blood pressure monitoring in the initial evaluation of hypertension in children. Pediatrics (2008) 1.16
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism (2011) 1.15
Uric acid and hypertension. Curr Hypertens Rep (2006) 1.15
Tubulointerstitial disease: role of ischemia and microvascular disease. Curr Opin Nephrol Hypertens (2003) 1.15
Management of a severe carbamazepine overdose using albumin-enhanced continuous venovenous hemodialysis. Pediatrics (2004) 1.14
Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr (2009) 1.12
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. PLoS One (2012) 1.12
Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations. Nephron Exp Nephrol (2012) 1.12
Uric acid as a mediator of diabetic nephropathy. Semin Nephrol (2011) 1.11
Dietary fructose and hypertension. Curr Hypertens Rep (2011) 1.11