Published in Biochem J on February 01, 2003
Dynamic dissociating homo-oligomers and the control of protein function. Arch Biochem Biophys (2011) 1.06
Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5. J Immunol (2008) 1.05
The B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pH. J Immunol (2006) 0.85
Allosteric control of βII-tryptase by a redox active disulfide bond. J Biol Chem (2013) 0.83
High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution. Immunogenetics (2010) 0.82
Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF action. J Biol Chem (2011) 0.79
Active monomers of human beta-tryptase have expanded substrate specificities. Int Immunopharmacol (2007) 0.79
Mast cell proteases as pharmacological targets. Eur J Pharmacol (2015) 0.78
Acidic pH is essential for maintaining mast cell secretory granule homeostasis. Cell Death Dis (2017) 0.75
Mast cells. Physiol Rev (1997) 6.51
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Nature (1999) 2.82
Tryptase from human pulmonary mast cells. Purification and characterization. J Biol Chem (1981) 2.37
Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer. J Biol Chem (1986) 1.79
Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology (2002) 1.56
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Nature (1998) 1.43
Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: selective enhancement of eosinophil recruitment by histamine. J Immunol (1997) 1.38
Human lung tryptase. Purification and characterization. J Biol Chem (1984) 1.33
Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6. J Immunol (1998) 1.30
The fibrinogenolytic activity of purified tryptase from human lung mast cells. J Immunol (1985) 1.28
Inhaled tryptase causes bronchoconstriction in sheep via histamine release. Am J Respir Crit Care Med (1996) 1.14
Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin. J Cell Biochem (1992) 1.12
Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. Am J Respir Crit Care Med (1995) 1.07
Mechanism for activation of mouse mast cell tryptase: dependence on heparin and acidic pH for formation of active tetramers of mouse mast cell protease 6. Biochemistry (2000) 1.04
Clinical utility of tryptase levels in systemic mastocytosis and associated hematologic disorders. Leuk Res (2001) 1.03
Heparin antagonists are potent inhibitors of mast cell tryptase. Biochemistry (2001) 0.99
Interactions of human mast cell tryptase with biological protease inhibitors. Arch Biochem Biophys (1990) 0.90
Recombinant human mast cell tryptase beta: stable expression in Pichia pastoris and purification of fully active enzyme. Biotechnol Appl Biochem (1998) 0.89
Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]-phenoxy]-pen tane (AMG-126737). Biochem Pharmacol (1999) 0.88
Regulation of human mast cell beta-tryptase: conversion of inactive monomer to active tetramer at acid pH. J Immunol (1998) 0.88
The human mast cell tryptase tetramer: a fascinating riddle solved by structure. Biochim Biophys Acta (2000) 0.87
Inactivation of human lung tryptase: evidence for a re-activatable tetrameric intermediate and active monomers. Biochemistry (1996) 0.85
Spontaneous inactivation of human tryptase involves conformational changes consistent with conversion of the active site to a zymogen-like structure. Biochemistry (1998) 0.79
Mast cells can enhance resistance to snake and honeybee venoms. Science (2006) 2.72
A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem (2004) 1.70
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation (2009) 1.43
Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A (2009) 1.34
Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem (2004) 1.32
Intracellular proteoglycans. Biochem J (2004) 1.25
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med (2008) 1.23
A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood (2010) 1.20
Neutrophil elastase depends on serglycin proteoglycan for localization in granules. Blood (2007) 1.16
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest (2011) 1.16
Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation. J Immunol (2009) 1.15
Increased levels of hypoxia-sensitive proteins in allergic airway inflammation. Am J Respir Crit Care Med (2004) 1.11
Serglycin: a structural and functional chameleon with wide impact on immune cells. J Immunol (2011) 1.11
Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J Biol Chem (2005) 1.09
Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan. J Allergy Clin Immunol (2008) 1.07
Biology of mast cell tryptase. An inflammatory mediator. FEBS J (2006) 1.06
Biological implications of preformed mast cell mediators. Cell Mol Life Sci (2010) 1.06
Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. J Biol Chem (2004) 1.05
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions. J Biol Chem (2007) 1.04
Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem J (2007) 1.03
Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J Biol Chem (2006) 1.02
Serglycin: the master of the mast cell. Methods Mol Biol (2012) 1.01
Human mast cell beta-tryptase is a gelatinase. J Immunol (2003) 0.99
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol (2010) 0.97
Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. J Biol Chem (2010) 0.96
Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis. FASEB J (2008) 0.96
The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol (2010) 0.95
Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity. J Biol Chem (2003) 0.95
A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J (2006) 0.94
Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood (2007) 0.93
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol (2012) 0.92
Mast cell proteoglycans. J Histochem Cytochem (2012) 0.92
Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Biol Chem (2002) 0.91
Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. J Biol Chem (2002) 0.91
A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci (2005) 0.90
Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem (2003) 0.90
Vitamin a is a negative regulator of osteoblast mineralization. PLoS One (2013) 0.89
Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One (2010) 0.89
Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin. J Immunol (2008) 0.88
Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. PLoS One (2011) 0.86
A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway. J Biol Chem (2010) 0.86
Canine uterine bacterial infection induces upregulation of proteolysis-related genes and downregulation of homeobox and zinc finger factors. PLoS One (2009) 0.86
Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem (2011) 0.86
Infection of mast cells with live streptococci causes a toll-like receptor 2- and cell-cell contact-dependent cytokine and chemokine response. Infect Immun (2009) 0.85
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation. Mol Immunol (2011) 0.85
Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase. J Mol Biol (2005) 0.85
Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo. Immunology (2014) 0.84
Histidines are critical for heparin-dependent activation of mast cell tryptase. J Immunol (2004) 0.84
Age-related enlargement of lymphoid tissue and altered leukocyte composition in serglycin-deficient mice. J Leukoc Biol (2008) 0.83
Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism. J Immunol (2014) 0.82
Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol (2012) 0.82
Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases. Biol Chem (2006) 0.82
Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase. Mol Immunol (2010) 0.82
Serglycin proteoglycan promotes apoptotic versus necrotic cell death in mast cells. J Biol Chem (2012) 0.82
Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin. J Allergy Clin Immunol (2011) 0.81
Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J (2012) 0.81
Actinonin induces apoptosis in U937 leukemia cells. Cancer Lett (2004) 0.81
Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis. Biol Chem (2012) 0.81
Active caspase-3 is stored within secretory compartments of viable mast cells. J Immunol (2013) 0.80
ADAMTS: novel proteases expressed by activated mast cells. Biol Chem (2013) 0.79
Reduction with dithiothreitol causes serglycin-specific defects in secretory granule integrity of bone marrow derived mast cells. Mol Immunol (2008) 0.79
The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy. Plast Reconstr Surg (2014) 0.78
Tumor-mast cell interactions: induction of pro-tumorigenic genes and anti-tumorigenic 4-1BB in MCs in response to Lewis Lung Carcinoma. Mol Immunol (2012) 0.78
Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction. Kidney Int (2013) 0.78
Serglycin proteoglycan is not implicated in localizing exocrine pancreas enzymes to zymogen granules. Eur J Cell Biol (2009) 0.78
Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B. Pancreatology (2006) 0.78
Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas. Breast Cancer Res Treat (2008) 0.78
Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner. Biol Chem (2012) 0.77
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol (2014) 0.77
Distorted secretory granule composition in mast cells with multiple protease deficiency. J Immunol (2013) 0.77
Granzyme D is a novel murine mast cell protease that is highly induced by multiple pathways of mast cell activation. Infect Immun (2013) 0.77
Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease. J Biol Chem (2014) 0.76
Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1. J Pharmacol Exp Ther (2013) 0.76
Diverse bone morphogenetic protein expression profiles and smad pathway activation in different phenotypes of experimental canine mammary tumors. PLoS One (2009) 0.75
Granzyme H is a novel protease expressed by human mast cells. Int Arch Allergy Immunol (2014) 0.75
Polycationic peptides as inhibitors of mast cell serine proteases. Biochem Pharmacol (2003) 0.75
Induction of mast cell apoptosis by a novel secretory granule-mediated pathway. Methods Mol Biol (2015) 0.75