Published in Am J Respir Crit Care Med on May 19, 2004
Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages. Infect Immun (2006) 1.76
Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. Allergy (2011) 1.73
Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest (2008) 1.43
Arginase and pulmonary diseases. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.16
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. Br J Pharmacol (2009) 1.16
Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid. J Proteome Res (2009) 1.10
Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. Int Arch Allergy Immunol (2009) 1.05
Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. Toxicol Appl Pharmacol (2008) 1.02
Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2012) 1.01
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol (2008) 0.99
Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia. Infect Immun (2008) 0.93
HIV-1-infected astrocytes and the microglial proteome. J Neuroimmune Pharmacol (2008) 0.92
A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics (2010) 0.86
Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma. J Biomed Res (2011) 0.84
The Three A's in Asthma - Airway Smooth Muscle, Airway Remodeling & Angiogenesis. Open Respir Med J (2015) 0.82
Migrating leukocytes are the source of peroxiredoxin V during inflammation in the airways. J Inflamm (Lond) (2006) 0.80
Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy. Am J Cancer Res (2014) 0.79
Vasoactive Intestinal Peptide Knockout (VIP KO) mouse model of sulfite-sensitive asthma: up-regulation of novel lung carbonyl reductase. BMC Immunol (2011) 0.79
Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma. Biomark Insights (2012) 0.79
Peroxiredoxin V contributes to antioxidant defense of lung epithelial cells. Lung (2008) 0.79
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. Transl Res (2016) 0.75
Mast cells can enhance resistance to snake and honeybee venoms. Science (2006) 2.72
A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem (2004) 1.70
Influence of smoking cessation on airway T lymphocyte subsets in COPD. COPD (2009) 1.65
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation (2009) 1.43
Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A (2009) 1.34
Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem (2004) 1.32
Intracellular proteoglycans. Biochem J (2004) 1.25
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med (2008) 1.23
A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood (2010) 1.20
Virulotyping and antimicrobial resistance typing of Salmonella enterica serovars relevant to human health in Europe. Foodborne Pathog Dis (2010) 1.17
Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888. Biochemistry (2010) 1.17
Neutrophil elastase depends on serglycin proteoglycan for localization in granules. Blood (2007) 1.16
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest (2011) 1.16
Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation. J Immunol (2009) 1.15
Serglycin: a structural and functional chameleon with wide impact on immune cells. J Immunol (2011) 1.11
Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J Biol Chem (2005) 1.09
Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan. J Allergy Clin Immunol (2008) 1.07
Biology of mast cell tryptase. An inflammatory mediator. FEBS J (2006) 1.06
Biological implications of preformed mast cell mediators. Cell Mol Life Sci (2010) 1.06
Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. J Biol Chem (2004) 1.05
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions. J Biol Chem (2007) 1.04
Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem J (2007) 1.03
Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J Biol Chem (2006) 1.02
Serglycin: the master of the mast cell. Methods Mol Biol (2012) 1.01
Human mast cell beta-tryptase is a gelatinase. J Immunol (2003) 0.99
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol (2010) 0.97
Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat. J Immunotoxicol (2011) 0.97
Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. J Biol Chem (2010) 0.96
Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis. FASEB J (2008) 0.96
Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity. J Biol Chem (2003) 0.95
The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol (2010) 0.95
Treatment with dexamethasone or liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury. Inhal Toxicol (2009) 0.94
gammadelta T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation. Immunology (2003) 0.94
A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J (2006) 0.94
Involvement of NADPH oxidase and iNOS in rodent pulmonary cytokine responses to urban air and mineral particles. Inhal Toxicol (2007) 0.93
Polymorph- and size-dependent uptake and toxicity of TiO₂ nanoparticles in living lung epithelial cells. Small (2011) 0.93
Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood (2007) 0.93
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol (2012) 0.92
Mast cell proteoglycans. J Histochem Cytochem (2012) 0.92
Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Biol Chem (2002) 0.91
Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. J Biol Chem (2002) 0.91
Vitamin E reduces transendothelial migration of neutrophils and prevents lung injury in endotoxin-induced airway inflammation. Am J Respir Cell Mol Biol (2003) 0.90
A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci (2005) 0.90
Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem (2003) 0.90
Vitamin a is a negative regulator of osteoblast mineralization. PLoS One (2013) 0.89
Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD. Respir Res (2011) 0.89
Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One (2010) 0.89
Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin. J Immunol (2008) 0.88
Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. PLoS One (2011) 0.86
Canine uterine bacterial infection induces upregulation of proteolysis-related genes and downregulation of homeobox and zinc finger factors. PLoS One (2009) 0.86
A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway. J Biol Chem (2010) 0.86
Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem (2011) 0.86
The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-kappaB and inflammatory response in lung epithelial cells. J Appl Toxicol (2005) 0.85
Inhalation of alkylating mustard causes long-term T cell-dependent inflammation in airways and growth of connective tissue. Toxicology (2010) 0.85
Bacterial and mammalian cell response to poly(3-sulfopropyl methacrylate) brushes loaded with silver halide salts. Biomaterials (2008) 0.85
Infection of mast cells with live streptococci causes a toll-like receptor 2- and cell-cell contact-dependent cytokine and chemokine response. Infect Immun (2009) 0.85
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation. Mol Immunol (2011) 0.85
Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase. J Mol Biol (2005) 0.85
Formation of active monomers from tetrameric human beta-tryptase. Biochem J (2003) 0.84
Human primary bronchial epithelial cells respond differently to titanium dioxide nanoparticles than the lung epithelial cell lines A549 and BEAS-2B. Nanotoxicology (2011) 0.84
Cytotoxic T cells expressing the co-stimulatory receptor NKG2 D are increased in cigarette smoking and COPD. Respir Res (2010) 0.84
Histidines are critical for heparin-dependent activation of mast cell tryptase. J Immunol (2004) 0.84
Increased intraepithelial T-cells in stable COPD. Respir Med (2008) 0.84
Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo. Immunology (2014) 0.84
Non-proteolytic aeroallergens from mites, cat and dog exert adjuvant-like activation of bronchial epithelial cells. Int Arch Allergy Immunol (2010) 0.84
Age-related enlargement of lymphoid tissue and altered leukocyte composition in serglycin-deficient mice. J Leukoc Biol (2008) 0.83
The antibacterial activity of Ga3+ is influenced by ligand complexation as well as the bacterial carbon source. Antimicrob Agents Chemother (2011) 0.83
Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism. J Immunol (2014) 0.82
Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. Shock (2004) 0.82
Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol (2012) 0.82
Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases. Biol Chem (2006) 0.82
Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase. Mol Immunol (2010) 0.82
Serglycin proteoglycan promotes apoptotic versus necrotic cell death in mast cells. J Biol Chem (2012) 0.82
Corticosteroid treatment inhibits airway hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation. Toxicology (2012) 0.81
Actinonin induces apoptosis in U937 leukemia cells. Cancer Lett (2004) 0.81
Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin. J Allergy Clin Immunol (2011) 0.81
Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis. Biol Chem (2012) 0.81
Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J (2012) 0.81
Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif. J Biol Chem (2010) 0.81
Active caspase-3 is stored within secretory compartments of viable mast cells. J Immunol (2013) 0.80
Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers. Environ Health (2014) 0.80
Early treatment of chlorine-induced airway hyperresponsiveness and inflammation with corticosteroids. Toxicol Appl Pharmacol (2013) 0.80
Oligodeoxynucleotides containing CpG motifs can induce T cell-dependent arthritis in rats. Arthritis Rheum (2004) 0.79
Inhalation exposure of nano-scaled titanium dioxide (TiO2) particles alters the inflammatory responses in asthmatic mice. Inhal Toxicol (2013) 0.79
ADAMTS: novel proteases expressed by activated mast cells. Biol Chem (2013) 0.79
Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase. Life Sci (2004) 0.79
Reduction with dithiothreitol causes serglycin-specific defects in secretory granule integrity of bone marrow derived mast cells. Mol Immunol (2008) 0.79
Tumor-mast cell interactions: induction of pro-tumorigenic genes and anti-tumorigenic 4-1BB in MCs in response to Lewis Lung Carcinoma. Mol Immunol (2012) 0.78
Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas. Breast Cancer Res Treat (2008) 0.78
Serglycin proteoglycan is not implicated in localizing exocrine pancreas enzymes to zymogen granules. Eur J Cell Biol (2009) 0.78
The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy. Plast Reconstr Surg (2014) 0.78
Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B. Pancreatology (2006) 0.78
Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction. Kidney Int (2013) 0.78
Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner. Biol Chem (2012) 0.77
Accumulation and elimination of 16 polycyclic aromatic compounds in the earthworm (Eisenia fetida). Environ Toxicol Chem (2002) 0.77
Granzyme D is a novel murine mast cell protease that is highly induced by multiple pathways of mast cell activation. Infect Immun (2013) 0.77
Distorted secretory granule composition in mast cells with multiple protease deficiency. J Immunol (2013) 0.77