Published in Mol Biol Cell on October 01, 2002
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A (2003) 5.95
A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes. Genome Biol (2004) 4.94
Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein. Proc Natl Acad Sci U S A (2009) 4.61
Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46
Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis. Plant Physiol (2005) 3.01
Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev (2004) 2.60
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell (2009) 2.50
Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. Cell (2005) 2.40
Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A (2008) 2.04
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc Natl Acad Sci U S A (2004) 1.91
α2δ expression sets presynaptic calcium channel abundance and release probability. Nature (2012) 1.90
Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet (2003) 1.86
Ancient origin of the integrin-mediated adhesion and signaling machinery. Proc Natl Acad Sci U S A (2010) 1.81
The mediator complex subunit PFT1 is a key regulator of jasmonate-dependent defense in Arabidopsis. Plant Cell (2009) 1.75
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond. Nat Rev Neurosci (2012) 1.73
The echinoderm adhesome. Dev Biol (2006) 1.71
The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels. Proc Natl Acad Sci U S A (2005) 1.65
Evolution of diverse cell division and vesicle formation systems in Archaea. Nat Rev Microbiol (2010) 1.55
Cyclic-di-GMP-mediated repression of swarming motility by Pseudomonas aeruginosa: the pilY1 gene and its impact on surface-associated behaviors. J Bacteriol (2010) 1.50
The origins of phagocytosis and eukaryogenesis. Biol Direct (2009) 1.49
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Proc Natl Acad Sci U S A (2004) 1.49
Putative surface proteins encoded within a novel transferable locus confer a high-biofilm phenotype to Enterococcus faecalis. J Bacteriol (2006) 1.47
TagR promotes PpkA-catalysed type VI secretion activation in Pseudomonas aeruginosa. Mol Microbiol (2009) 1.46
Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A. PLoS Pathog (2008) 1.45
The AAA+ superfamily of functionally diverse proteins. Genome Biol (2008) 1.44
Microneme proteins in apicomplexans. Subcell Biochem (2008) 1.40
The evolution of extracellular matrix. Mol Biol Cell (2010) 1.40
The evolution of metazoan extracellular matrix. J Cell Biol (2012) 1.39
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential. Pharmacol Rev (2015) 1.38
Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci (2009) 1.35
An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features. EMBO Rep (2006) 1.34
Proteomic analysis of secreted membrane vesicles of archaeal Sulfolobus species reveals the presence of endosome sorting complex components. Extremophiles (2008) 1.34
Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. J Biol Chem (2010) 1.31
Aberrant mitochondria in a Bethlem myopathy patient with a homozygous amino acid substitution that destabilizes the collagen VI α2(VI) chain. J Biol Chem (2014) 1.30
The role of CLCA proteins in inflammatory airway disease. Annu Rev Physiol (2009) 1.26
The extracellular matrix and blood vessel formation: not just a scaffold. J Cell Mol Med (2007) 1.25
The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family. BMC Evol Biol (2005) 1.23
Complete genomic sequence and mass spectrometric analysis of highly diverse, atypical Bacillus thuringiensis phage 0305phi8-36. Virology (2007) 1.21
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis. PLoS Biol (2007) 1.21
Diversity in domain architectures of Ser/Thr kinases and their homologues in prokaryotes. BMC Genomics (2005) 1.20
straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol (2008) 1.20
The alpha-kinase family: an exceptional branch on the protein kinase tree. Cell Mol Life Sci (2009) 1.16
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A (2008) 1.15
Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3. Hum Mutat (2005) 1.12
The calcium channel alpha2/delta1 subunit is involved in extracellular signalling. J Physiol (2007) 1.11
Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. Am J Pathol (2006) 1.11
Genomic and functional analyses of Rhodococcus equi phages ReqiPepy6, ReqiPoco6, ReqiPine5, and ReqiDocB7. Appl Environ Microbiol (2010) 1.09
The cytoplasmic domain of anthrax toxin receptor 1 affects binding of the protective antigen. Infect Immun (2008) 1.09
The dark sides of capillary morphogenesis gene 2. EMBO J (2011) 1.08
Identification of the cglC, cglD, cglE, and cglF genes and their role in cell contact-dependent gliding motility in Myxococcus xanthus. J Bacteriol (2012) 1.08
Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol (2012) 1.06
Regulation of Arabidopsis COPINE 1 gene expression in response to pathogens and abiotic stimuli. Plant Physiol (2003) 1.04
The regulation of integrin function by divalent cations. Cell Adh Migr (2012) 1.03
A novel marker of tissue junctions, collagen XXII. J Biol Chem (2004) 1.03
Overview: studying integrins in vivo. Methods Mol Biol (2012) 1.02
Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity. PLoS One (2012) 1.01
snRNA 3' end formation: the dawn of the Integrator complex. Biochem Soc Trans (2010) 1.01
Recessive COL6A2 C-globular missense mutations in Ullrich congenital muscular dystrophy: role of the C2a splice variant. J Biol Chem (2010) 1.01
Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development. Mol Cell Proteomics (2011) 1.01
Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1. J Biol Chem (2008) 1.00
An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2. J Cell Biol (2013) 0.98
Cochlin in the eye: functional implications. Prog Retin Eye Res (2007) 0.98
Functional characterization of a redundant Plasmodium TRAP family invasin, TRAP-like protein, by aldolase binding and a genetic complementation test. Eukaryot Cell (2008) 0.98
In yeast, loss of Hog1 leads to osmosensitivity of autophagy. Biochem J (2006) 0.97
Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases. J Biol Chem (2007) 0.96
Identification and characterization of a novel alpha-kinase with a von Willebrand factor A-like motif localized to the contractile vacuole and Golgi complex in Dictyostelium discoideum. Mol Biol Cell (2005) 0.95
Copine A, a calcium-dependent membrane-binding protein, transiently localizes to the plasma membrane and intracellular vacuoles in Dictyostelium. BMC Cell Biol (2005) 0.94
Role of protein misfolding in DFNA9 hearing loss. J Biol Chem (2010) 0.94
Cloning and characterization of the osteoarthritis-associated gene DVWA. J Bone Miner Metab (2010) 0.94
Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Mol Cell (2015) 0.94
Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry. J Proteome Res (2013) 0.93
L-type calcium channel targeting and local signalling in cardiac myocytes. Cardiovasc Res (2013) 0.93
Underexpression of the plant NOTCHLESS gene, encoding a WD-repeat protein, causes pleitropic phenotype during plant development. Planta (2006) 0.92
Unexpected diversity of cnidarian integrins: expression during coral gastrulation. BMC Evol Biol (2008) 0.91
Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea. Biol Direct (2010) 0.91
Characterization of the Bat proteins in the oxidative stress response of Leptospira biflexa. BMC Microbiol (2012) 0.90
Structural features of the Pseudomonas fluorescens biofilm adhesin LapA required for LapG-dependent cleavage, biofilm formation, and cell surface localization. J Bacteriol (2014) 0.90
The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins. BMC Bioinformatics (2003) 0.89
Comparative genomics of Bacillus thuringiensis phage 0305phi8-36: defining patterns of descent in a novel ancient phage lineage. Virol J (2007) 0.89
Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor. Biochem J (2005) 0.89
The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic Acids Res (2005) 0.89
Nitric oxide affects ERK signaling through down-regulation of MAP kinase phosphatase levels during larval development of the ascidian Ciona intestinalis. PLoS One (2014) 0.88
Limited polymorphism in Plasmodium falciparum ookinete surface antigen, von Willebrand factor A domain-related protein from clinical isolates. Malar J (2006) 0.88
Functional and phylogenetic characterization of proteins detected in various nematode intestinal compartments. Mol Cell Proteomics (2015) 0.88
Distribution in microbial genomes of genes similar to lodA and goxA which encode a novel family of quinoproteins with amino acid oxidase activity. BMC Genomics (2015) 0.88
Mitis group streptococci express variable pilus islet 2 pili. PLoS One (2011) 0.88
FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis. Nat Commun (2012) 0.88
Copine A is required for cytokinesis, contractile vacuole function, and development in Dictyostelium. Eukaryot Cell (2007) 0.88
Ancient origin of animal U-box ubiquitin ligases. BMC Evol Biol (2010) 0.87
Transgenic expression of the von Willebrand A domain of the BONZAI 1/COPINE 1 protein triggers a lesion-mimic phenotype in Arabidopsis. Planta (2004) 0.87
Cochlin and glaucoma: a mini-review. Vis Neurosci (2005) 0.87
B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes. Dev Cell (2014) 0.87
HYPERSENSITIVE TO HIGH LIGHT1 interacts with LOW QUANTUM YIELD OF PHOTOSYSTEM II1 and functions in protection of photosystem II from photodamage in Arabidopsis. Plant Cell (2014) 0.87
Structural and functional investigations of Matrilin-1 A-domains reveal insights into their role in cartilage ECM assembly. J Biol Chem (2010) 0.87
CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans. Mol Biol Cell (2013) 0.86
A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein. Structure (2013) 0.86
Chaperone role for proteins p618 and p892 in the extracellular tail development of Acidianus two-tailed virus. J Virol (2011) 0.86
The molecular evolution of the pif family proteins in various species of mollusks. Mar Biotechnol (NY) (2012) 0.86
Evolutionary reshaping of fungal mating pathway scaffold proteins. MBio (2011) 0.86
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Integrins: versatility, modulation, and signaling in cell adhesion. Cell (1992) 34.06
Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res (2002) 25.06
SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res (2000) 17.77
Genes expressed in human tumor endothelium. Science (2000) 10.75
The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem (1999) 8.97
Identification of the cellular receptor for anthrax toxin. Nature (2001) 8.78
Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science (2001) 8.12
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science (2002) 7.87
The general transcription factors of RNA polymerase II. Genes Dev (1996) 7.15
Computational inference of homologous gene structures in the human genome. Genome Res (2001) 6.96
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature (2001) 6.29
Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem (1998) 6.14
Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol (2001) 6.05
Structural basis of collagen recognition by integrin alpha2beta1. Cell (2000) 4.84
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell (1995) 4.73
DExD/H box RNA helicases: from generic motors to specific dissociation functions. Mol Cell (2001) 4.72
Bootstrap confidence levels for phylogenetic trees. Proc Natl Acad Sci U S A (1996) 4.19
Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell (2001) 3.95
Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct (2001) 3.74
The AAA team: related ATPases with diverse functions. Trends Cell Biol (1998) 3.48
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. J Biol Chem (1993) 3.34
Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J Mol Biol (1999) 3.28
Evolution of domain families. Adv Protein Chem (2000) 2.98
The evolution of cell adhesion. J Cell Biol (2000) 2.84
Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome. EMBO J (2001) 2.66
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol (2002) 2.56
Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea. J Bacteriol (2000) 2.46
RNA polymerase II holoenzymes and subcomplexes. J Biol Chem (1998) 2.39
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo. Proc Natl Acad Sci U S A (2001) 2.35
Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib. J Biol Chem (1998) 2.22
Evolution of organellar genomes. Curr Opin Genet Dev (1999) 2.17
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J Cell Biol (1999) 2.14
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc Natl Acad Sci U S A (1995) 2.12
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res (2000) 2.06
Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes. Science (2000) 1.93
Cation binding to the integrin CD11b I domain and activation model assessment. Structure (1998) 1.90
Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. Trends Biochem Sci (2000) 1.84
Homologues of 26S proteasome subunits are regulators of transcription and translation. Protein Sci (1998) 1.79
Cloning of an epithelial chloride channel from bovine trachea. J Biol Chem (1995) 1.77
Mutation analysis and molecular genetics of epidermolysis bullosa. Matrix Biol (1999) 1.70
A humidity-sensitive Arabidopsis copine mutant exhibits precocious cell death and increased disease resistance. Plant Cell (2001) 1.69
Crystal structure of the I domain from integrin alpha2beta1. J Biol Chem (1997) 1.69
Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions. Development (2001) 1.65
Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia. Nat Genet (2001) 1.64
p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair. EMBO J (1994) 1.59
Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins. Matrix (1993) 1.52
Plant growth homeostasis is controlled by the Arabidopsis BON1 and BAP1 genes. Genes Dev (2001) 1.52
The matrilins: a novel family of oligomeric extracellular matrix proteins. Matrix Biol (1999) 1.46
Changing ligand specificities of alphavbeta1 and alphavbeta3 integrins by swapping a short diverse sequence of the beta subunit. J Biol Chem (1997) 1.45
Structural and functional features of the alpha 3 chain indicate a bridging role for chicken collagen VI in connective tissues. Biochemistry (1990) 1.45
Inter-alpha-trypsin inhibitor proteoglycan family--a group of proteins binding and stabilizing the extracellular matrix. Eur J Biochem (1998) 1.44
Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain. J Biol Chem (2000) 1.43
Mechanism and regulation of Mg-chelatase. Biochem J (1997) 1.41
Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18). Proc Natl Acad Sci U S A (1994) 1.39
Subunits of purified calcium channels. Alpha 2 and delta are encoded by the same gene. J Biol Chem (1990) 1.39
Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit. J Biol Chem (1996) 1.37
Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland. Am J Physiol (1999) 1.37
The inter-alpha-inhibitor family: from structure to regulation. Biochem J (1996) 1.35
I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1. J Biol Chem (1994) 1.31
The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. J Biol Chem (1998) 1.28
Characterization of the nitric oxide reductase-encoding region in Rhodobacter sphaeroides 2.4.3. J Bacteriol (1997) 1.28
Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9. Hum Mol Genet (2001) 1.25
Ser968Thr mutation within the A3 domain of von Willebrand factor (VWF) in two related patients leads to a defective binding of VWF to collagen. Thromb Haemost (2001) 1.25
Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit. Eur J Neurosci (2000) 1.25
Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides. J Biol Chem (1995) 1.21
Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage? Mol Cell Biol (1999) 1.21
Molecular characteristics and functional diversity of CLCA family members. Clin Exp Pharmacol Physiol (2000) 1.21
Mediation of lung metastasis of murine melanomas by a lung-specific endothelial cell adhesion molecule. Proc Natl Acad Sci U S A (1991) 1.17
The Thrombospondin-related Protein Family of Apicomplexan Parasites: The Gears of the Cell Invasion Machinery. Parasitol Today (1998) 1.17
Complex evolution of photosynthesis. Annu Rev Plant Biol (2002) 1.16
Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem (2002) 1.14
The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. Biochemistry (2002) 1.13
A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain. FEBS Lett (1997) 1.11
Degradation of Id proteins by the ubiquitin-proteasome pathway. FASEB J (1999) 1.11
The von willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motif. J Biol Chem (1997) 1.10
Matrilin-3 forms disulfide-linked oligomers with matrilin-1 in bovine epiphyseal cartilage. J Biol Chem (1998) 1.10
Cloning and characterization of lung-endothelial cell adhesion molecule-1 suggest it is an endothelial chloride channel. J Biol Chem (1997) 1.08
Identification of the collagen-binding site of the von Willebrand factor A3-domain. J Biol Chem (2000) 1.06
Surface loops adjacent to the cation-binding site of the complement factor B von Willebrand factor type A module determine C3b binding specificity. Biochemistry (1997) 1.06
Evolution of von Willebrand factor A (VWA) domains. Biochem Soc Trans (1999) 1.06
Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23. Genomics (1997) 1.05
Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization. Dev Dyn (1999) 1.04
Assembly of a novel cartilage matrix protein filamentous network: molecular basis of differential requirement of von Willebrand factor A domains. Mol Biol Cell (1999) 1.04
Coelomocytes express SpBf, a homologue of factor B, the second component in the sea urchin complement system. J Immunol (1998) 1.03
Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis. Biochemistry (1999) 1.03
Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1. J Biol Chem (1999) 1.02
Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome. J Biol Chem (1997) 0.98
MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans. J Cell Biol (2001) 0.98
von Willebrand factor binds to native collagen VI primarily via its A1 domain. Biochem J (1997) 0.97
Use of site-directed antibodies to probe the topography of the alpha 2 subunit of voltage-gated Ca2+ channels. FEBS Lett (1995) 0.97
Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. Oncogene (1999) 0.96
Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels. Biochim Biophys Acta (1999) 0.96
Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein. Biochemistry (2000) 0.95
mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes. J Cell Biol (2001) 0.94
Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von Willebrand factor A domains. Biochem J (2000) 0.94
Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility. J Immunol (1998) 0.93
Beta 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (alpha L beta 2, CD11a/CD18) and MAC-1 (alpha M beta 2, CD11b/CD18). J Biol Chem (1995) 0.93
Complete replication of hepatitis C virus in cell culture. Science (2005) 18.59
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell (2011) 6.21
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med (2002) 4.87
Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell (2003) 3.68
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci U S A (2002) 3.10
CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nat Med (2002) 2.77
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc Natl Acad Sci U S A (2012) 2.51
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol Cell Proteomics (2011) 2.43
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 2.28
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A (2007) 2.18
Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (2004) 2.14
GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci U S A (2006) 2.08
Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res (2008) 1.99
Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol (2002) 1.97
GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci (2008) 1.93
A system for Cre-regulated RNA interference in vivo. Proc Natl Acad Sci U S A (2008) 1.87
Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arterioscler Thromb Vasc Biol (2006) 1.84
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
The echinoderm adhesome. Dev Biol (2006) 1.71
Fibronectins in vascular morphogenesis. Angiogenesis (2009) 1.66
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol (2002) 1.55
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nat Commun (2012) 1.47
Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development (2010) 1.42
In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell (2013) 1.42
The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov (2012) 1.40
Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol (2007) 1.38
Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J Cell Biol (2007) 1.35
Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Mol Cell Biol (2004) 1.34
Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res (2005) 1.33
Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proc Natl Acad Sci U S A (2004) 1.33
Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs. J Exp Med (2002) 1.32
αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest (2010) 1.23
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer (2014) 1.23
Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle (2006) 1.21
CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc Natl Acad Sci U S A (2011) 1.20
Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. Blood (2006) 1.19
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters. Elife (2014) 1.16
Protein 4.1B suppresses prostate cancer progression and metastasis. Proc Natl Acad Sci U S A (2007) 1.16
Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A (2011) 1.13
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development (2011) 1.13
Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities. J Biol Chem (2007) 1.13
GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Res (2011) 1.11
Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion. Development (2002) 1.09
GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle (2007) 1.09
A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Res (2005) 1.08
An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain. Proc Natl Acad Sci U S A (2005) 1.05
The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J Invest Dermatol (2004) 1.05
A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood (2005) 1.03
Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood (2003) 1.01
Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Blood (2005) 1.00
Mena binds α5 integrin directly and modulates α5β1 function. J Cell Biol (2012) 0.98
Towards definition of an ECM parts list: an advance on GO categories. Matrix Biol (2012) 0.97
The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. PLoS One (2010) 0.95
Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clin Exp Metastasis (2007) 0.94
Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development. Eur J Neurosci (2010) 0.94
Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev Biol (2011) 0.92
Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol (2008) 0.92
Extracellular matrix proteins in hemostasis and thrombosis. Cold Spring Harb Perspect Biol (2012) 0.90
Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mech Dev (2007) 0.90
An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. Exp Neurol (2012) 0.87
Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair. Oral Biosci Med (2005) 0.86
Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy. Biomaterials (2009) 0.86
Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells. Int J Cancer (2013) 0.86
Importance of donor- and recipient-derived selectins in cardiac allograft rejection. J Am Soc Nephrol (2007) 0.84
Tumor-lymphatic interactions in an activated stromal microenvironment. J Cell Biochem (2007) 0.84
GPR56 plays varying roles in endogenous cancer progression. Clin Exp Metastasis (2010) 0.83
Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Exp Cell Res (2005) 0.83
Plasma levels of fibronectin bearing the alternatively spliced EIIIB segment are increased after major trauma. J Lab Clin Med (2003) 0.82
The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster. Development (2004) 0.78
Natural killer cells require selectins for suppression of subcutaneous tumors. Cancer Res (2009) 0.78
Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol (2017) 0.75
Guidelines for human embryonic stem cell research. Nat Biotechnol (2005) 0.75