Published in J Biol Chem on March 12, 2010
Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity (2013) 1.50
Hearing and vestibular deficits in the Coch(-/-) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder. Hear Res (2010) 0.92
A novel mutation in COCH-implications for genotype-phenotype correlations in DFNA9 hearing loss. Laryngoscope (2010) 0.82
Extralabyrinthine manifestations of DFNA9. J Assoc Res Otolaryngol (2010) 0.80
Cochlin in normal middle ear and abnormal middle ear deposits in DFNA9 and Coch (G88E/G88E) mice. J Assoc Res Otolaryngol (2014) 0.78
Massively Parallel Sequencing of a Chinese Family with DFNA9 Identified a Novel Missense Mutation in the LCCL Domain of COCH. Neural Plast (2016) 0.75
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell (1998) 16.08
Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56
Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun (1984) 8.14
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell (1997) 7.59
Regulation of protein export from the endoplasmic reticulum. Annu Rev Cell Biol (1988) 4.53
Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Mol Biol Cell (2002) 4.27
Molecular pathways to neurodegeneration. Nat Med (2004) 2.94
Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nat Genet (1998) 2.04
Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9. Genomics (1997) 1.46
Subcellular localisation, secretion, and post-translational processing of normal cochlin, and of mutants causing the sensorineural deafness and vestibular disorder, DFNA9. J Med Genet (2003) 1.44
Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol (2000) 1.39
Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9. Hum Mol Genet (2001) 1.25
Cochlin, a secreted von Willebrand factor type a domain-containing factor, is regulated by leukemia inhibitory factor in the uterus at the time of embryo implantation. Endocrinology (2003) 1.17
Mouse models of Huntington's disease and methodological considerations for therapeutic trials. Biochim Biophys Acta (2009) 1.14
Identification of the protein product of the Coch gene (hereditary deafness gene) as the major component of bovine inner ear protein. Biochim Biophys Acta (2001) 1.13
NMR structure of the LCCL domain and implications for DFNA9 deafness disorder. EMBO J (2001) 1.11
Histopathology of the inner ear in DFNA9. Adv Otorhinolaryngol (2000) 1.11
Mutations in COCH that result in non-syndromic autosomal dominant deafness (DFNA9) affect matrix deposition of cochlin. Hum Genet (2003) 1.05
Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells. J Neurosci (1999) 1.04
Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. Hear Res (2006) 1.04
Mechanisms of cell death in polyglutamine expansion diseases. Curr Opin Pharmacol (2004) 1.02
DFNA9 is a progressive audiovestibular dysfunction with a microfibrillar deposit in the inner ear. Laryngoscope (2000) 1.01
Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases: exposed beta-sheet hypothesis. Curr Pharm Des (2008) 0.99
A novel technique for inducing local inner ear damage. Hear Res (2003) 0.98
A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction. Hum Mol Genet (2008) 0.98
Autosomal dominant sensorineural hearing loss. Pedigrees, audiologic findings, and temporal bone findings in two kindreds. Arch Otolaryngol Head Neck Surg (1991) 0.97
Identification of a novel Cochlin isoform in the perilymph: insights to Cochlin function and the pathogenesis of DFNA9. Biochem Biophys Res Commun (2004) 0.96
Targeted disruption of mouse Coch provides functional evidence that DFNA9 hearing loss is not a COCH haploinsufficiency disorder. Hum Genet (2005) 0.95
Classification and culture of spiral ligament fibrocytes from mice. Hear Res (2000) 0.94
The second von Willebrand type A domain of cochlin has high affinity for type I, type II and type IV collagens. FEBS Lett (2008) 0.92
Surgical techniques for cell transplantation into the mouse cochlea. Acta Otolaryngol Suppl (2004) 0.87
Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med (2010) 13.25
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med (2003) 5.14
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol (2008) 3.59
A decade of caspases. Oncogene (2003) 3.55
Dissecting eIF4E action in tumorigenesis. Genes Dev (2007) 3.53
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol (2003) 3.52
Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol (2010) 3.51
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature (2003) 2.60
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58
Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57
Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51
Elevated A1C in adults without a history of diabetes in the U.S. Diabetes Care (2009) 2.49
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell (2010) 2.40
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem (2006) 2.26
Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 2.10
Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab (2008) 2.06
Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol (2007) 2.01
Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science (2011) 1.97
Comparison of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for retrieval of choledocholithiasis: a meta-analysis of randomized controlled trials. J Gastroenterol (2012) 1.93
Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection. Autophagy (2007) 1.92
Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage (2007) 1.92
Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res (2010) 1.89
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol (2013) 1.89
The Jekyll and Hyde functions of caspases. Dev Cell (2009) 1.87
Lateralization of olfaction in the honeybee Apis mellifera. Curr Biol (2006) 1.79
Measurement of HbA1c from stored whole blood samples in the Atherosclerosis Risk in Communities study. J Diabetes (2010) 1.77
Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett (2005) 1.72
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell (2012) 1.72
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proc Natl Acad Sci U S A (2008) 1.69
Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci (2012) 1.69
Risk factors of primary thyroid dysfunction in early infants born to mothers with autoimmune thyroid disease. Acta Paediatr (2005) 1.67
Number-based visual generalisation in the honeybee. PLoS One (2009) 1.65
LKB1--a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer (2002) 1.62
Apple miRNAs and tasiRNAs with novel regulatory networks. Genome Biol (2012) 1.61
Diagnostic performance of urea breath test, rapid urea test, and histology for Helicobacter pylori infection in patients with partial gastrectomy: a meta-analysis. J Clin Gastroenterol (2012) 1.61
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A (2010) 1.61
Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes Dev (2008) 1.60
Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci (2002) 1.58
Primary glioblastoma of the cerebellopontine angle in adults. J Neurosurg (2011) 1.55
Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age. BMC Biol (2010) 1.55
Delta 2-specific opioid receptor agonist and hibernating woodchuck plasma fraction provide ischemic neuroprotection. Acad Emerg Med (2008) 1.51
Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy (2010) 1.51
Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity (2013) 1.50
Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chem Biol (2011) 1.50
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J (2004) 1.46
Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death. Endocrinology (2006) 1.43
Mitochondrial DNA evidence for a diversified origin of workers building First Emperor of China. PLoS One (2008) 1.40
Primary cardiac hemangioendothelioma: a case report. Chin Med J (Engl) (2006) 1.39
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev (2007) 1.38
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J Neurosci (2010) 1.38
Large scale homing in honeybees. PLoS One (2011) 1.38
Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Res (2006) 1.37
Control of life-or-death decisions by RIP1 kinase. Annu Rev Physiol (2013) 1.37
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci U S A (2002) 1.36
A novel tracing algorithm for high throughput imaging Screening of neuron-based assays. J Neurosci Methods (2006) 1.35
Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol Res (2005) 1.33
Inhibition of cellular autophagy deranges dengue virion maturation. J Virol (2012) 1.32
A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem (2005) 1.31
Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J Biol Chem (2004) 1.31
Pathways between nonmedical opioid use/dependence and psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depend (2009) 1.30
Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. J Comp Neurol (2007) 1.30
Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem (2007) 1.27
Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol (2008) 1.27
Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett (2006) 1.26
Microbial conversion of glycerol to 1,3-propanediol by an engineered strain of Escherichia coli. Appl Environ Microbiol (2009) 1.24
Structural basis of RIP1 inhibition by necrostatins. Structure (2013) 1.23
c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Mol Cell (2007) 1.23
Strain-dependent variability in growth and survival of Escherichia coli in agricultural soil. FEMS Microbiol Ecol (2003) 1.23
Prevalence of overweight, obesity, and associated risk factors among school children and adolescents in Tianjin, China. Eur J Pediatr (2011) 1.22
Activation of necroptosis in multiple sclerosis. Cell Rep (2015) 1.21
Detection of circulating cancer cells in lung cancer patients with a panel of marker genes. Biochem Biophys Res Commun (2008) 1.19
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. J Biol Chem (2007) 1.18
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities. J Med Chem (2002) 1.18
A genome-wide RNAi screen reveals multiple regulators of caspase activation. J Cell Biol (2007) 1.17
The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair. Mol Cell Biol (2004) 1.16
Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J Neurosci (2002) 1.15
Phylogenetic analysis of rubella virus isolated during a period of epidemic transmission in Italy, 1991-1997. J Infect Dis (2003) 1.14
Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals. J Org Chem (2006) 1.14
Nanotoxicity of TiO(2) nanoparticles to erythrocyte in vitro. Food Chem Toxicol (2008) 1.14