Published in Blood on September 26, 2002
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Iron control of erythroid development by a novel aconitase-associated regulatory pathway. Blood (2010) 0.95
Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells. Leukemia (2010) 0.92
Function of the hemochromatosis protein HFE: Lessons from animal models. World J Gastroenterol (2008) 0.85
Oxidative stress and the homeodynamics of iron metabolism. Biomolecules (2015) 0.79
Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation. PLoS One (2012) 0.78
Altered serum iron and copper homeostasis predicts cognitive decline in mild cognitive impairment. J Alzheimers Dis (2012) 0.78
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays. BMC Bioinformatics (2010) 0.75
Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation. J Thromb Haemost (2015) 0.75
Ferritin Level Is Positively Associated with Chronic Kidney Disease in Korean Men, Based on the 2010-2012 Korean National Health and Nutrition Examination Survey. Int J Environ Res Public Health (2016) 0.75
Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver. J Biol Chem (2015) 0.75
Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease. Dig Dis Sci (2015) 0.75
Molecular mechanisms of translational control. Nat Rev Mol Cell Biol (2004) 6.39
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell (2012) 6.22
Transient cyclical methylation of promoter DNA. Nature (2008) 5.19
Acute cholecystitis: early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study, NCT00447304). Ann Surg (2013) 5.12
Nonsense-mediated decay approaches the clinic. Nat Genet (2004) 5.12
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol (2005) 4.27
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature (2007) 3.77
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA (2006) 3.71
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Nat Struct Mol Biol (2007) 3.62
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
A neutral model of transcriptome evolution. PLoS Biol (2004) 3.44
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood (2006) 3.38
Optimization of oligonucleotide-based DNA microarrays. Nucleic Acids Res (2002) 3.36
Y14 and hUpf3b form an NMD-activating complex. Mol Cell (2003) 3.17
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr (2008) 2.98
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell (2005) 2.79
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell (2006) 2.77
3' end mRNA processing: molecular mechanisms and implications for health and disease. EMBO J (2008) 2.67
A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles. Genesis (2004) 2.65
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J (2008) 2.52
Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. Gastroenterology (2004) 2.43
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet (2003) 2.43
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med (2008) 2.18
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl) (2009) 2.15
The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Mol Cell (2010) 2.14
The RNA-binding protein repertoire of embryonic stem cells. Nat Struct Mol Biol (2013) 2.12
NMD: RNA biology meets human genetic medicine. Biochem J (2010) 2.09
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood (2010) 2.02
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol (2002) 1.98
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol (2007) 1.96
Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Nat Struct Biol (2003) 1.95
Endostatin's antiangiogenic signaling network. Mol Cell (2004) 1.95
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat Struct Mol Biol (2012) 1.91
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell (2005) 1.91
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90
Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood (2003) 1.84
Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res (2006) 1.82
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Mol Cell (2009) 1.82
Zinc monotherapy is not as effective as chelating agents in treatment of Wilson disease. Gastroenterology (2010) 1.80
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A (2002) 1.77
Translational control via protein-regulated upstream open reading frames. Cell (2011) 1.76
Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment. Gut (2011) 1.75
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Biochem J (2003) 1.74
Prognostic aspects of 18F-FDG PET kinetics in patients with metastatic colorectal carcinoma receiving FOLFOX chemotherapy. J Nucl Med (2004) 1.74
Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol (2003) 1.73
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med (2007) 1.73
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med (Berl) (2008) 1.71
Disassembly of exon junction complexes by PYM. Cell (2009) 1.69
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet (2004) 1.68
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One (2009) 1.67
The diagnosis and treatment of minimal hepatic encephalopathy. Dtsch Arztebl Int (2012) 1.67
Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction. Stem Cells (2005) 1.62
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood (2005) 1.59
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Genome Biol (2004) 1.59
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Genome Biol (2002) 1.58
Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues. Clin Chem (2003) 1.57
Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res (2004) 1.56
Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab (2008) 1.55
Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway. Digestion (2005) 1.55
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab (2008) 1.54
Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin Cancer Res (2006) 1.53
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway. Nucleic Acids Res (2007) 1.53
Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci (2006) 1.52
Using the lambdaN peptide to tether proteins to RNAs. Methods Mol Biol (2004) 1.52
Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis. Blood (2004) 1.51
FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell (2004) 1.51
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
Regulation of transferrin-induced endocytosis by wild-type and C282Y-mutant HFE in transfected HeLa cells. Am J Physiol Cell Physiol (2002) 1.47
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame. RNA (2010) 1.46
Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype. J Mol Med (Berl) (2003) 1.46
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA (2006) 1.46
Iron metabolism and the role of HFE gene polymorphisms in Wilson disease. Liver Int (2011) 1.44
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay. Blood (2002) 1.43
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes. Nat Protoc (2008) 1.43
Occult cytomegalovirus cholangitis as a potential cause of cholestatic complications after orthotopic liver transplantation? A study of cytomegalovirus DNA in bile. Liver Transpl (2013) 1.42
One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat (2007) 1.41
The influence of haemodialysis on haemodynamic measurements using transpulmonary thermodilution in patients with septic shock: an observational study. Eur J Anaesthesiol (2013) 1.40
RNA-binding proteins in Mendelian disease. Trends Genet (2013) 1.38
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol (2004) 1.37
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. Proc Natl Acad Sci U S A (2005) 1.36
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Mol Cell (2004) 1.36
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood (2009) 1.33
Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J Mol Med (Berl) (2006) 1.32
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription. EMBO J (2002) 1.30
Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis. Inflamm Bowel Dis (2009) 1.30
Late-onset Wilson's disease. Gastroenterology (2007) 1.30
Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J Biol Chem (2005) 1.29
Anti-inflammatory effects of phosphatidylcholine. J Biol Chem (2007) 1.29
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol (2012) 1.28
A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye. Dev Cell (2002) 1.27
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. EMBO J (2007) 1.27
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem (2006) 1.25
Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes. Oncogene (2003) 1.24
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. PLoS Biol (2009) 1.24
The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA. Mol Cell (2009) 1.23