Published in Oncogene on September 04, 2003
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med (2007) 3.48
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell Death Dis (2011) 1.79
Subcellular localization and function of alternatively spliced Noxo1 isoforms. Free Radic Biol Med (2006) 1.76
Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Pharmacol Ther (2010) 1.66
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer (2008) 1.48
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci (2012) 1.44
Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem (2011) 1.26
NADPH oxidases in vascular pathology. Antioxid Redox Signal (2013) 1.17
NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease. Antioxid Redox Signal (2012) 1.12
ROS-induced ROS release in vascular biology: redox-redox signaling. Am J Physiol Heart Circ Physiol (2011) 1.11
Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin. PLoS Pathog (2009) 1.11
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys. Oxid Med Cell Longev (2013) 0.95
Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. Free Radic Biol Med (2014) 0.94
Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy. Blood (2009) 0.93
BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells. PLoS One (2012) 0.92
Up-regulation of BLT2 is critical for the survival of bladder cancer cells. Exp Mol Med (2011) 0.91
Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Med Gas Res (2012) 0.90
Enhanced tumorigenicity by mitochondrial DNA mild mutations. Oncotarget (2015) 0.89
Ras promotes transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells. J Biol Chem (2014) 0.89
7-Dehydrocholesterol enhances ultraviolet A-induced oxidative stress in keratinocytes: roles of NADPH oxidase, mitochondria, and lipid rafts. Free Radic Biol Med (2006) 0.88
Thyroid hormone induces artery smooth muscle cell proliferation: discovery of a new TRalpha1-Nox1 pathway. J Cell Mol Med (2010) 0.85
Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes. Free Radic Biol Med (2007) 0.85
Targeting the redox balance in inflammatory skin conditions. Int J Mol Sci (2013) 0.84
Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells. Redox Biol (2015) 0.84
Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells. J Biol Chem (2013) 0.83
Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells. J Cancer Res Clin Oncol (2011) 0.78
Study designs to investigate Nox1 acceleration of neoplastic progression in immortalized human epithelial cells by selection of differentiation resistant cells. Redox Biol (2013) 0.76
Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218. Mol Cell Biochem (2016) 0.75
Antimicrobial activity does not predict cytokine response to adrenomedullin or its shortened derivatives. Mediators Inflamm (2007) 0.75
Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein. Redox Biol (2016) 0.75
The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol (2005) 6.27
Acute cholecystitis: early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study, NCT00447304). Ann Surg (2013) 5.12
Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med (2007) 3.44
A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles. Genesis (2004) 2.65
Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. Gastroenterology (2004) 2.43
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med (2008) 2.18
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J Invest Dermatol (2004) 1.97
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90
Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood (2003) 1.84
Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res (2006) 1.82
Zinc monotherapy is not as effective as chelating agents in treatment of Wilson disease. Gastroenterology (2010) 1.80
Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment. Gut (2011) 1.75
Prognostic aspects of 18F-FDG PET kinetics in patients with metastatic colorectal carcinoma receiving FOLFOX chemotherapy. J Nucl Med (2004) 1.74
Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol (2003) 1.73
The diagnosis and treatment of minimal hepatic encephalopathy. Dtsch Arztebl Int (2012) 1.67
Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chem Biol (2012) 1.60
Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues. Clin Chem (2003) 1.57
Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab (2008) 1.55
Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway. Digestion (2005) 1.55
Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin Cancer Res (2006) 1.53
Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci (2006) 1.52
FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell (2004) 1.51
Patient-specific finite element modeling of respiratory lung motion using 4D CT image data. Med Phys (2009) 1.48
Regulation of transferrin-induced endocytosis by wild-type and C282Y-mutant HFE in transfected HeLa cells. Am J Physiol Cell Physiol (2002) 1.47
Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype. J Mol Med (Berl) (2003) 1.46
Iron metabolism and the role of HFE gene polymorphisms in Wilson disease. Liver Int (2011) 1.44
Occult cytomegalovirus cholangitis as a potential cause of cholestatic complications after orthotopic liver transplantation? A study of cytomegalovirus DNA in bile. Liver Transpl (2013) 1.42
One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat (2007) 1.41
The influence of haemodialysis on haemodynamic measurements using transpulmonary thermodilution in patients with septic shock: an observational study. Eur J Anaesthesiol (2013) 1.40
Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain. Biochemistry (2010) 1.38
Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J Mol Med (Berl) (2006) 1.32
NAD(P)H oxidases in rat basilar arterial endothelial cells. Stroke (2005) 1.31
Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. J Immunol (2004) 1.30
Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis. Inflamm Bowel Dis (2009) 1.30
Late-onset Wilson's disease. Gastroenterology (2007) 1.30
Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J Biol Chem (2005) 1.29
Anti-inflammatory effects of phosphatidylcholine. J Biol Chem (2007) 1.29
Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. Am J Physiol Cell Physiol (2004) 1.28
A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells. Nucleic Acids Res (2013) 1.22
NADPH oxidases in the gastrointestinal tract: a potential role of Nox1 in innate immune response and carcinogenesis. Antioxid Redox Signal (2006) 1.21
An orthotopic colon cancer model for studying the B7-H3 antitumor effect in vivo. J Gastrointest Surg (2006) 1.21
Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes. Gastroenterology (2005) 1.21
Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20
Safety analysis of endoscopist-directed propofol sedation: a prospective, national multicenter study of 24 441 patients in German outpatient practices. J Gastroenterol Hepatol (2014) 1.20
Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts. Biochim Biophys Acta (2006) 1.19
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon. Cancer Lett (2005) 1.18
Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res (2013) 1.17
Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach. Free Radic Biol Med (2007) 1.16
The role of dominant stenoses in bacterial infections of bile ducts in primary sclerosing cholangitis. Eur J Gastroenterol Hepatol (2006) 1.16
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology (2007) 1.15
Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students. Int J Psychophysiol (2011) 1.14
Long-chain fatty acid uptake into adipocytes depends on lipid raft function. Biochemistry (2004) 1.14
NADPH oxidase-derived reactive oxygen species are essential for differentiation of a mouse macrophage cell line (RAW264.7) into osteoclasts. J Med Invest (2009) 1.14
Acyl-CoA synthetases: fatty acid uptake and metabolic channeling. Mol Cell Biochem (2008) 1.13
Translocation of long chain fatty acids across the plasma membrane--lipid rafts and fatty acid transport proteins. Mol Cell Biochem (2006) 1.13
Codon optimization of the human papillomavirus 11 (HPV 11) L1 gene leads to increased gene expression and formation of virus-like particles in mammalian epithelial cells. Virology (2004) 1.13
Posttranslationally modified proteins as mediators of sustained intestinal inflammation. Am J Pathol (2006) 1.13
Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). BMC Cell Biol (2008) 1.13
Identification of marker genes for differential diagnosis of chronic fatigue syndrome. Mol Med (2008) 1.12
Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection. J Hepatol (2003) 1.11
Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol (2008) 1.11
Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis. J Infect Dis (2002) 1.08
Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients. World J Gastroenterol (2010) 1.07
Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells. Am J Physiol Cell Physiol (2005) 1.07
Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells. J Gastroenterol (2012) 1.07
The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology (2007) 1.07
Gene expression and association analysis of LIM (PDLIM5) in major depression. Neurosci Lett (2006) 1.06
Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer (2010) 1.05
Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice. Physiol Genomics (2009) 1.05
Expression analysis of psychological stress-associated genes in peripheral blood leukocytes. Neurosci Lett (2005) 1.05
Excellent results with cementless total hip arthroplasty and alumina-on-alumina pairing: minimum ten-year follow-up. Int Orthop (2010) 1.04
Prognostic significance of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in patients with breast cancer. J Mol Med (Berl) (2009) 1.03
Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res (2002) 1.03
Alterations in intestinal fatty acid metabolism in inflammatory bowel disease. Biochim Biophys Acta (2006) 1.03
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Blood (2007) 1.03
Immunosuppression and modulation in liver transplantation. Nephrol Dial Transplant (2004) 1.03
Efficacy and safety of oral chelators in treatment of patients with Wilson disease. Clin Gastroenterol Hepatol (2013) 1.02
Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals. Immunology (2002) 1.01
Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor. Am J Physiol Lung Cell Mol Physiol (2003) 1.01
Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure? World J Gastroenterol (2007) 1.00
Testing for anti-p53 antibodies increases the diagnostic sensitivity of conventional tumor markers. Int J Oncol (2006) 1.00
Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer. Oncol Rep (2007) 0.99
Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J Invest Dermatol (2005) 0.99
Dominant negative (DeltaN) p63alpha induces drug resistance in hepatocellular carcinoma by interference with apoptosis signaling pathways. Biochem Biophys Res Commun (2010) 0.99
Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients. J Mol Med (Berl) (2004) 0.98
Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Blood (2002) 0.98
A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. J Invest Dermatol (2004) 0.98
Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site. FASEB J (2004) 0.98
TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells. BMC Gastroenterol (2009) 0.98
Bezafibrate, a peroxisome proliferator-activated receptors agonist, decreases body temperature and enhances electroencephalogram delta-oscillation during sleep in mice. Endocrinology (2008) 0.97
New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae. Proc Nutr Soc (2004) 0.97
Limitations of the MELD score in predicting mortality or need for removal from waiting list in patients awaiting liver transplantation. BMC Gastroenterol (2009) 0.97
Health-related quality of life correlates with clinical and endoscopic activity indexes but not with demographic features in patients with ulcerative colitis. Inflamm Bowel Dis (2006) 0.97
Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins. J Cell Biochem (2011) 0.97