Published in Mol Cell on November 25, 2009
UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell (2010) 2.04
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Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature (2007) 3.77
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Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood (2006) 3.38
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Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr (2008) 2.98
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell (2005) 2.79
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Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J (2008) 2.52
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet (2003) 2.43
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl) (2009) 2.15
The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Mol Cell (2010) 2.14
The RNA-binding protein repertoire of embryonic stem cells. Nat Struct Mol Biol (2013) 2.12
NMD: RNA biology meets human genetic medicine. Biochem J (2010) 2.09
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood (2010) 2.02
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol (2002) 1.98
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol (2007) 1.96
Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Nat Struct Biol (2003) 1.95
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat Struct Mol Biol (2012) 1.91
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell (2005) 1.91
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Mol Cell (2009) 1.82
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A (2002) 1.77
Translational control via protein-regulated upstream open reading frames. Cell (2011) 1.76
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Biochem J (2003) 1.74
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med (2007) 1.73
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med (Berl) (2008) 1.71
Disassembly of exon junction complexes by PYM. Cell (2009) 1.69
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet (2004) 1.68
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One (2009) 1.67
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood (2005) 1.59
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Genome Biol (2004) 1.59
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Genome Biol (2002) 1.58
Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab (2008) 1.55
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab (2008) 1.54
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway. Nucleic Acids Res (2007) 1.53
Using the lambdaN peptide to tether proteins to RNAs. Methods Mol Biol (2004) 1.52
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
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Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA (2006) 1.46
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
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RNA-binding proteins in Mendelian disease. Trends Genet (2013) 1.38
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol (2004) 1.37
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. Proc Natl Acad Sci U S A (2005) 1.36
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Mol Cell (2004) 1.36
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood (2009) 1.33
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol (2012) 1.28
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. EMBO J (2007) 1.27
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem (2006) 1.25
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. PLoS Biol (2009) 1.24
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev (2006) 1.22
Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon. RNA (2011) 1.19
The human intronless melanocortin 4-receptor gene is NMD insensitive. Hum Mol Genet (2002) 1.19
Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA. Mol Cell (2003) 1.18
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem (2005) 1.17
System-wide identification of RNA-binding proteins by interactome capture. Nat Protoc (2013) 1.15
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab (2013) 1.14
Iron regulatory proteins secure mitochondrial iron sufficiency and function. Cell Metab (2010) 1.14
Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J Neurosci Res (2003) 1.13
miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes. Methods (2007) 1.10
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat Genet (2006) 1.07
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. Blood (2004) 1.06
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD). Nucleic Acids Res (2006) 1.03
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Blood (2007) 1.03
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region. Nucleic Acids Res (2007) 1.03
A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA. EMBO J (2003) 1.02
A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells. Methods Mol Biol (2004) 1.02
Molecular analysis of iron overload in beta2-microglobulin-deficient mice. Blood Cells Mol Dis (2004) 1.01
p38 MAPK controls prothrombin expression by regulated RNA 3' end processing. Mol Cell (2011) 1.01
Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. RNA (2004) 1.00
From cis-regulatory elements to complex RNPs and back. Cold Spring Harb Perspect Biol (2012) 0.98
Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Blood (2002) 0.98
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. J Hepatol (2007) 0.97
The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast. RNA (2003) 0.97
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins. Blood (2011) 0.96
Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail. RNA (2008) 0.95
A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay. Biochem Biophys Res Commun (2006) 0.95
Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin. J Mol Med (Berl) (2003) 0.95
Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes. Genesis (2005) 0.95
Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay. EMBO Rep (2006) 0.94
Iron regulatory proteins control a mucosal block to intestinal iron absorption. Cell Rep (2013) 0.93
SIREs: searching for iron-responsive elements. Nucleic Acids Res (2010) 0.93
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism. Blood (2008) 0.93
An efficient factor-depleted mammalian in vitro translation system. Nat Protoc (2011) 0.92
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond. J Mol Med (Berl) (2013) 0.90
The molecular circuitry regulating the switch between iron deficiency and overload in mice. J Biol Chem (2006) 0.89
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays. Nat Protoc (2007) 0.88
Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis. Cell Microbiol (2004) 0.85
mRNA 3'end processing: A tale of the tail reaches the clinic. EMBO Mol Med (2014) 0.84
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation. J Mol Med (Berl) (2009) 0.83