Published in J Cell Biol on October 28, 2002
Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol (2004) 4.96
ER chaperones in mammalian development and human diseases. FEBS Lett (2007) 4.40
Protein quality control in the early secretory pathway. EMBO J (2008) 3.59
Gangliosides are receptors for murine polyoma virus and SV40. EMBO J (2003) 2.99
For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J (2003) 2.82
Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell (2010) 2.51
Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell (2003) 2.22
Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44. EMBO J (2003) 1.96
Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol Lett (2006) 1.65
Retrograde transport pathways utilised by viruses and protein toxins. Virol J (2006) 1.61
Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum. Biochem J (2004) 1.56
Derlin-1 facilitates the retro-translocation of cholera toxin. Mol Biol Cell (2007) 1.55
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel) (2010) 1.34
Cholera toxin - a foe & a friend. Indian J Med Res (2011) 1.31
Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase. J Cell Biol (2008) 1.28
Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep (2004) 1.28
Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J Clin Invest (2010) 1.19
TorsinA participates in endoplasmic reticulum-associated degradation. Nat Commun (2011) 1.18
The activities and function of molecular chaperones in the endoplasmic reticulum. Semin Cell Dev Biol (2007) 1.16
The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect. Mol Biol Cell (2005) 1.15
The catalytic activity of protein-disulfide isomerase requires a conformationally flexible molecule. J Biol Chem (2008) 1.12
Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a'. J Biol Chem (2011) 1.11
Oxidative activity of yeast Ero1p on protein disulfide isomerase and related oxidoreductases of the endoplasmic reticulum. J Biol Chem (2010) 1.06
N-terminal extension of the cholera toxin A1-chain causes rapid degradation after retrotranslocation from endoplasmic reticulum to cytosol. J Biol Chem (2010) 1.05
Protein-disulfide isomerase displaces the cholera toxin A1 subunit from the holotoxin without unfolding the A1 subunit. J Biol Chem (2011) 1.02
The cholera toxin A1(3) subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosol. Infect Immun (2006) 1.02
Generating an unfoldase from thioredoxin-like domains. J Biol Chem (2009) 0.99
Roles of protein-disulfide isomerase-mediated disulfide bond formation of yeast Mnl1p in endoplasmic reticulum-associated degradation. J Biol Chem (2009) 0.97
The endoplasmic reticulum-associated degradation pathways of budding yeast. Cold Spring Harb Perspect Biol (2012) 0.95
How viruses use the endoplasmic reticulum for entry, replication, and assembly. Cold Spring Harb Perspect Biol (2013) 0.93
The Ero1alpha-PDI redox cycle regulates retro-translocation of cholera toxin. Mol Biol Cell (2010) 0.93
Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front Cell Infect Microbiol (2012) 0.92
The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B. Mol Cell Biol (2004) 0.92
Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family. EMBO J (2003) 0.92
Protein disulfide isomerase and host-pathogen interaction. ScientificWorldJournal (2011) 0.91
Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD. EMBO J (2006) 0.91
Catalysis of protein folding by protein disulfide isomerase and small-molecule mimics. Antioxid Redox Signal (2003) 0.91
A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells. Mol Biol Cell (2007) 0.90
Live cell imaging of protein dislocation from the endoplasmic reticulum. J Biol Chem (2012) 0.90
Contribution of the HEDJ/ERdj3 cysteine-rich domain to substrate interactions. Arch Biochem Biophys (2007) 0.85
Cholera toxin: a paradigm of a multifunctional protein. Indian J Med Res (2011) 0.83
Identification and Characterization of Maize floury4 as a Novel Semidominant Opaque Mutant That Disrupts Protein Body Assembly. Plant Physiol (2014) 0.82
Retrograde trafficking of AB₅ toxins: mechanisms to therapeutics. J Mol Med (Berl) (2013) 0.81
BiP negatively affects ricin transport. Toxins (Basel) (2013) 0.80
Endoplasmic reticulum-dependent redox reactions control endoplasmic reticulum-associated degradation and pathogen entry. Antioxid Redox Signal (2012) 0.79
ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding. J Cell Biol (2015) 0.79
Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamer. Biophys J (2006) 0.78
A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease. Crit Rev Biochem Mol Biol (2015) 0.77
The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore. PLoS One (2015) 0.76
Cholera toxin induces a shift from inactive to active cyclooxygenase 2 in alveolar macrophages activated by Mycobacterium bovis BCG. Infect Immun (2012) 0.75
Design, synthesis, and evaluation of bisubstrate analog inhibitors of cholera toxin. Bioorg Med Chem Lett (2008) 0.75
Endoplasmic Reticulum Oxidase 1α is Critical for Collagen Secretion from and Membrane Type 1-Matrix Metalloproteinase levels in Hepatic Stellate Cells. J Biol Chem (2017) 0.75
Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane. Cell (1993) 7.63
Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol (2002) 4.29
Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science (2000) 3.87
Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell (2001) 3.78
The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum. Mol Cell (1998) 3.78
Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. Mol Cell (1998) 3.57
Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol Rev (1996) 3.46
Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Mol Cell (1999) 3.03
Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response. J Biol Chem (2000) 2.61
Membrane traffic and the cellular uptake of cholera toxin. Biochim Biophys Acta (1999) 2.27
ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem (2000) 2.24
Protein translocation: tunnel vision. Cell (1998) 2.23
ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J (2002) 1.98
Cholera toxin is exported from microsomes by the Sec61p complex. J Cell Biol (2000) 1.90
Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase. J Cell Biol (1999) 1.87
Active site mutations in yeast protein disulfide isomerase cause dithiothreitol sensitivity and a reduced rate of protein folding in the endoplasmic reticulum. J Cell Biol (1997) 1.41
Eps1, a novel PDI-related protein involved in ER quality control in yeast. EMBO J (1999) 1.16
Functional properties of the two redox-active sites in yeast protein disulphide isomerase in vitro and in vivo. J Mol Biol (1999) 1.03
X-ray structure of a protein-conducting channel. Nature (2003) 9.20
A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell (2006) 8.53
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell (2006) 5.54
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol (2003) 4.35
Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol (2002) 4.29
Mathematical models of protein kinase signal transduction. Mol Cell (2002) 4.08
A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell (2009) 3.88
Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature (2008) 3.73
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science (2008) 3.60
Mechanisms determining the morphology of the peripheral ER. Cell (2010) 3.35
Structural organization of the endoplasmic reticulum. EMBO Rep (2002) 3.25
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem (2008) 3.13
Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol (2005) 3.09
Gangliosides are receptors for murine polyoma virus and SV40. EMBO J (2003) 2.99
Rough sheets and smooth tubules. Cell (2006) 2.97
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 2.81
Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol (2009) 2.71
Mechanisms of Sec61/SecY-mediated protein translocation across membranes. Annu Rev Biophys (2011) 2.40
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell (2010) 2.33
The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell (2007) 2.18
Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell (2007) 2.17
Three-dimensional structure of the bacterial protein-translocation complex SecYEG. Nature (2002) 2.16
The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol (2007) 2.09
Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (2011) 2.06
The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell (2007) 2.03
Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell (2013) 1.97
Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell (2002) 1.97
Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol (2005) 1.97
Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol (2005) 1.93
A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A (2004) 1.86
A role for the two-helix finger of the SecA ATPase in protein translocation. Nature (2008) 1.75
Crystal structure of the long-chain fatty acid transporter FadL. Science (2004) 1.74
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep (2002) 1.71
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68
Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell (2007) 1.59
Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. J Biol Chem (2003) 1.55
Weaving the web of ER tubules. Cell (2011) 1.53
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A (2012) 1.46
Structure of a bacterial homologue of vitamin K epoxide reductase. Nature (2010) 1.44
Structure of the mammalian ribosome-channel complex at 17A resolution. J Mol Biol (2002) 1.43
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol (2012) 1.38
Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc Natl Acad Sci U S A (2010) 1.34
Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem (2005) 1.33
RecA-like motor ATPases--lessons from structures. Biochim Biophys Acta (2004) 1.33
A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol (2006) 1.27
Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J (2003) 1.27
Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature (2011) 1.23
Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic (2012) 1.21
Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell (2007) 1.19
Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A (2009) 1.18
Generation of nonidentical compartments in vesicular transport systems. J Cell Biol (2005) 1.17
Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell (2003) 1.12
Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol (2009) 1.11
Bacterial protein translocation requires only one copy of the SecY complex in vivo. J Cell Biol (2012) 1.08
Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane. Mol Biol Cell (2006) 1.04
E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A (2006) 1.04
Structural insight into the protein translocation channel. Curr Opin Struct Biol (2004) 0.99
Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem (2008) 0.98
Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol (2013) 0.95
A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep (2013) 0.91
A novel centrosome-associated protein with affinity for microtubules. J Cell Sci (2002) 0.87
The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett (2008) 0.87
Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem (2007) 0.85